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Volume 4




  Something To
Settle The Nerves!!
 (An in depth look into the nervous system through recipes!)




      Marisa, Courtney, Nathan, Lindsey, Victoria, & Braxten
In this section:
           • Endocrine System
               • Hormones
• Organs and Glands of the Endocrine System
                 • Tables
Recipe: Endocrine System
(25 & 26)
                                        Ingredients:
              1. How do the nervous and endocrine systems work together?
              2. What is the method in which the endocrine system undergoes its
                 functions?
   DIRECTIONS:
   1. The endocrine system is responsible for releasing and regulating hormones; the nervous
      system sends signals to release hormones and chemical messengers known as
      neurotransmitters. The master gland is known as the pituitary gland which is known to make
      these hormones and control other endocrine glands; it is located at the base of the brain.
      (maintain stability of internal environment.)
   2. The endocrine system is made up of glands that produce and secrete hormones and
      chemicals that regulate the body. Hormones are chemical messengers that transfer
      information from one set of cells to another. The major glands in this system are the
      hypothalamus: located beneath the thalamus – regulates satiety, metabolism and body
      temperature. Next is the pituitary gland – “the master gland” located at the base of the
      brain; it produces hormones and controls other glands in the endocrine system. Its mainly
      known to secrete growth hormones – located in the neck. It regulates the body’s metabolism
      and helps with bone growth and development, blood pressure, heart rate and digestion.
      Adrenal gland – located at the top of each kidney. It regulates metabolism, immune system
      and help cope with stress. Pineal body – located at the middle of the brain – secretes a
      hormone called melatonin which helps aid in sleep. Reproductive glands – sex hormones
      development of female and male growth and reproductive functions.
Recipe: Hormones
                            Ingredients:
1.   Classify by functions
2.   Classify by structure
3.   Describe Steroid Hormones
4.   Describe Nonsteriod Hormones
5.   How do Hormones work?
       1. Describe Lock and Key
       2. What happens when Hormones combine?
DIRECTIONS:

1. Hormone- Hormone molecules can be classified in various useful ways. When classified by
general function, hormones can be identified as tropic hormones, which are hormones that target
other endocrine glands and stimulate their growth and secretion. Sex hormones (hormones that
target reproductive tissues), anabolic hormones (hormones that stimulate anabolism in their
target cells), and many other functional names. In the endocrine system, secreting cells send
hormone molecules by way of bloodstream to signal specific target cells throughout the body.

3. All of many hormones secreted by endocrine tissues can be classified simply as steroid or non-
steroid. Steroid hormone molecules are manufactured by endocrine cells from cholesterol, and
important type of lipid in the human body.




                                       2. (24)
DIRECTIONS:
4. Nonsteroid hormones (water soluble) do not enter the cell but bind to plasma
membrane receptors, generating a chemical signal (second messenger) inside the
target cell. Five different second messenger chemicals, including cyclic AMP have been
identified. Second messengers activate other intracellular chemicals to produce the
target cell response.

5. Hormones produce a variety of responses throughout the body and may be grouped
according to their actions, although there is overlap between the groups.

5.1 The endocrine system is a collection of glands that secrete chemical messages we
call hormones. These signals are passed through the blood to arrive at a target organ,
which has cells possessing the appropriate receptor, they will not connect unless they
have the correct receptor, kind of like a lock and key. (22)

5. 2 First there are the metabolic hormones which control the digestion of food, its
storage and use. Second are the hormones which regulate the composition of the
blood, and hence of all the body fluids. Next are the stress hormones, primarily
adrenaline and noradrenaline, which are under the control the autonomic nervous
system. The final major group includes those hormones that control other endocrine
systems, and therefore interact with the other groups. (23)
(1)          Recipe: Organs and Glands of the Endocrine
                              System
                                        Ingredients:
      1.   Prostaglandins                          7. Pancreatic Islet
      2.   Pituitary Gland                         8. Gonads
      3.   Pineal Gland                            9. Placenta
      4.   Thyroid Gland                           10. Thymus
      5.   Parathyroid gland                       11. Gastric and intestinal mucosa
      6.   Adrenal Gland                           12. Heart

      DIRECTIONS:
      1. Group of naturally occurring lipid-based substances that act in a
      hormone like way to affect many body functions, including vasodilation,
      uterine smooth muscle contraction, and the inflammatory response.
      Hormones: 16 different prostaglandins falling into 9 structural classes –
      prostaglandins A-I.

