Daniela

•Transferir como PPTX, PDF•

0 gostou•647 visualizações

Martina y Aiora

Educação

Mais conteúdo relacionado

Destaque

Calendario2

Martina y Aiora

Cursos de música ACN

jreygue

Universidad de panamá

Power Point

2 enfoque didactico

Biblioteca Central

Cómo hacer diapositivas

Dazia Alejandra Urquidez Rojo

Camoil 2015

Camacho & Meuer

Ziegel 2015

Camacho & Meuer

Public transcriptomic studies have shown that several genes display pronounced gender differences in their expression in the human brain, which may influence the manifestations and risk for neuronal disorders. Here, we apply a transcriptome-wide analysis to discover genes with gender-specific expression and significant alterations in public postmortem brain tissue from Alzheimer’s disease (AD) patients compared to controls. We identify the sex-linked ubiquitin-specific peptidase 9 (USP9) as an outstanding candidate gene with highly significant expression differences between the genders and male-specific underexpression in AD. Since previous studies have shown that USP9 can modulate the phosphorylation of the AD-associated protein MAPT, we investigate functional associations between USP9 and MAPT in further detail. After observing a high positive correlation between the expression of USP9 and MAPT in the public transcriptomics data, we show that USP9 knockdown results in significantly decreased MAPT expression in a DU145 cell culture model and a concentration-dependent decrease for the MAPT orthologs mapta and maptb in a zebrafish model. From the analysis of microarray and qRT-PCR experiments for the knockdown in DU145 cells and prior knowledge from the literature, we derive a data-congruent model for a USP9-dependent regulatory mechanism modulating MAPT expression via BACH1 and SMAD4. Overall, the analyses suggest USP9 may contribute to molecular gender differences observed in tauopathies and provide a new target for intervention strategies to modulate MAPT expression. See associated publication: http://link.springer.com/article/10.1007%2Fs12035-016-0299-z

Modelling gender-specific regulation of tau in Alzheimer’s disease

Enrico Glaab

Ziegel fulva tomates

Camacho & Meuer

Agricultura moderna jesus vidal

Camacho & Meuer

Sales and managment

iqra mobeen

Micromplex 2015

Camacho & Meuer

9 convención mundial del chile.

Camacho & Meuer

Database backup and recovery basics

Shahed Mohamed

Destaque (16)

Calendario2

Cursos de música ACN

Universidad de panamá

Power Point

2 enfoque didactico

Biblioteca Central

Cómo hacer diapositivas

Camoil 2015

Ziegel 2015

Modelling gender-specific regulation of tau in Alzheimer’s disease

Ziegel fulva tomates

Agricultura moderna jesus vidal

Sales and managment

Micromplex 2015

9 convención mundial del chile.

Database backup and recovery basics

Mais de Martina y Aiora

Pasar el día Nacho

Martina y Aiora

Laura, Julia y Ana

Martina y Aiora

Alejandro, Carlos, Sammy y Leo

Martina y Aiora

Marco y Naroba

Martina y Aiora

Miguel Rodrigo Ainara

Martín

Alba V. y Nicolás

Naroba

Ainara y Miguel

Martín Leo G. Gabriel

Kyra

Leo P. y Martina

Valeria Marina v.

Nikki

Martina y Ana

Carrera solidaria 2

Vivenciamos la música

Martina y Aiora

Víctor Leo p. Ari Elia

Martina y Aiora

Salida a dínamo

Martina y Aiora

Plástica

Martina y Aiora

Mais de Martina y Aiora (20)

Pasar el día Nacho

Laura, Julia y Ana

Alejandro, Carlos, Sammy y Leo

Marco y Naroba

Miguel Rodrigo Ainara

Martín

Alba V. y Nicolás

Naroba

Ainara y Miguel

Martín Leo G. Gabriel

Kyra

Leo P. y Martina

Valeria Marina v.

Nikki

Martina y Ana

Carrera solidaria 2

Vivenciamos la música

Víctor Leo p. Ari Elia

Salida a dínamo

Plástica

Último

Grant Readiness 101 TechSoup and Remy Consulting

TechSoup

ICT role in 21st century education and it's challenges.

MaryamAhmad92

Basic Civil Engineering notes first year Notes Building notes Selection of site for Building Layout of a Building What is Burjis, Mutam Building Bye laws Basic Concept of sunlight ventilation in building National Building Code of India Set back or building line Types of Buildings Floor Space Index (F.S.I) Institutional Vs Educational Building Components & function Sills, Lintels, Cantilever Doors, Windows and Ventilators Types of Foundation AND THEIR USES Plinth Area Shallow and Deep Foundation Super Built-up & carpet area Floor Area Ratio (F.A.R) RCC Reinforced Cement Concrete RCC VS PCC

Basic Civil Engineering first year Notes- Chapter 4 Building.pptx

Denish Jangid

Explore the world of IT certification with CompTIA. Discover how the CompTIA Security+ Book SY0-701 can elevate your cybersecurity expertise and open doors to new career opportunities. This PDF provides essential insights into the CompTIA Security+ certification, guiding you through exam preparation and showcasing the benefits of becoming CompTIA-certified. Download now to embark on your journey to IT excellence with CompTIA.

