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MENINGITIS ,[object Object],[object Object],[object Object],[object Object]
 
What is meningitis? ,[object Object]
How is Meningitis Caused ,[object Object],[object Object]
 
How is Meningitis Caused ,[object Object]
How is Meningitis Caused ,[object Object]
How is Meningitis Caused ,[object Object],[object Object]
How is Meningitis Caused ,[object Object]
How is Meningitis Caused ,[object Object]
How is Meningitis Caused ,[object Object]
How is Meningitis Caused ,[object Object]
How is Meningitis Caused ,[object Object],[object Object],[object Object]
How is Meningitis Caused ,[object Object]
How is Meningitis Caused ,[object Object],[object Object]
How is Meningitis Caused ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
How is Meningitis Caused ,[object Object],[object Object],[object Object],[object Object],[object Object]
How is Meningitis Caused ,[object Object],[object Object],[object Object],[object Object]
How is Meningitis Caused ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
How is Meningitis Caused ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
How is Meningitis Caused ,[object Object],[object Object],[object Object],[object Object],[object Object]
Organisms Causing Meningitis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Organisms Causing Meningitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Organisms Causing Meningitis ,[object Object],[object Object]
Organisms Causing Meningitis ,[object Object]
Organisms Causing Meningitis ,[object Object]
Organisms Causing Meningitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Organisms Causing Meningitis ,[object Object],[object Object],[object Object]
Organisms Causing Meningitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Organisms Causing Meningitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Organisms Causing Meningitis ,[object Object],[object Object]
Organisms Causing Meningitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Organisms Causing Meningitis ,[object Object],[object Object],[object Object],[object Object]
Organisms Causing Meningitis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Organisms Causing Meningitis ,[object Object]
Organisms Causing Meningitis ,[object Object],[object Object],[object Object]
Organisms Causing Meningitis ,[object Object],[object Object]
Neisseria meningitidis   Bacteria http://www.waterscan.co.yu/viruses-and-bacteries.php?lng=sr
Hemophilus influenza (H flu) Strep pneumoniae
CSF-Gram stain: ,[object Object]
CSF-Gram stain: ,[object Object],[object Object]
CSF-Gram stain: ,[object Object],[object Object]
CSF-Gram stain: ,[object Object],[object Object]
CSF-Gram stain: ,[object Object]
Pathogenesis of Meningitis ,[object Object]
Pathogenesis of Meningitis ,[object Object]
Pathogenesis of Meningitis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Pathogenesis of Meningitis ,[object Object],[object Object],[object Object]
Pathogenesis of Meningitis ,[object Object],[object Object],[object Object],[object Object]
Pathogenesis of Meningitis ,[object Object],[object Object]
The white appearance of this calf brain is caused by neutrophils within the meninges – a condition known as meningitis.  This is usually due to a  bacterial infection.
This calf brain shows similar pathology.  If a glass slide is pressed to the  surface of the brain and stained it would show high numbers of  neutrophils.
Bovine  This brain shows irregular red spots which are areas of hemorrhage and necrosis caused by the bacteria,  Histophilus somni .
Brain: Purulent meningitis
Brain: meningitis.
Pathogenesis of Meningitis ,[object Object],[object Object]
The evolution of the abscess is as follows:   ,[object Object],[object Object]
evolution of the abscess ,[object Object]
evolution of the abscess ,[object Object]
evolution of the abscess ,[object Object],[object Object]
BRAIN ABCESS
BRAIN ABCESS ,[object Object]
 
 
Bacterial Meningitis:  (Library Pictures) Abscess-Cerebral Gross:
Abscess-Cerebral MRI
 
Bacterial Meningitis:  (Library Pictures) Meningial enhancement in a Bacterial meningitis - CT Scan Image
 
Signs & symptoms of Meningitis ,[object Object],[object Object]
Signs & symptoms of Meningitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Signs & symptoms of Meningitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Kernig’s Sign ,[object Object],[object Object]
Signs & symptoms of Meningitis
Brudzinski’s Sign ,[object Object],[object Object]
 
