SlideShare uma empresa Scribd logo
1 de 32
Baixar para ler offline
BIOPHARMACEUTICS Adapted by : S. Campbell-Elliott M. Pharm. Sc. Prepared by : A.S. Adebayo, Ph.D. &  M. A Williams. M.S.
General Overview/Definitions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
General Overview/Definitions  (Cont.) ,[object Object],[object Object],[object Object]
Biopharmaceutics ,[object Object],[object Object],[object Object]
Factors Influencing the time course of a drug in plasma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Bioavailability: rate & extent ,[object Object],[object Object]
Factors Influencing Drug Absorption ,[object Object],[object Object],[object Object],[object Object],[object Object]
Factors Influencing Drug Absorption ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Factors Influencing Drug Absorption ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Schematic illustration of the steps involved in the appearance of intact drug in systemic circulation following oral administration of a tablet   STOMACH (Gastric content. pH 1-3) SMALL INTESTINE (Intestinal cont. pH 5-7) Tablet Granules Fine particles Dissolution Drug in solution Tablet Granules Fine particles Dissolution Drug in solution Absorption Intact drug Liver Intact Drug in systemic Circulation Pharmacologic effect Intestinal metabolism Metabolites Urine Hepatic Metabolism (1 st  Pass Effect) Disintegration Deaggregation
Rate Limiting Steps of Absorption Rate of metabolism of drug during its initial passage through the liver (i.e. First-pass effect). Rate at which drug is metabolized by the enzymes in the intestinal mucosal cells en route into mesenteric blood vessels Rate of gastric emptying into small intestine Other factors Rate of release from the dosage form Dosage Design Rate at which drug crosses membrane of the GIT High aqueous solubility Rate of dissolution in gastrointestinal fluid Poor aqueous solubility Rate Limiting Step Nature of Drug
Physiological Factors  Affecting Oral Absorption
Fate of a Drug Product
Simplified Model of Membrane
Davson-Danielli Model
Examples of Biomembranes  ,[object Object],[object Object],[object Object],[object Object],[object Object]
Examples of Biomembranes   (cont’d) ,[object Object],[object Object],[object Object],[object Object]
Structure of the Gastro-intestinal Tract ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Physiology of the G.I.T. ,[object Object],[object Object],[object Object],[object Object],[object Object]
Physiology of the GIT :  Structure of the wall ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Physiology of the G.I.T. : The Mucosa ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Physiology of the G.I.T.: The Mucous Layer ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Physiology of the GIT: The Oesophagus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Physiology of the GIT: The Stomach ,[object Object],[object Object],[object Object],[object Object],[object Object]
Physiology of the GIT: The Stomach (cont’d) ,[object Object],[object Object],[object Object],[object Object],[object Object]
Physiology of the GIT:  The Small Intestine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Physiology of the GIT: The Small Intestine (cont’d) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Physiology of the GIT: The Small Intestine (cont’d) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Increase in Surface  Surface Area Structure (relative to cylinder)  sq cm simple cylinder 1 3,300 Folds of Kerckring 3 10,000 Villi 30 100,000 Microvilli 600 2,000,000
Physiology of the GIT: The Colon ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Physiology of the GIT: The Colon (cont’d) ,[object Object],[object Object],[object Object],[object Object]

Mais conteúdo relacionado

Mais procurados

Physicochemical Properties effect on Absorption of Drugs
Physicochemical Properties effect on Absorption of DrugsPhysicochemical Properties effect on Absorption of Drugs
Physicochemical Properties effect on Absorption of DrugsSuraj Choudhary
 
Factors affecting drug absorption
Factors affecting drug absorptionFactors affecting drug absorption
Factors affecting drug absorptionSURYAKANTVERMA2
 
Factors affecting biotransformation of drugs
Factors affecting biotransformation of drugsFactors affecting biotransformation of drugs
Factors affecting biotransformation of drugsZubia Arshad
 
Biopharmaceutics: Mechanisms of Drug Absorption
Biopharmaceutics: Mechanisms of Drug AbsorptionBiopharmaceutics: Mechanisms of Drug Absorption
Biopharmaceutics: Mechanisms of Drug AbsorptionSURYAKANTVERMA2
 
Gastrointestinal absorption of drugs
Gastrointestinal absorption of drugsGastrointestinal absorption of drugs
Gastrointestinal absorption of drugsSiddu K M
 
Non linear kinetics
Non linear kineticsNon linear kinetics
Non linear kineticsSujit Patel
 
