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Sorafenib
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Fecal  ( 77% )  and renal (19%)   Excretion 25-48hours Half life Hepatic oxidation and glucuronidation (CYP3A4 mediated) Metabolism 99,5% Protein binding 29-49% Bioavailability
[object Object],[object Object],[object Object],[object Object],[object Object],Contraindication
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[object Object],[object Object],[object Object],[object Object],[object Object],Refrence

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Sorafenib

  • 2.
  • 3.
  • 4.
  • 5.
  • 6.
  • 7. Fecal ( 77% ) and renal (19%) Excretion 25-48hours Half life Hepatic oxidation and glucuronidation (CYP3A4 mediated) Metabolism 99,5% Protein binding 29-49% Bioavailability
  • 8.
  • 9.
  • 10.
  • 11.