      2. Neuroendocrine gland located near base of the brain that has
      numerous and important regulatory functions; also called the hypophysis.
      Consists of two separate glands (adenohypophysis and neurohypophysis.)
(1)
DIRECTIONS:
3. Endocrine gland located in the diencephalon and thought to be involved with
regulating the body’s biological clock; produces melatonin.

4. Hormone that accelerates catabolism of glucose. Hormones: Triiodothyronine,
Tertaiodothyronine, and Calcitonin.

5. Endocrine gland located in the neck on the posterior aspect of the thyroid gland;
secretes parathyroid hormone. Hormones: Parathyroid Hormone.

6. Endocrine gland that rests on the top of each kidney; made up of cortex and
medulla regions. Hormones: Aldosterone, Cortisol, Adrenal Androgens, Adrenal
Estrogens, Epinephrine, and Norepinephrine.

7. Endocrine portion of the pancreas; made up of alpha and beta cells; among others;
source of insulin and glucagon. Hormones: Glucagon, Insulin, Somatostatin,
Pancreatic Polypeptide.

8. Sex glands in which reproductive cells are formed; ovaries in women, testes in men.

9. Structure that anchors the developing fetus to the uterus and provides a “bridge”
for the exchange of nutrients and waste products between the mother and
developing baby.
(1) DIRECTIONS:
    10. Endocrine gland located in the mediastinum; vital part of the body’s
    Immune system. Hormones: Thymosin and Thymopoietin.

   11. The mucosa lining of the gastrointestinal (GI) tract, like the pancreas,
   contains cells that produce both endocrine and exocrine secretions.
   Hormones: Gastrin, Secretin, Cholecystokinin-pancreozymin (CCK), and
   others, have important regulatory roles in coordinating the secretory and
   motor activities involved in the digestive process.

   12. Organ of circulatory system that pumps the blood; composed of
   cardiac muscle tissues, a specific area in its wall contains some hormone-
   producing cells. The cells produce a hormone called atrail natriuretic
   hormone.
(8)