Pharmacokinetics / Biopharmaceutics - Drug Elimination
Pharmacokinetics / Biopharmaceutics - Drug Elimination Pharmacokinetics / Biopharmaceutics - Drug Elimination
Pharmacokinetics / Biopharmaceutics - Drug Elimination Areej Abu Hanieh
 
Factors affecting drug absorption
Factors affecting drug absorptionFactors affecting drug absorption
Factors affecting drug absorptionDeepak Pandey
 
FACTORS AFFECTING DRUG ABSORPTION
FACTORS AFFECTING DRUG  ABSORPTIONFACTORS AFFECTING DRUG  ABSORPTION
FACTORS AFFECTING DRUG ABSORPTIONDrx Suraj Mandal
 

Mais procurados (20)

Pharmacokinetic models
Pharmacokinetic modelsPharmacokinetic models
Pharmacokinetic models
 
Bioavailability
BioavailabilityBioavailability
Bioavailability
 
Physicochemical Properties effect on Absorption of Drugs
Physicochemical Properties effect on Absorption of DrugsPhysicochemical Properties effect on Absorption of Drugs
Physicochemical Properties effect on Absorption of Drugs
 
MECHANISMS OF DRUG ABSORPTION
MECHANISMS OF DRUG  ABSORPTIONMECHANISMS OF DRUG  ABSORPTION
MECHANISMS OF DRUG ABSORPTION
 
Factors affecting drug absorption
Factors affecting drug absorptionFactors affecting drug absorption
Factors affecting drug absorption
 
Basics of Pharmacokinetics
Basics of PharmacokineticsBasics of Pharmacokinetics
Basics of Pharmacokinetics
 
Factors affecting biotransformation of drugs
Factors affecting biotransformation of drugsFactors affecting biotransformation of drugs
Factors affecting biotransformation of drugs
 
Pharmacokinetics I-ADME
Pharmacokinetics I-ADMEPharmacokinetics I-ADME
Pharmacokinetics I-ADME
 
Biopharmaceutics: Mechanisms of Drug Absorption
Biopharmaceutics: Mechanisms of Drug AbsorptionBiopharmaceutics: Mechanisms of Drug Absorption
Biopharmaceutics: Mechanisms of Drug Absorption
 
Novel drug delivery system
Novel drug delivery systemNovel drug delivery system
Novel drug delivery system
 
Gastrointestinal absorption of drugs
Gastrointestinal absorption of drugsGastrointestinal absorption of drugs
Gastrointestinal absorption of drugs
 
Adme
AdmeAdme
Adme
 
Non linear kinetics
Non linear kineticsNon linear kinetics
Non linear kinetics
 
ELIMINATION OF DRUGS BIOPHARMACEUTICS
ELIMINATION OF DRUGS BIOPHARMACEUTICSELIMINATION OF DRUGS BIOPHARMACEUTICS
ELIMINATION OF DRUGS BIOPHARMACEUTICS
 
Pharmacokinetics / Biopharmaceutics - Drug Elimination
Pharmacokinetics / Biopharmaceutics - Drug Elimination Pharmacokinetics / Biopharmaceutics - Drug Elimination
Pharmacokinetics / Biopharmaceutics - Drug Elimination
 
Factors affecting drug absorption
Factors affecting drug absorptionFactors affecting drug absorption
Factors affecting drug absorption
 
Drug distribution
Drug distributionDrug distribution
Drug distribution
 
Absorption of drug
Absorption of drugAbsorption of drug
Absorption of drug
 
FACTORS AFFECTING DRUG ABSORPTION
FACTORS AFFECTING DRUG  ABSORPTIONFACTORS AFFECTING DRUG  ABSORPTION
FACTORS AFFECTING DRUG ABSORPTION
 
Protein Drug Binding
Protein Drug BindingProtein Drug Binding
Protein Drug Binding
 

Destaque

Destaque (11)

Ppt microencapsulation
Ppt microencapsulationPpt microencapsulation
Ppt microencapsulation
 
Pdf seminar final
Pdf seminar finalPdf seminar final
Pdf seminar final
 
Capsule @ppm
Capsule @ppmCapsule @ppm
Capsule @ppm
 
Biopharm review1
Biopharm review1Biopharm review1
Biopharm review1
 
PPT MICROENCAPSULATION
PPT MICROENCAPSULATIONPPT MICROENCAPSULATION
PPT MICROENCAPSULATION
 
Transgenic and cloned organisms
Transgenic and cloned organismsTransgenic and cloned organisms
Transgenic and cloned organisms
 
