Product Spec Sheet for Proliposome formulation manufactured by Encapsula NanoSciences that is used specifically in the cosmetic industry. The brand name is Cosmesome-ACE (NE). The Cosmesome-ACE (NE) formulation is composed of saturated phospholipids and it does not contain alcohol. The proliposome formulation forms liposomes containing vitamins A,C and E upon dilution with water. During the dilution process water soluble active ingredients can be encapsulated inside the liposomes or liposoluble active ingredients can be incorporated into the lipid bilayers. The formulation is packaged under sterile conditions inside spout pouches.

1. COSMESOMETM
–ACE (NE)
CHARACTERISTICS
CosmesomeTM –ACE (NE) is a highly concentrated
lipid formulation for cosmetic industry that forms
nano-sized liposomes upon dilution of the
formulation with water using standard mixing
devices.
CosmesomeTM –ACE (NE) is composed of high purity
saturated soy phospholipids and vitamin A, vitamin E,
and lipid soluble form of vitamin C that form
liposomes with high encapsulation and incorporation
efficiency. The formulation is colorless and
odorless.
CosmesomeTM -ACE (NE) is composed of proprietary
blend of phospholipids, vitamin A, vitamin E, and
lipid soluble form of vitamin C in the form of
interdigitated lipids.
Hydration of these lipids with water causes
rearrangement of the lipid bilayers which
spontaneously forms liposomes. If water- soluble
active ingredients, such as peptides, minerals or
other water soluble molecules, are dissolved in water
and added to CosmesomeTM –ACE (NE), liposomes
with high entrapment of the active molecule is
formed. If lipid soluble molecules such as lipid
soluble molecules or antioxidants are added to
CosmesomeTM -ACE (NE) and hydrated with water,
the lipid soluble molecule will be incorporated into
the lipid bilayers of the liposomes. Up to 65% of a
water soluble molecule in the solution is
encapsulated inside the liposomes and almost 100%
of lipid soluble molecules is incorporated into the
lipid bilayers of the liposomes.
Since the lipids that are used in the formulation are
saturated, the formulation has to be heated to above
65°C after hydration for at least 20 minutes.
INCI NAME
WATER (and) GLYCERIN (and) BUTYLENE
GLYCOL(and) HYDROGENATED LECITHIN (and)
ASCORBYL DIPALMITATE (and) TOCOPHERYL
ACETATE (and) RETINYL PALMITATE
QUICK FACTS
CosmesomeTM products are made
from saturated phospholipids and
are used in processes that require
heating above 65oC. Before using
CosmesomeTM products make sure
that your active ingredient is stable
during processing. The formulation
is alcohol free.
If the active ingredient is
temperature sensitive use the
DermasomeTM product line.
*NE stands for non-ethanol based
formulation.
6 Cadillac Dr, Suite 245
Brentwood, TN 37027
United States of America
1-(800) 387-0620
info@encapsula.com
/company/encapsula-nanosciences-
llc
DISCLAIMER
Any formulation suggestions or
technical information is based on our
knowledge on the basis of current
scientific data and publications.
Encapsula is only a raw ingredient
manufacturer and cannot accept any
liabilities for products manufactured
by others. Every manufacturer and
formulator is responsible for
compliance with all statutory
regulations including those in the field
of patent legislation.

2. COMPOSITION
Phospholipids 20%
and ascorbyl dipalmtate
and tocopheryl acetate
and retinyl palmitate
Hydrophilic medium 80%
ANALYTICAL DATA
Peroxide value Max. 5
PH (pur) 5-7
MICROBIOLOGICAL DATA
Yeasts/g absence
Molds/g absence
S. aureus / C. albicans absence
and P. aeruginosa/g
PHYSIO-CHIMICAL PROPERTIES
Appearance: Amber liquid
Miscibility: Form liposomes spontaneously when
heated to above 65 C after the
addition of water.
STORAGE CONDITION
Stable for 24 months in its original closed packaging
below 8℃ (preferred to be kept in refrigerator).
Reclose container immediately after use and protect
from direct sunlight. If container is opened, keep
container in refrigerator at 4℃ and use within 3
months.
REGULATORY STATUS
No specific regulation
PACKAGING
2 oz, 18 oz, 1 Gallon
COSMESOMETM
–ACE (NE)
QUICK FACTS
CosmesomeTM products are made
from saturated phospholipids and
are used in processes that require
heating above 65oC. Before using
CosmesomeTM products make sure
that your active ingredient is stable
during processing. The formulation
is alcohol free.
If the active ingredient is
temperature sensitive use the
DermasomeTM product line.
*NE stands for non-ethanol based
formulation.
6 Cadillac Dr, Suite 245
Brentwood, TN 37027
United States of America
1-(800) 387-0620
info@encapsula.com
/company/encapsula-nanosciences-
llc
DISCLAIMER
Any formulation suggestions or
technical information is based on our
knowledge on the basis of current
scientific data and publications.
Encapsula is only a raw ingredient
manufacturer and cannot accept any
liabilities for products manufactured
by others. Every manufacturer and
formulator is responsible for
compliance with all statutory
regulations including those in the field
of patent legislation.