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LIFE TABLE Dr. Priyadarshini. C I M.D. ICM, MMC
INTRODUCTION 	Described as the ‘Biometer’ of the population by William Farr. 	Means of describing mortality, survival and other vital events in the population.
HISTORY OF THE LIFE TABLE
HISTORY OF THE LIFE TABLE 	 John Graunt(1620-1674) - Natural and Political Observations Made upon the Bills of Mortality (1662)
Graunt’s Life Table
HISTORY OF THE LIFE TABLE
HISTORY OF THE LIFE TABLE 	Edmund Halley (1656 – 1742) - ‘An estimate of the Degree of the Mortality of Mankind drawn from the curious Table of the Births and Funerals at the city of Breslaw’
Halley’s Life Table
IMPORTANCE OF LIFE TABLE - No. of survivors 	At 5 years, the no, of children likely to enter primary school 	At 15 years, no. of women entering fertile period 	At 21 years. no. eligible for voting - No. likely to die after life insurance or after joining service to budget for payment towards risk or pension
IMPORTANCE OF LIFE TABLE ,[object Object]
Population studies
Survival rate after treatment- Analysis by causes of death
CONSTRUCTION OF A LIFE TABLE Prerequisites 1. Population living at all individual ages in a selected period 2. No. of deaths that occurred in these ages during the selected period
Standard Notations
Construction of Life Table 1. 2. 3.
Construction of Life Table 4. 5. 6. 7.
DECREMENT TABLE 	The column of deaths or living can be split and analysed for new characteristics.
LIFE TABLE IN CLINICAL MEDICINEKAPLAN-MEIER METHOD Most commonly used approach to survival analysis in medicine. Also called as the Kaplan-Meier life table method or the product-limit method. 	Actuarial method used if there are large numbers of subjects but the Kaplan-Meier method more advantageous if the numbers of subjects are small.
KAPLAN-MEIER METHOD The actuarial method calculates survival rates based on fixed intervals whereas in the Kaplan-Meier method the intervals are uneven.  	Here, the deaths are not conceived of as occurring during an interval. Rather, they are seen as instantaneously terminating one interval and beginning a new interval.
KAPLAN-MEIER METHOD Data Timing of Deaths in 4 subjects: 0.8, 3.1, 5.4, 9.2 months Timing of loss to follow-up or censorship in four subjects: 1.0, 2.7, 7.0, 12.1 months
KAPLAN-MEIER METHODTabular Representation of Data
KAPLAN-MEIER METHODGraphic Representation of the Data
KAPLAN-MEIER METHOD Graphic Representation of comparison of two groups
TESTS OF SIGNIFICANCE 	Differences between actuarial survival curve – t-test and z-test 	Differences between Kaplan-Meier curves – Logrank test
LOGRANK TEST

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Life table

  • 1. LIFE TABLE Dr. Priyadarshini. C I M.D. ICM, MMC
  • 2. INTRODUCTION Described as the ‘Biometer’ of the population by William Farr. Means of describing mortality, survival and other vital events in the population.
  • 3. HISTORY OF THE LIFE TABLE
  • 4. HISTORY OF THE LIFE TABLE John Graunt(1620-1674) - Natural and Political Observations Made upon the Bills of Mortality (1662)
  • 6. HISTORY OF THE LIFE TABLE
  • 7. HISTORY OF THE LIFE TABLE Edmund Halley (1656 – 1742) - ‘An estimate of the Degree of the Mortality of Mankind drawn from the curious Table of the Births and Funerals at the city of Breslaw’
  • 9. IMPORTANCE OF LIFE TABLE - No. of survivors At 5 years, the no, of children likely to enter primary school At 15 years, no. of women entering fertile period At 21 years. no. eligible for voting - No. likely to die after life insurance or after joining service to budget for payment towards risk or pension
  • 10.
  • 12. Survival rate after treatment- Analysis by causes of death
  • 13. CONSTRUCTION OF A LIFE TABLE Prerequisites 1. Population living at all individual ages in a selected period 2. No. of deaths that occurred in these ages during the selected period
  • 15. Construction of Life Table 1. 2. 3.
  • 16. Construction of Life Table 4. 5. 6. 7.
  • 17. DECREMENT TABLE The column of deaths or living can be split and analysed for new characteristics.
  • 18. LIFE TABLE IN CLINICAL MEDICINEKAPLAN-MEIER METHOD Most commonly used approach to survival analysis in medicine. Also called as the Kaplan-Meier life table method or the product-limit method. Actuarial method used if there are large numbers of subjects but the Kaplan-Meier method more advantageous if the numbers of subjects are small.
  • 19. KAPLAN-MEIER METHOD The actuarial method calculates survival rates based on fixed intervals whereas in the Kaplan-Meier method the intervals are uneven. Here, the deaths are not conceived of as occurring during an interval. Rather, they are seen as instantaneously terminating one interval and beginning a new interval.
  • 20. KAPLAN-MEIER METHOD Data Timing of Deaths in 4 subjects: 0.8, 3.1, 5.4, 9.2 months Timing of loss to follow-up or censorship in four subjects: 1.0, 2.7, 7.0, 12.1 months
  • 23. KAPLAN-MEIER METHOD Graphic Representation of comparison of two groups
  • 24. TESTS OF SIGNIFICANCE Differences between actuarial survival curve – t-test and z-test Differences between Kaplan-Meier curves – Logrank test
  • 26. COX REGRESSION (POPULATION HAZARDS MODEL) Adjustment for potential confounding variables.