Microencapsulation
MicroencapsulationMicroencapsulation
Microencapsulation
 
Transgenic animals ppt
Transgenic animals pptTransgenic animals ppt
Transgenic animals ppt
 
Pharmacology of absorption and bioavailability
Pharmacology of absorption and bioavailabilityPharmacology of absorption and bioavailability
Pharmacology of absorption and bioavailability
 
methods of determining drug absorption ppt
methods of determining drug absorption pptmethods of determining drug absorption ppt
methods of determining drug absorption ppt
 
Transgenic plants ppt
Transgenic plants  pptTransgenic plants  ppt
Transgenic plants ppt
 

Semelhante a Biopharmaceutics lecture1

Floating drug delivery system review
Floating drug delivery system reviewFloating drug delivery system review
Floating drug delivery system reviewakshaymundhe
 
Dosage form design - Biopharmaceutical consideration
Dosage form design - Biopharmaceutical considerationDosage form design - Biopharmaceutical consideration
Dosage form design - Biopharmaceutical considerationAniruddha Roy
 
Patient Related factors of Drug Absorption
Patient Related factors of Drug AbsorptionPatient Related factors of Drug Absorption
Patient Related factors of Drug AbsorptionSouvik Chattopadhyay
 
Colonic Drug Deliverey System
Colonic Drug Deliverey SystemColonic Drug Deliverey System
Colonic Drug Deliverey SystemAnjali9410
 
GRDDS-Modulation to GI transit time,Approach to extend GI transit time
GRDDS-Modulation to GI transit time,Approach to extend GI transit timeGRDDS-Modulation to GI transit time,Approach to extend GI transit time
GRDDS-Modulation to GI transit time,Approach to extend GI transit timeRESHMAMOHAN24
 
Colon Specific Drug Delivery System: Basics and Approaches
Colon Specific Drug Delivery System: Basics and ApproachesColon Specific Drug Delivery System: Basics and Approaches
Colon Specific Drug Delivery System: Basics and ApproachesNone
 
2Factors affecting oral absorption.pptx
2Factors affecting oral absorption.pptx2Factors affecting oral absorption.pptx
2Factors affecting oral absorption.pptxAliElmehdawi2
 
04.0 drug absorption
04.0 drug absorption04.0 drug absorption
04.0 drug absorptionRichardPaul54
 
2.colon specific drug delivery system 2 nd sem
2.colon specific drug delivery system  2 nd sem2.colon specific drug delivery system  2 nd sem
2.colon specific drug delivery system 2 nd semHanmant Galande
 
Pharmacokinetics of drugs
Pharmacokinetics of drugsPharmacokinetics of drugs
Pharmacokinetics of drugskavya m
 
Colon Targeting by Novel Drug Delivery Drug System: Microsphere a Review Report
Colon Targeting by Novel Drug Delivery Drug System: Microsphere a Review ReportColon Targeting by Novel Drug Delivery Drug System: Microsphere a Review Report
Colon Targeting by Novel Drug Delivery Drug System: Microsphere a Review ReportBRNSSPublicationHubI
 
Biopharmaceutics Lec 02.pdf
Biopharmaceutics Lec 02.pdfBiopharmaceutics Lec 02.pdf
Biopharmaceutics Lec 02.pdfjadarc
 
Suppositories by G VIJAYA SINDHURI(Ph.D) Department of pharmaceutics
Suppositories by G VIJAYA SINDHURI(Ph.D) Department of pharmaceutics Suppositories by G VIJAYA SINDHURI(Ph.D) Department of pharmaceutics
Suppositories by G VIJAYA SINDHURI(Ph.D) Department of pharmaceutics gopu vijaya sindhuri
 
Gastro-retentive drug delivery systems.pptx
Gastro-retentive drug delivery systems.pptxGastro-retentive drug delivery systems.pptx
Gastro-retentive drug delivery systems.pptxABG
 
GRDDS.pptx
GRDDS.pptxGRDDS.pptx
GRDDS.pptxABG
 
Class drug absorption
Class drug absorptionClass drug absorption
Class drug absorptionRaghu Prasada
 
