A brief introduction of dkNET (NIDDK Information Network; https://dknet.org) and the services and resources that are available, including Resource Reports, Authentication Reports, FAIR Data Services, Discovery Portal and Hypothesis Center.
2. An NIDDK Resource dknet.org
About dkNET
• Research resource information portal for biomedical researchers
• Information network to connect DK researchers and NIH-funded
centers
• Funded by National Institute of Health (NIH) - National Institute of
Diabetes and Digestive and Kidney Diseases (NIDDK)
• Developed and maintained by the FAIR Data Informatics Laboratory
(fdilab.org) at UCSD (Supports major informatics projects in
neuroscience and biomedicine)
3. An NIDDK Resource dknet.org
• Basic and clinical researchers in diabetes, digestive, obesity, endocrine, metabolic,
kidney, urologic, nutrition, bone and blood diseases.
• Tools and services are relevant across all biomedical domains
Image credits: NIDDK, NLM
Diabetes Digestive System Endocrine System Urinary System
WhWHO IS dkNET’S TARGET AUDIENCE?
4. An NIDDK Resource dknet.org
5 AREAS IN THE PORTAL
● dkNET provides:
○ Resource Reports: helps researchers find and evaluate resources
○ Authentication Reports: assists researchers in preparing NIH authentication plans
○ FAIR Data Services: assists researchers in finding data repositories and standards
for preparing data management plans
○ Discovery Portal: connects researchers to more than 200 biomedical databases
○ Hypothesis Center: powerful tools for data mining and hypothesis generation of
FAIR ‘omics data
5. dknet.orgAn NIDDK Resource
How Can dkNET Help Researchers?
Construct a
hypothesis
Ask a question
Do background
research
Plan
experiments
Collect and
analyze
data
Publish
results
Discovery Portal Hypothesis Center Resource Reports
Authentication
Reports
Information
Material
Data
Tools
Funded grant and
funding opportunities
Literature
Tutorials
Resource Reports
Hypothesis Center
FAIR Data Resources
Data Management
Data Repositories
Resource Reports
Cite RRID
Track Resources
Resource Identification
Authentication
plansNIH Mandates on Rigor
and Reproducibility for
grant submission
7. An NIDDK Resource dknet.org
Resource Reports
Find and evaluate key research resources:
Antibodies, organisms, cell lines, tools and services, plasmids, biosamples
I’m planning my
experiments, and
would like to find and
evaluate key
resources.
I’m publishing a
paper, and would like
to find RRIDs for
citing key resources.
Construct a
hypothesis
Ask a question
Do background
research
Plan
experiments
Collect and
analyze data
Publish
results
8. dknet.orgAn NIDDK Resource
Resource Reports
Report includes:
● Citations of usage
and mentions
● Who is using them?
● Do they have issues?
● How do they
compare?
● Is anyone near me
familiar with them?
9. dknet.orgAn NIDDK Resource
The resource information network
Alerts
RRID
Sources and
metadata
Literature
Collaborators
Validation &
Ratings
Assembled a unique
data set that
aggregates
information about
key research
resources for
biomedical research
using Research
Resource Identifiers
(RRIDs)
10. dknet.orgAn NIDDK Resource
RRID:AB_1855196
Fothergill LJ et al. Cell and Tissue Research. 375 (2) 359-69, 2019.
WHAT ARE RRIDS?
● A persistent identifier for
research resources
● FDILabs was instrumental in the
development and adoption of
RRIDs
● Supplied by authors to identify
resources in the materials and
methods section
● Designed to answer two simple
questions:
○ What resources were used in a
study
○ Who else has published with this
resource?
