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Analgesics and  Anti-inflammatories Pharmacology 49.222 Bill Diehl-Jones RN, PhD Faculty of Nursing and Department of Zoology
Major Drug Classifications
Agenda ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Drugs Used to Alleviate Pain and Inflammation ,[object Object],[object Object],[object Object],[object Object]
Analgesics (Drugs to Treat Pain) ,[object Object],[object Object],[object Object],[object Object],Sensory Cortex Thalamus Spinothalamic Nerve Tract
A Few Word About Prostglandins Arachidonic Acid Prostaglandins Leukotrienes Lipoxygenase Cyclooxygenase Phospholipase A2 Cell Membrane (What’s the significance?  We’ll talk later …)
So How do Non-Narcotic Analgesics Work? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
How About Narcotic Analgesics? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Excitatory  Neurotransmitters (Eg: Substance P) Opioid Receptors
Examples of Opiate Agonists: Morphine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Examples of Opiate Agonists: Meperidine ,[object Object],[object Object],[object Object]
Two More Opioid Narcotics: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Morphine, Meperidine, Methadone and Fentanyl are STRONG Opioid Agonists What does that mean?
Moderate Opioid Agonist: Codeine ,[object Object],[object Object],[object Object]
Mixed Agonist-Antagonist: Pentazocine ,[object Object],[object Object],[object Object],[object Object]
Opioid Antagonist: Naloxone (Narcan) ,[object Object],[object Object],[object Object],Opioid Receptor Naloxone Morphine Just beat it!
Clinical Pearls on Narcotics
Morphine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Meperidine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Codeine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
And Now, NSAIDs ….
How Do They Work? ,[object Object],[object Object],[object Object],Anti-inflammatory Analgesic Antipyretic Analgesic Antipyretic N S A I D s A C E T A M I N O P H E N
Where do NSAIDs Work? Arachidonic Acid Prostaglandins Leukotrienes Lipoxygenase Cyclooxygenase Phospholipase A2 Cell Membrane Steroids works here: NSAIDs
NSAIDs We Know And Love: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical Pearls on NSAIDS
Aspirin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Ibuprofen ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Indomethacin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Naproxen ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
And now, a word about VIOXX
Vioxx ,[object Object],[object Object]
So, what happened …? ,[object Object],[object Object],[object Object]
Some Clinical Pointers on NSAIDS ,[object Object]

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