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Clinical impression septic arthritis Patient Presents With Acute Increase In Pain +/- Swelling In One  Or More Joints G.P Refer for urgent A&E or specialist assessment Definite alternative diagnosis Inflammatory arthritis Crystal arthritis Haemarthrosis Trauma Bursitis/Cellulitis Treat as appropriate No definite alternative diagnosis but could be septic Self referral to A&E MUST ASPIRATE  and other investigations History Examination History Examination Diagnosis SEPTIC ARTHRITIS Empirical antibiotic treatment (as per local protocol) Alter if necessary once results available NOT SEPTIC Seek rheumatology or orthopaedic advice if in doubt
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EXAMINATION Joint   Effusion / heat / erythema / restriction of movement  - if all 4 signs are  present then sepsis is likely Large joints more commonly affected than small joints.  The majority of joint sepsis occurs in the hip or knee  1 st  MTP only joint affected – consider gout. Joints involved   monoarticular/polyarticular - 22% septic arthritis affects >1 joint Pyrexia   May be absent in 50% of patients with septic arthritis and present in  cases of crystal arthritis General Examination Look for - Signs of systemic involvement: pulse, BP - Sites of infection Skin lesions  - blisters/pustules suggest gonococcal arthritis - tophi suggest gout Bursitis/cellulitis   suggested by local warmth and erythema without joint effusion and  without restriction of joint movement
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INVESTIGATION OF SYNOVIAL FLUID Synovial fluid must be aspirated prior to starting antibiotics, Gram stained and   cultured (If affected joint is prosthetic seek orthopaedic advice) Send specimen fresh to the laboratory for immediate microscopy and culture Polarising microscopy to evaluate crystals must be carried out on all synovial fluid samples.  The samples should be fresh and the microscopy performed by a microscopist experienced in crystal identification.   (If unable to process samples immediately they should be stored at room temperature overnight to prevent artefactual crystal formation) Neither the absence of organisms on Gram stain, nor a negative synovial fluid culture excludes the diagnosis of septic arthritis, although they make it less likely and alternative diagnoses should be considered
Antibiotic choice will need to be modified in the light of results of Gram stain and culture.  This table is based on expert opinion, and should be reviewed locally by microbiology IV antibiotics should be used and continued for at least 2 weeks Repeat joint aspiration/surgical intervention may be required – all patients should be referred for a rheumatological or orthopaedic opinion Joints should be aspirated to dryness as often as is required Further treatment with oral antibiotics for at least 4 weeks.  Do not stop antibiotics until symptoms and signs resolve, and ESR/CRP are returning to normal Summary of recommendations for initial empirical antibiotic choice in suspected septic arthritis Patient Group Antibiotic Choice No risk factors for atypical organisms Flucloxacillin 2g qds iv.  Local policy may be to add gentamicin iv. If penicillin allergic, Clindamycin 450-600mg qds iv. or 2 nd  or 3 rd  generation cephalosporin iv. High risk of Gram –ve sepsis (elderly, frail, recurrent UTI, recent abdominal surgery) 2 nd  or 3 rd  generation cephalosporin eg cefuroxime 1.5g tds iv.  Local policy may be to add flucloxacillin iv to 3 rd  generation cephalosporin.  Discuss allergic patients with microbiology-Gram stain may influence antibiotic choice MRSA risk ( known MRSA, recent inpatient, nursing home resident, leg ulcers or catheters, or other risk factors determined locally) Vancomycin iv. plus 2 nd  or 3 rd  generation cephalosporin iv. Suspected gonococcus or meningococcus Ceftriaxone iv. or similar dependent on local policy / resistance iv drug users Discuss with microbiologist ITU patients, known colonisation of other organs (eg cystic fibrosis) Discuss with microbiologist

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Swollen Joint Guideline

  • 1. Clinical impression septic arthritis Patient Presents With Acute Increase In Pain +/- Swelling In One Or More Joints G.P Refer for urgent A&E or specialist assessment Definite alternative diagnosis Inflammatory arthritis Crystal arthritis Haemarthrosis Trauma Bursitis/Cellulitis Treat as appropriate No definite alternative diagnosis but could be septic Self referral to A&E MUST ASPIRATE and other investigations History Examination History Examination Diagnosis SEPTIC ARTHRITIS Empirical antibiotic treatment (as per local protocol) Alter if necessary once results available NOT SEPTIC Seek rheumatology or orthopaedic advice if in doubt
  • 2.
  • 3. EXAMINATION Joint Effusion / heat / erythema / restriction of movement - if all 4 signs are present then sepsis is likely Large joints more commonly affected than small joints. The majority of joint sepsis occurs in the hip or knee 1 st MTP only joint affected – consider gout. Joints involved monoarticular/polyarticular - 22% septic arthritis affects >1 joint Pyrexia May be absent in 50% of patients with septic arthritis and present in cases of crystal arthritis General Examination Look for - Signs of systemic involvement: pulse, BP - Sites of infection Skin lesions - blisters/pustules suggest gonococcal arthritis - tophi suggest gout Bursitis/cellulitis suggested by local warmth and erythema without joint effusion and without restriction of joint movement
  • 4.
  • 5. INVESTIGATION OF SYNOVIAL FLUID Synovial fluid must be aspirated prior to starting antibiotics, Gram stained and cultured (If affected joint is prosthetic seek orthopaedic advice) Send specimen fresh to the laboratory for immediate microscopy and culture Polarising microscopy to evaluate crystals must be carried out on all synovial fluid samples. The samples should be fresh and the microscopy performed by a microscopist experienced in crystal identification. (If unable to process samples immediately they should be stored at room temperature overnight to prevent artefactual crystal formation) Neither the absence of organisms on Gram stain, nor a negative synovial fluid culture excludes the diagnosis of septic arthritis, although they make it less likely and alternative diagnoses should be considered
  • 6. Antibiotic choice will need to be modified in the light of results of Gram stain and culture. This table is based on expert opinion, and should be reviewed locally by microbiology IV antibiotics should be used and continued for at least 2 weeks Repeat joint aspiration/surgical intervention may be required – all patients should be referred for a rheumatological or orthopaedic opinion Joints should be aspirated to dryness as often as is required Further treatment with oral antibiotics for at least 4 weeks. Do not stop antibiotics until symptoms and signs resolve, and ESR/CRP are returning to normal Summary of recommendations for initial empirical antibiotic choice in suspected septic arthritis Patient Group Antibiotic Choice No risk factors for atypical organisms Flucloxacillin 2g qds iv. Local policy may be to add gentamicin iv. If penicillin allergic, Clindamycin 450-600mg qds iv. or 2 nd or 3 rd generation cephalosporin iv. High risk of Gram –ve sepsis (elderly, frail, recurrent UTI, recent abdominal surgery) 2 nd or 3 rd generation cephalosporin eg cefuroxime 1.5g tds iv. Local policy may be to add flucloxacillin iv to 3 rd generation cephalosporin. Discuss allergic patients with microbiology-Gram stain may influence antibiotic choice MRSA risk ( known MRSA, recent inpatient, nursing home resident, leg ulcers or catheters, or other risk factors determined locally) Vancomycin iv. plus 2 nd or 3 rd generation cephalosporin iv. Suspected gonococcus or meningococcus Ceftriaxone iv. or similar dependent on local policy / resistance iv drug users Discuss with microbiologist ITU patients, known colonisation of other organs (eg cystic fibrosis) Discuss with microbiologist