Black Box Science Producing irreproducible bioinformatics analyses Not collecting the provenance of the analysis. Not testing during software development. Try re-running experiments described in the journal Bioinformatics from before 5 years ago UniGene What is happening during UniGene clustering? ‘ Human’ descriptions (via NCBI), are not exact. The Human Transcriptome Map project and other microarray analysts ended up reclustering UniGene [Marco Roos].