dina patho

2. Osteoma. The radiog raph shows a pedunculatedOsteoma. The radiog raph shows a pedunculated
cancellousosteomaarising from the lingualsurface of thecancellousosteomaarising from the lingualsurface of the
mandib le near t he crest of t he alveolar ridge.mandib le near t he crest of t he alveolar ridge.

3. Osteoma. This compact osteo ma is composedOsteoma. This compact osteo ma is composed
ofof
dense bone. with only minimal marrowdense bone. with only minimal marrow
elements.elements.

6. Gardner syndrome. Panoramic radiographGardner syndrome. Panoramic radiograph
showing multip le osteomas of the mandible.showing multip le osteomas of the mandible.

7. Osteomas of Gardner's syndrome.Osteomas of Gardner's syndrome.

8. Gardner syndrome . A segment of resected largeGardner syndrome . A segment of resected large
bowel showing polyp formationbowel showing polyp formation (arrow) .(arrow) .

9. Gardner syndrome. This patient has multiple,Gardner syndrome. This patient has multiple,
large epidermoid cysts. (Courtesy of Dr.large epidermoid cysts. (Courtesy of Dr.
William Welton.)William Welton.)

14. Radiograph illustrating mandibular benign osteoblastoma or
cementoblastoma without calcification that was associated with
periapical regions of permanent premolars (arrows).

17. Typical radiographic appearance of cementoblastoma. A dense,
homogeneous mass is seen in continuity with the tooth root.

19. Osteoblastoma. Numerous neoformed osteoid trabeculae are lined
by osteoblasts and separated by a highly vascularized matrix.

24. Desmoplastic fibromaDesmoplastic fibroma . Microscopic differential diagnosis. Microscopic differential diagnosis
included fibrosarcoma.included fibrosarcoma.

25. Desmoplastic fibroma.Desmoplastic fibroma. Note evenly distributed and benign-Note evenly distributed and benign-
appearing fibroblasts in collagenousappearing fibroblasts in collagenous
stroma.stroma.

26. Desmoplastic fibroma.Desmoplastic fibroma. Note evenly distributed and benign-Note evenly distributed and benign-
appearing fibroblasts in collagenousappearing fibroblasts in collagenous
stroma.stroma.

27. Hemangioma of boneHemangioma of bone showing honeycomb radiographic pattern withshowing honeycomb radiographic pattern with
associated root resorption.associated root resorption.

28. HemangiomaHemangioma

29. Hemangioma of bone. Note numerous vascular channelsHemangioma of bone. Note numerous vascular channels
surrounded by trabeculae of bone.surrounded by trabeculae of bone.

32. OsteosarcomaOsteosarcoma surrounding the roots of first molar tooth.surrounding the roots of first molar tooth.
Note widened periodontal ligament.Note widened periodontal ligament.

33. A, Central low-grade osteosarcomaA, Central low-grade osteosarcoma of the mandible.of the mandible.

36. OsteosarcomaOsteosarcoma between a mandibular lateral incisor and a canine. Note slightbetween a mandibular lateral incisor and a canine. Note slight
widening of periodontalwidening of periodontal
ligaments of both teeth.ligaments of both teeth. BB andand C,C, Surgical specimen shows a malignant bone-Surgical specimen shows a malignant bone-
producing neoplasm occupying theproducing neoplasm occupying the
periodontal ligament space. The tooth is to the right, and alveolar bone is to theperiodontal ligament space. The tooth is to the right, and alveolar bone is to the
left.left.

37. OsteosarcomaOsteosarcoma of the mandible showing a sunburst pattern of tumorof the mandible showing a sunburst pattern of tumor
bone radiating from the alveolar ridge.bone radiating from the alveolar ridge.

38. Osteosarcoma of the mandibleOsteosarcoma of the mandible exhibiting sunburst pattern.exhibiting sunburst pattern.

39. C, CT scan of persistent tumor 15 years later, now a high-gradeC, CT scan of persistent tumor 15 years later, now a high-grade
tumor.tumor.

40. Gross appearance of osteosarcoma of mandible.

41. D, Surgical specimen of the high-grade tumor (chondroblasticD, Surgical specimen of the high-grade tumor (chondroblastic
osteosarcoma).osteosarcoma).

42. Chondroblastic osteosarcoma.Chondroblastic osteosarcoma. Note cartilage and bone atNote cartilage and bone at
lower left.lower left.

43. Fibroblastic osteosarcomaFibroblastic osteosarcoma composed of spindled tumor cells andcomposed of spindled tumor cells and
small islands of tumor bone.small islands of tumor bone.

