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Department of Epidemiology and Public
                      Health




Predictors of overestimation of recalled
mobile phone use among children and
adolescents
Denis Aydin, Maria Feychting, Joachim Schüz, Lars Klæboe, and
Martin Röösli
Introduction
• Increase of mobile phone ownership and
  use among children and adolescents in the
  last 10 years.
• Worries about adverse health effects.
• Until recently: most studies among adults.
• Brain tumours, sleep disturbances,
  behavioural problems, problematic use of
  mobile phones etc.
Example

   Cross-sectional associations
                                 Sleep disturbances   Symptoms of depression
                                 PR    95%-CI         PR    95%-CI
   Mobile phone use
   Men      Low                  1.0                  1.0
            Medium               1.1      0.87-1.47   1.1   0.90-1.43
            High                 1.7      1.40-2.19   1.3   1.02-1.58
   Women Low                     1.0                  1.0
            Medium               1.1      0.98-1.31   1.1   0.98-1.26
            High                 1.4      1.21-1.56   1.2   1.06-1.34




   Thomée et al. BMC Public Health 2011, 11:66
Introduction
• Studies mainly rely on self-reported
  mobile phone use.
• Accuracy of recall among adults is poor
  overall.
Recall accuracy of adults




Vrijheid et al. Occup Environ Med 2006, 63.
Exposure misclassification



        Regular users



        Nonregular users
How bad is it?

          Case Control              Case Control
Regular                  Regular    300   600
           300   600                300   600
user                     user       280 560
Nonregular               Nonregular 200   400
           200   400                200   400
user                     user       220 440


     300  400          280  440
OR             1 OR            1
     600  200          560  220
                 20% random
                 misclassification
How bad is it?

          Case Control                Case Control
Regular                    Regular    375   600
           375   600
user                       user       325 560
Nonregular                 Nonregular 125   400
           125   400
user                       user       175 440



     375  400                325  440
OR            2        OR             1.46
     600 125                 560  175
                 20% random
                 misclassification
How bad is it?

          Case Control               Case Control
Regular                   Regular    300   600
           300   600
user                      user       340
Nonregular                Nonregular 200   400
           200   400
user                      user       160



     300  400           340  400
OR            1   OR             1.42
     600  20020% differential160
                         600
                 misclassification
Potential problems
• Inaccurately reported mobile phone use
  could lead to exposure misclassification.
• Random: usually bias towards 1.
• Differential: either direction possible.
• Bias if estimation of mobile phone use is
  associated with health status (or specific
  health-related characteristics) of study
  participants.
CEFALO
                    Multinational case-
                    control study about
                    mobile phone use and
                    brain tumour risk
                    among children and
Source: Photocase   adolescents aged 7–19
                    years.
CEFALO
• Study period: 2004–2008
• Detailed questionnaire about mobile phone
  use.
• Consent to get network operator data
• Operator data:
  • Sweden & Denmark (59/39% cases, 91/33%
  controls)
  • Number of calls, duration of calls, subscription
  start and end dates.
Methods
• Ratio = recalled/operator-recorded
• Ratio > 1: Overestimation
• Ratio < 1: Underestimation
• Research question:
  • Predictors of overestimation (i.e. ratio ≥ 1.5,
  logistic regression)
Recall accuracy of children
                                                                                                                         100000
                             10000


                                                                                                                         10000
                              1000




                                                                                     Duration of calls recalled (Min.)
  Number of calls recalled




                                                                                                                           1000
                               100
                                                                                                                            100

                               10
                                                                                                                             10


                                 1
                                                                                                                              1
                                      Median ratio cases = 1.09                                                                    Median ratio cases = 1.52
                                      Median ratio controls = 1.34                                                                 Median ratio controls = 2.63
                               0.1                                                                                          0.1
                                     0.1   1       10        100      1000   10000                                                0.1    1      10       100    1000 10000
                                               Number of calls operator                                                                 Duration of calls operator (Min.)

