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CBD VS CBDA AND CBGA
CBD vs CBDa and CBGa - What's the
Difference?
How is CBDa and CBGa different from CBD and why do you need to take some?
Posted by:
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CBD vs CBDA and CBGA: You've probably heard about CBD. But what about CBDA and CBGA? What are
CBDA and CBGA? Do CBDA and CBGA offer any therapeutic benefits? The blog provides the answers to the
questions mentioned above.
Check out the latest CBGA CBDA supplements (https://thoughtcloud.net/product-category/cbga-cbda/)now
available at ThoughtCloud, a reputed CBD Company.
CBD vs CBDA And CBGA: What’s The Difference
Let’s discuss the differences between CBD, CBGA, and CBDA.
What Is CBD?
CBD derived from hemp is a kind of cannabis plant with very low THC content, thus it does not make you
high. The Food and Medication Administration (FDA) (https://www.fda.gov/news-events/congressional-
testimony/hemp-production-and-2018-farm-bill-07252019)authorized CBD as a drug in 2018 under the
brand name "Epidiolex" for the treatment of seizures in children with severe types of epilepsy. Apart from
that, CBD is apparently used by many individuals all over the world for a variety of conditions such as
anxiety (https://thoughtcloud.net/product-category/benefits/stress-anxiety/), pain alleviation, sleep
(https://thoughtcloud.net/product-category/benefits/sleep/), and overall wellbeing.

5/1/22, 7:26 AM CBD vs CBDa and CBGa - What's the Difference?
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How Does CBD Work?
CBD is a phytocannabinoid found in cannabis and hemp plants. CBD extracted from hemp is now the only
cannabinoid that is widely available in the United States. CBD, unlike other cannabinoids, does not bind to
endocannabinoid receptors.
It works with the human body in the most basic way by inhibiting the breakdown of our own
endocannabinoids, allowing our systems to utilize more of what it already produces naturally.
CBD oil contains phytocannabinoids, which interact with the endocannabinoid system in a variety of ways.
CBD has a low affinity for both CB1 and CB2 receptors. It serves to block
(https://www.sciencedirect.com/science/article/abs/pii/S1054358917300273) CB1 receptors when paired
with a low dosage of THC. As a result, CBD does not have intoxicating properties and will not get you high.
Furthermore, CBD interacts with the TRPV1 receptor, which is implicated in endocannabinoid system
signaling. Activating this receptor influences a variety of physiological processes depending on the stimuli.
It binds to cannabinoid receptors in the brain and body, causing inflammation and discomfort to be
reduced. This makes it ideal for arthritis, injuries, and other aches and pains. CBD is also popular for mood
enhancement, anxiety and depression reduction, and getting a good night's sleep.

5/1/22, 7:26 AM CBD vs CBDa and CBGa - What's the Difference?
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What Is CBDA?
CBDA (Cannabidiolic acid) acidic precursor of CBD is found in cannabis plants' stalks, stems, leaves, seeds,
and flowers. CBDA is the raw form of CBD that was previously thought to be pharmacologically inactive. It is
one of the most abundant cannabinoids found in hemp seed oil; nevertheless, it is particularly sensitive to
heat, light, and oxygen. Hence, it is advised to store it in opaque, sealed containers at room temperature.
(https://thoughtcloud.net/product/cbga-cbda-oil/)
CBDA is converted into CBD by a process known as decarboxylation, which involves the elimination of
carbon, oxygen, and hydrogen atoms. When CBDA is decarboxylated, the chemical structure and
pharmacological characteristics of CBDA are somewhat altered.
Health Benefits Of CBDA
CBDA, like its derivative CBD, has the capacity to inhibit inflammation on several levels, resulting in a
powerful overall anti-inflammatory impact. Compounds with broad anti-inflammatory action are frequently
useful for treating inflammation, which may be at the root of a range of chronic health disorders.
CBDA also reduces inflammation by blocking pro-inflammatory enzymes (COX-2) and instructing
immune cells to reduce inflammation via TRP family receptors
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321064/). As COX-2 is a driver of inflammation-
related illnesses such as breast cancer, decreasing excessive COX-2 activity might be beneficial.
Another compelling reason to combine the two is that CBDA may boost the effects of other 5HT1A
(serotonin receptor) (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596650/) activators such as
CBD. This might help with anxiety, sadness, and other problems connected to serotonin function, such
as nausea and vomiting.
CBGA, an acidic derivative of CBG is a non-intoxicating cannabinoid. The application of heat leads to the
conversion of CBGA into CBG.
How Does CBGA Work?