ComPTIA Overview | Comptia Security+ Book SY0-701

bronxfugly43

Measures of Central Tendency: Mean, Median and Mode

Thiyagu K

Asian American Pacific Islander Month DDSD 2024.pptx

David Douglas School District

microwave assisted reaction. General introduction

Maksud Ahmed

Key note speaker Neum_Admir Softic_ENG.pdf

Admir Softic

Sociology 101 Demonstration of Learning Exhibit

jbellavia9

Russian Escort Service in Delhi 11k Hotel Foreigner Russian Call Girls in Delhi Welcome to VIP Call Girl In Delhi Hello! Delhi Call Girls is one of the most popular cities in India. Girls who call in Delhi frequently Advertise their services in small promgons in magazines, as well as on the Internet but We do not act as a direct-promoter. We will do everything we can to make sure that you're safe to the max to the best of our abilities and making sure of our ability and ensuring that you're obtained to the best of our abilities and making sure that you get what you want. Sexuality of our females is recognized by our Business proposals. Top-of-the-line, fully-featured Delhi girl call number and we offer To be aware of it is a major reason in deciding to use our services to ensure that our customers realize the worth of their lives swiftly and in a pleasant manner by engaging with web series performers for a cost of 10000.Here you are able to be Relax knowing that personal information is stored in the business proposals, giving an appearance of like you're as if you are a full affirmation. Call Girls Service Now Delhi +91-9899900591 *********** N.M.************* 01/04/2024 ▬█⓿▀█▀ 𝐈𝐍𝐃𝐄𝐏𝐄𝐍𝐃𝐄𝐍𝐓 CALL 𝐆𝐈𝐑𝐋 𝐕𝐈𝐏 𝐄𝐒𝐂𝐎𝐑𝐓 SERVICE ✅ ❣️ ⭐➡️HOT & SEXY MODELS // COLLEGE GIRLS AVAILABLE FOR COMPLETE ENJOYMENT WITH HIGH PROFILE INDIAN MODEL AVAILABLE HOTEL & HOME ★ SAFE AND SECURE HIGH CLASS SERVICE AFFORDABLE RATE ★ SATISFACTION,UNLIMITED ENJOYMENT. ★ All Meetings are confidential and no information is provided to any one at any cost. ★ EXCLUSIVE PROFILes Are Safe and Consensual with Most Limits Respected ★ Service Available In: - HOME & HOTEL Star Hotel Service .In Call & Out call SeRvIcEs : ★ A-Level (star escort) ★ Strip-tease ★ BBBJ (Bareback Blowjob)Receive advanced sexual techniques in different mode make their life more pleasurable. ★ Spending time in hotel rooms ★ BJ (Blowjob Without a Condom) ★ Completion (Oral to completion) ★ Covered (Covered blowjob Without condom SAFE AND SECURE

Russian Escort Service in Delhi 11k Hotel Foreigner Russian Call Girls in Delhi

kauryashika82

Ecological Succession. ( ECOSYSTEM, B. Pharmacy, 1st Year, Sem-II, Environmen...

Shubhangi Sonawane

Food Chain and Food Web (Ecosystem) EVS, B. Pharmacy 1st Year, Sem-II

Shubhangi Sonawane

TỔNG ÔN TẬP THI VÀO LỚP 10 MÔN TIẾNG ANH NĂM HỌC 2023 - 2024 CÓ ĐÁP ÁN (NGỮ Â...

Nguyen Thanh Tu Collection

Holdier Curriculum Vitae (April 2024).pdf

agholdier

Python Notes for mca i year students osmania university.docx

Ramakrishna Reddy Bijjam

The global implications of DORA and NIS 2 Directive are significant, extending beyond the European Union. Amongst others, the webinar covers: • DORA and its Implications • Nis 2 Directive and its Implications • How to leverage directive and regulation as a marketing tool and competitive advantage • How to use new compliance framework to request additional budget Presenters: Christophe Mazzola - Senior Cyber Governance Consultant Armed with endless Excel files, a meme catalog worthy of the best X'os (formerly twittos), and a risk register to make your favorite risk manager jealous, I swapped my computer scientist cape a few years ago for that of a (cyber) threat hunter with the honorary title of CISO. Ah, and I am also a quadruple senior certified ISO27001/2/5, Pas mal non ? C'est francais. Malcolm Xavier Malcolm Xavier has been working in the Digital Industry for over 18 Years now. He has worked with Global Clients in South Africa, United States and United Kingdom. He has achieved Many Professional Certifications Like CISSP, Google Cloud Practitioner, TOGAF, Azure Cloud, ITIL v3 etc. His core competencies include IT strategy, cybersecurity, IT infrastructure management, data center migration and consolidation, data protection and compliance, risk management and governance, and IS program development and management. Date: April 25, 2024 Tags: Information Security, Digital Operational Resilience Act (DORA) ------------------------------------------------------------------------------- Find out more about ISO training and certification services Training: Digital Operational Resilience Act (DORA) - EN | PECB NIS 2 Directive - EN | PECB Webinars: https://pecb.com/webinars Article: https://pecb.com/article Whitepaper: https://pecb.com/whitepaper ------------------------------------------------------------------------------- For more information about PECB: Website: https://pecb.com/ LinkedIn: https://www.linkedin.com/company/pecb/ Facebook: https://www.facebook.com/PECBInternational/ Slideshare: http://www.slideshare.net/PECBCERTIFICATION

Beyond the EU: DORA and NIS 2 Directive's Global Impact

PECB

PROCESS RECORDING FORMAT.docx

PoojaSen20

Presentation by Andreas Schleicher Tackling the School Absenteeism Crisis 30 ...

EduSkills OECD

Unit-V; Pricing (Pharma Marketing Management).pptx

VishalSingh1417

Micro-Scholarship, What it is, How can it help me.pdf

Poh-Sun Goh

Daniela

Recomendados

Recomendados

Mais conteúdo relacionado

Destaque

Destaque (16)

Mais de Martina y Aiora

Mais de Martina y Aiora (20)

Último

Último (20)