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By:
Megan Foster
and
Raven Leonard
What is Parkinson’s Disease
• Motor system disorder
• Progressive
degenerative disorder
• Imbalance of the
neurotransmitte...
Dopamine imbalance exhibited in
Parkinson’s Disease
Acetylcholine

Dopamine

Normal balance
(Average Joe)
Acetylcholine

D...
5 Stages of Parkinson’s Disease
• Stage 1 – Mild symptoms that inconvenience
day to day tasks.
• Stage 2 – Bilateral sympt...
Major Symptoms
Treatment of Parkinson’s
• Currently there is no cure.
• There is a wide variety of medications on the
market use to treat...
Drugs Used to Treat Parkinson’s
Dopaminergic Drugs
Generic Name

Brand Name

Route Pharmacokinetics regarding
Parkinson’s ...
Parkinson’s Disease Research
• NINDS is using animal models to study the
progression of Parkinson’s.
• NINDS is searching ...
Differences between Parkinson’s and
Alzheimer’s

• Movement
disorder
• Loss of dopamine
producing neurons

• Onset late in...
Acetylcholine imbalance exhibited in
Alzheimer’s Disease
Acetylcholine

Dopamine

Normal balance
(Average Joe)

Acetylchol...
Summary
Parkinson’s disease mainly affects the elderly,
but can occur at any age. The main cause results
from gradual dege...
References
•

•
•

•
•

NINDS Parkinson's Disease Information Page. (n.d.). Parkinson's Disease
Information Page: National...
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Parkinsons megan raven_phm1810

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Parkinsons megan raven_phm1810

  1. 1. By: Megan Foster and Raven Leonard
  2. 2. What is Parkinson’s Disease • Motor system disorder • Progressive degenerative disorder • Imbalance of the neurotransmitters, acetylcholine and dopamine in the brain
  3. 3. Dopamine imbalance exhibited in Parkinson’s Disease Acetylcholine Dopamine Normal balance (Average Joe) Acetylcholine Dopamine Parkinson’s Disease (Michael J. Fox)
  4. 4. 5 Stages of Parkinson’s Disease • Stage 1 – Mild symptoms that inconvenience day to day tasks. • Stage 2 – Bilateral symptoms, affecting both limbs on both sides of the body. • Stage 3 – Severe symptoms. • Stage 4 – Severe symptoms progress. • Stage 5 - Complete immobility
  5. 5. Major Symptoms
  6. 6. Treatment of Parkinson’s • Currently there is no cure. • There is a wide variety of medications on the market use to treat the symptoms of Parkinson’s Disease.
  7. 7. Drugs Used to Treat Parkinson’s Dopaminergic Drugs Generic Name Brand Name Route Pharmacokinetics regarding Parkinson’s Disease Amantadine HCl Symmetrel PO Dopamine agonist- increases the amt. of dopamine in brain Bromocriptine mesylate Parlodel PO Dopamine receptor stimulantencourages the release of dopamine Carbidopalevodopa Sinemet PO Enters the brain, then converted to dopamine Pergolide myselate Permax PO Produces the same effects as dopamine Pramipexole Mirapex PO Stimulates dopamine receptors Ropinirole HCl Requip PO Inhibits nerve responses Selegiline HCl Carbex, Eldepryl PO Increases dopaminergic activity Tolcapone Tasmar PO Selective inhibitor- slows the metabolism of levodopa, prolonging
  8. 8. Parkinson’s Disease Research • NINDS is using animal models to study the progression of Parkinson’s. • NINDS is searching for the cause of Parkinson’s, such as; environmental factors, (i.e. toxins) and genetic factors.
  9. 9. Differences between Parkinson’s and Alzheimer’s • Movement disorder • Loss of dopamine producing neurons • Onset late in life • Neurodegenerative diseases • Progressive • Memory disorder • Acetylcholine progressively diminishes overtime
  10. 10. Acetylcholine imbalance exhibited in Alzheimer’s Disease Acetylcholine Dopamine Normal balance (Average Joe) Acetylcholine Alzheimer’s Disease (Ronald Regan) Dopamine
  11. 11. Summary Parkinson’s disease mainly affects the elderly, but can occur at any age. The main cause results from gradual degeneration of nerve cells in the portion of the midbrain that controls motor skills. Early signs are likely to be barely noticeable, such as: weakness or stiffness of limbs or a trembling of the hands when they are at rest. This disease is more commonly seen in men than in women, and it is not directly life threatening.
  12. 12. References • • • • • NINDS Parkinson's Disease Information Page. (n.d.). Parkinson's Disease Information Page: National Institute of Neurological Disorders and Stroke (NINDS). Retrieved October 30, 2013, from http://www.ninds.nih.gov/disorders/parkinsons_disease/parkinsons_disease.htm Stages of Parkinson's: Stages 1-5 Symptoms. (n.d.). WebMD. Retrieved October 30, 2013, from http://www.webmd.com/parkinsons-disease/guide/parkinsons-stages Moini, Jahangir. "Drug Therapy for Parkinson's and Alzheimer's Disease." Fundamental Pharmacology for Pharmacy Technicians. Clifton Park, NY: Delmar Cengage Learning, 2013. 106-16. Print. Parkinson's Disease/Parkinsonism Causes, Age, and More. (n.d.). WebMD. Retrieved October 30, 2013, from http://www.webmd.com/parkinsonsdisease/guide/understanding-parkinsons-disease-basics Parkinson's Disease Symptoms. (n.d.). The Michael J. Fox Foundation for Parkinson's Research. Retrieved November 1, 2013, from https://www.michaeljfox.org/understanding-parkinsons/living-withpd/topic.php?symptoms

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