Factors affecting oral absorption by- Deepak kumar
Factors affecting oral absorption by- Deepak kumarFactors affecting oral absorption by- Deepak kumar
Factors affecting oral absorption by- Deepak kumarDeepak Kumar
 
chap no 1 INTRODUCTION TO PHARMACOLOGY 2.pptx
chap no 1 INTRODUCTION TO PHARMACOLOGY 2.pptxchap no 1 INTRODUCTION TO PHARMACOLOGY 2.pptx
chap no 1 INTRODUCTION TO PHARMACOLOGY 2.pptxMahnoorFatima92
 
General Pharmacokinetics
General PharmacokineticsGeneral Pharmacokinetics
General PharmacokineticsEneutron
 

Semelhante a Biopharmaceutics lecture1 (20)

Floating drug delivery system review
Floating drug delivery system reviewFloating drug delivery system review
Floating drug delivery system review
 
Dosage form design - Biopharmaceutical consideration
Dosage form design - Biopharmaceutical considerationDosage form design - Biopharmaceutical consideration
Dosage form design - Biopharmaceutical consideration
 
Patient Related factors of Drug Absorption
Patient Related factors of Drug AbsorptionPatient Related factors of Drug Absorption
Patient Related factors of Drug Absorption
 
Colonic Drug Deliverey System
Colonic Drug Deliverey SystemColonic Drug Deliverey System
Colonic Drug Deliverey System
 
GRDDS-Modulation to GI transit time,Approach to extend GI transit time
GRDDS-Modulation to GI transit time,Approach to extend GI transit timeGRDDS-Modulation to GI transit time,Approach to extend GI transit time
GRDDS-Modulation to GI transit time,Approach to extend GI transit time
 
Colon Specific Drug Delivery System: Basics and Approaches
Colon Specific Drug Delivery System: Basics and ApproachesColon Specific Drug Delivery System: Basics and Approaches
Colon Specific Drug Delivery System: Basics and Approaches
 
2Factors affecting oral absorption.pptx
2Factors affecting oral absorption.pptx2Factors affecting oral absorption.pptx
2Factors affecting oral absorption.pptx
 
04.0 drug absorption
04.0 drug absorption04.0 drug absorption
04.0 drug absorption
 
2.colon specific drug delivery system 2 nd sem
2.colon specific drug delivery system  2 nd sem2.colon specific drug delivery system  2 nd sem
2.colon specific drug delivery system 2 nd sem
 
Pharmacokinetics of drugs
Pharmacokinetics of drugsPharmacokinetics of drugs
Pharmacokinetics of drugs
 
Colon Targeting by Novel Drug Delivery Drug System: Microsphere a Review Report
Colon Targeting by Novel Drug Delivery Drug System: Microsphere a Review ReportColon Targeting by Novel Drug Delivery Drug System: Microsphere a Review Report
Colon Targeting by Novel Drug Delivery Drug System: Microsphere a Review Report
 
Biopharmaceutics Lec 02.pdf
Biopharmaceutics Lec 02.pdfBiopharmaceutics Lec 02.pdf
Biopharmaceutics Lec 02.pdf
 
Suppositories by G VIJAYA SINDHURI(Ph.D) Department of pharmaceutics
Suppositories by G VIJAYA SINDHURI(Ph.D) Department of pharmaceutics Suppositories by G VIJAYA SINDHURI(Ph.D) Department of pharmaceutics
Suppositories by G VIJAYA SINDHURI(Ph.D) Department of pharmaceutics
 
Gastro-retentive drug delivery systems.pptx
Gastro-retentive drug delivery systems.pptxGastro-retentive drug delivery systems.pptx
Gastro-retentive drug delivery systems.pptx
 
GRDDS.pptx
GRDDS.pptxGRDDS.pptx
GRDDS.pptx
 
Drug Pharmacokinetics
Drug Pharmacokinetics Drug Pharmacokinetics
Drug Pharmacokinetics
 
Class drug absorption
Class drug absorptionClass drug absorption
Class drug absorption
 
Factors affecting oral absorption by- Deepak kumar
Factors affecting oral absorption by- Deepak kumarFactors affecting oral absorption by- Deepak kumar
Factors affecting oral absorption by- Deepak kumar
 
chap no 1 INTRODUCTION TO PHARMACOLOGY 2.pptx
chap no 1 INTRODUCTION TO PHARMACOLOGY 2.pptxchap no 1 INTRODUCTION TO PHARMACOLOGY 2.pptx
chap no 1 INTRODUCTION TO PHARMACOLOGY 2.pptx
 
General Pharmacokinetics
General PharmacokineticsGeneral Pharmacokinetics
General Pharmacokinetics
 

