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Entropic effects in chromatin folding - Alberto Colliva

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Entropic effects in chromatin folding - Alberto Colliva

  1. 1. Entropic effects in chromatin folding Alberto Colliva Quantitative Laws II16/06/2016
  2. 2. How is DNA packing organized? Tark-Dame et. al., PLOS Comp. Biol., 2009 What is driving the 3D organization? Polymers 3C techniques Dixon et. al., Nature, 2011
  3. 3. GC and Hi-C integration Different cell lines and Hi-C experiments Juicebox Hi-C data suffer major bias S. Rao et. al., «Juicebox», Cell, 2014 GC profile chromosome 2 Chromosome coordinates: X ,Y YX
  4. 4. Enrichment in GC similar contats HindIII NcoI GC content (5 kb) GCcontent(5kb) GCcontent(5kb) GC content (5 kb) Data from: Lieberman-Aiden et. Al., Science. 2009 Log(Survivalfunction) Log(Survivalfunction) 5 kb resolution windows Two different restriction enzyme
  5. 5. GC content as a flexibility indicator P. Cook D. Marenduzzo, J Cell Biol., 2009 A mixture of two sets of polymers show the emergence of segregation. Molecular dynamics simulation GC content (5 kb) GCcontent(5kb) flexiblestiff
  6. 6. Acknowledgement Michele Caselle Andrea Mazzolini Matteo Osella Antonio Rosanova

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