2. Schizophrenia: new updates
Dr. Hani Hamed Dessoki, M.D.Psychiatry
Prof. Psychiatry
Chairman of Psychiatry Department
Beni Suef University
Supervisor of Psychiatry Department
El-Fayoum University
APA member

3. Evidence-Based Psychotherapy for
Schizophrenia 2011 Update
 any patients with schizophrenia have psychological distress and
receive some form of psychotherapy.
 Several different psychotherapeutic approaches for schizophrenia
have been developed and studied.
 Of these approaches, cognitive behavior therapy (CBT) has the
strongest evidence base and has shown benefit for symptom
reduction in outpatients with residual symptoms.
 In addition to CBT, other approaches include compliance
therapy, personal therapy, acceptance and commitment therapy,
and supportive therapy.
Faith B. Dickerson; Anthony F. Lehman, FOCUS 2012;10:217-225.

4. Evidence-Based Psychotherapy for
Schizophrenia 2011 Update
 Although usually studied as distinct approaches, these therapies
overlap with each other in their therapeutic elements.
 Psychotherapy for schizophrenia continues to evolve with the recent
advent of such approaches as meta-cognitive therapy, narrative
therapies, and mindfulness therapy.

 Future research may also consider three different goals of
psychotherapy in this patient population: to provide emotional support,
to enhance functional recovery, and to alter the underlying illness
process.
Faith B. Dickerson; Anthony F. Lehman, FOCUS 2012;10:217-225.

5. Schizophrenia and autoimmune
diseases
New data show that individuals with
schizophrenia are at increased risk of developing
autoimmune diseases, according to a study
reported yesterday in AJP in Advance.
Michael Benros

6. New Data
The increased risk of subsequent autoimmune
diseases in individuals with schizophrenia may
involve neuropsychiatric manifestations from the
undiagnosed autoimmune disease, medical
treatment or lifestyle associated with
schizophrenia, or common etiological
mechanisms, such as infections and shared
genetic factors.

7. New Data
 An increased risk of schizophrenia in those with
autoimmune diseases, but that theirs is the first
study to investigate the link between
schizophrenia and subsequent development of
an autoimmune disease "and to consider the
effect of infections, a possible risk factor for
both schizophrenia and autoimmune
diseases."

8. Immune System Protein Could Give
Clue to Late-Onset Schizophrenia
An immune system component called Creactive protein appears to be associated with
late-onset schizophrenia, suggesting that
immune-system-provoked inflammation
contributes to the illness.
Psychiatric News, Clinical and Research News,October 10, 2013

9. Sodium Benzoate May Improve
Symptoms, Cognition in
Schizophrenia, Study Suggests
Sodium benzoate—commonly used as a food
preservative—appears to improve symptoms and
cognition in schizophrenia when used as an
adjunct to antipsychotic medication therapy.

10. Mechanism
Benzoate blocks the metabolism of d-amino
acids, which in turn enhances the function of the
NMDA receptor in the brain; NMDA is believed to
be vital to cognition, a crucial symptom domain of
schizophrenia.
“The preliminary results show promise for damino acid oxidase inhibition as a novel approach
for new drug development for schizophrenia,” the
authors said.