2. Carbohydrates: oligo- and
polysaccharides

3. Glycosidic Linkage

4. Disaccharides
maltose
(a-D-glucosyl-(1->4)-b-D-glucopyranose)

5. cellobiose
(b-D-glucosyl-(1->4)-b-D-glucopyranose)

6. Lactose
(b-D-galactosyl-(1->4)-b-D-glucopyranose)

7. sucrose
(a-D-glucosyl-(1->2)-b-D-fructofuranose)

8. Higher Oligosaccharides

9. Oligosaccharide groups are incorporated in to
many drug structures

10. Polysaccharides

11. Amylose and Amylopectin

12. Iodine binding to starch

13. glycogen

14. Dextrans

15. Cellulose

16. Cellulose vs Amylose
Amylose
Cellulose
Glucose units rotated 180o relative to next residue

17. Cellulose

18. Chitin

19. Chitin vs Cellulose

20. Glycoproteins

21. O-linked Glycoproteins

22. Blood ABO Antigens
• Structure of the ABO blood group
carbohydrates,
R represents the linkage to protein in the
secreted forms, sphingolipid in the cell-surface
bound form
• open square = GlcNAc, open diamond =
galactose, filled square = fucose, filled diamond
= GalNAc, filled diamond = sialic acid (NANA)

24. N-linked Glycoproteins