Aydin et al. Bioelectromagnetics. 2011. doi: 10.1002/bem.20651
Predictors of overestimation
  Variable                                            Number of calls                   Duration of calls
                                              Overest. Other                    Overest. Other
                                                No.     No.  aOR(95%-CI)          No.     No.    aOR (95%-CI)
  Country
  Denmark                                          13   36                1.0        31    18                 1.0
  Sweden                                           41   44   1.77 (0.71-4.40)        46    39    0.47 (0.18-1.21)
  Health status
  Case                                             17   31                1.0        24    24                 1.0
  Control                                          37   49   1.16 (0.52-2.57)        53    33    1.83 (0.83-4.06)
  Age group
  7-14                                             24   46                1.0        33    36                 1.0
  15-19                                            30   34   2.34 (1.03-5.32)        44    21    3.13 (1.36-7.18)
  Gender
  Male                                             22   37                1.0        28    30                 1.0
  Female                                           32   43   1.09 (0.50-2.38)        49    27    2.67 (1.18-6.01)
  SES of parents
  Low                                              14   12                1.0        15    10                 1.0
  Intermediate                                     43   23   0.92 (0.32-2.65)        39    27    0.73 (0.24-2.19)
  High                                             23   19   1.16 (0.38-3.50)        23    20    0.68 (0.22-2.14)
  Time between reference and interview date
  < 1.5 years                                      52   36                1.0        44    44                 1.0
  ≥ 1.5 years                                      28   18   0.77 (0.31-1.86)        33    13    1.62 (0.66-3.96)
  Amount of phone use (operator recorded)
  Low                                              26   16                1.0        30    12                 1.0
  Medium                                           15   30   0.31 (0.12-0.79)        25    20    0.54 (0.20-1.44)
  High                                             13   34   0.21 (0.08-0.56)        22    25    0.27 (0.10-0.78)
Strengths & Limitations
+ First study that used objective operator
  data.
− Only operator data from Denmark and
  Sweden, no data from Switzerland and
  Norway.
− Transferability to other countries?
− Amount of use representative nowadays?
Summary
• Children and adolescents rather
  overestimate cumulative number and
  duration of calls.
• Age, possibly gender and actual amount of
  mobile phone use are predictors of
  overestimation.
Conclusions
• No association between health status and
  risk of overestimation but health-relevant
  factors.
• Don‘t: Use only self-reported mobile
  phone use.
• Do: Use objective exposure data.
• Self-reported use only in prospective
  studies, adjustment needed to prevent
  confounding.
Acknowledgements
• Tore Tynes             • Michaela Prochazka
• Tina Veje Andersen     • Birgitta Lannering
• Lisbeth Samsø Schmidt • Tone Eggen
• Aslak Harbo Poulsen    • Daniela Jenni
• Christoffer Johansen   • Michael Grotzer
• Claudia E. Kuehni      • Nicolas Von der Weid
Thank you.