Mais de homebwoi

Glaucoma Treatment
Glaucoma TreatmentGlaucoma Treatment
Glaucoma Treatmenthomebwoi
 
THE POWER OF PERSUASION How We’re Bought and Sold - Robert Levine.PDF
THE POWER OF PERSUASION How We’re Bought and Sold - Robert Levine.PDFTHE POWER OF PERSUASION How We’re Bought and Sold - Robert Levine.PDF
THE POWER OF PERSUASION How We’re Bought and Sold - Robert Levine.PDFhomebwoi
 
Mastery - The Keys To Success And Long-Term Fulfillment - George Leonard
Mastery - The Keys To Success And Long-Term Fulfillment - George LeonardMastery - The Keys To Success And Long-Term Fulfillment - George Leonard
Mastery - The Keys To Success And Long-Term Fulfillment - George Leonardhomebwoi
 
Therapeutic systems lecture 5
Therapeutic systems lecture 5Therapeutic systems lecture 5
Therapeutic systems lecture 5homebwoi
 
Drug excretion lecture 10
Drug excretion  lecture 10Drug excretion  lecture 10
Drug excretion lecture 10homebwoi
 
Cpt htn march 2010
Cpt   htn march 2010Cpt   htn march 2010
Cpt htn march 2010homebwoi
 
Copd lecture notes
Copd lecture notesCopd lecture notes
Copd lecture noteshomebwoi
 
Case presentation pud
Case presentation pudCase presentation pud
Case presentation pudhomebwoi
 
Biopharmaceutics lecture 2(2)
Biopharmaceutics lecture 2(2)Biopharmaceutics lecture 2(2)
Biopharmaceutics lecture 2(2)homebwoi
 
Biopharmaceutics lecture 2
Biopharmaceutics lecture 2Biopharmaceutics lecture 2
Biopharmaceutics lecture 2homebwoi
 
Biopharmaceutics lecture4(2)
Biopharmaceutics lecture4(2)Biopharmaceutics lecture4(2)
Biopharmaceutics lecture4(2)homebwoi
 
Biopharmaceutics lecture4
Biopharmaceutics lecture4Biopharmaceutics lecture4
Biopharmaceutics lecture4homebwoi
 
Biopharmaceutics lecture1(2)
Biopharmaceutics lecture1(2)Biopharmaceutics lecture1(2)
Biopharmaceutics lecture1(2)homebwoi
 
Bioavailability studies lecture7
Bioavailability studies lecture7Bioavailability studies lecture7
Bioavailability studies lecture7homebwoi
 
Bioavailability studies ii
Bioavailability studies iiBioavailability studies ii
Bioavailability studies iihomebwoi
 
Therapeutic systems lecture 5 b
Therapeutic systems lecture 5 bTherapeutic systems lecture 5 b
Therapeutic systems lecture 5 bhomebwoi
 

Mais de homebwoi (16)

Glaucoma Treatment
Glaucoma TreatmentGlaucoma Treatment
Glaucoma Treatment
 
THE POWER OF PERSUASION How We’re Bought and Sold - Robert Levine.PDF
THE POWER OF PERSUASION How We’re Bought and Sold - Robert Levine.PDFTHE POWER OF PERSUASION How We’re Bought and Sold - Robert Levine.PDF
THE POWER OF PERSUASION How We’re Bought and Sold - Robert Levine.PDF
 
Mastery - The Keys To Success And Long-Term Fulfillment - George Leonard
Mastery - The Keys To Success And Long-Term Fulfillment - George LeonardMastery - The Keys To Success And Long-Term Fulfillment - George Leonard
Mastery - The Keys To Success And Long-Term Fulfillment - George Leonard
 
Therapeutic systems lecture 5
Therapeutic systems lecture 5Therapeutic systems lecture 5
Therapeutic systems lecture 5
 
Drug excretion lecture 10
Drug excretion  lecture 10Drug excretion  lecture 10
Drug excretion lecture 10
 
Cpt htn march 2010
Cpt   htn march 2010Cpt   htn march 2010
Cpt htn march 2010
 
Copd lecture notes
Copd lecture notesCopd lecture notes
Copd lecture notes
 
Case presentation pud
Case presentation pudCase presentation pud
Case presentation pud
 
Biopharmaceutics lecture 2(2)
Biopharmaceutics lecture 2(2)Biopharmaceutics lecture 2(2)
Biopharmaceutics lecture 2(2)
 
Biopharmaceutics lecture 2
Biopharmaceutics lecture 2Biopharmaceutics lecture 2
Biopharmaceutics lecture 2
 
