Doxophylline and asthma

Doxophylline The safer methylxanthine Dr. B. K. Iyer

Topics for discussion ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Topics for discussion ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

What is doxophylline? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

What are methylxanthines? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Is there scope for doxophylline? ,[object Object],[object Object],[object Object],[object Object]

Limitations to Theophylline ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Theophylline concentrations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Mechanism of action [MOA] ,[object Object],[object Object],[object Object],[object Object]

Uses of doxophylline ,[object Object],[object Object],[object Object],[object Object],[object Object],What is COPD, Asthma, chronic bronchitis and emphysema?

Airway innervations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Respiratory defense mechanism Phagocyte system Muco- Ciliary clearance Goblet Cell function Cough / Sneeze Respiratory Defense mechanism

Respiratory defense mechanism ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Respiratory system Pathophysiology of diseases

Airway Inflammation [AI] ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Receptors & mediators ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Receptors & mediators - outcomes

What is COPD? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

What is Asthma? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

What happens in Asthma? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

How do you define Asthma? ,[object Object],[object Object],[object Object],[object Object]

Severity classifications of asthma ,[object Object],[object Object],[object Object],[object Object]

What is emphysema? ,[object Object]

What is chronic bronchitis? ,[object Object]

Principles of management of COPD

What is the therapeutic approach? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

What are the therapy approaches? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Bronchodilators Sympathomimetic Adrenaline Adrenergic Ipratropium bromide Anticholinergics Theophylline Aminophylline Doxophylline Methylxanthines Salmetrol, Salbutamol, Terbutaline Non adrenergic

Sympathomimetics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Methylxanthines ,[object Object],[object Object],[object Object],[object Object],[object Object]

Respiratory investigations… ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Assessment / Monitoring measures ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Goals of Asthma Management ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Success of Asthma Management ,[object Object],[object Object],[object Object],[object Object],[object Object]

Recommended monitoring ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Doxophylline ,[object Object],Dioxolane Ring CH 3 N O H 3 C N O N N CH 2 O O

Doxophylline ,[object Object],[object Object],Reference: Cirillo R et al . Arch Int Pharmacodyn Ther 1988;295:221-237 . Interaction with A1 adenosine receptors:

Doxophylline - MOA ,[object Object],[object Object],[object Object],[object Object],[object Object]

Doxophylline and sleep ,[object Object],[object Object],[object Object]

Doxophylline studies ,[object Object],[object Object]

Clinical studies ,[object Object],Dolcetti A at al. J Int Med Res 1988;16:264-269 .

Comparative clinical studies in ADRs ,[object Object],Reference: Eandi M: Farmacoeconomia e Percorsi Terapeutici 2002;3:2. 3 ADR Doxophylline Theophylline 1 ADR 2 ADR

Comparative clinical studies in Asthma ,[object Object],Reference: Marino O et al. Uomo Med 1988;4:33-37.

Comparative clinical studies in COPD ,[object Object],Reference: Marino O et al. Uomo Med 1988; 4: 33-37 .

Comparative clinical studies in heart rate ,[object Object],[object Object],Reference: Giorgi M et al. (Abstr) Eur Respir J 1993;6 (Suppl 17):417.

Doxophylline and heart ,[object Object],[object Object],[object Object]

Doxophylline and ventilation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Doxophylline and chronic bronchitis ,[object Object],Reference: Cogo R et al. Farmaci 1990; 14: 295-299 .

Doxophylline and histopathologic abnormalities ,[object Object],Cogo R, Castronuovo A: Eur Rev Med Pharmacol Sci 2000;4:15-20. Basal 3 Months After Therapy Basal

Summary ,[object Object],Safer No activity on adenosine receptors No side effects on heart No CNS / sleep disturbances Better functional improvement Better histological improvement Better tolerated

Doxophylline and asthma

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