(17) Prostaglandins
(18) Intestinal Mucosa




                         (18) Gastric
Charts
Hormone                 Source            Target            Principal Action
Growth Hormone-         Hypothalamus      Adenohypophysis   Stimulates
releasing hormone                         (somatotrophs)    secretion of growth
(GRH)                                                       hormone
Growth Hormone-         Hypothalamus      Adenohypophysis   Inhibits secretion of
inhibiting hormone                        (Somatotrophs)    growth hormone
(GIH)
Corticotrophin-         Hypothalamus      Adenohypophysis   Stimulates release
releasing hormone                                           of
(CRH)                                                       adrenocorticotropic
                                                            hormone (ACTH)
Thyrotrophin-           Hypothalamus      Adenohypophysis   Stimulates the
releasing hormone                                           release of thyroid
(TRH)                                                       stimulating
                                                            hormone (TSH)
Gonadotropin-           Hypothalamus      Adenohypophysis   Stimulates the
releasing hormone                                           release of
(GNRH)                                                      gonadotropins
                                                            (FSH and LH)
Prolactin- releasing    Hypothalamus      Adenohypophysis   Stimulates
hormone (PRH)                                               secretion of
                                                            prolactin
Prolactin- inhibiting   Hypothalamus      Adenohypophysis   Inhibits secretion of
hormone (PIH)                                               prolactin
Growth hormone          Adenohypophysis   General           Promotes growth
(GH) (somatotropin      (somatotrophs)                      by stimulating
(STH))                                                      protein anabolism
                                                            and fat mobilization
Prolactin (PRL)         Adenohypophysis   Mammary glands    Promotes milk
(lactogenic             (lactotrophs)                       secretion
hormone)
Thyroid stimulating     Adenohypophysis   Thyroid gland     Stimulates
hormone (TSH)                                               development and
                                                            secretion in the
                                                            thyroid gland
Adrenocorticotropic     Adenohypophysis   Adrenal cortex    Promotes
hormone (ACTH)                                              development and
                                                            secretion in the
                                                            adrenal cortex
Follicle- stimulating   Adenohypophysis   Gonads (Primary   Female: promotes
hormone (FSH)                             sex organs)       development of
                                                            ovarian follicle;
                                                            stimulates estrogen
                                                            Males: promotes
Luteinizing          Adenohypophysis      Gonads            Female: triggers
                       hormone (LH)                                                ovulation;
                                                                                   promotes
                                                                                   development of
                                                                                   corpus luteum
Charts Continued....
                                                                                   Male: stimulates
                                                                                   production of
                                                                                   testosterone
                       Antidiuretic         Neurohypophysis      Kidney            Promotes water
                       hormone (ADH)                                               retention by
                                                                                   kidney tubules
                       Oxytocin (OT)        Neurohypophysis      Uterus and        Stimulates uterus
                                                                 mammary glands    contractions;
                                                                                   stimulates ejection
                                                                                   of milk into
                                                                                   mammary ducts
                       Triidothyroninie     Thyroid gland        General           Increase rate of
                       (T3)                 (follicular cells)                     metabolism
                       Tetraiodothyronine   Thyroid gland        General           Increase rate of
                       (T4) of thyroxine    (follicular cells)                     metabolism
                                                                                   (usually converted
                                                                                   to T3 first)
                       Calcitonin (CT)      Thyroid gland        Bone tissue       Increase calcium
                                            (parafollicular                        storage in bone,
                                            cells)                                 lowering blood
                                                                                   Ca++ levels
                       Parathyroid          Parathyroid glands   Bone tissue and   Increase calcium
                       hormone (PTH)                             kidney            removal from
                                                                                   storage in bone
                                                                                   and produces the
                                                                                   active form o
                                                                                   vitamin D in the
                                                                                   kidneys, increasing
                                                                                   absorption of
                                                                                   calcium by
                                                                                   intestines and
                                                                                   increasing blood
                                                                                   Ca++ levels
Charts Continued....
Aldosterone         Adrenal cortex         Kidney              Stimulates kidney
                                                               tubuals to conserve
                                                               sodium, which, in
                                                               turn, triggers the
                                                               release of ADH and
                                                               the resulting
                                                               conservation of
                                                               water by the kidney
Cortisol            Adrenal cortex         General             Influences
(hydrocortisone)                                               metabolism of food
                                                               molecules; in large
                                                               amounts, it has an
                                                               anti-inflammatory
                                                               effect
Adrenal androgens   Adrenal cortex         Sex organs, other   Exact role
                                           effectors           uncertain, but may
                                                               support sexual
                                                               functions
Adrenal estrogens   Adrenal cortex         Sex organs          Thought to be
                                                               physiologically
                                                               insignificant
Epinephrine         Adrenal medulla        Sympathetic         Enhances and
                                           effectors           prolongs the
                                                               effects of the
                                                               sympathetic
                                                               division of the
                                                               autonomic nervous
                                                               system
Norepinephrine      Adrenal medulla        Sympathetic         Enhances and
                                           effectors           prolongs the
                                                               effects of the
                                                               sympathetic
                                                               division of the
                                                               autonomic nervous
                                                               system
Glucagon            Pancreatic             General             Promotes
                    isles(alpha cells or                       movement of
                    A cells)                                   glucose from
                                                               storage and into
                                                               the blood
Charts Continued....
Insulin       Pancreatic islets   General                Promotes
              (beta cells or B                           movement of
              cells)                                     glucose out of the
                                                         blood and into cells
Somatostin    Pancreatic isleta   Pancreatic cells       Can have general
              (delat cells or D   and other effectors    effects in the body,
              cells)                                     but primary role
                                                         seems to be
                                                         regulation of
                                                         secretion of other
                                                         pancreatic
                                                         hormones
Pancreatic    Pancreatic          Intestinal cells and   Exact function
polypeptide   polypeptide (PP)    other effectors        uncertain, but
              or F cells                                 seems to influence
                                                         absorption in the
                                                         digestive tract