Biopharmaceutics lecture4(2)
Biopharmaceutics lecture4(2)Biopharmaceutics lecture4(2)
Biopharmaceutics lecture4(2)
 
Biopharmaceutics lecture4
Biopharmaceutics lecture4Biopharmaceutics lecture4
Biopharmaceutics lecture4
 
Biopharmaceutics lecture1(2)
Biopharmaceutics lecture1(2)Biopharmaceutics lecture1(2)
Biopharmaceutics lecture1(2)
 
Bioavailability studies lecture7
Bioavailability studies lecture7Bioavailability studies lecture7
Bioavailability studies lecture7
 
Bioavailability studies ii
Bioavailability studies iiBioavailability studies ii
Bioavailability studies ii
 
Therapeutic systems lecture 5 b
Therapeutic systems lecture 5 bTherapeutic systems lecture 5 b
Therapeutic systems lecture 5 b
 

Último

Adenomyosis or Fibroid- making right diagnosis
Adenomyosis or Fibroid- making right diagnosisAdenomyosis or Fibroid- making right diagnosis
Adenomyosis or Fibroid- making right diagnosisSujoy Dasgupta
 
SGK RỐI LOẠN KALI MÁU CỰC KỲ QUAN TRỌNG.pdf
SGK RỐI LOẠN KALI MÁU CỰC KỲ QUAN TRỌNG.pdfSGK RỐI LOẠN KALI MÁU CỰC KỲ QUAN TRỌNG.pdf
SGK RỐI LOẠN KALI MÁU CỰC KỲ QUAN TRỌNG.pdfHongBiThi1
 
Role of Soap based and synthetic or syndets bar
Role of  Soap based and synthetic or syndets barRole of  Soap based and synthetic or syndets bar
Role of Soap based and synthetic or syndets barmohitRahangdale
 
Unit I herbs as raw materials, biodynamic agriculture.ppt
Unit I herbs as raw materials, biodynamic agriculture.pptUnit I herbs as raw materials, biodynamic agriculture.ppt
Unit I herbs as raw materials, biodynamic agriculture.pptPradnya Wadekar
 
The Importance of Mental Health: Why is Mental Health Important?
The Importance of Mental Health: Why is Mental Health Important?The Importance of Mental Health: Why is Mental Health Important?
The Importance of Mental Health: Why is Mental Health Important?Ryan Addison
 
"Radical excision of DIE in subferile women with deep infiltrating endometrio...
"Radical excision of DIE in subferile women with deep infiltrating endometrio..."Radical excision of DIE in subferile women with deep infiltrating endometrio...
"Radical excision of DIE in subferile women with deep infiltrating endometrio...Sujoy Dasgupta
 
Generative AI in Health Care a scoping review and a persoanl experience.
Generative AI in Health Care a scoping review and a persoanl experience.Generative AI in Health Care a scoping review and a persoanl experience.
Generative AI in Health Care a scoping review and a persoanl experience.Vaikunthan Rajaratnam
 
FDMA FLAP - The first dorsal metacarpal artery (FDMA) flap is used mainly for...
FDMA FLAP - The first dorsal metacarpal artery (FDMA) flap is used mainly for...FDMA FLAP - The first dorsal metacarpal artery (FDMA) flap is used mainly for...
FDMA FLAP - The first dorsal metacarpal artery (FDMA) flap is used mainly for...Shubhanshu Gaurav
 
Pregnacny, Parturition, and Lactation.pdf
Pregnacny, Parturition, and Lactation.pdfPregnacny, Parturition, and Lactation.pdf
Pregnacny, Parturition, and Lactation.pdfMedicoseAcademics
 
Physiotherapy Management of Rheumatoid Arthritis
Physiotherapy Management of Rheumatoid ArthritisPhysiotherapy Management of Rheumatoid Arthritis
Physiotherapy Management of Rheumatoid ArthritisNilofarRasheed1
 
introduction to neurology (nervous system, areas, motor and sensory systems)
introduction to neurology (nervous system, areas, motor and sensory systems)introduction to neurology (nervous system, areas, motor and sensory systems)
introduction to neurology (nervous system, areas, motor and sensory systems)Mohamed Rizk Khodair
 
DNA nucleotides Blast in NCBI and Phylogeny using MEGA Xi.pptx
DNA nucleotides Blast in NCBI and Phylogeny using MEGA Xi.pptxDNA nucleotides Blast in NCBI and Phylogeny using MEGA Xi.pptx
DNA nucleotides Blast in NCBI and Phylogeny using MEGA Xi.pptxMAsifAhmad
 
