Osteoarthritis is a degenerative joint disease characterized by the breakdown of articular cartilage. This leads to fibrillation, fissures, and eventually the loss of full thickness cartilage. Cytokines like TNF-α and IL-1 are believed to play a pivotal role in the initiation and progression of osteoarthritis by stimulating cartilage breakdown and synovial inflammation. A complex interaction between pro-inflammatory and anti-inflammatory cytokines contributes to the imbalance between cartilage matrix synthesis and degradation in osteoarthritis.