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Hormones the perfect storm

  • 1. Volume 4 Something To Settle The Nerves!! (An in depth look into the nervous system through recipes!) Marisa, Courtney, Nathan, Lindsey, Victoria, & Braxten
  • 2. In this section: • Endocrine System • Hormones • Organs and Glands of the Endocrine System • Tables
  • 3. Recipe: Endocrine System (25 & 26) Ingredients: 1. How do the nervous and endocrine systems work together? 2. What is the method in which the endocrine system undergoes its functions? DIRECTIONS: 1. The endocrine system is responsible for releasing and regulating hormones; the nervous system sends signals to release hormones and chemical messengers known as neurotransmitters. The master gland is known as the pituitary gland which is known to make these hormones and control other endocrine glands; it is located at the base of the brain. (maintain stability of internal environment.) 2. The endocrine system is made up of glands that produce and secrete hormones and chemicals that regulate the body. Hormones are chemical messengers that transfer information from one set of cells to another. The major glands in this system are the hypothalamus: located beneath the thalamus – regulates satiety, metabolism and body temperature. Next is the pituitary gland – “the master gland” located at the base of the brain; it produces hormones and controls other glands in the endocrine system. Its mainly known to secrete growth hormones – located in the neck. It regulates the body’s metabolism and helps with bone growth and development, blood pressure, heart rate and digestion. Adrenal gland – located at the top of each kidney. It regulates metabolism, immune system and help cope with stress. Pineal body – located at the middle of the brain – secretes a hormone called melatonin which helps aid in sleep. Reproductive glands – sex hormones development of female and male growth and reproductive functions.
  • 4. Recipe: Hormones Ingredients: 1. Classify by functions 2. Classify by structure 3. Describe Steroid Hormones 4. Describe Nonsteriod Hormones 5. How do Hormones work? 1. Describe Lock and Key 2. What happens when Hormones combine?
  • 5. DIRECTIONS: 1. Hormone- Hormone molecules can be classified in various useful ways. When classified by general function, hormones can be identified as tropic hormones, which are hormones that target other endocrine glands and stimulate their growth and secretion. Sex hormones (hormones that target reproductive tissues), anabolic hormones (hormones that stimulate anabolism in their target cells), and many other functional names. In the endocrine system, secreting cells send hormone molecules by way of bloodstream to signal specific target cells throughout the body. 3. All of many hormones secreted by endocrine tissues can be classified simply as steroid or non- steroid. Steroid hormone molecules are manufactured by endocrine cells from cholesterol, and important type of lipid in the human body. 2. (24)
  • 6. DIRECTIONS: 4. Nonsteroid hormones (water soluble) do not enter the cell but bind to plasma membrane receptors, generating a chemical signal (second messenger) inside the target cell. Five different second messenger chemicals, including cyclic AMP have been identified. Second messengers activate other intracellular chemicals to produce the target cell response. 5. Hormones produce a variety of responses throughout the body and may be grouped according to their actions, although there is overlap between the groups. 5.1 The endocrine system is a collection of glands that secrete chemical messages we call hormones. These signals are passed through the blood to arrive at a target organ, which has cells possessing the appropriate receptor, they will not connect unless they have the correct receptor, kind of like a lock and key. (22) 5. 2 First there are the metabolic hormones which control the digestion of food, its storage and use. Second are the hormones which regulate the composition of the blood, and hence of all the body fluids. Next are the stress hormones, primarily adrenaline and noradrenaline, which are under the control the autonomic nervous system. The final major group includes those hormones that control other endocrine systems, and therefore interact with the other groups. (23)
  • 7. (1) Recipe: Organs and Glands of the Endocrine System Ingredients: 1. Prostaglandins 7. Pancreatic Islet 2. Pituitary Gland 8. Gonads 3. Pineal Gland 9. Placenta 4. Thyroid Gland 10. Thymus 5. Parathyroid gland 11. Gastric and intestinal mucosa 6. Adrenal Gland 12. Heart DIRECTIONS: 1. Group of naturally occurring lipid-based substances that act in a hormone like way to affect many body functions, including vasodilation, uterine smooth muscle contraction, and the inflammatory response. Hormones: 16 different prostaglandins falling into 9 structural classes – prostaglandins A-I. 2. Neuroendocrine gland located near base of the brain that has numerous and important regulatory functions; also called the hypophysis. Consists of two separate glands (adenohypophysis and neurohypophysis.)
