Received First Prize at ASCICON 2009 in competitive Platform Presentation category

1. A STUDY ON MICROALBUMINURIA AS A PREDICTIVE MARKER OF TARGET ORGAN DAMAGE IN HYPERTENSION Dr. Tanoy Bose Co authors: Kalita HC, Laskar B, Gogoi GN, Baruah K, Kotokey D, Das K, Dutta A

2. Introduction Accurate cardiovascular risk evaluation: a prerequisite for devising cost-effective therapeutic strategies in patients with essential HTN. Microalbuminuria, an integrated marker of target organ damage and, therefore, of global risk, could prove to be a valuable tool in the screening and identification of hypertensive patients who are at higher cardiovascular risk. Evidence : Regression of left ventricular hypertrophy parallels the reduction of albuminuria to some degree regardless of BP changes.† †Olsen MH, Wachtell K, Borch-Johnsen K, Okin PM, Kjeldsen SE, Dahlof B, Devereux RB, Ibsen HA:. Losartan Intervention For Endpoint reduction. J Hum Hypertens 16: 591 595, 2002

3. Aims and Objectives Prevalence of microalbuminuria (MAU) among hypertensive patients Co-relationship of microalbuminuria with duration & severity of hypertension, sex, dyslipidemia and ceratin specific target organ damage due to hypertension

4. Methodology Non-randomized, cross-sectional, observational study. 128 cases of hypertension : JNC 7 criteria. Duration: 1 year from July 2005 to June 2006. Examined clinically, routinely investigated along with creatinine clearance, lipid profile, ophthalmoscopy, ECG and urine MAU estimation.

7. Renal failure

8. CCF

9. Pre-existing renal disease

10. UTI

11. Pregnancy

12. Fever

13. Drugs affecting kidneys [eg. Aminoglycosides, NSAIDs]

14. Rx with ACEI or ARB

15. Macroalbuminuria

17. Results

18. Results

20. 40.38% of Stage II Htn had MAU vs 25% in Stage I Htn.

21. In MAU group, mean BP was 169.75±12.68 / 91.5±5.96 mm Hgvs145.62 ± 10.32/ 90.4 ± 2.45 mm Hg in non MAU group.

23. Prevalence of MAU increased with age [38.88% in 31-40yrs vs 61.53% in >60yrs]

24. 58.33% of pts having MAU had a disease duration of >9yrs vs 18.75% with a duration of 4-6 yrs.

27. Microalbuminuria showed a positive correlation with the

28. Duration of Hypertension

29. Severity

30. Male sex

31. Obesity

32. Low HDL levels (<40mg/dl)

33. High LDL levels (>150mg/dl)

34. Retinopathy

36. May be considered as an indicator of early interventions to prevent or retard organ damageTake Home Message

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