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Goldenseal

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Goldenseal

  1. 1. Egyptian Russian University Faculty of pharmacy <ul><li>Research in: </li></ul>SUBTERRANEAN ORGANS OF PLANT GOLDENSEAL SUPERVISED BY … Dr.mohamed el-giNDI
  2. 2. GOLDENSEAL
  3. 3. <ul><li>Origin </li></ul><ul><li>Root & rhizomes of, Hydrastis canadensis </li></ul><ul><li>family Ranunculaceae </li></ul><ul><li>. </li></ul><ul><li>Kingdom: Plant </li></ul><ul><li>Class: Magnoliopsida </li></ul><ul><li>Division: Magnoliophyta </li></ul><ul><ul><li>Order: Ranunculales </li></ul></ul>
  4. 4. <ul><li>Shape </li></ul><ul><li>is a small perennial herb,with a horizontal, irregularly knotted, bright yellow root-stock from 6 to 12 inches high, erect, cylindrical, hairy, with downward-pointing hairs, especially above, surrounded at the base with a few short, brown scales., dark green, hairy leaves. </li></ul>
  5. 5. <ul><li>The flower </li></ul><ul><li>is solitary, terminal, erect, small, with three small greenish-white sepals, no petals and numerous stamens. </li></ul><ul><li>The fruit </li></ul><ul><li>is a head of small, fleshy, oblong, crimson berries, tipped with the persistent styles and containing one or two hard black, shining seeds. </li></ul><ul><li>Shape (continued) </li></ul>
  6. 6. Active constituent of golden seal <ul><li>The active constituents of goldenseal include hydrastine, berberine, berberastine, canadine, candaline, and hydrastinine. </li></ul><ul><li>Fatty acids, resin. </li></ul><ul><li>Polyphenolic acids, meconin, chlorogenic acid, phytosterins. </li></ul><ul><li>And contain small amounts of volatile oil. </li></ul>
  7. 7. <ul><li>Chemical test </li></ul><ul><li>Berberine </li></ul><ul><li>is a quaternary ammonium salt from </li></ul><ul><li>the group of isoquinoline alkaloids . </li></ul><ul><li>Berberine is strongly yellow colored and shows </li></ul><ul><li>a strong yellow fluorescence by reacting with H2O2 </li></ul><ul><li>berberine + 2 H2O2 (S)-tetrahydroberberine + 2 O2 </li></ul><ul><li>yellow fluorescence </li></ul><ul><li>Hydrastine </li></ul><ul><li>is a natural alkaloids which </li></ul><ul><li>by hydrolysis give Hydrastinine. </li></ul><ul><li>mayer ’s reagent </li></ul>Berberine Hydrastine
  8. 8. Uses of goldenseal <ul><li>Goldenseal was used for treatment of cancers and swellings of the breasts. </li></ul><ul><li>G oldenseal have been used for various health conditions such as skin diseases, ulcers, and gonorrhea. </li></ul><ul><li>Now, goldenseal is used for colds and other respiratory tract infections, eye infections, and (inflammation or infection of the vagina. </li></ul><ul><li>It is also applied to wounds and canker sores, and is used as a mouthwash for sore gums, mouth, and throat. </li></ul><ul><li>goldenseal i s being useful for functional disorders of the stomach, catarrhal gastritis, atonic dyspepsia, chronic constipation, hepatic congestion. </li></ul>
  9. 9. <ul><li>Uses (continued) </li></ul><ul><li>Goldenseal tea </li></ul><ul><li>Goldenseal Tea may be helpful in relieving intestinal infections. </li></ul><ul><li>Goldenseal Tea may be helpful in overall fight against diabetes. </li></ul><ul><li>Goldenseal Tea may help in relief of yeast infections. </li></ul><ul><li>Goldenseal Tea may helpful in treating liver problems in alcoholics. </li></ul><ul><li>Goldenseal Tea may also be helpful in digesting fat. </li></ul>
  10. 10. <ul><li>Side Effects and Safety </li></ul><ul><li>berberine, cause uterine contractions and increase levels of bilirubin. Those with heart conditions should only use goldenseal under the supervision of a health professional. </li></ul><ul><li>The safety of goldenseal in children,and people with kidney and liver disease is unknown. </li></ul><ul><li>It may cause irritation of the mouth and throat, nausea, increased nervousness, and digestive problems. </li></ul><ul><li>. Taking goldenseal over a long period of time can reduce absorption of B vitamins. </li></ul>
  11. 11. <ul><li>Contra-indication </li></ul><ul><li>Golden seal not be administrated to children under two years of age . </li></ul><ul><li>Avoid goldenseal during pregnancy . </li></ul><ul><li>Avoid with gastrointestinal inflammation, and with proinflammatory disorders. </li></ul><ul><li>Golden seal is contra-indicated in hypertension as large amount of hydrastine lead to restrict preferal blood vessel </li></ul><ul><li>It dose not used to treat purulent ear discharge as it may cause rupture in eardrum. </li></ul><ul><li>. </li></ul><ul><li>. </li></ul>
  12. 12. Some drugs which contain Goldenseal
  13. 13. THANK YOU
  14. 15. <ul><li>Made By... </li></ul><ul><li>Ahmed Hussien Abd Elwahed…(18) </li></ul><ul><li>Mohamed Ashraf Abd Elrahman …(151) </li></ul><ul><li>Nourhan Mahmoud Hassanen…(195) </li></ul><ul><li>Mayada Essam Eldien Mohamed …(137) </li></ul><ul><li>Omnia Ahmed Abd Elmeged…(204) </li></ul><ul><li>Heba Abd Elmeged Ahmed…(191) </li></ul><ul><li>Reham Abd Elwahab Khamis…(219) </li></ul><ul><li>Hanaa Samir Mashaly…(87) </li></ul><ul><li>Hebatoallah Ahmed Ahmed …(95) </li></ul><ul><li>Diana samy Aziz…(59) </li></ul>

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