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1. Disclaimer Products or ingredients discussed herein are not intended to diagnose, treat, cure or prevent any disease. 免责声明投影片内容为教育用途，产品或成分不可用于诊断丶治疗或预防疾病。

2. Market Singapore® I SG.SHOP.COM Product Symposium 2019 美安新加坡™ I SG.SHOP.COM 2019产品专题会 FIND YOUR BALANCE IN WEIGHT MANAGEMENT 寻找您均衡的体重管理

3. OBESITY POPULATION CONTINUES TO INCREASE 肥胖人口持续增加 The obesity rate rose from 5.1% in 1992 to 8.7% in 2017. Overweight rate also increased from 26.2% to 36.2% 肥胖率从1992年的5.1%上升到2017年的8.7%。超重率也从26.2%增加至36.2%

4. COMPARISON AMONGST SOUTHEAST ASIA 東南亚比一比 Prevalence of overweight in adult men and women (%) (BMI >25kg/m2) 成年男女的超重盛行率 (%) (BMI >25kg/m2 ) Vietnam Indonesia Philippines Singapore Thailand Malaysia Poor hydration habits Sedentary lifestyle Unhealthy diet choice Source: WHO Non-Communicable Diseases Country Profiles, 2011

5. 方法二:体脂肪率男性＞ 25 % (17 - 23 %)，腰围≧ 90 公分女性＞ 30 % (20 - 27 %)，腰围≧ 80 公分 Method 1: Body Mass Index (BMI) 身体质量指数 (BMI) = 体重 / 身高2 (kg/m2) 体重過轻 BMI ＜ 18.5 正常范围 18.5 ≦ BMI ＜ 24 異常范围体重過重： 24 ≦ BMI ＜ 27 轻度肥胖： 27 ≦ BMI ＜ 30 中度肥胖： 30 ≦ BMI ＜ 35 重度肥胖： BMI ≧ 35 WHAT IS OBESITY? 什么叫做肥胖？ Body Mass Index (BMI) = body weight/ height2 (kg/m2) Underweight BMI ＜ 18.5 Normal range 18.5 ≦ BMI ＜ 24 Abnormal range Overweight： 24 ≦ BMI ＜ 27 Mild obesity： 27 ≦ BMI ＜ 30 Moderate obesity： 30 ≦ BMI ＜ 35 Severe obesity： BMI ≧ 35 方法一:身体质量指数 (BMI) Method 2: Body fat percentage Male＞ 25 % (17 - 23 %) ，waistline ≧ 90 cm Female＞ 30 % (20 - 27 %)，waistline ≧ 80 cm

6. 腰圍  腰围，代表的意义为腹部的脂肪堆积情形。  美国心脏病医学年会发表的一份研究发现，用腰围做为心脏病发作的预测因子，优于使用体重、 BMI。若以美国男性腰围102公分、女性88公分为准，超过标准的男性罹患心脏病风险会增加24％，女性会高出21％ WAIST CIRCUMFERENCE 腰围  Waist circumference, representing the meaning of the abdominal fat accumulation situation  A study published by the American College of Cardiology found that using waist circumference as a predictor of heart attack is superior to using weight and BMI. If the American male has a waist circumference of 102 cm and a female 88 cm, the risk of heart disease will increase by 24% for men who exceed the standard, and 21% for women

7. 114 KG VS 55 KG 114 公斤 VS. 55 公斤 OBESITY AND HEALTH 肥胖与健康

8. • 世界卫生组织于1997 年报告宣布肥胖为一种疾病 • 肥胖已发现是许多疾病的危险因子，例如：心脏病、糖尿病、高血胆固醇、睡眠呼吸中止症、以及部分的癌症 The effects of obesity on health 肥胖对健康的影响 • The World Health Organization reported in 1997 that obesity is a disease • Obesity has been found to be a risk factor for many diseases such as heart disease, diabetes, high blood cholesterol, sleep apnea, and some cancers

9. OBESITY EVEN AFFECTS INTELLIGENCE 肥胖甚至影响智力 • 一项早期肥胖对智能影响的研究发现，四岁前严重肥胖的孩子，其智商较非肥胖者低约30分 (78分vs 106分)，在核磁共振造影(MRI)发现，这些肥胖孩子都有通常见于阿兹海默症患者的大脑白质病变 (J Pediatr. 2006 Aug;149(2):192-8.) • 孕妇过胖的话甚至会影响小孩长大后的智商高低 (Matern Child Health J. 2013 Feb;17(2):222-9..) • In the early research on the effects of obesity on intelligence found that obese children before the age of four has lower intelligence quotient than non-obese children by 30 points (78 vs 106 points). Under the Magnetic Resonance Imaging (MRI) these obese children’s brains are found with white matter lesions, similar to an Alzheimer disease patients (J Pediatr. 2006 Aug;149(2):192-8.) • If a pregnant woman is overweight, it may even affect the IQ of the child when they grow up (Matern Child Health J. 2013 Feb;17(2):222-9..)

10. Repeat 重复 Diet 节食 Starvation 飢餓反应 Weight loss 体重減轻 Feast 大吃大喝 VICIOUS CYCLE OF DIETING 节食产生的恶性循环 TLSTM WEIGHT MANAGEMENT SOLUTION IS DESIGNED TO STOP THIS CYCLE TLSTM体重管理计划就是用來中止這个循环

11. WHAT IS THE TLSTM WEIGHT MANAGEMENT SOLUTION? 什么是TLSTM体重管理计划？ • 低升糖飲食不是少吃，是吃的正确 • 改变体組成著重在減少体脂肪，而不是体重 • 具科学根据的营养素帮助身体增加效果 • 教育支援改变不健康的生活习惯 4 KEY ELEMENTS IN LINE WITH SCIENCE 符合科学基础的4大要素 • Low-glycaemic diet It's not eating less, it's eating right • Change body composition Focus on reducing body fat, not weight • Scientifically based nutrients Helps the body increase its effectiveness • Educational support Change unhealthy living habits

12. LOW-GLYCAEMIC DIET CHOOSE THE RIGHT FOOD 低升糖飲食食物挑选正确

13. • 有助支持身体对胰岛素的敏感度 • 帮助维持正常的血糖值 • 帮助减少和控制体重 • 帮助维持正常血胆固醇值(Diabetes Care. 2002 May;25(5):822-8) • 帮助维持心脏健康(Nutr Metab Cardiovasc Dis. 2013 Aug;23(8):699-706) • 帮助减少对碳水化合物的食欲 • 调节饥饿感，维持较久的饱足感 • 帮助减少无力的现象 • 帮助增强身体的耐力(Pediatrics. 2003 Mar; 111(3):488-94) BENEFITS OF LOW-GLYCAEMIC DIET 低升糖飲食的好处 There are many benefits to switching from a traditional diet to a low-glycaemic diet: 从传统的饮食习惯转换到低升糖饮食有很多好处： • Helps support the body's sensitivity to insulin • Helps maintain normal blood sugar levels • Helps reduce and control weight • Helps maintain normal blood cholesterol levels (Diabetes Care. 2002 May;25(5):822-8) • Helps maintain heart health (Nutr Metab Cardiovasc Dis. 2013 Aug;23(8):699-706) • Helps reduce appetite for carbohydrates • Regulate hunger and maintain a long-lasting sense of satiety • Helps reduce weakness • Helps strengthen the body's endurance (Pediatrics. 2003 Mar; 111(3):488-94)

14. • 改善多囊性卵巢症候群患者的月经周期 (Am J Clin Nutr. 2010 Jul;92(1):83-92) • 可有助降低体内发炎指数 (Am J Clin Nutr. 2014 Apr;99(4):813-33) • 可显著减少过重或肥胖儿童的体脂肪率 (J Am Coll Nutr. 2008 Feb;27(1):12-21.) • 食用低GI饮食早餐的儿童，可在早上维持较好的记忆力及注意力 (Appetite. 2007 Jul; 49(1):240-4.) • 相较于高升糖饮食，低升糖饮食可减少体内血糖浓度的波动，提供脑部稳定的血糖 (PLoS One. 2010; 5(12): e15213. ) BENEFITS OF LOW-GLYCAEMIC DIET 低升糖飲食的好处 • Improve the menstrual cycle of patients with polycystic ovarian syndrome (Am J Clin Nutr. 2010 Jul;92(1):83-92) • May helps reduce inflammation in the body (Am J Clin Nutr. 2014 Apr;99(4):813-33) • Can significantly reduce the body fat rate of overweight or obese children (J Am Coll Nutr. 2008 Feb;27(1):12-21.) • Children who have low-GI breakfast maintain better memory and attention in the morning (Appetite. 2007 Jul; 49(1):240-4.) • Compared with high-glycaemic diets, low-glycemic diets reduce fluctuations in blood sugar levels in the body and provide stable blood sugar to the brain (PLoS One. 2010; 5(12): e15213. )

15. CHANGINGOFBODYCOMPOSITION EXERCISE–MUSCLESDETERMINEMETABOLISM 改变体组成运动 - 肌肉決定代谢

16.  运动是达成减重并且维持成果的关键。选择正确的运动类型是相当重要  最有效的运动计画必须包含心肺运动、肌力训练和柔软度训练  TLSTM体重管理计划能帮助您学会如何开始执行一套均衡的运动计画，也会让您了解在每周的运动中都纳入这三种训练的重要性  当运动时，您的身体燃烧储存的脂肪，并且保存身体的肌肉量。肌肉能增进您的新陈代谢 EXERCISE 运动 ※请注意：在开始进行任何运动计画之前，请咨询您的医师。  Exercise is the key to achieving weight loss and maintaining results. Choosing the right type of exercise is important  The most effective exercise programme must include cardiopulmonary strength training and flexibility training  TLSTM teaches you how to start a well balanced exercise programme and showing you the importance of incorporating these three types of training in your weekly workout  When exercising, your body burns the stored fat and keeps the body’s muscle mass. Muscle can boost your metabolism ※ Please note: consult your doctor before starting any exercise programme

17. SCIENTIFICALLYBASEDNUTRIENTS TLS™ SUPPLEMENTS 具有科学根据的营养素 TLS™辅助营养素

18. REDUCE CARBOHYDRATE ABSORPTION 減少碳水化合物的吸收

19. WHITE KIDNEY BEAN 白肾豆  在白肾豆中发现淀粉酶抑制剂(α-amylase inhibitor) 之成份Phaseolarmin，具有可以抑制淀粉分解的作用，使淀粉无法消化，而达到部份减少淀粉热量被人体吸收的目的  生的白肾豆具有毒性，但煮熟后又散失淀粉酶抑制剂的活性。故需利用科学技术萃取  A component Phaseolarmin, Amylase Inhibitor (α-amylase inhibitor) is found in white kidney beans, that can inhibit the role of starch decomposition so that starch cannot be digest thus partially reducing starch absorption by the body  Uncooked white kidney beans are toxic, but cooked beans will lose the amylase inhibitor. Thus, it is necessary to use scientific methods to extract the amylase inhibitor that we want.