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Aydin

  • 1. Department of Epidemiology and Public Health Predictors of overestimation of recalled mobile phone use among children and adolescents Denis Aydin, Maria Feychting, Joachim Schüz, Lars Klæboe, and Martin Röösli
  • 2. Introduction • Increase of mobile phone ownership and use among children and adolescents in the last 10 years. • Worries about adverse health effects. • Until recently: most studies among adults. • Brain tumours, sleep disturbances, behavioural problems, problematic use of mobile phones etc.
  • 3. Example Cross-sectional associations Sleep disturbances Symptoms of depression PR 95%-CI PR 95%-CI Mobile phone use Men Low 1.0 1.0 Medium 1.1 0.87-1.47 1.1 0.90-1.43 High 1.7 1.40-2.19 1.3 1.02-1.58 Women Low 1.0 1.0 Medium 1.1 0.98-1.31 1.1 0.98-1.26 High 1.4 1.21-1.56 1.2 1.06-1.34 Thomée et al. BMC Public Health 2011, 11:66
  • 4. Introduction • Studies mainly rely on self-reported mobile phone use. • Accuracy of recall among adults is poor overall.
  • 5. Recall accuracy of adults Vrijheid et al. Occup Environ Med 2006, 63.
  • 6. Exposure misclassification Regular users Nonregular users
  • 7. How bad is it? Case Control Case Control Regular Regular 300 600 300 600 300 600 user user 280 560 Nonregular Nonregular 200 400 200 400 200 400 user user 220 440 300  400 280  440 OR   1 OR  1 600  200 560  220 20% random misclassification
  • 8. How bad is it? Case Control Case Control Regular Regular 375 600 375 600 user user 325 560 Nonregular Nonregular 125 400 125 400 user user 175 440 375  400 325  440 OR  2 OR   1.46 600 125 560  175 20% random misclassification
  • 9. How bad is it? Case Control Case Control Regular Regular 300 600 300 600 user user 340 Nonregular Nonregular 200 400 200 400 user user 160 300  400 340  400 OR  1 OR   1.42 600  20020% differential160 600 misclassification
  • 10. Potential problems • Inaccurately reported mobile phone use could lead to exposure misclassification. • Random: usually bias towards 1. • Differential: either direction possible. • Bias if estimation of mobile phone use is associated with health status (or specific health-related characteristics) of study participants.
  • 11. CEFALO Multinational case- control study about mobile phone use and brain tumour risk among children and Source: Photocase adolescents aged 7–19 years.
  • 12. CEFALO • Study period: 2004–2008 • Detailed questionnaire about mobile phone use. • Consent to get network operator data • Operator data: • Sweden & Denmark (59/39% cases, 91/33% controls) • Number of calls, duration of calls, subscription start and end dates.
  • 13. Methods • Ratio = recalled/operator-recorded • Ratio > 1: Overestimation • Ratio < 1: Underestimation • Research question: • Predictors of overestimation (i.e. ratio ≥ 1.5, logistic regression)
  • 14. Recall accuracy of children 100000 10000 10000 1000 Duration of calls recalled (Min.) Number of calls recalled 1000 100 100 10 10 1 1 Median ratio cases = 1.09 Median ratio cases = 1.52 Median ratio controls = 1.34 Median ratio controls = 2.63 0.1 0.1 0.1 1 10 100 1000 10000 0.1 1 10 100 1000 10000 Number of calls operator Duration of calls operator (Min.) Aydin et al. Bioelectromagnetics. 2011. doi: 10.1002/bem.20651
  • 15. Predictors of overestimation Variable Number of calls Duration of calls Overest. Other Overest. Other No. No. aOR(95%-CI) No. No. aOR (95%-CI) Country Denmark 13 36 1.0 31 18 1.0 Sweden 41 44 1.77 (0.71-4.40) 46 39 0.47 (0.18-1.21) Health status Case 17 31 1.0 24 24 1.0 Control 37 49 1.16 (0.52-2.57) 53 33 1.83 (0.83-4.06) Age group 7-14 24 46 1.0 33 36 1.0 15-19 30 34 2.34 (1.03-5.32) 44 21 3.13 (1.36-7.18) Gender Male 22 37 1.0 28 30 1.0 Female 32 43 1.09 (0.50-2.38) 49 27 2.67 (1.18-6.01) SES of parents Low 14 12 1.0 15 10 1.0 Intermediate 43 23 0.92 (0.32-2.65) 39 27 0.73 (0.24-2.19) High 23 19 1.16 (0.38-3.50) 23 20 0.68 (0.22-2.14) Time between reference and interview date < 1.5 years 52 36 1.0 44 44 1.0 ≥ 1.5 years 28 18 0.77 (0.31-1.86) 33 13 1.62 (0.66-3.96) Amount of phone use (operator recorded) Low 26 16 1.0 30 12 1.0 Medium 15 30 0.31 (0.12-0.79) 25 20 0.54 (0.20-1.44) High 13 34 0.21 (0.08-0.56) 22 25 0.27 (0.10-0.78)
  • 16. Strengths & Limitations + First study that used objective operator data. − Only operator data from Denmark and Sweden, no data from Switzerland and Norway. − Transferability to other countries? − Amount of use representative nowadays?
  • 17. Summary • Children and adolescents rather overestimate cumulative number and duration of calls. • Age, possibly gender and actual amount of mobile phone use are predictors of overestimation.
  • 18. Conclusions • No association between health status and risk of overestimation but health-relevant factors. • Don‘t: Use only self-reported mobile phone use. • Do: Use objective exposure data. • Self-reported use only in prospective studies, adjustment needed to prevent confounding.
  • 19. Acknowledgements • Tore Tynes • Michaela Prochazka • Tina Veje Andersen • Birgitta Lannering • Lisbeth Samsø Schmidt • Tone Eggen • Aslak Harbo Poulsen • Daniela Jenni • Christoffer Johansen • Michael Grotzer • Claudia E. Kuehni • Nicolas Von der Weid