1. Pediatric Renal Tumors
Presenter –
Dr Utsab Das
Dept of Pathology ,Calcutta National Medical
College
Moderator –
Dr Piyali Ghosh
Demonstrator ,Dept of Pathology ,Calcutta
National Medical College
47. Rhabdoid Tumor of Kidney. The nuclear grade is high.
An eosinophilic amorphous (“hyaline”) material fills the scanty
cytoplasm and pushes the nucleus aside
50. • Molecular Genetics-
• hSNF5/INI-1 (chr22q11.2) deletion/mutation
• SMARCB1 retaining – SMARCA4/BRG1
• Markers-
• Vimentin or cytokeratin
• Loss of SMARCB1 (hSNF5)
• Prognosis-
* High tumor stage and male sex
-unfavorable
55. • Genetic profile
• Polysomy of chromosomes 8, 11, 17,20
*Cellular CMN – t(12;15)(p13;q25)
results in ETV6–NTRK3 gene fusion
Treatment & Prognosis-
*Nephrectomy
*7% recurrence with local invasion
*Age at diagnosis & adequacy of excision -more
important than morphology
56. 4)Ossifying renal tumour of infancy
• Intracalyceal mass composed of -
1) Osteoid trabeculae
2) Osteoblast-like cells
3) Spindle cell component
* Arise from and attached to Medullary Pyramid.
• Clinical features-
• Male predominance,
• Age <2 years
• Gross haematuria **
57. • Macroscopy-
• Well circumscribed , 1 -6 cm diameter
• Histopathology
• Osteoid core
• Osteoblastic cells within and periphery
• Bland spindle cells
• Genetic profile
• Relation with other paediatric renal neoplasms
uncertain
• A small number of cases shown trisomy 4
59. My references-
• 1) WHO Classification of Tumours of
Urogenital system -2016
• 2) ROSAI AND ACKERMAN’S Surgical Pathology
11th Ed
• 3) Sternberg's Diagnostic Surgical Pathology
6th Ed