This document outlines a course on pharmaceutical chemistry taught by Dr. Moona Mehboob Khan at Dow University of Health Sciences. The course covers topics such as basic concepts in pharmaceutical chemistry, organic reactions like electrophilic and nucleophilic substitution, functional groups, carbonium ions, and carbanions. The objectives are to provide a basic understanding of pharmaceutical chemistry and its role in healthcare. The document defines key terms related to pharmaceutical chemistry, organic chemistry, and medicine.

1. Dr. Moona Mehboob Khan
Ph.D (Pharmaceutical Chemistry)
Assistant Professor
D.C.O.P, Dow University of Health Sciences
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2. Course Outline
Introduction to Pharm chem & basic concepts
Electrophillic & nucleophillc substitution reactions
Orientations
Organic reactions
Carbonium ion
Carbanion
Free radicals
Different functional groups
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3. Learning Objectives
Basic concept regarding pharmaceutical chemistry in
health care system.
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4. Introduction
Introduction to Pharmaceutical chemistry
Classification of pharm chem.
Nomenclature of organic pharmaceutical compounds.
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5. Basic concepts in Pharm chem
Conjugation & hyperconjugation
Steric effect
Inductive effect
Mesomeric effect
Hydrogen bonding
Theory of resonance
Effect of structure on reactivity of compounds
Tautomerization of carbonyl compounds
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6. Carbonium Ion rearangement &
their stability
Pinacolone
Wagner-Merrwein
Wolf, Hofman & Beckmann rearrangement
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7. Carbanions & their stability
Condensation reactions
Aldol condensation
Favorskii rearrangement
Witting reactions
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8. Functional Groups
Alcohols & phenols
Ethers
Ketones & aldehydes
Carboxyllic acids
Esters
Amines, amide & imides
Anilines
Lactum & lactones
Diazonium salts
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9. Pharmaceutical chemistry
What is science?
What is chemistry?
What is organic chemistry?
What is Pharmacy?
What is Pharmaceutical chemistry?
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10. Pharmaceutical Chemistry-The science that deals with the discovery or design
of new therapeutic chemicals and the development of
these chemicals into useful medicine.
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11. Medicine
A compound that interacts with a biological system, and
produces a biological response (ideally desired and
positive). ORs
According to world health organization medicine is
defined as “ A medicine is any substance or product that is
used to modify pathalogical states for benefit of
recipient”.
These compounds may be organic & inorganic
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12. Types of Pharm.chem
Organic
Inorganic
Physical chemistry
Analytical chemistry
Synthetic chemistry
Instrumental chemistry
Medicinal chemistry
Bio-stats
Maths
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13. References
Organic chemistry by IL Finar
Organic chemistry by Solomons & Fryhle
Organic chemistry by Brown Foote Inversion
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