BioChain Institute is a privately held company founded in 1994 that provides biological samples and integrated solutions. It has over 200 employees worldwide and facilities in the US and China. BioChain has a large collection of nucleic acids, proteins, tissues and antibodies from various species. It offers extraction and purification services and sample collection from hospitals. BioChain aims to help customers in life science research and clinical diagnostics through high quality products and services.

1. BioChain Institute, Inc. Turn Ideas into Reality Bio-Sample Preparation for Life Science and Diagnostics 1

2. Company Profile Founded in 1994, Privately held Group Companies : Biochain Institute, Inc in Hayward, CA, USA Biochain(Beijing) Science-Tech Corp. in Beijing, China Beijing Modern Gaoda Biotechnology Co. in Beijing, China Branch over 35 distributors worldwide About 200 employees around the world Revenue has been growing annually in double digits. Profitable since 1999 Over ten thousand customers, industry and academic Over 5000 products and providing various custom services ISO 9001, 13485 Certified & GMP 2

3. Facility USA Facility Location: 3517 Breakwater Avenue, Hayward, CA, USA Size: 10,000 sq ft Level: R&D and Manufacture facility China Facility Location: No.7A,Yongchang North Road, Economic and Technological Development Area, Beijing, China Size: 80,000 sq ft manufacture Level: Clinical Diagnostic GMP manufacture and laboratory 3

4. Facility - USA 4

5. Facility - USA . 5

6. Facility - China 6

7. Company Culture Respect Integrity Improvement Innovation Honor 7

8. Team Scientific Team 35 Ph.D. and over 40 Master’s Degree scientists who are well trained in the related research and technology development field. Many of them have over 10 years of working experience in the industry. 8

10. Customers’ Satisfaction.

11. Quality Products.

12. Continuous Improvement. 9

13. Quality Certificate - USA 10

14. Quality Certificate - China 11

15. Business Scope Biochain Institute Inc. USA Sample Preparation for Diagnostics & Life Science Research Biochain(Beijing) Science-Tech Corp. Molecular Diagnostics and Central Lab Beijing Modern Gaoda Biotechnology Co. Immunodiagnostics 12

16. Product Category DNA cDNA RNA Protein Tissue Antibody Cell & Cell Culture Biomarker Bioassay Enzymes Custom Service Diagnostic Kit 13

17. Nucleic Acid Extraction and Purification Gene Expression Profiling and Analysis Gene Amplification and Cloning Gene Regulation and Sequencing Proteins Extraction and Purification Protein Expression Profiling and Analysis Tissue Analysis & Antibodies Tissue Section and Array IHC and ISH Conjugated Antibodies Cell and Cell Culture Primary Cell and Culture Media Custom Service Preclinical Animal Service Cancer Patient Sample Collection and Analysis Custom Antibodies Molecular Biology Service Product Application for Life Science Research 14

18. Product Application forDiagnostics Molecular Diagnostics PCR Sequencing Immunodiagnostics ELISA Point of Care Strip - Colloidal Gold-Based Immunoassay Biochemical Diagnostics Biochemical Detector and Bioassay 15

19. Bio-Sample Preparation Process Sample Collection Storage & Transportation Extraction & Purification Extracts of Bio-Sample Detection and Analysis 16

20. Bio-Sample Collection Sample Resource From licensed venders and Hospitals with Supply Agreement Collected under strict IRB ethical consenting practices (human patient samples) Annotated with associated clinical data and pathological diagnosis Preserved using stringent protocols to maximize sample quality Species Human: Normal, Cancer, Diseases Animal: Monkey, Mouse, Nude Mouse, Rat, Rabbit, Hamster, Porcine, Guinea Pig, Bovine Plant: Arabidopsis , Corn , Wheat , Soy bean , Potato , Rice , Orange Type Tissue, Whole Blood, Serum, Plasma, Urine, Stool 17

21. Vast Tissue Variety Broadest tissue collection Brain Throat Thyroid Lymphoma Esophagus Lung Artery Breast Spleen Liver Bone marrow Gallbladder Stomach Kidney Vein Pancreas Skin Intestine, colon, rectum Bladder Ovary, Uterus, Cervix, Testis Prostate

22. Total RNA, mRNA, microRNA Quality High quality RNA for high efficiency in PCR, reverse transcription, and microRNA studies Extensive quality control procedures MicroRNA certified total RNA Documentation of donors' clinical history available Variety Human normal, cancer (primary and metastasis) and diseased tissues & blood Matched Pairs: normal and primary pair (PP), primary and metastatic pair (PM) Control genomic DNA, human and animal Human cancer cell lines Animals and plants Format Single organ, single donor or multi-donors, male or female Multi-organs, single donor or multi-donors, male or female 19

