In-Silico Drug Designing Approach

IN –SILICO DRUG TARGET DESIGNING FOR MIGRAINE UNDER GUIDANCE OF Mr. ARVIND SINGH FACULTY BII,NOIDA,INDIA BY- CHINMAYA MAHAPATRA

INTRODUCTION ,[object Object],[object Object]

In silico methods ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

MIGRAINE ,[object Object],[object Object],[object Object],[object Object]

SYMPTOMS OF MIGRAINE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

TYPES OF MIGRAINE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

PATHOPHYSIOLOGY ,[object Object],[object Object],[object Object]

DRUGS PREVIOUSLY PRESCRIBED TO CURE MIGRAINE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

DESCRIPTION OF PROCESS WITH SOFTWARES USED ,[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object]

BETA SHEET ALPHA LEFTHELIX ALPHA HELIX

[object Object],COLOUR KEY GREEN - ALPHA REGION BLUE - ADDITIONAL ALLOWED REGIONS RED- GENEROUSLY ALLOWED REGIONS

DESINING OF INHIBITOR(LIGAND) FOR THE PROTEIN MOLECULE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

PROPERTIES OF THE DRUGS THAT WERE CACULATED ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

TABLE CONTAINING LIGAND WITH THEIR PROPERTIES

FOR LIGAND DERIVATIVES ,[object Object]

RESULTS OF DOCKING ,[object Object]

DRUGS,THEIR DERIVATIVES AND THEIR BINDING ENERGY VALUE[EVALUE] -174.74 SUMATRIPTAN DERIVATIVES -162.74 SUMATRIPTAN -120.22 PARACETAMOL DERIVATIVES -156.39 PARACETAMOL -161.20 NAPROXEN DERIVATIVES -156.39 NAPROXEN -155.34 IBUPROFEN DERIVATIVES -147.18 IBUPROFEN -128.96 ASPIRIN DERIVATIVES -136.47 ASPIRIN

REFERENCES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

In-Silico Drug Designing Approach

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