Clinical Research Informatics Year-in-Review 2024
Clinical Research Informatics Year-in-Review 2024Clinical Research Informatics Year-in-Review 2024
Clinical Research Informatics Year-in-Review 2024Peter Embi
 
CONNECTIVE TISSUE (ANATOMY AND PHYSIOLOGY).pdf
CONNECTIVE TISSUE (ANATOMY AND PHYSIOLOGY).pdfCONNECTIVE TISSUE (ANATOMY AND PHYSIOLOGY).pdf
CONNECTIVE TISSUE (ANATOMY AND PHYSIOLOGY).pdfDolisha Warbi
 
Using Data Visualization in Public Health Communications
Using Data Visualization in Public Health CommunicationsUsing Data Visualization in Public Health Communications
Using Data Visualization in Public Health Communicationskatiequigley33
 
World-TB-Day-2023_Presentation_English.pptx
World-TB-Day-2023_Presentation_English.pptxWorld-TB-Day-2023_Presentation_English.pptx
World-TB-Day-2023_Presentation_English.pptxsumanchaulagain3
 
How to cure cirrhosis and chronic hepatitis naturally
How to cure cirrhosis and chronic hepatitis naturallyHow to cure cirrhosis and chronic hepatitis naturally
How to cure cirrhosis and chronic hepatitis naturallyZurück zum Ursprung
 
concept of total quality management (TQM).
concept of total quality management (TQM).concept of total quality management (TQM).
concept of total quality management (TQM).kishan singh tomar
 
Different drug regularity bodies in different countries.
Different drug regularity bodies in different countries.Different drug regularity bodies in different countries.
Different drug regularity bodies in different countries.kishan singh tomar
 

Último (20)

Adenomyosis or Fibroid- making right diagnosis
Adenomyosis or Fibroid- making right diagnosisAdenomyosis or Fibroid- making right diagnosis
Adenomyosis or Fibroid- making right diagnosis
 
SGK RỐI LOẠN KALI MÁU CỰC KỲ QUAN TRỌNG.pdf
SGK RỐI LOẠN KALI MÁU CỰC KỲ QUAN TRỌNG.pdfSGK RỐI LOẠN KALI MÁU CỰC KỲ QUAN TRỌNG.pdf
SGK RỐI LOẠN KALI MÁU CỰC KỲ QUAN TRỌNG.pdf
 
Role of Soap based and synthetic or syndets bar
Role of  Soap based and synthetic or syndets barRole of  Soap based and synthetic or syndets bar
Role of Soap based and synthetic or syndets bar
 
Unit I herbs as raw materials, biodynamic agriculture.ppt
Unit I herbs as raw materials, biodynamic agriculture.pptUnit I herbs as raw materials, biodynamic agriculture.ppt
Unit I herbs as raw materials, biodynamic agriculture.ppt
 
The Importance of Mental Health: Why is Mental Health Important?
The Importance of Mental Health: Why is Mental Health Important?The Importance of Mental Health: Why is Mental Health Important?
The Importance of Mental Health: Why is Mental Health Important?
 
"Radical excision of DIE in subferile women with deep infiltrating endometrio...
"Radical excision of DIE in subferile women with deep infiltrating endometrio..."Radical excision of DIE in subferile women with deep infiltrating endometrio...
"Radical excision of DIE in subferile women with deep infiltrating endometrio...
 
Cone beam CT: concepts and applications.pptx
Cone beam CT: concepts and applications.pptxCone beam CT: concepts and applications.pptx
Cone beam CT: concepts and applications.pptx
 
Generative AI in Health Care a scoping review and a persoanl experience.
Generative AI in Health Care a scoping review and a persoanl experience.Generative AI in Health Care a scoping review and a persoanl experience.
Generative AI in Health Care a scoping review and a persoanl experience.
 
FDMA FLAP - The first dorsal metacarpal artery (FDMA) flap is used mainly for...
FDMA FLAP - The first dorsal metacarpal artery (FDMA) flap is used mainly for...FDMA FLAP - The first dorsal metacarpal artery (FDMA) flap is used mainly for...
FDMA FLAP - The first dorsal metacarpal artery (FDMA) flap is used mainly for...
 
