2. ………………..……………………………………………………………………………………………………………………………………..
Anup Patel, MD
• Section Chief Neurology at Nationwide Children’s
Hospital
• Associate Professor at the Ohio State University College
of Medicine
• Director Complex Epilepsy Clinic
• Chair Professional Advisory Board Lennox Gastaut
Syndrome Foundation
3. ………………..……………………………………………………………………………………………………………………………………..
Definition of Lennox Gastaut (LGS)
• Multiple seizure types, to include tonic, atonic, and
atypical absence seizures, with tonic seizures
predominantly occurring at night
• Abnormal EEG, consisting primarily of an interictal
pattern of diffuse, slow spike-wave (SSW) complexes at
<3Hz, occurring during wakefulness
• Additional features, required as diagnostic by many,
include paroxysmal fast rhythms (10–20 Hz) during
sleep
• Developmental delay or regression
8. ………………..……………………………………………………………………………………………………………………………………..
Connection of Brain Pathways
• Suggest that the mediodorsal and ventrolateral thalamus
may be the main pathways of seizures for LGS patients
• May be targets for changing the abnormal network in
LGS
• Potential for treatment using thalamic neurostimulation
therapies like deep brain stimulation (DBS)
11. ………………..……………………………………………………………………………………………………………………………………..
Evidence for Devices
• 50% of patients respond to Vagus nerve stimulation
(VNS) therapy with a > 50% reduction in seizures, and
the response may improve over time
• 2014 AAN Guideline Paper states that VNS should be
considered
• No evidence exists for responsive neurostimulation
(RNS) by NeuroPace
• Limited evidence exists for deep brain stimulation (DBS)
by Medtronic
• 4 patients Lennox-Gastaut syndrome showed >50%
reduction in seizure frequency
26. ………………..……………………………………………………………………………………………………………………………………..
Track it App for Apple Watch
• Track it is a seizure diary app (iOS and Android) to
record seizures and data about seizures
• Developed by Rob and Lisa Moss
• Working on data input into EPIC
• Nationwide Children’s Hospital built the Apple Watch App
for them
• Now can input data about seizures from the Apple Watch