The document summarizes a systematic review and meta-analysis of worldwide HIV prevalence among transgender women. It finds an overall pooled HIV prevalence of 19.1% among 11,066 transgender women across 15 countries. Prevalence was higher in high-income countries (21.6%) than in low- and middle-income countries (17.7%). The odds of HIV infection were 48.8 times higher for transgender women compared to all adults of reproductive age in the same countries. The analysis suggests transgender women represent a very high-risk population for HIV globally.