20.  Alpha-amylase inhibitors  α-淀粉酶抑制剂 Starch 淀粉 Oligosaccharides 低聚糖 Monosaccharide 单糖 Oral, Small Intestine 口腔、小腸 Intestinal villus 小肠絨毛 α-Amylase α-淀粉酶 α-glucosidase α-葡萄糖苷酶 Not absorbed by small intestine Indirect control of blood sugar level Reduce Fats from forming 小肠不吸收血糖间接被控制降低脂肪形成 Nutrition Journal 2011, 10:24 White Kidney Bean Extract 白肾豆萃取物

21. NORMAL APPETITE 正常食欲

22.  萃取自天然成分，经临床证实，专为体重管理设计之专利成 (Lipids Health Dis. 2010 Feb 19;9:20.)  由植物多糖、蓝绿藻、石榴萃取物及β胡萝卜素所组成 What is LeptiCore™ 什么是 LeptiCore™  Extracted from natural ingredients, clinically proven, designed for Weight Management (Lipids Health Dis. 2010 Feb 19;9:20.)  Composed of plant polysaccharide, blue green algae extract and beta carotene

23.  主要和瘦体素(leptin)的敏感度有关何谓瘦体素(Leptin):  由白色脂肪组织所分泌的一种荷尔蒙  调节热量的摄取与支出 :  減低食欲  增加体内脂肪的燃烧  减少食物的摄取，增加热量支出与调控血糖代谢  所以适当的体脂=释放适当的瘦体素=减少食物摄取并增加热量利用 FUNCTIONS OF LEPTICORE™ LEPTICORE™ 的作用  Mainly related to the sensitivity of leptin What is Leptin:  A hormone that is secreted by white adipose tissue  Regulate caloric intake and expenditure:  Appetite reduction  Increases body fat burning  Reduce food intake, increase calorie expenditure and regulate blood sugar metabolism  An appropriate amount of body fat = release of appropriate amount of leptin = reduction in food intake and increase heat utilisation

24. Nature Medicine 12, 425 - 432 (2006) Lower hypothalamus 下视丘饱食中枢 Reduce appetite 降低食欲 Decrease fat cells 脂肪细胞減少 Increase appetite 增加食欲 Increase fat cells 脂肪细胞增加 Leptin 瘦体素 CRP CRP瘦体素复合体 Eat more and fatter 越吃越胖 LEPTIN IMPEDANCE EFFECT OF C-REACTIVE PROTEIN (CRP) 瘦体素阻抗 C-反应蛋白的影响 (CRP)

25.  支援瘦体素敏感性，加强饱足感讯号  減少食欲  增加体脂燃烧  增加热量消耗，调节血糖  抑制多余碳水化合物转变为脂肪囤积  临床研究证实有助减少体重、脂肪储存、腰围、臀围 (Lipids Health Dis. 2010 Feb 19;9:20.) FUNCTION OF LEPTICORE™ LEPTICORE™ 的作用  Support leptin sensitivity to enhance the sense of satiety  Reduce appetite  Increase body fat burning  Increase calorie consumption, regulate blood sugar  Inhibit excess carbohydrate into fat accumulation  Clinical studies have shown that it helps in reduction in body weight, fat storage, waist circumference and hip circumference.

26. TLS™ CORE Fat & Carb Inhibitor TLS™ CORE控脂控醣修身配方 • Helps suppress appetite • Helps increase satiety • Helps reduce fat accumulation • Helps support weight management • Helps inhibit amylase and slows down the absorption of carbohydrates • Helps prevent carbohydrates from being absorbed in the body • Helps support normal blood sugar levels • Helps maintain normal cholesterol levels • 有助抑制食欲 • 有助增加饱足感 • 有助减少脂肪囤积 • 有助支援体重管理 • 有助抑制淀粉酵素，减缓碳水化合物的吸收 • 有助阻止碳水化合物在体内吸收 • 有助支援正常的血糖值 • 有助维持正常的胆固醇值

27. NORMAL METABOLISM 正常代谢

28. Patent Green Coffee Bean Extract Chlorogenic acids, CGAs 专利绿咖啡豆萃取物绿原酸

29.  能量产生的场所  脂肪燃烧的场所  存在于所有细胞(除红血球外)  以心肌、骨骼肌、肝脏最多骨骼肌量提高粒线体活性 COMBUSTION DETERMINING FACTOR - MITOCHONDRIAL 燃烧力决定因素 -粒线体  Energy production site  Fat burning places  Found in all cells (except the red blood cells)  Heart muscle, skeletal muscle and liver have the most Skeletal muscle mass Increased mitochondrial activity

30.  存在于咖啡原豆中，为多酚类的一种，但只要经高温烘培，就会被破坏  绿原酸可增加体内氧气消耗量 - 细胞内90%能量由粒线体产生，而粒线体产生能量必须有氧气，细胞内90%的氧为粒线体所使用 (J Health Sci 56, 2010 科学发展，2011年10月，466期)  绿原酸可使脂肪顺利进入粒线体内燃烧 - 显著增加肝脏脂肪氧化酶的活性 (Eur J Biochem, 244, 1-14)  绿原酸可抗氧化(J Agric Food Chem. 2013 Dec 26;61) CHLOROGENIC ACIDS – INCREASE MITOCHONDRIAL ACTIVITY 提高粒线体的活性 ~绿原酸  Found in coffee beans, it is a kind of polyphenol. However, it can be destroyed once heated  Chlorogenic acid can increase oxygen consumption in the body - Within the cell, 90% of the energy is generated by the mitochondria, and the mitochondria generates energy which requires oxygen, and 90% of the oxygen in the cell is used by the mitochondria (J Health Sci 56, 2010 Scientific Development, October 2011, issue 466)  Chlorogenic acid can cause fats to enter the mitochondria and burn - The activity of carnitine palmitoyltransferase was significantly increased. (Eur J Biochem, 244, 1-14)  Chlorogenic acid can resist oxidation Agric Food Chem. 2013 Dec 26;61)

31.  人体实验证实，连续60天每日摄取400毫克之Svetol，可显著降低 5.7%之体重，并增加4%之肌肉量  2014年获韩国FDA认证，可于包装上标示有助减少体脂肪  2014年获加拿大 The Natural Health Product Directorate (NHPD) 认可，可使用于体重控制和心血管健康有关之宣称 PATENT INGREDIENT SVETOL™ 专利成分 SVETOL™  Studies show that daily intake of 400mg of Svetol™ daily for 60 days could significantly reduce body weight by 5.7% and increase muscle mass by 4%  Year 2014: approved by Korean FDA certification, allowing it to be labelled on the packaging that it helps in body fat reduction  Year 2014: Approved by Canada's Natural Health Product Directorate (NHPD), allowing it to be used for weight control and cardiovascular health claims (Phytothérapie, 4, 2006) Can Help to reduce body fat, 健康産業流通新聞 Health Industry Marketing News Online, 2014. 9. 11 (Health Canada, www.hc-sc.gc.ca. October 7,2014)

32.  改善胰岛素阻抗，增加脑部能量 (Nutr Neurosci. 2012 Jan;15(1):37-45.Dietary supplementation with decaffeinated green coffee improves diet-induced insulin resistance and brain energy metabolism in mice.)  抑制葡萄糖6磷酸酶，降低肝糖分解而释放出葡萄糖，因此可降低血糖 (J Agric Food Chem. 2010 Apr 14;58(7))  抑制小肠对葡萄糖的吸收 (Appl Physiol Nutr Metab. 2011 Oct;36(5):650-9.)  肪促进脂肪组织分解为脂肪酸 (Phytother Res. 2013 Dec 12) OTHER BENEFITS OF CHLOROGENIC ACID 绿原酸的其他益处  Improve insulin resistance and increase brain energy (Nutr Neurosci. 2012 Jan;15(1):37-45.Dietary supplementation with decaffeinated green coffee improves diet-induced insulin resistance and brain energy metabolism in mice.)  Inhibits glucose 6 phosphatase, lowers glycaemic decomposition and release of glucose, hence helps in lowering blood sugar (J Agric Food Chem. 2010 Apr 14;58(7))  Inhibits intestinal absorption of glucose (Appl Physiol Nutr Metab. 2011 Oct;36(5):650-9.)  Promotes decomposition of adipose tissue into fat to inhibit the small intestine of glucose absorption of acid (Phytother Res. 2013 Dec 12)

33. GARCINIA CAMBOGIA EXTRACT 藤黃果萃取物  藤黄果为市售常见的减重成份之一  果皮上富含羟基柠檬酸（HCA, Hydroxycitric Acid），具有抑制脂肪生成酵素（Citric acid lyase）的作用  调控脑部血清素浓度，控制食欲 Fitoterapia. 2015 Apr;102:134-48. doi: 10.1016  Garcinia Cambogia is one of the most commonly used weight loss ingredients in the market  The skin is rich in hydroxy citric acid (HCA), which has the effect of inhibiting the enzyme of Citric acid lyase  Regulates serotonin concentration in the brain and controls appetite

34. GREEN TEA EXTRACT 绿茶萃取物  含有儿茶素  可促进褐色脂肪之产热作用，增加人体热量支出(Int J Obes Relat Metab Disord. 2000 Feb;24(2):252-8.)  可促进肝脏中脂肪燃烧酵素的量，使肝脏中脂肪燃烧增加3倍(Int J Obes Relat Metab Disord. 2002 Nov;26(11):1459-64.)  Contains EGCG (epigallocatechin-3-gallate)  Helps promote the production of brown fat and increase the calorie expenditure (Int J Obes Relat Metab Disord. 2000 Feb;24(2):252-8.)  Helps promote the amount of fat burning enzyme in the liver, thus increasing fat burning in the liver by 3 times (Int J Obes Relat Metab Disord. 2002 Nov;26(11):1459-64.)

35. GUARANA SEED POWDER YERBA MATE POWDER 瓜拿纳籽粉马黛茶叶粉  巴西人及阿根廷人传统提振精神的草本健康饮料  人体实验证实，瓜拿纳 (Guaraná)能提高认知功能改善精神疲劳 (Appetite. 2008 Mar-May;50(2-3),2007 )  动物实验发现，马黛茶可能会透过抑制腺甘酸(一种会减少脑部活动之物质)与受体结合，而提高学习力与记忆力。 (J Ethnopharmacol. 2008 Dec 8;120(3),2008)  摄取含瓜拿纳及马黛茶之配方，可减少肥胖者之体重及延缓胃的排空 (J Hum Nutr Diet. 2001 Jun;14(3):243-50.)  Brazilian and Argentine traditional herbal health drinks  Human studies confirm that Guaraná can improve cognitive function and improve mental fatigue (Appetite. 2008 Mar-May;50(2-3),2007 )  Animal studies have found that Yerba Maté may enhance learning and memory by inhibiting the binding of adenosine, a substance that reduces brain activity, to receptors (J Ethnopharmacol. 2008 Dec 8;120(3),2008)  Intake of Guaraná and Yerba Maté formula can reduce the weight of obese people and delay gastric emptying (J Hum Nutr Diet. 2001 Jun;14(3):243-50.)

36. CHROMIUM 铬  Assist blood glucose into the cells, thus helping to maintain normal insulin activity level, called glucose tolerance factor. Able to help to metabolise carbohydrates and fat, and maintain good health  Helps to maintain healthy cholesterol level and other blood lipids  Promotes the role of metabolism  能协助血糖进入细胞, 从而帮助维持正常的胰岛素活动，故被称为葡萄糖耐受因子。能帮助身体正常代谢碳水化合物和脂肪，并维持身体健康  有助于维持健康水平的胆固醇和其他血脂  促进新陈代谢发挥的作用

37. • 有助体内脂肪燃烧，促进体重管理效果 • 支援健康体重管理 • 可能有助抑制糖分转化为脂肪 • 可能有助抑制食欲并增加饱足感 • 支援健康的肌肉-脂肪比率 • 促进健康体脂，同时保留肌肉组织 TLS™ Green Coffee Plus Garcinia Cambogia TLS™绿咖啡藤黄果消脂配方 • Promotes better weight management by helping the body burn fat • Support healthy weight management • May help to inhibit the conversion of sugar into fat • May help suppress appetite and increase satiety • Support healthy muscle-to-fat ratio • Promotes a healthy body fat while preserving muscle tissue

38. BUILDING MUSCLE 建构肌肉

39. High Quality Protein: United Nation FAO indicates 1 to represent fast and complete absorption 优质的蛋白：联合国FAO机构评订1 表示吸收快速而完全 (大豆蛋白) (乳清蛋白) (酪蛋白) (牛奶) (鸡蛋) (牛肉) (黃豆) (水果) (蔬菜) (豆类) (谷类) (全麥)

40. HIGH QUALITY PROTEIN – WHEY PROTEIN 优良蛋白质 - 乳清蛋白  牛奶中的蛋白质含量约 3.5%，其中80%为酪蛋白， 20%为乳清蛋白 - 珍贵  增加免疫能力 (Arch Immunol Ther Exp. 2001；49(4)：325-333.)  降低血压、血脂 (J Dairy Sci. 2000；83(2)：255-263.)  减少体脂肪，降低肌肉的流失、明显增加瘦体组织的重量 (Nutr J. 2004；8(3)：22.)  The protein content in milk is about 3.5%, of which 80% is casein and 20% is whey protein – Precious  Increases Immunity (Arch Immunol Ther Exp. 2001；49(4)：325-333.)  Lowers blood pressure, blood lipids ( J Dairy Sci. 2000；83(2)：255-263.)  Reduce body fat, Reduce muscle loss, significantly increase the weight of lean tissue (Nutr J. 2004；8(3)：22.)