Normal fundus
Increased intracranial pressure (ICP) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Meningococcemia - Petechiae
Signs & symptoms of Meningitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Signs & symptoms of Meningitis ,[object Object],[object Object],[object Object],[object Object]
Meningococcemia - Purpura fulminans
Signs & symptoms of Meningitis ,[object Object]
Complications and Outcome of Meningitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Complications and Outcome of Meningitis ,[object Object],[object Object],[object Object],[object Object]
Complications and Outcome of Meningitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Complications and Outcome of Meningitis ,[object Object],[object Object]
Complications and Outcome of Meningitis ,[object Object],[object Object],[object Object],[object Object]
Increased intracranial pressure Headache Vomiting Decreased Level of Consciousness Papilledema Herniation
TYPES OF HERNIATION ,[object Object],[object Object],[object Object],[object Object]
TRANSTENTORIAL (UNCAL) HERNIATION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
HYDROCEPHALUS ,[object Object],[object Object],[object Object]
Complications and Outcome of Meningitis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Complications and Outcome of Meningitis ,[object Object],[object Object],[object Object]
Complications and Outcome of Meningitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Complications and Outcome of Meningitis ,[object Object],[object Object],[object Object]
Complications and Outcome of Meningitis ,[object Object],[object Object],[object Object]
Complications and Outcome of Meningitis ,[object Object],[object Object],[object Object]
Complications and Outcome of Meningitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Differential Diagnosis of Meningitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Differential Diagnosis of Meningitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Differential Diagnosis of Meningitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Investigations & Diagnosis of  Meningitis
CSF & LUMBER PUNCTURE ,[object Object]
CSF & LUMBER PUNCTURE ,[object Object]
CSF & LUMBER PUNCTURE ,[object Object]
CSF & LUMBER PUNCTURE ,[object Object],[object Object]
CSF & LUMBER PUNCTURE ,[object Object]
CSF & LUMBER PUNCTURE ,[object Object]
CSF & LUMBER PUNCTURE ,[object Object],[object Object]
CSF & LUMBER PUNCTURE ,[object Object],[object Object],[object Object],[object Object]
CSF & LUMBER PUNCTURE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
CSF & LUMBER PUNCTURE ,[object Object]
CSF & LUMBER PUNCTURE ,[object Object],[object Object],[object Object]
CSF & LUMBER PUNCTURE ,[object Object],[object Object],[object Object],[object Object]
CSF & LUMBER PUNCTURE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Positioning INCORRECT CORRECT
CSF & LUMBER PUNCTURE ,[object Object],[object Object]
Skin Preparation ,[object Object],[object Object]
 
Spinal Needle Insertion ,[object Object],[object Object],[object Object],[object Object]
CSF & LUMBER PUNCTURE ,[object Object]
CSF & LUMBER PUNCTURE ,[object Object]
CSF & LUMBER PUNCTURE ,[object Object]
CSF & LUMBER PUNCTURE ,[object Object]
CSF & LUMBER PUNCTURE ,[object Object]
CSF & LUMBER PUNCTURE ,[object Object],[object Object]
CSF & LUMBER PUNCTURE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
CSF & LUMBER PUNCTURE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
CSF & LUMBER PUNCTURE ,[object Object],[object Object],[object Object],[object Object]
CSF & LUMBER PUNCTURE ,[object Object],[object Object],[object Object],[object Object]
CSF & LUMBER PUNCTURE ,[object Object],[object Object],[object Object]
CSF & LUMBER PUNCTURE ,[object Object],[object Object]
CSF & LUMBER PUNCTURE ,[object Object],[object Object]
CSF & LUMBER PUNCTURE ,[object Object]
CSF & LUMBER PUNCTURE ,[object Object],[object Object]
CSF & LUMBER PUNCTURE ,[object Object],[object Object]
CSF & LUMBER PUNCTURE ,[object Object],[object Object]
CSF & LUMBER PUNCTURE ,[object Object]
CSF & LUMBER PUNCTURE ,[object Object],[object Object]
CSF & LUMBER PUNCTURE ,[object Object]
CSF & LUMBER PUNCTURE ,[object Object],[object Object]
CSF & LUMBER PUNCTURE ,[object Object]
CSF & LUMBER PUNCTURE ,[object Object],[object Object]
CSF & LUMBER PUNCTURE ,[object Object],[object Object]
CSF & LUMBER PUNCTURE ,[object Object]
CSF & LUMBER PUNCTURE ,[object Object],[object Object],[object Object],[object Object]
CSF & LUMBER PUNCTURE ,[object Object],[object Object],[object Object]
CSF & LUMBER PUNCTURE ,[object Object]
CSF PRESSURE ,[object Object]
CSF PRESSURE ,[object Object]
CSF PRESSURE ,[object Object],[object Object]
Investigations & Diagnosis of Meningitis ,[object Object],[object Object],[object Object]
Investigations & Diagnosis of Meningitis ,[object Object],[object Object]
Investigations & Diagnosis of Meningitis ,[object Object],[object Object],[object Object],[object Object]
Investigations & Diagnosis of Meningitis ,[object Object]
CSF evaluation <50 25-500 25 – 500 Fungal <50 100-500 <500 TB Low to normal 100+ <1000 Viral Low 100-500 >1000K PMN’s Bacterial, acute >50 5-50 <5 , lymphs mainly Normal Glucose (mg/dL) Protein (mg/dL) WBC Condition
CSF Diagnosis Elevated (>100) Low (<50) Elevated (PMN’s early, lymphs late TB Meningitis Normal or slightly elevated Normal to low Elevated (PMN’s early, lymphs late) Aseptic Meningitis Elevated (>100) Low compared to serum (<20) >1000 PMN’s predominate Bacterial Meningitis 20-50 (½ serum level) 2/3 serum glucose <5 (lymphs 70%, PMN’s 3%) Normal Protein Glucose WBC
CSF Abnormalities In Bacterial Meningitis Positive in >60% Gram stain 100-500mg/dl Protein <0.4 CSF/serum glucose <2.2 mmol/l Glucose 1000-100 000 cells/mm3 White blood cells More than 180 mm H2O Opening pressure
CSF evaluation Normal 50-100 <500-1000 Viral <50 25-500 <500 Fungal <50 100-500 <500 TB Low to normal 100+ 1 – 10,000 Bacterial, part rx’d Low 100-500 >1000 PMN’s Bacterial, acute >50 5-45 <7, lymphs mainly Normal Glucose (mg/dL) Protein (mg/dL) WBC Condition
Summary of Typical  CSF Findings +TB Negative Positive Negative Culture Increased +/- Increased Increased 5-40 Protein < 30% Normal <40% 66% CSF plasma: Glucose ratio Decreased Normal Decreased 60-80 Glucose Increased Predominate Late 5 Lymphocytes +/- increased Early Predominate 0 Polymorphs 25-500 <1000 >1000 0-5 Cells TB Viral  Bacterial Normal
TREATMENT of MENINGITIS ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object]
[object Object]
[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Meningitis By Dr Bashir Ahmed Dar Associate Professor Medicine Chinkipora Sopore Kashmir

