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PRIMARY
SOURCES
SECONDARY
SOURCES
Feces and urine
of cases and
carriers
Contaminated
• Food
• Water
• Milk
• Flies
• finger
MODE OF TRANSMISSION
• Feaco-oral route
• Urine oral route
RESEVOIR OF INFECTION
• Man is the only reservoir and may exist as a case or a carrier
INCUBATION PERIOD
10 -14 days
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CONTROL
CONTROL OF RESERVIOR
Case control:
Chloramphenicol, cortimoxazole, amoxicillin
Carrier:
ampicillin, probenecid+cholecystectomySANITATION CONTROL
Clean water preservation
Food hygiene
Health education
IMMUNIZATION
Given at >1 year
Anti-typhoid vaccine:
Monovalent( immunity against only 1 antigen source)
Divalent (immunity against both typhi, paratyphi)
TAB VACCINE (Typhi, paratyphiA&B)
DOSE: 2 doses 0.5ml every month subcutaneously
BOOSTER DOSE: after every 3 years
TREATMENT OF TYPHOID FEVER:
• Chloramphenicol for 5-7 days
• Low caloric diet with soups, vegetables, milk, eggs and
potatoes.
• CIPROFLOXACIN is now drug of choice.
CARRIER PRESENCE OF DISEASE TIME PERIOD
Convalescent carrier After onset of
symptoms→50% pt.
secrete S.typhi in feces.
3 weeks after onset
Healthy Carrier Clinically unrecognized
disease
--
Chronic Permanent Carrier No typhoid fever at the
time but still discharge
S.typhi
After 12 months of post-
infection

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Typhoid fever

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  • 4. PRIMARY SOURCES SECONDARY SOURCES Feces and urine of cases and carriers Contaminated • Food • Water • Milk • Flies • finger MODE OF TRANSMISSION • Feaco-oral route • Urine oral route RESEVOIR OF INFECTION • Man is the only reservoir and may exist as a case or a carrier INCUBATION PERIOD 10 -14 days
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  • 9. CONTROL CONTROL OF RESERVIOR Case control: Chloramphenicol, cortimoxazole, amoxicillin Carrier: ampicillin, probenecid+cholecystectomySANITATION CONTROL Clean water preservation Food hygiene Health education IMMUNIZATION Given at >1 year Anti-typhoid vaccine: Monovalent( immunity against only 1 antigen source) Divalent (immunity against both typhi, paratyphi) TAB VACCINE (Typhi, paratyphiA&B) DOSE: 2 doses 0.5ml every month subcutaneously BOOSTER DOSE: after every 3 years
  • 10. TREATMENT OF TYPHOID FEVER: • Chloramphenicol for 5-7 days • Low caloric diet with soups, vegetables, milk, eggs and potatoes. • CIPROFLOXACIN is now drug of choice.
  • 11. CARRIER PRESENCE OF DISEASE TIME PERIOD Convalescent carrier After onset of symptoms→50% pt. secrete S.typhi in feces. 3 weeks after onset Healthy Carrier Clinically unrecognized disease -- Chronic Permanent Carrier No typhoid fever at the time but still discharge S.typhi After 12 months of post- infection