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The document discusses refinements made to Caco-2 and in situ brain perfusion models for predicting drug absorption and permeability. It also describes simulations of amitriptyline transport across the blood-brain barrier and issues with leakage in pre-coated PAMPA plates from BD Biosciences. The presentation is copyrighted by in-ADME Research.

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www.in-ADME.com in-ADME Research pCEL-X Rev 3.1 Overview 1. Atenolol Caco-2 Refinement 2. Amitriptyline Caco-2 Simulation 3. Amitriptyline in situ brain perfusion Refinement 4. BD Pre-coated PAMPA Plates Leak Presentation Copyrighted (C) 2011. in-ADME Research. All rights reserved. page 1 in-ADME Research Copyright © 2011 
Caco-2 Refinement Example page 2 in-ADME Research Copyright © 2011 
page 3 in-ADME Research Copyright © 2011 
page 4 in-ADME Research Copyright © 2011 
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Simulation Example page 16 in-ADME Research Copyright © 2011 
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page 25 in-ADME Research Copyright © 2011 
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Refinement of in situ Data page 29 in-ADME Research Copyright © 2011 
page 30 in-ADME Research Copyright © 2011 
page 31 in-ADME Research Copyright © 2011 
page 32 in-ADME Research Copyright © 2011 
page 33 in-ADME Research Copyright © 2011 
page 34 in-ADME Research Copyright © 2011 
page 35 in-ADME Research Copyright © 2011 
BD Pre-Coated PAMPA Plates page 36 in-ADME Research Copyright © 2011 
Thin Membranes Leak Water & Can’t be Stirred page 37 in-ADME Research Copyright © 2011 
Thin Membranes Leak Water & Can’t be Stirred page 38 in-ADME Research Copyright © 2011 
Thin Membranes Leak Water & Can’t be Stirred page 39 in-ADME Research Copyright © 2011 
Thin Membranes Leak Water & Can’t be Stirred page 40 in-ADME Research Copyright © 2011 

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in-ADME Research pCEL-X slides

  • 1. www.in-ADME.com in-ADME Research pCEL-X Rev 3.1 Overview 1. Atenolol Caco-2 Refinement 2. Amitriptyline Caco-2 Simulation 3. Amitriptyline in situ brain perfusion Refinement 4. BD Pre-coated PAMPA Plates Leak Presentation Copyrighted (C) 2011. in-ADME Research. All rights reserved. page 1 in-ADME Research Copyright © 2011 
  • 2. Caco-2 Refinement Example page 2 in-ADME Research Copyright © 2011 
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  • 16. Simulation Example page 16 in-ADME Research Copyright © 2011 
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  • 29. Refinement of in situ Data page 29 in-ADME Research Copyright © 2011 
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  • 36. BD Pre-Coated PAMPA Plates page 36 in-ADME Research Copyright © 2011 
  • 37. Thin Membranes Leak Water & Can’t be Stirred page 37 in-ADME Research Copyright © 2011 
  • 38. Thin Membranes Leak Water & Can’t be Stirred page 38 in-ADME Research Copyright © 2011 
  • 39. Thin Membranes Leak Water & Can’t be Stirred page 39 in-ADME Research Copyright © 2011 
  • 40. Thin Membranes Leak Water & Can’t be Stirred page 40 in-ADME Research Copyright © 2011