41. HIGH QUALITY PROTEIN – SOY PROTEIN 优良蛋白质 - 大豆蛋白  Reduce insulin resistance, lower LDL cholesterol, raise high density cholesterol, and reduce fat accumulation in the body (Int J Med Sci. 2007; 4(2): 72–82.)  Prevents cancer (J AOAC Int. 2006 Jul-Aug;89(4):1215-27.)  Lowers Blood Pressure (Am J Clin Nutr. 2012 Apr;95(4):966-71.)  降低胰岛素抵抗性，降低低密度胆固醇，提高高密度胆固醇，减少体内脂肪的囤积 (Int J Med Sci. 2007; 4(2): 72–82.)  预防癌症 (J AOAC Int. 2006 Jul-Aug;89(4):1215-27.)  降低血压 (Am J Clin Nutr. 2012 Apr;95(4):966-71.)

42. • 每份提供超过18公克的蛋白质 • 膳食纤维的良好来源 • 提供高量的钙质 • 提供22种不同维他命与矿物质每日推荐摄取量 1/3以上的营养 • 正餐之间的营养补充 • 无反式脂肪 • 不添加砂糖 TLS™ Nutrition Shake TLS™ 高纤蛋白营养奶昔 • Provides >18 grams of protein per serving • Good source of fibre • High in calcium • Provides over 1/3 of the recommended daily value of 22 different vitamins and minerals • Nutritional supplements between meals • No trans fat • No added sugar 产品测试没有可检测的转基因生物

43. LOWER BODY FAT 下半身脂肪

44. WHAT IS TONALIN ™ CLA? 什么是 TONALIN ™ CLA?  共轭亚麻油酸(CLA)，萃取自红花油  共轭亚麻油酸(CLA)是亚麻油酸(LA)的同分异构物，和亚麻油酸一样，都属于 ω-6不饱和脂肪酸  针对顽固的腹部脂肪  针对下半身肥胖  帮助维持肌肉  減少脂肪囤积  Conjugated linoleic acid (CLA), extracted from red flower oil  Conjugated linoleic acid (CLA) is an isomer of linoleic acid (LA), which is an omega-6 fatty acid, as is linoleic acid  Targeted the stubborn belly fat  Targeted at lower body fat  Helps maintain muscles  Reduces fat accumulation

45. MECHANISM OF ACTION – TONALIN™ CLA TONALIN™ CLA 的作用机制 • 抑制脂蛋白脂解酶 (lipoprotein lipase)活性，使血液中脂肪无法储存到脂肪细胞中 • 活化CPT酵素活性(carnitine palmityltransferase)，加速脂肪进入粒线体中燃烧  Inhibits lipoprotein lipase activity, which does not allow the fat in the blood to be stored in fat cells  Activates CPT enzyme activity (carnitine palmityltransferase) to accelerate the fat into the mitochondria and burn

46. RESEARCH ON CLA 有关CLA研究  使用CLA约12个月，体脂肪减少约2公斤，肌肉增加0.7公斤  可显著减少肥胖女性大腿的脂肪  针对肥胖男女所做的研究显示，每天食用3.4公克的CLA能得到最佳减少体脂肪之效果  食用4周即可显著减少代谢症候群患者的腰围  Using CLA for about 12 months, body fat decreased by about 2 kg and muscle by 0.7 kg  Significantly reduces thigh fat in fat females  A study of obese men and women revealed that consuming 3.4g of CLA a day has the best effect of reducing body fat  Four weeks of consumption can significantly reduce the waist circumference of patients with metabolic syndrome (Am J Clin Nutri 2004;79: 118-25) (Br J of Nutrition 2007; 97:550-60) (J of Nutrition 2000; 130: 2943-8) (J Obes Relat Metab Disord 2001; 25(8): 1129-35)

47. TLS TONALIN™ CLA TLS TONALIN™ CLA红花油塑身去脂配方 • 促进肌肉生成 • 配合运动增强减重效果 • 有助提高肌肉质量，支援体重管理 • 支援身体脂肪作为能源的运用率 • Assists in promoting lean muscle mass • Coordinate with exercise to enhance weight loss • Supports weight management by promoting lean muscle mass • Supports the utilization of body fat as fuel 产品测试没有可检测的转基因生物

48. REGULATORY HORMONE 调节荷尔蒙

49. RECOGNIZE ADIPONECTIN 认识脂联素  由脂肪细胞分泌  可增加胰岛素敏感度  减少肝脏细胞的糖质新生作用 (Gluconeogenesis)  促进血糖的利用  与心血管疾病危险因子数据成反比（如血压，LDL值，血脂肪量）  与体重，体脂肪与腰围成反比  研究发现，脂联素能活化粒线体中AMPK，达到燃烧脂肪的效果 https://en.wikipedia.org/wiki/Adiponectin  Secreted by fat cells  Increase insulin sensitivity  Reduce the gluconeogenesis of liver cells  Promote the use of blood sugar  In inverse proportion to cardiovascular disease risk factor data (Eg., blood pressure, LDL value, blood fat mass)  In inverse proportion to body weight and body fat  Studies have found that adiponectin can activate AMPK in mitochondria and achieve fat burning effect

50. BALANCING THREE HORMONES 平衡三种荷尔蒙 Insulin 胰岛素 Adiponectin 脂联素 Leptin 瘦体素

51. AFRICAN MANGO SEED EXTRACT 非洲芒果种子萃取物  经过人体双盲测试，发现可以有效降低体重  与对照组比较，可以降低血胆固醇、低密度脂蛋白LDL、三酸甘油脂  与对照组比较，可提高高密度脂蛋白HDL Lipids in Health and Disease 2005, 4:12  After double-blind testing of the human body, it was found that it can effectively reduce weight  Compared with the control group, it can lower blood cholesterol, low- density lipoprotein LDL, triglyceride  High-density lipoprotein HDL compared with the control group

52. PPARγ(Peroxisome proliferator-activated receptor γ)：其作用为分化干细胞而成脂肪组织 于脂肪细胞实验(In Vitro)，发现非洲芒果种子萃取物可抑制PPARγ基因的表现 Lipids in Health and Disease 2008, 7:44 AFRICAN MANGO SEED EXTRACT 非洲芒果种子萃取物 PPARγ (Peroxisome proliferator-activated receptor γ): its role is to differentiate stem cells into adipose tissue In the ad cell experiment (In Vitro), it was found that African mango seed extract can inhibit the expression of PPARγ gene

53. WHAT IS WellTrim® (IGOB131®)? 什么是 WellTrim® (IGOB131®)?  是一种经临床测试的非洲芒果萃取物，也称为野生芒果。其天然成分已被证明可促进健康的体重管理  获得美国食药署GRAS认证  获得美国专利健康宣称 (U.S. Patent 7,537,790)  经双盲，安慰剂控制组人体实验证实  藉由多重作用机制，不仅可促进健康窈窕还有助改善整体健康  It is a clinically tested African mango extract Irvingia gabonensis, also known as wild mango. Its natural ingredients have been proven to promote healthy weight management  Obtained GRAS certification from the US Food and Drug Administration  Obtained the US Patent Health Claim (U.S. Patent 7,537,790)  Double-blind, placebo-controlled group confirmed by human experiment  Through multiple mechanisms of action, not only can promote health, but also help improve overall health.

54. Well Trim iG® LEPTIN Well Trim iG® 瘦体素  人体实验证实，WellTrim能可改善瘦體素阻抗的狀況减少51.7% 的C反应蛋白(CRP)浓度  可改善瘦体素阻抗的状况 Lipids in Health and Disease 2009, 8:7 Lower hypothalamus 下视丘饱食中枢 Reduce appetite 降低食欲 Decrease fat cells 脂肪细胞減少 Increase appetite 增加食欲 Increase fat cells 脂肪细胞增加 Leptin 瘦体素 CRP  Human experiments have confirmed that WellTrim can improve leptin impedance and reduced c-reactive protein concentration by 51.7%  Can improve the condition of lean voxel impedance

55. Well Trim® iG ADIPONECTIN AND BLOOD SUGAR Well Trim® iG 脂联素与血糖  增加脂联素浓度，可改善血糖浓度  相较于安慰剂组， Welltrim组增加了 159%的脂联素浓度  相较于安慰剂组只减少安了5.3%的血糖浓度，Welltrim组减少了 22.5% 的血糖浓度  Welltrim研究发现可以改善胰岛素阻抗 Lipids in Health and Disease 2009, 8:7  Increase adiponectin concentration and improve blood glucose concentration  Compared to the placebo group, the Welltrim group increased the adiponectin concentration by 159%  Compared with the placebo group, the blood glucose concentration was reduced by 5.3%, and the Welltrim group was reduced by 22.5%.  Welltrim study found that insulin resistance can be improved

56.  G3PDH是血糖转换成脂肪时所需的酵素  G3PDH 是导致肥胖的重要因素  减少G3PDH，就能减少血糖转换成脂肪  与控制组相比，Welltrim可减少71.6%的G3PDH  可減少80.9%的脂肪合成 Well Trim® iG— SUPRESS G3PDH Well Trim® iG— 抑制 G3PDH Lipids in Health and Disease 2009, 8:7  G3PDH is the enzyme needed to convert blood sugar into fat.  G3PDH is an important factor leading to obesity  By reducing G3PDH, you can reduce blood sugar into fat  Compared with the control group, Welltrim can reduce 71.6% of G3PDH  Can reduce fat synthesis by 80.9%

57. Lipids in Health and Disease 2009, 8:7 BODY FAT 体脂肪

58. TLS™ Trim Tea and Trim Café TLS™ 修身茶與修身咖啡 • 有助抑制食欲 • 有助提高饱足感 • 支援健康的体重管理 • 促进体内脂肪燃烧 • Helps suppress appetite • Helps increase satiety • Support healthy weight management • Promote body fat burning

59. INTRODUCTIONOF EDUCATIONALTOOLS TLSTM HEALTHGUIDEANDJOURNAL 教育支援工具介绍 TLS健康手冊及日志

60. TLSTM Health Guide TLSTM健康手冊 • Chapter 0: Detoxification 排毒 • Chapter 1: Low-Glycaemic Diet 低升糖饮食 • Chapter 2: How to Read Product Labels 如何阅读标签 • Chapter 3: Enhance Metabolism 促進新陈代谢 • Chapter 4: Composition of Exercise and Body 运动和身体组成 • Chapter 5: Plan your take-out food 计划与外食 • Chapter 6: Nutrients 营养素 • Chapter 7: Develop Healthy Habit 养成健康的好习惯 • Chapter 8: Believe in Yourself 相信自己 • Chapter 9: Overcoming Obstacles 克服障碍 • Chapter 10: Stress Management 管理压力 • Chapter 11: Maintaining Results 取终身可维持的成果 • Chapter 12: Living TLS™ 实践TLS™