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  • 38. Neisseria meningitidis Bacteria http://www.waterscan.co.yu/viruses-and-bacteries.php?lng=sr
  • 39. Hemophilus influenza (H flu) Strep pneumoniae
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  • 51. The white appearance of this calf brain is caused by neutrophils within the meninges – a condition known as meningitis. This is usually due to a bacterial infection.
  • 52. This calf brain shows similar pathology. If a glass slide is pressed to the surface of the brain and stained it would show high numbers of neutrophils.
  • 53. Bovine This brain shows irregular red spots which are areas of hemorrhage and necrosis caused by the bacteria, Histophilus somni .
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  • 65. Bacterial Meningitis: (Library Pictures) Abscess-Cerebral Gross:
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  • 68. Bacterial Meningitis: (Library Pictures) Meningial enhancement in a Bacterial meningitis - CT Scan Image
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  • 75. Signs & symptoms of Meningitis
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  • 90. Increased intracranial pressure Headache Vomiting Decreased Level of Consciousness Papilledema Herniation
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  • 104. Investigations & Diagnosis of Meningitis
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  • 158. CSF evaluation <50 25-500 25 – 500 Fungal <50 100-500 <500 TB Low to normal 100+ <1000 Viral Low 100-500 >1000K PMN’s Bacterial, acute >50 5-50 <5 , lymphs mainly Normal Glucose (mg/dL) Protein (mg/dL) WBC Condition
  • 159. CSF Diagnosis Elevated (>100) Low (<50) Elevated (PMN’s early, lymphs late TB Meningitis Normal or slightly elevated Normal to low Elevated (PMN’s early, lymphs late) Aseptic Meningitis Elevated (>100) Low compared to serum (<20) >1000 PMN’s predominate Bacterial Meningitis 20-50 (½ serum level) 2/3 serum glucose <5 (lymphs 70%, PMN’s 3%) Normal Protein Glucose WBC
  • 160. CSF Abnormalities In Bacterial Meningitis Positive in >60% Gram stain 100-500mg/dl Protein <0.4 CSF/serum glucose <2.2 mmol/l Glucose 1000-100 000 cells/mm3 White blood cells More than 180 mm H2O Opening pressure
  • 161. CSF evaluation Normal 50-100 <500-1000 Viral <50 25-500 <500 Fungal <50 100-500 <500 TB Low to normal 100+ 1 – 10,000 Bacterial, part rx’d Low 100-500 >1000 PMN’s Bacterial, acute >50 5-45 <7, lymphs mainly Normal Glucose (mg/dL) Protein (mg/dL) WBC Condition
  • 162. Summary of Typical CSF Findings +TB Negative Positive Negative Culture Increased +/- Increased Increased 5-40 Protein < 30% Normal <40% 66% CSF plasma: Glucose ratio Decreased Normal Decreased 60-80 Glucose Increased Predominate Late 5 Lymphocytes +/- increased Early Predominate 0 Polymorphs 25-500 <1000 >1000 0-5 Cells TB Viral Bacterial Normal
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