23. Total RNA and mRNA Normal: >50 Organs Vast Variety Cancers: >40 Types Cancer Matched Pair: Normal & primary/primary and metastatic Neurological Diabetic Cancer cell lines: Hela, Jurkat, A431, K562, MCF7, Raji Human Cardiovascular Adult diseased Pulmonary Liver cirrhosis Lupus disease Total and message RNA Fetal normal: >30 Organs Animal: Bovine, Equine, Chicken, Dog, Mouse, Rat, Hamster, Guinea pig, Rabbit, Cynomolgus monkey, Rhesus monkey Plant Human (male and female): multiple organs Control Genomic DNA Animal (male and female): Bovine, Equine, Chicken, Dog, Mouse, Rat, Hamster, Guinea pig, Rabbit, Cynomolgus monkey, Rhesus monkey 20

25. Applicable for microRNA regulation profiling

27. Northern Blotting, RT-PCR, and RACE

28. MicroRNA study

29. cDNA probe for profiling study in gene expression

30. RNA protection and primer extension

31. RNA display

32. Purification of mRNA 21

35. Western Analysis of Protein lysate

36. IHC and ISH test for tissue sections and tissue arrays22

37. Clinical info collection 23

38. Collection Network Many hospitals in China Tissue vendors world wide BioChain Customers 24

40. Tissues selected by board-certified pathologists

41. Tissues collected under strict IRB and ethical consenting practices

42. Clinical data available including age, gender, tumor TNM and stageVariety In both paraffin-embedded/FFPE and frozen formats Human normal, cancer (primary and metastasis) and diseased tissues Matched Pairs: normal and primary pair (PP), primary and metastatic pair (PM) Human cancer cell lines Animals and plants 25

43. High-throughput tool for therapeutic and diagnostic antibody validation 30 human normal organs arrayed according to FDA guidelines 3 donors per organ for better statistics under FDA regulations Cost- and time-efficient screening of cross-reactivity FDA Standard FFPE Tissue Array available FDA Standard Frozen Tissue Array H &E stained FDA Standard Frozen Tissue Array. A total of 90 tissues spotted on 2 glass slides. Examples of BioChain’s Frozen Tissue Array OCT Blocks 26

44. Features Large cancer tissue collection Pre-arrayed and ready-to-use 12 to 150 different tissues are spotted on one array In both paraffin-embedded/FFPE and frozen formats Multi-cancers, Multi-donors, Multi-applications Matched tissue DNA, RNA, protein and single sections available Clinical Information Tissue samples selected by board-certified pathologists, collected under strict IRB and ethical consenting practices Accompanied with pathological and clinical annotation including patient age, gender, tumor diagnosis, tumor stage (or TNM), tumor size, tumor differentiation, tumor history and H&E images of the source, etc Cancer Tissue Array 27

45. Selected cancer tissue arrays Cancer Tissue Array For complete product list, visit www.biochain.com or call 1-888-762-2568 28

46. FFPE and Frozen Tissue Sections Fig. 1 (left) In Situ Hybridization and Immunohistochemistry of p53 gene in human colon cancer tissue FFPE sections. Three serial paraffin embedded tissue sections were analyzed for p53 gene expression in human colon cancer tissue. It is shown that p53 mRNA and p53 protein are localized in the same area under 400x magnification. Top: H.E. stained image Middle: Image of immunohistochemistry Bottom: Image of in situ hybridization Fig. 2 (left) H. E. stained image of both paraffin embedded and frozen kidney tissue sections. Top: Paraffin embedded kidney section Bottom: Frozen kidney section Tumor Matched Pair sections - Same Donor – Adjacent normal and Primary tumor pair - Primary and Metastasis tumor pair A B C D Fig. 3 (above) H.E. stained tumor matched pair tissue sections. A: Paraffin embedded breast cancer tissue B: Paraffin embedded breast cancer adjacent normal tissue C: Frozen breast cancer tissue D: Frozen breast cancer adjacent normal tissue 29

48. IHC Service CD 29 Negative Control L0061 L0039 L0055 L0039 has stronger expression of CD 29. Due to our OCT blocks were made for micro dissection RNA quality, we have quick frozen procedure, which possibly generates ice crystal. However, the staining is clearly showed and negative control is listed as well. 31

49. HMGA1 Is Induced by Wnt/β-Catenin Pathway and Maintains Cell Proliferation in Gastric Cancer Shin-ichi Akaboshi, et al. Am. J. Pathol., Oct 2009; 175: 1675 - 1685. Up-regulation of C-Terminal Tensin-like Molecule Promotes the Tumorigenicity of Colon Cancer through β-Catenin Yi-Chun Liao, et al. Cancer Res., Jun 2009; 69: 4563 - 4566. HMGA2 Maintains Oncogenic RAS-Induced Epithelial-Mesenchymal Transition in Human Pancreatic Cancer Cells Sugiko Watanabe, et al. Am. J. Pathol., Mar 2009; 174: 854 - 868. MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activityLifeng Liu, et al. J. Biol. Chem., Feb 2009; 284: 5165 - 5174. Genetic and Epigenetic SLC18A2 Silencing in Prostate Cancer Is an Independent Adverse Predictor of Biochemical Recurrence after Radical ProstatectomyKarina Dalsgaard Sørensen, et al. Clin. Cancer Res., Feb 2009; 15: 1400 - 1410. References

51. 16 years of growing company experience

52. Highly trained scientists

53. Global business with the advantages of both US and China

55. Thank you! 35