61. TLSTM TOOLS TLSTM 工具 sg.tlsSlim.com • TLSTM问卷及个人化饮食计划建议 • 教育影片 • 身体质量指数 (BMI)计算工具 • 体脂肪计算工具 • 健康部落格 • 成功故事分享 • TLS21天挑战 • 如何成為TLS 教练 • 下载及更多资讯 sg.tlsSlim.com • TLS™ questionnaire and personalized dietary recommendations • Educational video • Body Mass Index (BMI) calculation tool • Body Fat calculation tool • Healthy blog • TLS™ Success Stories • TLS™ 21 Day Challenge • How to be a TLS™ Coach • TLS™ Downloads and more information

62. TLSTM JOURNAL TLSTM日志 RESULTS TRACKING HEALTHY DIET TIPS DAILT MOTIVATIONAL QUOTES STRESS RELIEVE TIPS 成果追踪健康饮食秘诀每日正面能量每日纾压秘诀

63. Use TLSTM Weight Management Profile find your suitable diet plan 利用TLSTM问卷，找出适合的饮食计划

64. TLSTM Dietary Programme TLSTM饮食计划建议在开始任何饮食计划之前，先进行7天体内环保饮食计划哪项计划最适合您？ • 14天密集燃脂饮食计划 • 短期加速冲刺饮食计划 • 短期均速渐进饮食计划 • 长期持续维持饮食计划 Which programme works best for you? • 14-Day Fat Burning: 14 days of intensive fat burning diet plan • Rapid Results： Short-term sprint diet plan • Sure & Steady：Short-term average gradual diet plan • Continued Commitment ：Long-term sustained diet plan Before starting any dietary plan, start 7-day Detox

65. WHAT EXACTLY ARE WE CONSUMING? 我们都在吃什么？

71. TLS™ Weight Management Solution TLSTM体重管理计划 20% 30% 50% Healthy Lifestyle 健康生活 Change of behaviour 改变行为 Exercise 运动 Find new food, Low glycaemic diet, Protein, Vegetables, Fruit, Fibre, Healthy fat, water 找到喜欢的新食物、低升糖作用饮食、蛋白质、蔬菜、水果、纤维、健康脂肪、水 Unconscious exercise, Dancing, Bowling, Golf, Walk, Cycling, Walk the stairs, Love and laughter 无意识运动、跳舞、保龄球、高尔夫、走路、骑單車、走樓梯、爱与欢笑 Create new behaviour, Journaling, Education, Nutritional supplements, Responsible to the coach 建立新行为、写日志、教育、营养補充品、对教练负责任

72. Science Theory – Experience as prove 科学为本－经验为据  TLSTM 体重管理计划採用最新的科学资讯，并由医生、研究员、博士和体适能专家组成的美国研究团队研发而成  TLS 体重管理计划研发团队在体重管理、人体营养研究和成功系统的经验累计超过一百年 Lieberman et al, Alt. Comp. Therapies (2005)11:307-313  TLS™ Weight Management Solution utilizes the latest scientific information and is developed and researched by physicians, researchers, PhDs and body fitness specialists  TLS™ Weight Management Solution R&D team has accumulated more than a hundred years of experience in weight management, human nutrition and successful system

73. This is the result! 这就是效果！  After completing the 12 weeks programme, as compared to Atkins, Ornish, Wt.Watchers and Zone 12 months plan: 2 x weight loss; 3 x waist circumference reduction (inches).  Significantly reduce in Body Fat  Experimental study published  12 week research  本12周计划达成之后，相对于 Atkins、Ornish、Wt.Watchers 及 Zone等12个月计画：重量减少 2 倍；腰围减少（英吋） 3倍。  体脂肪统计后明显减少  出版之试验性研究  TLS12 周完全介入性试验研究 Lieberman et al, Alt. Comp. Therapies (2005)11:307-313

74. 77 12週全新生活TM支援學習課程見證 (本簡報中之所有見證純屬個案，並非每個人均可達到相同效果) 什么是TLS 以及我们如何不同

75. 12 weeks Personal Challenge Group 12周个人挑战组 TLSTM Creates A Health Challenge TLSTM打造健康窈窕挑战赛

76. 吴台生  Weight 体重 ↓ 26.0 kg  Body Fat 体脂肪 ↓ 17.2 %  Waist Circumference 腰围 ↓ 34.5 cm 个人组第1名 Before 之前 After 之后 Individual Group 1st Place

77. 吴台生 Individual Group 1st Place 个人组第1名  Weight 体重 ↓ 26.0 kg  Body Fat 体脂肪 ↓ 17.2 %  Waist Circumference 腰围 ↓ 34.5 cm Before 之前 After 之后

78. 黄世铭  Weight 体重 ↓ 36.4 kg  Body Fat 体脂肪 ↓ 13.6 %  Waist Circumference 腰围 ↓ 37.5 cm 13.6% Individual Group 1st Place 个人组第1名 Before 之前 After 之后

79. 37.5cm 黄世铭 After 之后  Weight 体重 ↓ 36.4 kg  Body Fat 体脂肪 ↓ 13.6 %  Waist Circumference 腰围 ↓ 37.5 cm Individual Group 1st Place 个人组第1名 Before 之前

80. 吴宏飞  Weight 体重 ↓ 35.4 kg  Body Fat 体脂肪 ↓ 18.9 %  Waist Circumference 腰围 ↓ 43 cm Before之前 After 之后 18.9% Men’s Group 1st Place 男子组第1名

81. 43cm Men’s Group 1st Place 男子组第1名吴宏飞  Weight 体重 ↓ 35.4 kg  Body Fat 体脂肪 ↓ 18.9 %  Waist Circumference 腰围 ↓ 43 cm Before之前 After 之后

82. 吴庭榛 10.8% Before 之前 After 之后  Weight 体重 ↓ 20.0 kg  Body Fat 体脂肪 ↓ 10.8 %  Waist Circumference 腰围 ↓ 29.0 cm Women’s Group 1st Place 女子组第1名

83. 吴庭榛 29.0cm Before 之前 After 之后 Women’s Group 1st Place 女子组第1名  Weight 体重 ↓ 20.0 kg  Body Fat 体脂肪 ↓ 10.8 %  Waist Circumference 腰围 ↓ 29.0 cm

84. 40cm The weight lost is the original weight(%) 減下的体重佔原本体重% Reduced body fat as a percentage of lost body weight(%) 減少的体脂佔減少的体重(%) 20.3 75.4 Men’s Group 1st Place 男子组第1名谢岳霖 Before之前 After 之后

85. 12 weeks Group Challenge Group 12周团体挑战组 TLSTM Creates A Health Challenge TLSTM打造健康窈窕挑战赛

86.  Final Weight 终体重 ↓ 62.7 kg  Final Body Fat 终体脂肪 ↓ 31.1 %  Final Waist Circumference 终腰围 ↓ 60.7 cm 团体组第1名 Team Leader 队长 : 吴梅兰 Team Member 1 队员1: 吴梅婷 Team Member 2 队员2: 吴高淑华 Group 1st Place Before 之前 After 之后

87. Team Leader 队长: 陈姵君 Team Member 1 队员1:李彦青 Team Member 2 队员2: 林君铮 53.5cm Group 1st Place 团体组第1名  Final Weight 终体重 ↓ 32.8 kg  Final Body Fat 终体脂肪 ↓ 14.2 %  Final Waist Circumference 终腰围 ↓ 53.5 cm Before 之前 After 之后

88. 双人组第1名 Team Leader 队长:刘美玲 Team Member 队员:刘佳燕 61.0cm Before 之前 After 之后  Final Weight 终体重 ↓ 46.6 kg  Final Body Fat 终体脂肪 ↓ 25.5 %  Final Waist Circumference 终腰围 ↓ 61.0 cm Double Team 1st Place

89. Team Leader Team Member Double Team 1st Place Before After Final Weight 46.6 kg Final Body Fat 19.2 % Final Waist Circumference 56.5 cm

90. Are You Ready？ • Ready to eliminate fatigue, relieve stress, lose weight and restore confidence? • Are you ready to accept change? • Are you ready for a fulfil life? • Start your TLS™ now! 您准备好了吗？ • 准备好消除疲惫、解除压力、减轻体重和恢复信心吗? • 准备好接受改变吗？ • 准备好开展充实的人生吗？ • 就是现在－开始TLS™体重管理计划

91. Market Singapore® I SG.SHOP.COM Product Symposium 2019 美安新加坡™ I SG.SHOP.COM 2019产品专题会 FIND YOUR BALANCE IN WEIGHT MANAGEMENT 寻找您均衡的体重管理

92. UPGRADE Your DIGESTIVE S Y S T E M 改善您的消化系统

93. DIGESTIVE HEALTH WHY IS SO CRUCIAL TO HEALTH 消化健康为什么对于健康如此重要

94. INGESTION 摄取 DIGESTION 消化 ABSORPTION 吸收 ASSIMILATION 同化 METABOLISM 代谢 ELIMINATION 排泄 NUTRITION PROCESS 营养过程 DIGESTION 消化

95. Biochemical Breakdown Of FOOD 食物的生化分解 Become Useable Nutrients 成为可使用的营养素 Colon Absorb or Eliminate 结肠吸收或排出 DIGESTION 消化

96. Large “sausage” when empty 大“香肠”空的时候

97. Size varies slightly in individuals 个体的大小略有不同

98. Ability to stretch due to the folds (rugae) 能够伸缩因为有褶皱（皱襞）

99. Churns To Break Down Food 搅动来分解食物

100. STOMACH’S 胃部

101. Holding Area For FOOD 食物的容器 Starts Digestion of Proteins 开始消化蛋白质 Continues Digestion of Fats 继续消化脂肪 Converts Bolus To Chyme 转化小块食物至食糜

102. 605 kcal 617 kcal 576 kcal 317 kcal 376 kcal 360 kcal 571 kcal559 kcal510 kcal 511 kcal 420 kcal 411 kcal

103. Carbohydrates 碳水化合物 Proteins 蛋白质 TYPES 类型 Fats 脂肪

104. MOUTH 口腔 SMALL INTESTINES 小肠 HOW CARBOHYDRATES DIGEST 如何消化碳水化合物 Started by Salivary Amylase Starches become Sugar Completed by Pancreatic Enzymes Sugar become Glucose FOR ENERGY https://www.livestrong.com/article/273627-chemical-digestion-of-carbohydrates-proteins-and-fats/ 由唾液淀粉酶开始淀粉转变为糖完成于胰酵素糖转变为葡萄糖作为能量

105. STOMACH 胃 SMALL INTESTINES 小肠 Started by Pepsin Proteins become peptides (smaller proteins) 从胃蛋白酶开始蛋白质转变为肽（更小的蛋白质） Completed by Pancreatic Enzymes Peptides become Amino Acids (building blocks, support, structure of cells) 完成于胰酵素肽转变为氨基酸（构件，支援细胞结构） https://www.livestrong.com/article/273627-chemical-digestion-of-carbohydrates-proteins-and-fats/ HOW PROTEINS DIGEST 如何消化蛋白质

106. HOW FATS DIGEST 如何消化脂肪 SMALL INTESTINES 小肠LIVER 肝脏 Bile emulsifies fats 胆汁乳化脂肪 By Pancreatic Lipase Fats become fatty acids For insulation, hormones, stored fuel 通过胰脂肪酶脂肪转变为脂肪酸用于保暖、荷尔蒙、储存的能量https://www.livestrong.com/article/273627-chemical-digestion-of-carbohydrates-proteins- and-fats/

