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LT #2
I can define mutation and explain how mutations of a segment of DNA may
or may not affect an organism
   Mutations are heritable changes in genetic
    information.

   Mutagen: physical or chemical agent that
    can cause mutations in DNA

   Examples:
   X-rays, tobacco, pesticides, U-V light
   1) change DNA base sequence
   2) Increase error rate in DNA replication
   3) Weaken DNA strand causing breaks and
    inversions that change the chromosomes.
   1) Gene mutations
     Change in one or a few nucleotides (A,C,G,T)


    2) Chromosomal mutations
     Changes in whole chromosomes
   1) Substitution
     One base is changed to a different base.
    2) Insertions:
        An extra base is added
    3) Deletions:
        A base has been lost
   Original DNA strand: ATGCTATG

   1) ATCTATG

   2) ATGCTAATG

   3) ATGCAATG
   1) Deletion:
     Loss of all or part of a chromosome



    2) Duplication:
       Extra copy of all or part of a chromosome
   3) Inversion:
     Reverses the direction of parts of a chromosome



    4) Translocation:
        Part of one chromosome breaks off and attaches
        to another.
   1) Most little or no effect
   2) Few produce beneficial results
   3) May disrupt gene function- negative
    results
 Genetic Mutations in Humans

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Mutations

  • 1. LT #2 I can define mutation and explain how mutations of a segment of DNA may or may not affect an organism
  • 2. Mutations are heritable changes in genetic information.  Mutagen: physical or chemical agent that can cause mutations in DNA  Examples:  X-rays, tobacco, pesticides, U-V light
  • 3. 1) change DNA base sequence  2) Increase error rate in DNA replication  3) Weaken DNA strand causing breaks and inversions that change the chromosomes.
  • 4. 1) Gene mutations  Change in one or a few nucleotides (A,C,G,T) 2) Chromosomal mutations  Changes in whole chromosomes
  • 5. 1) Substitution  One base is changed to a different base. 2) Insertions: An extra base is added 3) Deletions: A base has been lost
  • 6.
  • 7. Original DNA strand: ATGCTATG  1) ATCTATG  2) ATGCTAATG  3) ATGCAATG
  • 8. 1) Deletion:  Loss of all or part of a chromosome 2) Duplication: Extra copy of all or part of a chromosome
  • 9. 3) Inversion:  Reverses the direction of parts of a chromosome 4) Translocation: Part of one chromosome breaks off and attaches to another.
  • 10.
  • 11. 1) Most little or no effect  2) Few produce beneficial results  3) May disrupt gene function- negative results