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BioKnowledgy DP 8.1 Metabolism - bottom line

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BioKnowledgy DP 8.1 Metabolism - bottom line

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BioKnowledgy DP 8.1 Metabolism - bottom line

  1. 1. 8 Metabolism, cell respiration and photosynthesis (AHL) – 8.1 Metabolism Name: http://bioknowledgy.weebly.com/ (Chris Paine) 8.1 Metabolism notes - the bottom line The learning Statements The can you statements tell you what you notes should enable you to do. They are guidance to a minimum expectation. The deeper your understanding the easier you will find it to respond to questions and communicate your understanding. 8.1.U1 Metabolic pathways consist of chains and cycles of enzyme-catalyzed reactions. Can you define metabolism? Can you define metabolic pathway? Can you distinguish metabolic chains from metabolic cycles? 8.1.U2 Enzymes lower the activation energy of the chemical reactions that they catalyze. Can you define activation energy? Can you sketch a graph that compares an un-catalysed reaction with a catalysed reaction? Can you annotate the graph to show activation energies, the reduction in activation energy and the free energy generated by the reaction? Can you explain why enzymes lower the activation energy? 8.1.U3 Enzyme inhibitors can be competitive or non-competitive. Can you define enzyme inhibitor? Can you distinguish between the structure and action of competitive and non-competitive enzyme inhibitors? Can you state one example of a competitive enzyme inhibitor and one example of a non-competitive enzyme inhibitor? 8.1.S2 Distinguishing different types of inhibition from graphs at specified substrate concentration. Given a graph of substrate concentration and enzyme activity can you distinguish between competitive and non-competitive enzyme inhibitors? Can you sketch and annotate a graph to show the effect of substrate concentration on uninhibited, competitively inhibited and non-competitively inhibited enzyme activity? 8.1.U4 Metabolic pathways can be controlled by end-product inhibition. Can you describe how end-product inhibition works, with reference to the allosteric site, conformational change and end product? Can you explain why end-product inhibition is an example of negative feedback control? 8.1.A1 End-product inhibition of the pathway that converts threonine is isoleucine. Can you explain why isoleucine synthesis is an example of end-product inhibition? Can you explain why the isoleucine concentration would fall and what the consequence would be to the metabolic pathway? 8.1.A2 Use of databases to identify potential new anti-malarial drugs. AND Nature of science: Developments in scientific research follow improvements in computing - developments in bioinformatics, such as the interrogation of databases, have facilitated research into metabolic pathways. (3.8)
  2. 2. http://bioknowledgy.weebly.com/ (Chris Paine) Can you explain why the development of new anti-malarial drugs is an example of a successful use of bioinformatics? Can you explain why bioinformatics, e.g. anti-malarial drug development , is dependent on databases and improvements in computing? 8.1.S1 Calculating and plotting rates of reaction from raw experimental results. Can you explain and give the formula to calculate the rate of enzyme activity? Can you state an example of the units used for rate of reaction of an enzyme? Can you calculate the rate of enzyme activity from raw data? Can you plot a graph of both the rate of activity and the raw data and explain the link between the trends shown on both graphs? Recommended resources http://www.bioknowledgy.info/81-metabolism.html Allott, Andrew. Biology: Course Companion. S.l.: Oxford UP, 2014. Print.

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