107. Chief digestive enzyme that breaks down proteins into polypeptides 主要消化酵素，将蛋白质分解成多肽 Small amount in stomach breaks down short and medium chain fats 胃部仅有少量，分解中短链脂肪 Not a catalyst enzyme but a glyco- protein necessary for absorption of B12 in small intestines 并非催化酵素，而是小肠吸收B12时必需的一种糖蛋白 Pepsin 胃蛋白酶 Gastric Lipase 胃脂肪酶 https://www.livestrong.com/article/273627-chemical-digestion-of-carbohydrates-proteins-and-fats/ Enzymes in Stomach that Digest Food 酵素位于胃部帮助消化食物 Intrinsic Factor 内在因素

108. WHAT IS IT Incomplete breakdown of nutrients in the Gastrointestinal tract LIKELY CAUSE Lack of digestive enzymes SUGGESTION Support the Pancreas in completing the digestive process with supplemental digestive enzymes MALDIGESTION 消化不良 http://www.nutrientsreview.com/articles/maldigestion-malabsorption.html 这是什么营养素在胃肠道中没有完全分解可能的原因缺乏消化酵素建议通过补充消化酵素帮助完成消化过程来支援胰腺

109. Gastritis 胃炎 COMMON GUT DISEASES & STOMACH ISSUES 常见的肠道与胃部问题 Irritable Bowel DISEASE 肠易激综合症 GERD or Reflux 胃食道逆流或胃酸倒流 Inflammatory Bowel Disease 发炎性肠道疾病 Crohn’s Disease 克隆氏症 Celiac 腹腔 Ulcerative Colitis 溃疡性结肠炎 Hemorrhoids 痔疮 Diverticulitis 憩室炎 Colon polyps or Cancer 结肠息肉或癌症

110. Supports enzyme production Supports immune health in the gut Helps make Vitamins K and B Vitamins Promote healthy gut Improve symptoms of gut diseases – IBS, allergies, chronic constipation, diarrhea B A L A N C EIt is about the 1. https://www.webmd.com/digestive-disorders/what-are-probiotics#1 2. Good Digestive Health Is Not a Dream Slide 26 支援酵素制造支援肠道内的免疫健康帮助制造维生素K与维生素B群促进肠道健康改善肠道类疾病症状 – 肠易激综合症(IBS)、过敏、慢性便秘、腹泻平衡一切都在于

111. Probiotics 10 益生菌10 BENEFITS • Provides beneficial bacteria to promote healthy digestion • Supports bowel health 益处 • 提供益菌，以促进消化系统健康 • 支援肠道健康

112. Unique Selling Point 1 Colony Forming Units or CFU Quantifies how many of the bacteria are capable of dividing and forming colonies ie they are alive and active 独特卖点一菌落形成单位或CFU 量化出有多少细菌能够分裂形成菌落，即它们存活且具有活性 Probiotics 10 益生菌10

113. Unique Selling Point 2 LiveBac Keeps bacteria alive in bottle, extends shelf-life without need for refrigeration. BIO-tract Patented, delivery technology protects probiotic organisms from stomach acid on their way to the bowel, allowing live bacteria to reach multiple places in the bowel for best results. 独特卖点二 LiveBac 在瓶中即可保持细菌活性，无需冷藏也可具有较长的保质期 BIO-tract 专利传输技术可保护益生菌在胃肠道内免受胃酸的侵蚀，因此活性菌得以到达肠道的多个地方，从而获得最佳效果。 Probiotics 10 益生菌10

114. PROBIOTICS 10 BENEFITS Lactobacillus plantarum Promote bacterial balance Lactobacillus acidophilus Synthesize Lactase to help break down lactose Lactobacillus rhamnosus Supports bowel health Lactobacillus salivarius Effective in helping to reduce bacteria involved in plague formation on teeth Lactobacillus casei Overall bowel health Unique Selling Point 3 独特卖点三益生菌10 益处胚芽乳杆菌促进细菌平衡嗜酸乳杆菌合成乳糖酵素来分解乳糖鼠李糖乳杆菌支援肠道健康唾液乳杆菌有效减少形成牙垢的细菌干酪乳杆菌整体肠道健康

115. PROBIOTICS 10 BENEFITS Lactobacillus helveticus Overall bowel health Bifidobacterium bifidum Supports protective barrier in bowel Bifidobacterim longum Minimise growth of pathogenic bacteria in bowel Bifidobacterium breve Promote bowel health Bifidobacterium infantis Supports overall digestion and metabolism Unique Selling Point 3 (Continued) 独特卖点三（继续）益生菌10 益处瑞士乳杆菌整体肠道健康两叉双歧杆菌支援肠道中的保护性屏障长双歧杆菌最大程度地减少肠道病原细菌的生长短双歧杆菌促进肠道健康婴儿双歧杆菌支援整体消化和代谢

116. ISOTONIX® DIGESTIVE ENZYMES WITH PROBIOTICS Isotonix®益生菌消化酵素 BENEFITS • Provides digestive support • Improves nutrient absorption • Probiotics support healthier intestinal tract and digestive system 益处 • 提供消化支援 • 改善营养吸收 • 益生菌支援更健康的肠道和消化系

117. Unique Selling Point 1 Comprehensive Blend Of the basic but beneficial enzymes to digest most foods we eat 独特卖点一全方位包含基本要素以及有益酵素来消化我们食用的绝大多数食物 ISOTONIX® DIGESTIVE ENZYMES WITH PROBIOTICS Isotonix®益生菌消化酵素

118. Unique Selling Point 2 DigeZyme Multi-enzyme complex with amylase, protease, lipase, cellulase, lactase Lactospore® Contains Bacillus coagulans, lactic acid producing bacteria that can survive stomach acid to form colonies in the intestines for gut health 独特卖点二 DigeZyme 含多种消化酵素，包括淀粉酵素、蛋白酵素、脂肪酵素、纤维酵素、和乳糖酵素 Lactospore® 含有凝结芽孢杆菌，一种可以产生乳酸的细菌，这种细菌耐胃酸并可在肠道中形成菌落来促进肠道健康 ISOTONIX® DIGESTIVE ENZYMES WITH PROBIOTICS Isotonix®益生菌消化酵素

119. NUTRICLEAN™ ADVANCED FIBRE POWDER NUTRICLEAN™ 肠道营养纤维粉 BENEFITS • Helps maintain bowel regularity • Supports digestive health • Supports bacterial balance in the colon 益处 • 有助于维持肠道活动规律 • 支援消化系统健康 • 支援肠道内的细菌平衡

120. Unique Selling Point 1 Soluble Fibre + Probiotics Blend that teams up to maintain digestive health 独特卖点一可溶性膳食纤维+益生菌两者协效运作，共同维持消化健康 NUTRICLEAN™ ADVANCED FIBRE POWDER NUTRICLEAN™ 肠道营养纤维粉

121. Unique Selling Point 2 Fibersol-2 High in naturally occurring chemical bonds that remain undigested in the digestive tract, thus supporting overall health L-Glutamine & Inulin L-glutamine is fuel for the intestines and Inulin a prebiotic that feeds the probiotics 独特卖点二 Fibersol-2 大量天然存在于化学键中，并在消化道中保持未消化的状态，因此可支援整体健康左旋麸醯胺酸与菊糖左旋麸醯胺酸是肠道的动力，而菊糖是一种益生元，是益生菌的食物 NUTRICLEAN™ ADVANCED FIBRE POWDER NUTRICLEAN™ 肠道营养纤维粉

122. ULTIMATE ALOE® Ultimate Aloe®芦荟汁益处 • 支援良好的消化系统健康 • 支援免疫系统健康 • 达到或超过国际芦荟科学协会(IASC)的芦荟纯度及含量标准 BENEFITS • Supports good digestive health • Supports immune health • Meets or exceeds the IASC standards for aloe purity and content

123. Unique Selling Point 1 TotalAloe™ Proprietory extraction process. Undesirable components, Aloin and emodin removed. GMP, harvesting methods specific to time and temperature guidelines. 独特卖点一 TotalAloe™ 独家萃取工艺。去除不需要部分、芦荟素以及大黄素。符合优良制造作业规范，采集方式严格遵照精确的时间和温度指导。 ULTIMATE ALOE® Ultimate Aloe®芦荟汁

124. Unique Selling Point 2 International Aloe Science Council or IASC Seal Demonstrates quality of aloe validated and certified by independent group of professionals. Exceeds IASC standards for aloe purity and content. 独特卖点二国际芦荟科学协会或IASC标记证明芦荟的品质经过独立专家组的验证和认证。 ULTIMATE ALOE® Ultimate Aloe®芦荟汁

125. UPGRADE Your DIGESTIVE S Y S T E M 改善您的消化系统

126. STRONGER FRAME, GREATER LIFE • Statistics • In the Beginning • Signs & Symptoms • Prevention • Essential supporting minerals • Supplementation 强健骨骼，活力人生 • 统计分析 • 开始了解骨骼 • 迹象和症状 • 预防之道 • 必要的支持性矿物质 • 营养补充品

127. STATISTICS 统计分析 Stronger Frame, Greater Life 强健骨骼，活力人生

128. Title and Content Layout with List - 骨质疏松症和骨折 - 全球危机髋部骨折增加女性男性高风险的人数增加一倍百万百万

129. Title and Content Layout with List 拉丁美洲亚洲中国巴西世界上最快速老化的地区全球性髋部骨折发生在亚洲髋部骨折髋部骨折世界各地日益增加的负担

130. 骨质疏松症的事实和数字保护新加坡人未来的骨骼健康现在是新加坡保护未来的时候了！

131. “Over the last 30 years in Singapore, cases of hip fractures have increased five times in women aged 50 and above, and one and a half times in men of the same age group. Studies have shown that one in every five people with osteoporotic hip fractures died within a year. Therefore, it is important to know more about your bones to protect your bone health.” http://www.iofbonehealth.org/osteoporosis-musculoskeletal-disorders “近30年来在新加坡，50岁以上女性髋部骨折的病例增加了5倍，同年龄段男性的髋部骨折病例则增加了1.5倍。研究显示，每5例骨质疏松性髋部骨折患者中就有1例在一年内死亡。因此，了解骨骼以保护骨骼健康十分重要” https://www.healthhub.sg/a-z/diseases-and-conditions/19/bonehealth

132. In the Beginning 开始了解骨骼 Stronger Frame, Greater Life 强健骨骼，活力人生

133. Importance of Bones • Store and supply calcium as needed for all of the cells and organs of the body • Give our bodies support and muscle attachments which allow us to move and use our limbs • Enclose and protect our vital organs • Provide space for bone marrow, where all types of blood and bone cells are made • Bone cells respond to their environment to strengthen the structure of individual bones to resist fracture • Unlike a rock, a bone is living tissue that is constantly changing 骨骼的重要性 • 储存及供应人体所有细胞和器官所需的钙 • 支撑我们的身体并使肌肉附着于骨，让我们得以行动并运用四肢 • 包裹并保护我们重要的器官 • 为骨髓提供空间，以制造各型血液和骨细胞 • 骨细胞响应周遭环境，强化个别骨骼结构以抵御骨折 • 不同于岩石，骨骼是不断变化的活体组织

134. 骨量男性女性绝经峰值骨量青春期老年年龄（岁） https://www.healthhub.sg/live-healthy/759/keeping-bones-strong

135. Why male has larger skeletal size and bone mass than females, despite comparable body size? Male • Higher lean mass (92%) than female (79%) • Greater Bone Mineral Content (BMC) and Bone Mineral Density (BMD) at the hip and distal tibia and greater tibial cortical thickness • Hence, bone mass and geometry contribute to the lower incidence of stress and osteoporotic fractures in males 为何尽管体型相当，但男性的骨骼尺寸和质量却比女性大? 男性 • 瘦肉比例(92%)高于女性(79%) • 髋部和远端胫骨的矿物质含量(BMC) 及骨质密度(BMD)较高，且胫骨皮质较厚 • 因此，良好的骨质与骨几何结构有助于降低男性应力性骨折和骨质疏松性骨折的发生率 https://www.ncbi.nlm.nih.gov/pubmed/15746999