  • 8. (1) DIRECTIONS: 3. Endocrine gland located in the diencephalon and thought to be involved with regulating the body’s biological clock; produces melatonin. 4. Hormone that accelerates catabolism of glucose. Hormones: Triiodothyronine, Tertaiodothyronine, and Calcitonin. 5. Endocrine gland located in the neck on the posterior aspect of the thyroid gland; secretes parathyroid hormone. Hormones: Parathyroid Hormone. 6. Endocrine gland that rests on the top of each kidney; made up of cortex and medulla regions. Hormones: Aldosterone, Cortisol, Adrenal Androgens, Adrenal Estrogens, Epinephrine, and Norepinephrine. 7. Endocrine portion of the pancreas; made up of alpha and beta cells; among others; source of insulin and glucagon. Hormones: Glucagon, Insulin, Somatostatin, Pancreatic Polypeptide. 8. Sex glands in which reproductive cells are formed; ovaries in women, testes in men. 9. Structure that anchors the developing fetus to the uterus and provides a “bridge” for the exchange of nutrients and waste products between the mother and developing baby.
  • 9. (1) DIRECTIONS: 10. Endocrine gland located in the mediastinum; vital part of the body’s Immune system. Hormones: Thymosin and Thymopoietin. 11. The mucosa lining of the gastrointestinal (GI) tract, like the pancreas, contains cells that produce both endocrine and exocrine secretions. Hormones: Gastrin, Secretin, Cholecystokinin-pancreozymin (CCK), and others, have important regulatory roles in coordinating the secretory and motor activities involved in the digestive process. 12. Organ of circulatory system that pumps the blood; composed of cardiac muscle tissues, a specific area in its wall contains some hormone- producing cells. The cells produce a hormone called atrail natriuretic hormone.
  • 11. (18) Intestinal Mucosa (18) Gastric
  • 12. Charts Hormone Source Target Principal Action Growth Hormone- Hypothalamus Adenohypophysis Stimulates releasing hormone (somatotrophs) secretion of growth (GRH) hormone Growth Hormone- Hypothalamus Adenohypophysis Inhibits secretion of inhibiting hormone (Somatotrophs) growth hormone (GIH) Corticotrophin- Hypothalamus Adenohypophysis Stimulates release releasing hormone of (CRH) adrenocorticotropic hormone (ACTH) Thyrotrophin- Hypothalamus Adenohypophysis Stimulates the releasing hormone release of thyroid (TRH) stimulating hormone (TSH) Gonadotropin- Hypothalamus Adenohypophysis Stimulates the releasing hormone release of (GNRH) gonadotropins (FSH and LH) Prolactin- releasing Hypothalamus Adenohypophysis Stimulates hormone (PRH) secretion of prolactin Prolactin- inhibiting Hypothalamus Adenohypophysis Inhibits secretion of hormone (PIH) prolactin Growth hormone Adenohypophysis General Promotes growth (GH) (somatotropin (somatotrophs) by stimulating (STH)) protein anabolism and fat mobilization Prolactin (PRL) Adenohypophysis Mammary glands Promotes milk (lactogenic (lactotrophs) secretion hormone) Thyroid stimulating Adenohypophysis Thyroid gland Stimulates hormone (TSH) development and secretion in the thyroid gland Adrenocorticotropic Adenohypophysis Adrenal cortex Promotes hormone (ACTH) development and secretion in the adrenal cortex Follicle- stimulating Adenohypophysis Gonads (Primary Female: promotes hormone (FSH) sex organs) development of ovarian follicle; stimulates estrogen Males: promotes
  • 13. Luteinizing Adenohypophysis Gonads Female: triggers hormone (LH) ovulation; promotes development of corpus luteum Charts Continued.... Male: stimulates production of testosterone Antidiuretic Neurohypophysis Kidney Promotes water hormone (ADH) retention by kidney tubules Oxytocin (OT) Neurohypophysis Uterus and Stimulates uterus mammary glands contractions; stimulates ejection of milk into mammary ducts Triidothyroninie Thyroid gland General Increase rate of (T3) (follicular cells) metabolism Tetraiodothyronine Thyroid gland General Increase rate of (T4) of thyroxine (follicular cells) metabolism (usually converted to T3 first) Calcitonin (CT) Thyroid gland Bone tissue Increase calcium (parafollicular storage in bone, cells) lowering blood Ca++ levels Parathyroid Parathyroid glands Bone tissue and Increase calcium hormone (PTH) kidney removal from storage in bone and produces the active form o vitamin D in the kidneys, increasing absorption of calcium by intestines and increasing blood Ca++ levels
  • 14. Charts Continued.... Aldosterone Adrenal cortex Kidney Stimulates kidney tubuals to conserve sodium, which, in turn, triggers the release of ADH and the resulting conservation of water by the kidney Cortisol Adrenal cortex General Influences (hydrocortisone) metabolism of food molecules; in large amounts, it has an anti-inflammatory effect Adrenal androgens Adrenal cortex Sex organs, other Exact role effectors uncertain, but may support sexual functions Adrenal estrogens Adrenal cortex Sex organs Thought to be physiologically insignificant Epinephrine Adrenal medulla Sympathetic Enhances and effectors prolongs the effects of the sympathetic division of the autonomic nervous system Norepinephrine Adrenal medulla Sympathetic Enhances and effectors prolongs the effects of the sympathetic division of the autonomic nervous system Glucagon Pancreatic General Promotes isles(alpha cells or movement of A cells) glucose from storage and into the blood
  • 15. Charts Continued.... Insulin Pancreatic islets General Promotes (beta cells or B movement of cells) glucose out of the blood and into cells Somatostin Pancreatic isleta Pancreatic cells Can have general (delat cells or D and other effectors effects in the body, cells) but primary role seems to be regulation of secretion of other pancreatic hormones Pancreatic Pancreatic Intestinal cells and Exact function polypeptide polypeptide (PP) other effectors uncertain, but or F cells seems to influence absorption in the digestive tract