11. dknet.orgAn NIDDK Resource
Growth of RRIDs
● RRIDs in use across
major publishers:
○ Cell Press
○ Elsevier
○ Wiley
○ Nature
● 2019: Part of JATS
standard (Journal Article
Tag Suite)
● Over 205,700 resources
have been identified
+1,000
Distinct
Journals
12. dknet.orgAn NIDDK Resource
Resources Rating and Alerts
RRIDs provide us with an
opportunity to alert
researchers to issues with a
particular resource at time
of publication
dkNET aggregates information from multiple sources about
known issues with these resources
13. The Resource Information Network is inserted into the Publication
Process
● RRIDs stand between
authors and publications
● Authors go to a single portal,
the Resource Information
Portal, to obtain RRIDs,
which are issued by over 25
distinct authorities for
different types of resources
● Powered by dkNET
14. dknet.orgAn NIDDK Resource
Impact of RRIDs: Use of RRIDs associated with a
lower reported use of problematic cell lines
Babic Z, et al. eLIFE 2019; 8:e41676 DOI: 10.7554/eLife.41676
8.66%
3.33%
16.11%
5.36%
61.55%
decrease
66.73%
decrease
15. dknet.orgAn NIDDK Resource
Authentication Reports
1. Alert researchers of any issues with cell lines and
antibodies before the study is performed
2. Compliance with the NIH requirements for grant
applications
I’m writing a proposal,
and would like to know
how to prepare
“authentication of key
biological resources”
section.
I’m planning my
experiments and
would like to know
how to identify and
validate resources.
Construct a
hypothesis
Ask a question
Do background
research
Plan
experiments
Collect and
analyze data
Publish
results
16. dknet.orgAn NIDDK Resource
NIH Rigor & Reproducibility Guidelines
https://grants.nih.gov/reproducibility/documents/grant-guideline.pdf
dkNET provides help to
researchers:
● Comply with new
mandates for
research rigor and
reproducibility
● Make it easier for
identifying resources
and preparing
authentication plans
● Manage and share
FAIR research data
17. dknet.orgAn NIDDK Resource
Custom Authentication Report - Cell lines and Antibodies
• NIH requires that
you create an
authentication plan
for key research
resources in your
grant application
• dkNET can help!
• Tool for evaluating
how your resources
perform and best
practices for
designing an
authentication plan
18. dknet.orgAn NIDDK Resource
FAIR data resources for
biomedicine
FDILabs: Co-authors of the FAIR data principles
I’m writing a proposal,
and would like to know
how to prepare data
management plan.
Construct a
hypothesis
Ask a question
Do background
research
Plan
experiments
Collect and
analyze data
Publish
results
I’m publishing a
paper, and would like
to find a data
repository to share my
data.
19. dknet.orgAn NIDDK Resource
FAIR Data Resources
We are assisting with the interpretation of FAIR
for DK domains and providing tools to help with
● Research data management to support FAIR
● Sharing data: Suggested data repositories
and the standards they use
20. dknet.orgAn NIDDK Resource
FAIR data principles
High level principles to make data:
• Findable
• Accessible
• Interoperable
• Re-usable
Mark D. Wilkinson et al. The FAIR Guiding Principles for scientific data management and stewardship,
Scientific Data (2016). DOI: 10.1038/sdata.2016.18
…for humans and machines
21. Findable
● F1. (meta)data are assigned a globally unique and
persistent identifier
● F2. data are described with rich metadata
● F3. metadata clearly and explicitly include the identifier
of the data it describes
● F4. (meta)data are registered or indexed in a
searchable resource
Accessible
● A1. (meta)data are retrievable by their identifier using a
standardized communications protocol
● A1.1 the protocol is open, free, and universally
implementable
● A1.2 the protocol allows for an authentication and
authorization procedure, where necessary
● A2. metadata are accessible, even when the data are no
longer available
15 attributes of FAIR
● I1. (meta)data use a formal, accessible, shared, and
broadly applicable language for knowledge
representation.
● I2. (meta)data use vocabularies that follow FAIR
principles
● I3. (meta)data include qualified references to other
(meta)data
Re-usable
● R1. meta(data) are richly described with a plurality of
accurate and relevant attributes
● R1.1. (meta)data are released with a clear and
accessible data usage license
● R1.2. (meta)data are associated with detailed
provenance
● R1.3. (meta)data meet domain-relevant community
standards
Interoperable
22. FAIR Partnership
Researchers Repositories and
Registries
Indexers
Aggregators
• Good data
management
• Good
documentation
• Rich metadata
• Prepare to share
• Submit to
repository
• Persistent identifier
• Machine based access
• Clear license
• Open, domain
specific standards
• Machine readable
metadata
• Persistent metadata
• Bidirectional links
• Data citation
• Index
• Effective Search
• Persistent
metadata
Community Organizations
23. dknet.orgAn NIDDK Resource
Research Data Management Overview
Provide information about:
• What is research data
management?