136. Signs & Symptoms 迹象和症状 Stronger Frame, Greater Life 强健骨骼，活力人生

137. Signs of bone loss 骨质流失的迹象 ▪ Receding Gums ▪ Decreased grip strength (hands, balance, muscle) ▪ Weak and brittle finger nails ▪ Cramps, muscle aches and bone pain ▪ Leg cramps at night signal that calcium, magnesium and/or potassium blood levels have dropped too low during the night ▪ Height loss (poor posture and vertebral fractures) ▪ Low overall fitness (aerobic, muscle strength, balance) https://www.betterbones.com/bone-health-basics/natures-tips-on-bone-loss-6-signs-and-symptoms-of-bone-health/ ▪ 牙龈萎缩 ▪ 握力减弱（手、平衡感、肌肉） ▪ 指甲脆弱易碎 ▪ 痉挛、肌肉酸痛和骨头疼痛 ▪ 夜间腿部抽筋表示血液中钙、镁和/或钾的水平在夜间降至过低 ▪ 身高萎缩（姿势不良与脊椎骨折） ▪ 整体健康状况不佳（有氧、肌力、平衡）

138. https://www.ncbi.nlm.nih.gov/pubmed/15746999 J Bone Miner Res. 2005 Mar;20(3):529-35. Epub 2004 Oct 11 Know your risk factors 了解您的风险因素 - 骨质疏松症和骨折 - 全球危机 50岁以后骨折？如果你患有1次骨折，您有加倍的风险再患有骨折更常见的风险因素采取预防措施引领骨骼健康的生活方式和您的医生谈谈要求测试如果处方，坚持治疗采取IOF一分钟骨质疏松症风险测试了解更多抽烟？父母骨质疏松症？糖皮质激素或癌症治疗？提前更年期（45岁以前）？变矮了>3cm? 类风湿关节炎乳糜泻，克罗恩病，糖尿病？

139. Identify your risk factors 确认您的风险因素 • You are on prolonged use of steroids • You have a family history of hip fractures • You have been immobilised for a long period of time e.g., bedridden due to illness or hospital care • You have a thin or small frame • 您长期使用类固醇 • 您有髋部骨折的家族病史 • 您已长期行动不便，例如因疾病或住院治疗而卧床不起 • 您的骨架比较纤薄或细小

140. • You had a previous fracture due to a fall • You reached menopause before the age of 45 • You are a younger woman who has missed menstrual periods for a long time • You have an eating disorder such as anorexia nervosa or bulimia • Lifestyle – smoke, drink alcohol, caffeinated drinks • 您曾因跌倒而骨折 • 您45岁之前就进入了更年期 • 您是一位长期错过月经的年轻女性 • 您患有饮食失调症，如神经性厌食症或贪食症 • 生活方式 — 吸烟、喝酒、含咖啡因的饮料 Identify your risk factors 确认您的风险因素

141. Prevention 预防之道 Stronger Frame, Greater Life 强健骨骼，活力人生

142. Bone mass is influenced by many factors, such as nutrition, physical activity, smoking and alcohol intake, as well as by genetic factors. 骨质受许多因素的影响，例如营养、运动、吸烟和饮酒、以及遗传因素。 https://www.ncbi.nlm.nih.gov/pubmed/26598829

143. Thus, a healthy diet providing balanced nutrients including calcium, vitamin D, vitamin K and protein, regular physical activity, and not smoking help maintain bone health and delay or prevent osteoporosis. 因此，健康的饮食会提供均衡的营养素，包括钙、维生素D、维生素K和蛋白质等；而规律运动、不吸烟都有助于维持骨骼健康，延缓或预防骨质疏松症。 https://www.ncbi.nlm.nih.gov/pubmed/26598829

144. Some functional foods containing soy isoflavones, milk basic protein and n-3 fatty acid may help promote bone health. 一些含有大豆异黄酮、牛奶碱性蛋白和n-3脂肪酸的功能性保健食品都可有利于促进骨骼健康 https://www.ncbi.nlm.nih.gov/pubmed/26598829

145. Assess your risk 评估您的风险 If you are worried about your osteoporosis risk, try these: • Osteoporosis Self-Assessment Tool for Asians (OSTA) (for Asian women aged 45 years or older) https://www.healthhub.sg/a-z/diseases-and- conditions/19/bonehealth • IOF One Minute Osteoporosis Risk Test (for women younger than 45 years and men) http://www.iofbonehealth.org/iof-one-minute- osteoporosis-risk-test 如果您担心骨质疏松症的风险，不妨阅读以下网页： • 亚洲人骨质疏松症自我评估工具(OSTA) （适用于45岁以上的亚洲女性） https://www.healthhub.sg/a-z/diseases-and- conditions/19/bonehealth • 国际骨质疏松基金会(IOF)的一分钟骨质疏松症风险测试（适用于45岁以下的女性和男性） http://www.iofbonehealth.org/iof-one-minute- osteoporosis-risk-test

146. Bone health action list You can protect your bones with these 5 steps: 1. Exercise regularly 2. Get enough bone-healthy nutrients 3. Quit smoking and reduce intake of alcohol and caffeinated drinks 4. Assess your risk 5. Take your prescribed osteoporosis medication 骨骼健康行动清单您可以通过以下5个步骤保护您的骨骼： 1. 规律运动 2. 摄取足够的有益骨骼健康的营养素 3. 戒烟、减少酒精及含咖啡因饮料的摄入量 4. 评估您的风险 5. 服用骨质疏松症的处方药

147. Essential supporting minerals 必要的支持性矿物质 Stronger Frame, Greater Life 强健骨骼，活力人生

148. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3330619/ Common Nutrients for Bone Health 骨骼健康常见营养素养分维生素D 钙镁硅维生素K 硼维生素C 铜锌锰建议的膳食津贴中位摄入量作者的首选补充剂对于骨骼健康对于骨骼健康无，除了素食者或老人无

149. Nutrient and Dietary Sources 营养素及饮食来源 https://www.ncbi.nlm.nih.gov/pmc/ar ticles/PMC3330619/ Stronger Frame, Greater Life 强健骨骼，活力人生

150. Supplementation • Calcium Plus • Prime Joint Support • Bromelain Stronger Frame, Greater Life 强健骨骼，活力人生营养补充品 • 强钙配方 • Prime™ 健络关节配方 • 凤梨酵素

151. Isotonix® Calcium Plus Isotonix® 强钙配方 Stronger Frame, Greater Life 强健骨骼，活力人生不含可检测出之基改成分

152. Isotonix® Calcium Plus Isotonix® 强钙配方 What can Calcium Plus do for you? • Essential for maintaining strong bones and healthy teeth • Supports cardiovascular health • Supports healthy enzyme and hormone functions 强钙配方对您有什么好处? • 对维持强壮的骨骼与健康的牙齿必不可少 • 可支持心血管健康 • 支持酵素及荷尔蒙的健康功能

153. What makes Calcium Plus unique? 强钙配方有何独特之处？ • Natural lemon-lime flavour • 2 capfuls provide 750mg of calcium • An isotonic-capable food supplement • Optimal blend of calcium, vitamin D3, magnesium, vitamin c and boron – necessary to aid in the absorption and use of calcium • Do not need stomach acid to be digested – calcium solution more readily absorbed by the intestine • 柠檬莱姆口味 • 2瓶盖的粉末提供750毫克的钙 • 等渗透压的膳食营养补充品 • 优质配方包括钙、维生素D3、镁、维生素C及硼（帮助钙的吸收与利用） • 钙溶液无需胃酸来消化运用，可更快速被小肠吸收

154. Prime™ Joint Support Formula by Isotonix® Prime™ Isotonix® 健络关节配方 Stronger Frame, Greater Life 强健骨骼，活力人生不含可检测出之基改成分

155. Prime™ Joint Support Formula by Isotonix® Prime™ Isotonix®健络关节配方 What can Prime™ Joint Support Formula by Isotonix® do for you? • Helps to promote normal synthesis and regeneration of cartilage • Helps to maintain joint comfort • Helps to support joint fluidity and flexibility Prime™ Isotonix®健络关节配方的益处？ • 有助促进软骨的正常合成与再生 • 有助保持关节舒适 • 有助支援关节液及关节灵活

156. Glucosamine • Can support normal, healthy cartilage cell production to help maintain overall joint health. Pycnogenol® • Has the ability to support the cross- linking of collagen fibres and other connective tissue. Pycnogenol® is a registered trademark of Horphag Research Ltd. 葡萄糖胺 • 可帮助维持整体关节健康碧容健 • 可支援胶原蛋白纤维的结构与其他结缔组织 Prime™ Joint Support Formula by Isotonix® Uniqueness Prime™ Isotonix®健络关节配方有何独特之处

157. The only product on the market delivering Glucosamine, Pycnogenol® and hyaluronic acid in isotonic form. Hyaluronic acid • Plays an important role in tissue hydration and lubrication. • Help maintain strong, healthy cartilage and enhance synovial fluid production. 玻尿酸 • 在组织的保水和润滑中起重要作用 • 有助维持强壮健康的软骨，促进关节滑液的产生。是市场上唯一以等渗透方式传输葡萄糖胺、碧容健、玻尿酸的产品。 Prime™ Joint Support Formula by Isotonix® Uniqueness Prime™ Isotonix®健络关节配方有何独特之处

158. Isotonix® Bromelain Plus Isotonix® 凤梨酵素 Stronger Frame, Greater Life 强健骨骼，活力人生

159. Isotonix® Bromelain Plus • Supports the body’s normal healing process • Supports the body’s natural recovery process • Supports healthy joint function What can Isotonix® Bromelain Plus do for you? Isotonix®凤梨酵素 • 支援身体正常的痊愈过程 • 支援身体正常的修护过程 • 支援关节健康功能 Isotonix®凤梨酵素有何益处？

160. What makes Isotonix® Bromelain Plus unique? • An isotonic-capable food supplement • Contains a combination of bromelain, white willow bark and protease • Bromelain supports healthy joint function by helping support the body’s normal healing process Isotonix®凤梨酵素有什么独特之处？ • 是一款以等渗透方式传输的膳食营养补充品 • 配方中包含凤梨酵素、白柳树皮萃取物及蛋白酵素 • 凤梨酵素通过支援身体正常的疗愈能力来维持健康的关节的功能 Stronger Frame, Greater Life 强健骨骼，活力人生

161. Thank you 谢谢 Stronger Frame, Greater Life 强健骨骼，活力人生 STRONG BONES ARE THE FOUNTAIN OF YOUTH! 健壮的骨骼是青春活力的源泉！

162. ACHIEVE A HEALTHIER BLOOD SUGAR LEVEL 达到更健康的血糖水平

163. AreYou At Risk of Having High Blood Sugar Level? 您有患高血糖的风险吗？ 1. Find out your Body Mass Index (BMI) KG / m2 BMI = 2. Do you have a parent, sibling and/or child diagnosed withType 2 diabetes? Yes No 3. Have you ever been told by your doctor that you have high blood pressure (hypertension)? Yes No Ministry of Health Singapore Diabetes Risk Assessment (DRA) https://www.healthhub.sg/programmes/DRA?utm_source=GovsgFactually 1.计算出您的身体质量指数(BMI) kg/mm2 BMI = 2.您的父母、兄弟姐妹和/或孩子中是否有人被诊断患有2型糖尿病? 是否 3. 您的医生是否曾告知您患有高血压? 是否注:BMI不应用于计算孕妇、肌肉发达人群和老年人的健康风险。这些BMI范围也不适用于18岁以下的青少年

