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4. Inflammation-4
“Inflame” – to set fire.
Inflammation is “dynamic response of
vascularised tissue to injury.”
Is a protective response.
Serves to bring defense & healing
mechanisms to the site of injury.
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19. Inflammation-19
Chemical substances synthesised or released
which mediate the changes in inflammation.
Histamine by mast cells - vasodilatation.
Prostaglandins – Cause pain & fever.
Bradykinin - Causes pain.
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21. Inflammation-21
“Never let the competition define you.
Instead, you have to define yourself
based on a point of view you care
deeply about.”
– Tom Chappel
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33. Inflammation-33
Flush, Flare &
Weal
Acute
inflammatory cells
- Neutrophils
Vascular damage
More exudation
Little or no fibrosis
Little signs Fibrosis,
Chronic
inflammatory
cells –
Lymphocytes
Neovascularisation
No/less
exudation
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34. Inflammation-34
"People who soar, are those
who refuse to sit back and
wish things would change."
Charles R. Swindoll
Author and Pastor
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38. Inflammation-38
Regeneration of injured tissue by parenchymal
cells of the same type
Replacement by connective tissue
In other words
Regeneration
Scar
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40. Inflammation-40
Most Important Mediators affecting Cell Growth
Present in serum or produced locally
Exert pleiotropic effects; proliferation, cell
migration, differentiation, tissue remodeling
Regulate growth of cells by controlling
expression of genes that regulate cell
proliferation
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41. Inflammation-41
Occurs when repair by parenchymal
regeneration alone cannot be accomplished
Involves production of Granulation Tissue
replacement of parenchymal cells with
proliferating fibroblasts and vascular
endothelial cells
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42. Inflammation-42
Angiogenesis - New vessels budding from old
Fibrosis, consisting of emigration and
proliferation of fibroblasts and deposition of
ECM
Scar remodeling, tightly regulated by
proteases and protease inhibitors
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43. Inflammation-43
Induction of acute inflammatory response by
an initial injury
Parenchymal cell regeneration
Migration and proliferation of parenchymal
and connective tissue cells
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44. Inflammation-44
Synthesis of ECM proteins
Remodeling of parenchymal elements to
restore tissue function
Remodeling of connective tissue to achieve
wound strength
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47. Inflammation-47
After sutures are removed at one week, wound
strength is only 10% of unwounded skin
(Walker’ Law)
By 3-4 months, wound strength is about 80% of
unwounded skin (Walker’s Law)
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52. Inflammation-52
Healing – Proliferation & Differentiation.
Labile, Stabe & Permanent cells
Stages of Healing: 1-2-3-4….
Healing by First or Second intention.
Skin wound healing - bone healing.
Factors affecting healing – Local / Systemic
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53. "Each time you are honest and conduct
yourself with honesty, a success force will
drive you toward greater success. Each
time you lie, even with a little white lie,
there are strong forces pushing you
toward failure."
Joseph Sugarman
Author and Marketing Specialist
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