• Provide links to
resource, such as
California Digital Library
data management
planning tool
• Provide specificity for
DK applications
24. dknet.orgAn NIDDK Resource
Where Can I Deposit My Data?
• List of DK specific
repositories,
recommended by
NLM and various
journals
• Created in
conjunction with
NIDDK
25. dknet.orgAn NIDDK Resource
dkNET Summer of Data Student Internship Program
Project Duration: 6 weeks starting June 22 to July 31, 2020
Application Due Date: April 17, 2020
Goal:
• Provide students an opportunity to use the dkNET tools and resources for their research projects
• Enable students to provide feedback on their experience to the dkNET team
• Students will learn best practices to enhance rigor and reproducibility
• Students will learn the basics of good data management by following the FAIR data principles
Award: $1000 awards to a limited number of students who are working in a lab during summer 2020
https://dknet.org/about/Summer-Internship
26. dknet.orgAn NIDDK Resource
Discovery Portal
I would like to know
what research
resources such as
information, data or
materials are
available.
I’m looking for funding
opportunities or
funded grant
information.
Construct a
hypothesis
Ask a question
Do background
research
Plan
experiments
Collect and
analyze data
Publish
results
27. dknet.orgAn NIDDK Resource
Discovery Portal
• 200+ biomedical
databases
• Literature
• Centralized search
• DK specific content
• Funding
opportunities -
original databases
29. dknet.orgAn NIDDK Resource
Hypothesis Center
I would like to find top
genes that are
relevant to a signaling
pathway.
Construct a
hypothesis
Ask a question
Do background
research
Plan
experiments
Collect and
analyze data
Publish
results
I have a gene or a list
of genes and would
like to find relevant
signaling pathways.
30. dknet.orgAn NIDDK Resource
Hypothesis Center - Signaling Pathways Project
SPP simplifies data mining of ‘omics data,
connects bench researchers to FAIR data
to allow them to easily interrogate the data
to generate hypotheses
● Find genes with important roles in
receptors, enzymes, organs and
tissues
● Define signaling pathways relevant
to a single gene or a regulation
32. dknet.orgAn NIDDK Resource
Summary - How Can dkNET Help
Researchers?
• Resource Reports
• help researchers find resources for their research
• Keeps researchers updated on resources with warnings, ratings and validation information
• Find RRIDs and register resources
• Find who else used the resources
• Rigor and Reproducibility Support
• Authentication Reports: assists in creating authentication plans
• FAIR Data Services: assists in developing DMP by finding appropriate data repositories
• Discovery Portal connects researchers to the broader biomedical community (+200 databases)
• Hypothesis Center enables researchers to harness the power of FAIR big data
• Analyze omics data to develop research hypotheses
33. dknet.orgAn NIDDK Resource
Get involved in the dkNET Community
dkNET Homepage: dkNET.org
Sign up
Newsletter
Join Webinar
Join Summer Program
Follow us
@dknet_info
Check Out or Post
News and Funding
Opportunities
Blog, Calendar
34. dknet.orgAn NIDDK Resource
Links to Available Resources
General Information
• dkNET Information https://dknet.org/about/product_info
• Research Resource Identifier (RRID) Information https://dknet.org/about/rrid
• What is Resource Reports? https://dknet.org/about/resource_reports_info
• NIH Mandates on Rigor and Transparency https://dknet.org/about/NIH-Policy-Rigor-Reproducibility
Services
• Resource Reports https://dknet.org/rin/rrids
• Authentication Reports https://dknet.org/rin/rrid-report
• Discovery portal https://dknet.org/data/search#all
• Hypothesis Center https://dknet.org/about/hypothesis_center
• Pilot funding databases https://dknet.org/about/funding
Data management
• FAIR data/research data management https://dknet.org/rin/research-data-management
• Suggested data repositories https://dknet.org/about/Suggested-data-repositories-niddk
Newsletter (Funding opportunity,
events, news, new tools...etc.)
• https://dknet.org/about/maillist
Webinar
• Upcoming webinar https://dknet.org/about/webinar
• dkNET recorded webinar https://www.youtube.com/channel/UCwukSrB8L61Fhwjv3x20lOQ
Summer of Data Student
Internship
• https://dknet.org//about/Summer-Internship
• Download Flyer