164. AreYou At Risk of Having High Blood Sugar Level? 您有患高血糖的风险吗？ 4. On average, how much time do you spend on physical activity in a week? Examples of physical activity are housework, cycling, jogging, swimming & playing sports/games. Less than 100 minutes Between 100 – 150 minutes More than 150 minutes 5. How often do you drink sugary beverages? Examples of sugary beverages are soft drinks, fruit juice, yoghurt drinks, coffee, tea and bubble tea. 0 to 2 times per week 3 to 6 times per week 7 or more times per week *Visit your doctor for health screening to understand more about your health status. *造访您的医生并做健康检查，更多地了解自己的健康状况。Ministry of Health Singapore Diabetes Risk Assessment (DRA) https://www.healthhub.sg/programmes/DRA?utm_source=GovsgFactually 4. 您一周平均花多少时间从事体力活动? 体力活动包括做家务、骑自行车、慢跑、游泳及参加体育运动/竞赛。少于100分钟 100至150分钟 150分钟以上 5. 您有多么经常饮用含糖饮料? 例如汽水、果汁、优酪乳、咖啡、茶及珍珠奶茶。每周0至2次每周3至6次每周7次以上

165. • Frequent passing of urine • Increased thirst and hunger •Tiredness • Difficulty in seeing clearly •Weight loss Warning Symptoms of Having High Blood Sugar Level 患高血糖的警示症状 Ministry of Health Singapore 新加坡卫生部 •尿频 •经常感到口渴或饥饿 •疲劳 •视力模糊 •体重减轻

166. Diabetes is common in Singapore 糖尿病在新加坡很普遍对抗糖尿病: 一个令人担忧的趋势您可能会面临长期的并发症，这会影响您的生活质量如今，65岁及以上的人群中，每3人中就有1 人患有糖尿病您一生中患糖尿病的几率是三分之一 2014年，有44万18 岁以上的新加坡人患有糖尿病到2050年，近100万新加坡人可能受到糖尿病的影响 Ministry of Health Singapore 新加坡卫生部失明肾功能衰竭心脏病中风截肢

167. 血糖的基础知识 • Our body prefer to get its energy from carbohydrates. • Carbohydrates will be digested and turn into glucose (blood sugar) to fuel our body or to store as body fat. • Insulin transports sugar to various cells in the body that need and want it. • 我们的身体倾向于从碳水化合物中获取能量。 • 碳水化合物被消化后会转化成葡萄糖（血糖），为我们身体提供能量或储存为体脂肪。 • 胰岛素将身体所需要的和想要的糖分传送到各种细胞。 Prediabetes & Insulin Resistance. - The National Institute of Diabetes and Digestive and Kidney Diseases Health Information Center. Retrieved: March 01, 2017 Ministry of Health Singapore新加坡卫生部 Image illustration from Toesters

168. 胰岛素抗性 Excess intake of sugar 糖摄入过量 High blood sugar level in the blood vessel 血管中的血糖水平太高 Body produces more Insulin 身体产生较多的胰岛素 Insulin resistance 胰岛素抗性 Ministry of Health Singapore 新加坡卫生部

169. 持续的胰岛素抗性？ ↑Sugar ↑糖分 ↑Insulin Resistance ↑胰岛素抗性 ↑Leptin Resistance ↑瘦体素抗性 ↑Cholesterol & Triglycerides ↑胆固醇及三酸甘油酯 ↑ BP ↑血压 Diabetes 糖尿病 BP - Blood Pressure BP - 高血压

170. Excessive Sugar with It’s Impact on Our HEALTH 糖摄入过量会影响我们的健康 Vasanti S. Malik, Barry M. Popkin, George A. Bray, MD, Jean-Pierre Després,,Walter C. Willett,Frank B. Hu, MD. Sugar-SweetenedBeveragesandRiskofMetabolicSyndromeandType2Diabetes.2010.Diabetes Care. Nov; 33(11): 2477-2483.https://doi.org/10.2337/dc10-1079 Isabelle Aeberli, Philipp A Gerber, Michel Hochuli, Sibylle Kohler, Sarah R Haile, Ioanna Gouni-Berthold, Heiner K Berthold, Giatgen ASpinas, Kaspar Berneis. Low to moderate sugar-sweetened beverage consumption impairs glucose and lipid metabolism and promotes inflammation in healthy young men: a randomized controlled trial. 2011. The American Journal of Clinical Nutrition, Volume 94, Issue 2, 1 August 2011, Pages 479–485, https://doi.org/10.3945/ajcn.111.013540 • Unstable blood glucose levels • Increases risk of obesity, diabetes & heart disease • Correlated with low chromium • Can accelerate ageing (inflammation) • 血糖不稳定 • 增加罹患肥胖症、糖尿病和心脏病的风险 • 与铬元素不足有关 • 会加速老化（炎症）

171. Aubrey Shiham, W Philip T James. A reappraisal of the quantitative relationship between sugar intake and dental caries: the need for new criteria for developing goals for sugar intake. 2014. BMC Public Health 14:863 Jessica E. Beilharz, Jayanthi Maniam and Margaret J. Morris. Diet-Induced Cognitive Deficits: The Role of Fat and Sugar, Potential Mechanisms and Nutritional Interventions. Nutrients 2015, 7(8), 6719-6738; doi:10.3390/nu7085307 • Causes tooth decay • Contributes to gum disease • Affects cognition • Can lead to stress response Excessive Sugar with It’s Impact on Our HEALTH 糖摄入过量会影响我们的健康 • 引起蛀牙 • 引发牙龈疾病 • 影响认知 • 可导致压力反应

172. How to Maintain A Healthy Blood Sugar Level? 如何维持健康的血糖水平？ Healthy lifestyle choices: • Low glycaemic impact eating • Appropriate exercise • Quality sleep • Chromium supplementation S. W. Rizkalla, F. Bellisle, G. SlamaHealth benefits of low glycaemic index foods, such as pulses, in diabetic patients and healthy individuals.2002. British Journal of Nutrition. Vol: 88, Suppl. 3, S255–S262. Kristen L. Knutson, Eve Van Cauter. Associations between sleep loss and increased risk of obesity and diabetes. 2008. Annuals of the New York Academy of Sciences. 1129:287-304. M. Derouich, A. Boutayeb. The effect of physical exercise on the dynamics of glucose and insulin. 2002. Journal of Biomechanics 35 (2002) 911–917. Ethan M.Balk, Athina Tatsioni, Alice H. Lichtenstein, Joseph Lau, Anastassios G. Pittas. Effect of Chromium Supplementation on Glucose Metabolism and Lipids A systematic review of randomized controlled trials. 2004. Int. J.Vitamin. Nutr. Res. 74(3), 178-182. Image illustration from Toesters 健康的生活方式之选：: • 低升糖影响饮食 • 适当运动 • 高品质的睡眠 • 补充铬元素

173. What is Chromium? 铬是什么？ • Essential trace mineral • Promotes binding of insulin • Critical for sugar and fat metabolism Jim Mann, A. Steward Truswell. Essentials of Human Nutrition. 1998. Oxford University Press. Chp 10.06. pg 176. • 重要的微量矿物质 • 促进胰岛素的结合 • 对糖和脂肪的代谢起关键作用

174. Why Consider Chromium Supplementation? 为什么要考虑补充铬? • Normal dietary intake may be sub-optimal in humans • Chromium (Cr) in foods is not easily absorbed • Cr content is lost while processing (grains) • Cr levels decrease as we age, starting in our early 40’s • High amounts of sugar in the diet cause a loss of Cr in the body Z. Krejpcio.Essentiality of Chromium for Human Nutrition and Health. 2001. Polish journal of Environmental Studies. Vol.10, No.6, 399-404. U.S. Department of Health & Human Services: National Institutes of Health office of Dietary Supplements: Chromium Dietary Supplement Fact Sheet. • 人类的正常饮食或许并非是首选的最佳摄取途径 • 食物中的铬不易被吸收 • 加工（谷物）的过程会使铬含量受到损失 • 体内的铬水平会随着年龄增长（始于40岁早期）而逐渐下降 • 高糖饮食会导致体内铬损失

175. Chromium Ingredients 铬成分  Chromium Picolinate • Promotes efficient functioning of insulin  - Good insulin activity is critical for hunger control, supporting metabolism, building, retaining muscle and vital organ tissue  Chromium Arginate • Together with Cr Picolinate, it helps support cardiovascular health by helping to maintain normal insulin sensitivity • Supports insulin activity and metabolism of protein, fat, and carbohydrates Lukaski, Henry C. "Chromium as a supplement." Annual review of nutrition 19.1 (1999): 279-302.  吡啶甲酸铬 • 促进胰岛素的有效运作  -良好的胰岛素活性对于控制饥饿、支援代谢、建立并保持肌肉和重要器官组织非常重要  精氨酸铬 • 与吡啶甲酸铬协同作用，有助于维持胰岛素正常的敏感性，从而支援心血管健康 • 支援胰岛素活性，以及蛋白质、脂肪和碳水化合物的代谢

176. Isotonix® Isochrome Isotonix® 等渗铬配方 • Helps support healthy blood sugar levels • Helps with energy and stamina • Supports cardiovascular health • 有助支援健康的血糖值 • 补充体力，提升耐力 • 支援心血管健康

177. Chromium Supports healthy blood sugar levels. Supports metabolism of proteins, fats and carbohydrates. Coenzyme Q10 Helps to generate energy in the form of ATP. Isotonix® Isochrome – Ingredient Isotonix ® 等渗铬配方 — 成分 Magnus Bentinger, Kerstin Brismar, Gustav Dallner. The Antioxidant role of Coenzyme Q10. 2007. Mitochondrion 7S, S41-S50 William T. Cefalu, Frank B. Hu. RoleofChromiuminHumanHealthandinDiabetes.Diabetes Care.2004.27(11): 2741-2751.https://doi.org/10.2337/diacare.27.11.2741 铬支援健康的血糖水平。支援蛋白质、脂肪和碳水化合物的代谢。辅酵素Q10 有助于以三磷酸腺苷的形式产生能量。

178. L-Carnitine Supports fatty acid metabolism. Functions in the body cell for energy production. Lipase Supports the body's breakdown of dietary fats into an absorbable form. Francis B. Stephens, Dumitru Constantin‐Teodosiu, Paul L. Greenhaff. New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle. 2007. The Journal of Physiology. Lauralee Sherwood. Human Physiology from cells to system 3rd edition1997.West Publishing Company. Chp 16, 573. Isotonix® Isochrome – Ingredient Isotonix ® 等渗铬配方 — 成分左旋肉硷支援脂肪酸代谢。在身体细胞中有产生能量的作用。脂肪酵素支援身体将膳食脂肪分解成可吸收的形式。

179. Boron May play a role in supporting bone health. Vitamin B2 Supports energy production and breakdown of fats. Vitamin B6 Support protein metabolism. Aids in break down of glycogen to glucose for energy in muscle. Supports production of niacin and red blood cells. Helps support cardiovascular health. Lauralee Sherwood. Human Physiology from cells to system 3rd edition1997.West Publishing Company. Chp 16, 573. Isotonix® Isochrome – Ingredient Isotonix ® 等渗铬配方 — 成分硼对于维持骨骼健康至关重要。维生素B2 支援能量生产和脂肪分解。维生素B6 支援蛋白质代谢。帮助肌肉将糖原分解为葡萄糖以获取能量。支援烟碱酸及红细胞的产生。有助于支援心血管健康。

