Ban on Synthetic Cannabinoids and Lab testing for these chemicals

1. SyntheticCannabinoids

2. Today’s “FAKE MARIJUANA” COMMONLY KNOWN AS K2, SPICE, SERENITY, GENIE, TWISTED XXX Synthetic Cannabinoids

3. In 1995 Dr. John W. Huffman, first experimented and synthesized the compound known as JWH018 while performing research at Clemson University. He never performed any testing with this and later other JWH chemicals on humans. Since that time several of these synthesized compounds with varying names have been produced with a wide range of potency and effects. History

4. US Legislative Profile Nov. 24th DEA instituted an emergency Ban on 5 Synthetic Cannabinoids which become effective 1/2011 for one year States and Municipalities have instituted various restrictions on Synthetic Cannabinoids ranging from unregulated to felony charges for possession

5. U U 2/25/10** U * U 10/15/10 ** U * HWH018,073,015, 200,250, HU210, CP47, CP497 U 10/15/10 ** *** U U U *** JWH018 U U *** U * JWH01811/1/2011 * 8/28/10 Synthetic Compounds mimic THC @ U * Spice *** JWH018 **JWH018 U @ *** 4/13/10** K2 JWI018 JWH073 11/1/10 ** U U HU 210 JWH018 JWH073 Salvia K2,Spice JWH018 U 9/3/10 ** **8/15/10 JWH018, 073,CP47, 497 all synthetics *** 1/11/11 *** Possession a Felony *Municipal Restrictions ** Statewide Ban *** Proposed Regulation U Unregulated @ Marijuana Legalized Proposed Legislation

6. Texas Legislative Timeline Proposed bill to floor 1/11/11 by Senator Florence Shapiro Most comprehensive bill in the US with 12+ compounds Congressional Coalition Support 9 Texas Senators 9 House of Representatives

7. Proposed Texas Testing Panel 1. JWH-018 2. JWH-073 DEA BANNED LIST 3. JWH-200 4. CP 47 5. CP 497 6. JWH-019 7. JWH-250 8. JWH-015 9. CP 297-C8 Homolog 10. CP 55, 940 11. HU-308 12. HU-331 13. WIN 55212-2

8. Research In drug studies on rats and pigeons HU-210 was found to be 66 to 80 times more potent than THC Human Study by NMS presented by Dr. Barry Logan shows varying degrees of impairment Current on going human studies at St. Louis University of effects of synthetic cannabinoid use

9. Research More Human Studies related to driving under the influence are ongoing to be published 2011 Synthesized to create “Lock and Key” effect with the same neurotransmitters in the brain as THC; i.e. addition

10. Myths These products are herbal and incense and somehow natural substances Not harmful Non-toxic Not for human consumption

11. Facts Products created in a laboratory environment Mixtures of herbal compounds and chemicals - No QC on what is generated Is not detected in standard drug test panels Easy to change Trade names and mixture ingredients

12. Facts Jan 2010-July 2010 500-800 cases of adverse reactions to synthetic marijuana across the country in the past year, according to the American Association of Poison Control Centers. At least 8 known/suspected deaths in Texas 2010 to date

14. Internal restlessness

15. Palpitations and increase blood pressure

16. Reduced Body Temperature

17. Insomnia

18. Headache

19. Diarrhea

21. Tremors and in rare cases seizure

22. Anxiety and paranoia without reason

23. Manic episodes (hyperactivity, agitation)

24. Sudden emotional and personality changes

25. Feeling of depression and desperation

27. Analytical Testing Individual Compounds or Panels 1. JWH-018 2. JWH-073 DEA BANNED LIST 3. JWH-200 4. CP 47 5. CP 497 6. JWH-019 7. JWH-250 8. JWH-015 9. CP 297-C8 Homolog 10. CP 55, 940 11. HU-308 12. HU-331 13. WIN 55212-2

31. Questions? Loretta Anderson, President ExperTox Laboratory Ph. 281-476-4600 Fax. 281-930-8856 www.expertox.com Contact Information: Mauri Barefoot, National Sales Rep mbarefoot@expertox.com