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Non-invasive glucometer based on NMR spectrometer
1/11 people ill with diabetes
On the materials International Diabetes Federation (IDF)
Diabetes in the world
420 million patients with diabetes
mellitus in the world
- 415 million in 2015
- 642 million by 2040
The number of children with type 1
diabetes exceeded 500,000
Control of blood sugar for diabetics
is a daily, repeated and extremely
Every day people with diabetes are forced to
use a glucometer - a device for monitoring
blood glucose level.
Almost all types of modern glucometers require
human skin puncture.
Creating a non-invasive glucose
monitor that works on the wrist
and makes measurements every
The operation of the device is
based on the phenomenon of
nuclear magnetic resonance
Nuclear magnetic resonance (NMR)
NMR spectroscopy - analytical method for studying chemical which uses the
phenomenon of nuclear magnetic resonance (NMR)
NMR spectrometer provides data on
the molecular structure of chemical
These features make NMR
spectroscopy a convenient tool for
analyzing the composition of human
Why the NMR?
The NMR measurement method
makes it possible to determine all
organic substances, both qualitatively
At the moment, NMR is the best
method of chemical and biological
How does it work
NMR is a very sensitive magnetic
field meter for organic molecules that
make up the blood plasma.
And technically, NMR is a magnetic
system and a low-power transceiver.
Surface NMR bio-sensor
MIRENOR ● Used Halbach array of permanent magnets
as a way to obtain a powerful and
homogeneous magnetic field
● The impulse method allows you to get results
in a few seconds after the measurement
● The method of markers allows you to make
measurements of glucose in the blood
relative to a constant container with a known
● A marker of maleic acid or a marker of
tetramethylsilane (TMS) allows to eliminate
measurement errors at the hardware level
Progress of work 2014-2017 years
By working out possible methods of performing TK, three
methods of analysis were tested:
● Method for determining the optical angles of the
polarization of glucose in a pulsed magnetic field
(the Faraday effect was used)
● Nuclear magnetic resonance.
The NMR method showed the best results and, despite a
lot of technical problems, was chosen as the main one.
Further, all the work was done only in the direction of
Despite technical difficulties, we consider the
development of NMR as a non-invasive
glucometer an achievable task.
This device will make the life of people with
diabetes more comfortable.
We are ready to make every effort to achieve