180. Frequently Asked Questions 常见问题 Why is sugar (fructose) present in Isotonix® Isochrome? Shouldn’t this product help to support blood sugar levels? Fructose is needed to ensure the isotonicity of the product. Fructose is the sweetest of all naturally-occurring sugars. It helps to make Isotonix Isochrome pleasant tasting with fewer calories. Consuming fructose does not produce the highs and lows in blood sugar levels that ordinary table sugar might. 为何Isotonix等渗铬配方显示其中含糖（果糖）？这个产品不是应该帮助支援血糖水平吗？果糖用来确保本产品的等渗透特性。果糖是所有天然糖类中最甜的一种，它所含热量极少，有助于Isotonix等渗铬配方的愉悦口感。食用果糖并不会如食用砂糖般使血糖水平上下波动。

181. Frequently Asked Questions 常见问题 When is the best time to take Isotonix® Isochrome? Isotonix Isochrome contains CoQ10, a fat soluble coenzyme, Isotonix Isochrome is best taken with a meal. 什么时候是食用Isotonix等渗铬配方的最佳时间？由于Isotonix等渗铬配方含有辅酵素Q10，这是一种脂溶性辅酵素，所以随餐食用可达最佳效果。

182. ACHIEVE A HEALTHIER BLOOD SUGAR LEVEL 达到更健康的血糖水平

183. BODY IMMUNE SYSTEM 身体免疫系统

184. BODY’S IMMUNE IS BODY’ DEFENCE MECHANISMS IMMUNE SYSTEM ENCOUNTERS THESE 当免疫系统遇到这些挑战 IMMUNE RESPONSES ARE TRIGGERED TO DESTROY THEM 就会被触发来摧毁它们 https://www.medicalnewstoday.com/articles/320721.php 身体的免疫系统是身体的防御机制

185. A Healthy Immune System can Counteract Sources of STRESS In Your Body Including Pathogens and Environmental Stressors That Make You Sick 健康的免疫系统可对抗您体内的压力來源包括那些让您生病的病原体及环境压力源 https://articles.mercola.com/sites/articles/archive/2018/02/01/boost-immune-system.aspx

186. LIFESTYLE & ENVIRONMENTAL TOXINS 生活模式及环境毒素 WHAT ARE WE EXPOSED TO 我们暴露在什么环境下 Photo: https://vaguiarpulido.wordpress.com/2016/04/06/the-exposome-connecting-environmental-factors-with-health/

187. ENVIRONMENTAL TOXINS 环境毒素 https://ensia.com/features/environment-diseases-immune-system/

188. STRESS UV FROM THE SUN DEHYDRATION SLEEP EXERCISING LIFESTYLE FACTORS 生活模式因素 https://ensia.com/features/environment-diseases-immune-system/ 睡眠压力脱水太阳紫外线运动肥胖

189. HOW THESE FACTORS IMPACT OUR IMMUNITY 这些因素如何影响我们的免疫力

190. LIFESAVER OR SABOTEUR https://www.webmd.com/cold-and-flu/immune-system-disorders#1 WHEN IT IS ON POINT WHEN IT GETS OVERWHELMED 救命恩人或破坏者当它在点上的时候当它被淹没时

191. COLD HANDS WHITE PATCHES DRY EYES FATIGUE MILD FEVER RASH JOINTS ACHE PATCHY HAIR LOSS RECURRENT INFECTIONS SUN SENSITIVITY UNEXPLAINED WEIGHT CHANGE PERSISTENT DIARRHEA YELLOWING SKIN/EYES WARNING SIGNS OF IMMUNE SYSTEM CHALLENGES 免疫系统受到挑战的警讯 https://www.webmd.com/cold-and-flu/immune-system-disorders#1 手冰冷白斑眼睛干涩疲劳轻微的发烧皮疹关节疼痛斑状脱发反复感染阳光过敏阳光过敏持续腹泻皮肤/眼睛泛黄

192. BRAIN 大脑 BODY IMMUNE SYSTEM 身体免疫系統 GUT 肠道 Prolonged Immune Response Brain health is challenged Pro-inflammation Challenged body immune Poor gut health Microbes, bacterial imbalance https://www.healthline.com/nutrition/gut-brain-connection GUT-BRAIN AXIS 肠－脑轴免疫反应延长大脑健康受到挑战促发炎身体免疫力受到挑战肠道健康欠佳微生物及细菌数量失衡

193. Type 1 Diabetes Rheumatoid Arthritis Systemic Lupus Erythematosus Inflammatory Bowel Disease Multiple sclerosis Psoriasis Graves’ Disease Hashimoto’s AUTOIMMUNE DISEASES 自身免疫疾病 https://www.webmd.com/a-to-z-guides/autoimmune-diseases 一型糖尿病类风湿性关节炎系统性红斑狼疮发炎性肠道疾病多发性硬化症牛皮癣甲状腺机能亢进桥本甲状腺炎

194. IMMUNE DFFENCE TRIGGERED 免疫防御被触发 OVERACTIVE IMMUNE 过度活跃的免疫系统 AUTOIMMUNE 自身免疫 FREE RADICALS 自由基 OXIDATIVE STRESS 氧化压力 CELL DAMAGE 细胞损伤 INFLAMMATION 炎症 PAIN SWELLING HEAT 疼痛肿胀发热 https://www.ncbi.nlm.nih.gov/pubmed/21506934

195. EXERCISING 运动 GOOD ? BAD ? https://livehealthy.chron.com/bad-effects-exercising-2902.html Potentially Of course 有益？有害？当然可能

196. EXERCISE elevates Aerobic metabolism & Increases Production of Free Radicals 运动可促进有氧代谢并增加产生自由基

197. OVER EXERCISING LEADS TO HIGHER CORTISOL LEVELS CORTISOL HAS IMMUNO SUPPRESSIVE EFFECTS 皮质醇具有免疫抑制运动过量导致皮质醇水平升高 IMMUNE SYSTEM PAYS THE PRICE 免疫系统为此付出代价 STRESS HORMONE ALWAYS HIGH Liver, muscles Work harder 压力荷尔蒙持续居高不下肝脏及肾脏更加辛苦 FIGHT OR FLIGHT Mode is always ON 战斗或逃跑模式总是打开的 https://www.telegraph.co.uk/health-fitness/body/much-exercise-bad-gut-dangers-training/

198. ANTIOXIDANTS 抗氧化物 CHEMICALS OR NUTRIENTS that scavenge and neutralise free radicals Donate electrons to STABILISE RADICALS Help PREVENT OXIDATIVE STRESS in the body 化学品或营养素可清除、中和自由基可提供电子稳定自由基帮助体内预防氧化压力

199. BENEFITS OF ANTIOXIDANTS 抗氧化物的益处 Supporting antioxidant Pathways may help: Support a healthy immune system Support cardiovascular health Support strong bones Promote mental clarity Maintain normal metabolic functioning Promote healthy growth and repair of tissues 支援性抗氧化途径可能有助于： 支援免疫系统健康 促进心血管健康 支援骨骼强健 促进头脑清晰 维持正常的代谢功 促进健康的生长与组织修护

200. Some of the most effective antioxidants include… Vitamin E Vitamin C Pycnogenol® and OPCs Coenzyme Q10 Astaxanthin Curcuminoids Endogenous Antioxidants - Minerals TYPES OF ANTIOXIDANTS 抗氧化物的类型一些最有效的抗氧化物包括… 维生素 E 维生素C 碧容健和原花色素(OPC) 辅酵素Q10 虾红素 类姜黄素 内源性抗氧化物 — 矿物质

201. OPCs in anti-ageing, blood sugar & Cardiovascular Disease 原花色素(OPC) 应用于抗衰老、血糖和心血管疾病 ARE ALL ANTIOXIDANTS THE SAME? 所有的抗氧化物功能都一样吗？ Antioxidants have specific application in certain disorders or diseases 抗氧化物在某些失调症或疾病中有其特定的应用： CoQ10 in Mitochondrial function 辅酵素Q10 应用于线粒体功能 Curcumin in brain function 姜黄素应用于大脑功能

202. Antioxidants work together and are synergistic Two or three antioxidants have a combined effect greater than the sum of the individual antioxidants 各种抗氧化物一起协效运作食用2种或3种抗氧化物，其联合功效明显大于各个氧化物加起来的总和 Antioxidants are best taken in combination 抗氧化物最好联合使用

203. NUTRITIONAL SUPPORT RECOMMENATIONS FOR IMMUNE SYSTEM 免疫系统营养支援推荐产品 Isotonix OPC3® Isotonix® Maximum ORAC Isotonix® Vitamin C Isotonix OPC3®（含碧容健） Isotonix®莓果配方 Isotonix® 维他命 C

204. Pycnogenol® Grape Seed Extract Red Wine Extract Bilberry Extract Citrus Bioflavonoids ISOTONIX OPC3® Ingredients 碧容健葡萄籽提取物红酒提取物越桔提取物柑橘生物类黄酮 ISOTONIX OPC3® 成分

205.  Powerful antioxidant  Promotes cardiovascular & joint health  Helps maintain healthy cholesterol and blood glucose levels  Supports blood vessel function  Supports a healthy complexion ISOTONIX OPC3® BENEFITS ISOTONIX OPC3 ® 好处  强效抗氧化物  促进心血管及关节健康  有助保持健康的胆固醇与血糖  支援血管功能  支援健康好气色

206. Isotonix® Maximum ORAC Isotonix®莓果配方 What is “Oxygen Radical Absorbance Capacity” A lab test to quantify the total antioxidant capacity of a food. A food sample is placed in a test tube, with certain molecules that generate free radical activity. Later, the sample is measured for it is protected from oxidation. The less free radical damage there is, the higher the antioxidant capacity of the test substance. A good ORAC supplement should contain at least 3,000 ORAC units per serving https://www.scientificamerican.com/article/what-are-orac-values/ 什么是“氧自由基吸收能力” 这是一项实验测试，以量化食物的总抗氧化能力。将食物样本置于试管内，其中某些分子会产生自由基活动。随后，测量样本的抗氧化能力。自由基受损越少，该受测物质的抗氧化能力就越高。一种良好的ORAC营养保健品每份应该至少包含3,000个ORAC单位

207. Isotonix® Maximum ORAC Ingredients Isotonix®莓果配方成分 Mixed Berry Extracts Vitamin C Vitamin E Blueberry Fruit Extract Cranberry Concentrate Grape Juice Powder Raspberry Fruit Powder Elderberry Extract Pomegranate Fruit Extract Black Currant Fruit Extract 混合莓果萃取物维生素C 维生素E 蓝莓萃取物蔓越莓浓缩物葡萄汁粉末覆盆莓粉接骨木莓萃取物石榴萃取物黑醋栗萃取物

208. Isotonix® Maximum ORAC BENEFITS Isotonix®莓果配方好处  High ORAC value  Provides antioxidant support  Contains various high ORAC berries and fruits  Isotonic-capable  高的ORAC值  提供抗氧化保护  富含各种高ORAC值的莓果和水果  以等渗透方式传输

209. Isotonix® Maximum ORAC Isotonix®莓果配方 A good ORAC supplement should contain high-ORAC value. The use of Vitamin C and E can contribute to an antioxidant network inside cells, which may offer more protection than using a single agent. 优良的ORAC营养保健品应含有较高的ORAC值。维生素C和E可有助于构件细胞内的抗氧化网络，这比仅使用单一抗氧化物更能提供较多的保护。

210. Isotonix® Vitamin C Ingredients Vitamin C Beta Carotene Potassium Isotonix®维他命 C 好处维生素 C Β-胡萝卜素钾

211. Isotonix® Vitamin C BENEFITS Isotonix®维他命 C 好处 Provides antioxidant protection Supports a healthy immune system Maintains skeletal, muscle, cardiovascular and skin health 提供抗氧化保护支援免疫系统健康维持骨骼、肌肉、心血管与肌肤的健康

212. BODY IMMUNE SYSTEM 身体免疫系统

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Peter Chen

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