Pregnacny, Parturition, and Lactation.pdf
Pregnacny, Parturition, and Lactation.pdfPregnacny, Parturition, and Lactation.pdf
Pregnacny, Parturition, and Lactation.pdf
 
Physiotherapy Management of Rheumatoid Arthritis
Physiotherapy Management of Rheumatoid ArthritisPhysiotherapy Management of Rheumatoid Arthritis
Physiotherapy Management of Rheumatoid Arthritis
 
introduction to neurology (nervous system, areas, motor and sensory systems)
introduction to neurology (nervous system, areas, motor and sensory systems)introduction to neurology (nervous system, areas, motor and sensory systems)
introduction to neurology (nervous system, areas, motor and sensory systems)
 
DNA nucleotides Blast in NCBI and Phylogeny using MEGA Xi.pptx
DNA nucleotides Blast in NCBI and Phylogeny using MEGA Xi.pptxDNA nucleotides Blast in NCBI and Phylogeny using MEGA Xi.pptx
DNA nucleotides Blast in NCBI and Phylogeny using MEGA Xi.pptx
 
Clinical Research Informatics Year-in-Review 2024
Clinical Research Informatics Year-in-Review 2024Clinical Research Informatics Year-in-Review 2024
Clinical Research Informatics Year-in-Review 2024
 
CONNECTIVE TISSUE (ANATOMY AND PHYSIOLOGY).pdf
CONNECTIVE TISSUE (ANATOMY AND PHYSIOLOGY).pdfCONNECTIVE TISSUE (ANATOMY AND PHYSIOLOGY).pdf
CONNECTIVE TISSUE (ANATOMY AND PHYSIOLOGY).pdf
 
Using Data Visualization in Public Health Communications
Using Data Visualization in Public Health CommunicationsUsing Data Visualization in Public Health Communications
Using Data Visualization in Public Health Communications
 
World-TB-Day-2023_Presentation_English.pptx
World-TB-Day-2023_Presentation_English.pptxWorld-TB-Day-2023_Presentation_English.pptx
World-TB-Day-2023_Presentation_English.pptx
 
How to cure cirrhosis and chronic hepatitis naturally
How to cure cirrhosis and chronic hepatitis naturallyHow to cure cirrhosis and chronic hepatitis naturally
How to cure cirrhosis and chronic hepatitis naturally
 
concept of total quality management (TQM).
concept of total quality management (TQM).concept of total quality management (TQM).
concept of total quality management (TQM).
 
Different drug regularity bodies in different countries.
Different drug regularity bodies in different countries.Different drug regularity bodies in different countries.
Different drug regularity bodies in different countries.
 

Biopharmaceutics lecture1

  • 1. BIOPHARMACEUTICS Adapted by : S. Campbell-Elliott M. Pharm. Sc. Prepared by : A.S. Adebayo, Ph.D. & M. A Williams. M.S.
  • 2.
  • 3.
  • 4.
  • 5.
  • 6.
  • 7.
  • 8.
  • 9.
  • 10. Schematic illustration of the steps involved in the appearance of intact drug in systemic circulation following oral administration of a tablet STOMACH (Gastric content. pH 1-3) SMALL INTESTINE (Intestinal cont. pH 5-7) Tablet Granules Fine particles Dissolution Drug in solution Tablet Granules Fine particles Dissolution Drug in solution Absorption Intact drug Liver Intact Drug in systemic Circulation Pharmacologic effect Intestinal metabolism Metabolites Urine Hepatic Metabolism (1 st Pass Effect) Disintegration Deaggregation
  • 11. Rate Limiting Steps of Absorption Rate of metabolism of drug during its initial passage through the liver (i.e. First-pass effect). Rate at which drug is metabolized by the enzymes in the intestinal mucosal cells en route into mesenteric blood vessels Rate of gastric emptying into small intestine Other factors Rate of release from the dosage form Dosage Design Rate at which drug crosses membrane of the GIT High aqueous solubility Rate of dissolution in gastrointestinal fluid Poor aqueous solubility Rate Limiting Step Nature of Drug
  • 12. Physiological Factors Affecting Oral Absorption
  • 13. Fate of a Drug Product
  • 16.
  • 17.
  • 18.
  • 19.  
  • 20.
  • 21.
  • 22.
  • 23.
  • 24.
  • 25.
  • 26.
  • 27.
  • 28.
  • 29.
  • 30. Increase in Surface Surface Area Structure (relative to cylinder) sq cm simple cylinder 1 3,300 Folds of Kerckring 3 10,000 Villi 30 100,000 Microvilli 600 2,000,000
  • 31.
  • 32.