46. Osteosarcoma of jaw. The neoplastic bone (left) is clearly
distinguishable from the residual normal bone (right)).

52. OsteosarcomaOsteosarcoma between a mandibular lateral incisor and a canine. Note slightbetween a mandibular lateral incisor and a canine. Note slight
widening of periodontal ligaments of both teeth.widening of periodontal ligaments of both teeth. BB andand C,C, Surgical specimenSurgical specimen
shows a malignant bone-producing neoplasm occupying the periodontalshows a malignant bone-producing neoplasm occupying the periodontal
ligament space. The tooth is to the right, and alveolar bone is to the left.ligament space. The tooth is to the right, and alveolar bone is to the left.

54. AA andand B, OsteosarcomaB, Osteosarcoma composed of atypical cells in association withcomposed of atypical cells in association with
tumor bone.tumor bone.

55. OsteosarcomaOsteosarcoma exhibiting a partially myxoid microscopic appearance.exhibiting a partially myxoid microscopic appearance.

71. Pigmented neuroectodermal tumor of infancy. The neoplastic
islands located between the bone trabeculae contain abundant
melanin pigment.

72. Pigmented neuroectodermal tumor of infancy. This example shows
the classic pattern of neuroblast-like cells surrounded by larger
melanin-containing cells.

78. A, Anaplastic large cell lymphoma. B,A, Anaplastic large cell lymphoma. B,
Immunohistochemical stain for CD20 confirming B-cell lineage ofImmunohistochemical stain for CD20 confirming B-cell lineage of
tumor.tumor.

79. A, Anaplastic large cell lymphoma. B,A, Anaplastic large cell lymphoma. B,
Immunohistochemical stain for CD20 confirming B-cell lineage ofImmunohistochemical stain for CD20 confirming B-cell lineage of
tumor.tumor.

80. Burkitt's lymphomaBurkitt's lymphoma of the left maxilla.of the left maxilla.

81. Burkitt's lymphomaBurkitt's lymphoma presenting as a periapicalpresenting as a periapical
radiolucency (mandibular left first molar). The patient alsoradiolucency (mandibular left first molar). The patient also
had a numb lip.had a numb lip.

84. Burkitt's lymphomaBurkitt's lymphoma exhibiting starry sky effect. Pale cells areexhibiting starry sky effect. Pale cells are
tingible body macrophages.tingible body macrophages.

85. Angiocentric T-cell lymphoma. A. This 62 ~ ye a r- o l d man had a
destructive palatal lesion that proved to be a "l-celllymphoma. and
evaluation showed cervical lymph node involvement aswell. B.
Resolution of the lesion 1 month later.after multiagent chemotherapy

86. Midline granulomaMidline granuloma presenting as oropharyngeal ulcers.presenting as oropharyngeal ulcers.

87. Angiocentric T-cell lymphoma. Thismediumpower photomicrograph
shows atypical lymphoid cells infiltrating the wall and filling the lumen
of a blood vessel. Such a pattern is termedangiocentric (meaning
"around blood vessels").

88. Multiple myeloma. AMultiple myeloma. A andand B,B, Right mandibular mass.Right mandibular mass.

89. Multiple myelomaMultiple myeloma involving the left maxillary tuberosity.involving the left maxillary tuberosity.

90. Multiple myelomaMultiple myeloma presenting orally as an ulcerated gingivalpresenting orally as an ulcerated gingival
mass.mass.

91. Multiple myeloma. AMultiple myeloma. A andand B,B, Right mandibular mass.Right mandibular mass.

94. Multiple myelomaMultiple myeloma showing multiple punched-out lesions of theshowing multiple punched-out lesions of the
skull.skull.

95. A,A, Axial CT of a 71-year-old man withAxial CT of a 71-year-old man with multiplemultiple
myelomamyeloma showing multiple lytic lesions in the mandible.showing multiple lytic lesions in the mandible.
B,B, Multiple lytic lesions also involved the cranium.Multiple lytic lesions also involved the cranium.

96. A,A, Axial CT of a 71-year-old man withAxial CT of a 71-year-old man with multiplemultiple
myelomamyeloma showing multiple lytic lesions in the mandible.showing multiple lytic lesions in the mandible.
B,B, Multiple lytic lesions also involved the cranium.Multiple lytic lesions also involved the cranium.

100. Multiple myelomaMultiple myeloma composed of neoplastic plasma cells.composed of neoplastic plasma cells. BB andand
C,C, Immunohistochemical stains for kappa (Immunohistochemical stains for kappa (BB) and lambda () and lambda (CC))
light chains demonstrating monoclonality of the plasma cells.light chains demonstrating monoclonality of the plasma cells.

101. Multiple myelomaMultiple myeloma composed of neoplastic plasma cells.composed of neoplastic plasma cells. BB andand
C,C, Immunohistochemical stains for kappa (Immunohistochemical stains for kappa (BB) and lambda () and lambda (CC))
light chains demonstrating monoclonality of the plasma cells.light chains demonstrating monoclonality of the plasma cells.

104. langerhans cell histiocytosis. There is a diffuse infiltrate of pale-
staining langerhans cells intermixed with numerous red granular
eosinophils.