5/1/22, 7:26 AM CBD vs CBDa and CBGa - What's the Difference?
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It works as an antagonist, which may inhibit the occurrence of such a reaction. CBGA, like CBG, interacts
with endocannabinoid receptors to activate their response. It is vital to note that these receptors play an
active role in regulating behaviors such as mood, hunger, and pain response. The endocannabinoid system
can really cause diverse responses depending on the cannabinoids, or endocannabinoids, that we eat.
CBGA is the first step in the cascade reaction that results in the three primary cannabinoid lines:
THCA (tetrahydrocannabinolic acid)
CBDA (cannabidiolic acid)
CBCA (cannabichromenic acid)
These are eventually converted into THC, CBD, or CBC, respectively. CBGA may potentially convert to CBG,
however in most strains, CBGA is converted to either THC or CBD.
Health Benefits of CBGA
CBGA and CBDA both being non-psychoactive in nature offers the same therapeutic properties. Check out
the therapeutic properties of CBGA discussed below:
Inflammatory Bowel Disease (IBD)
According to 2013 research (https://www.ncbi.nlm.nih.gov/pubmed/23415610), CBGA helps in alleviating
the symptoms of IBD. CBGA was shown to inhibit the formation of nitric oxide and oxidizing agents in the
small intestine. As per the findings of the research, CBGA also helps in mitigating the severity of colitis in
rats that were induced with it.
Metabolic Disorders
A 2019 silico research (https://www.sciencedirect.com/science/article/abs/pii/S0304416519300029?
via%3Dihub) found that CBGA stimulated Peroxisome Proliferator-Activated Receptors (PPARs), boosting
lipid metabolism and minimizing excessive buildup. This research still requires animal and human testing.
Cardiovascular Disease
CBGA inhibits the enzyme aldose reductase, which is the major contributor to oxidative stress that leads to
diabetes problems, according to in vitro research (https://www.ncbi.nlm.nih.gov/pubmed/29427593).
CBDA and CBGA Prevents Coronavirus from Entering Human
Cells
According to a study published in Oregon State University, both CBDA and CBGA prevent the entry of
coronavirus into human cells. This research was led by Richard Van Breeman.

5/1/22, 7:26 AM CBD vs CBDa and CBGa - What's the Difference?
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According to research on cannabis for COVID (https://thoughtcloud.net/cannabis-for-covid/), it was found
that the hemp components [CBGA and CBDA] were equally effective against strains of SARS-CoV-2,
including version B.1.1.7, which was first found in the United Kingdom, and variant B.1.351, which was first
detected in South Africa," Van Breeman said.
Final Thoughts
CBD being the talk of the town is present everywhere. CBDA, CBGA, and other cannabinoids are already
making their way onto the health supplement market.
MORE ON CBDa and CBGa, READ THESE..
(https://cannabis.net/blog/medical/cbda-a-cannabinoid-
acid-with-therapeutic-promise)
A DEEP DIVE INTO CBDa AND HOW IT WORKS IN THE BODY. (https://cannabis.net/blog/medical/cbda-a-
cannabinoid-acid-with-therapeutic-promise)
OR..
(https://cannabis.net/blog/medical/exploring-cbga-the-
mother-of-all-phyto-cannabinoids)

5/1/22, 7:26 AM CBD vs CBDa and CBGa - What's the Difference?
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IS CBGa THE MOTHER OF ALL CANNABINIOIDS? READ THIS!
(https://cannabis.net/blog/medical/exploring-cbga-the-mother-of-all-phyto-cannabinoids)
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(https://cannabis.net/blog/medical/cbddominant-extracts-improve-autism-symptoms-in-children-say-new-medical-studies)
MEDICAL
CBD-Dominant Extracts Improve Autism Symptoms in Children Say New Medical Studies
Specifically, they found that 30% of patients saw significant improvement after 6 months of treatment, 53.7% saw moderate beneficial changes,
while 15% had a slight or no change. Additionally, the study examined the benefits of cannabis on the quality of life of the participants. The
researchers looked at mood, quality of life, and their ability to do activities pertaining to daily living before treatment as well as after 6 months.…

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(https://cannabis.net/blog/opinion/ripped-in-half-a-cannabis-growers-nightmare)
OPINION
Ripped in Half - A Cannabis Grower's Nightmare!
What was on top of the shelf however, nose-dived to the floor and hit the grate that I had in front of the plants to protect them from my
cannabis-leaf-munching cats (and dog). That grate – was attached to the stems that was pulling half of the cannabis plant to one side a-la-LTS.
With the force of the “shit on top of the shelf” – the grate was sent hurling forward and with it…RIPPED MY PLANTS IN HALF!

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(https://cannabis.net/blog/b2b/cannabis-packaging-trends-for-new-future-normal)
B2B
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Since the increasing legalization of cannabis, there has been a need for a regulation in terms of packaging as cannabis packaging all over the
United States has to meet some minimum requirements such as the Child Resistant Packaging that came into effect by Jan 1st, 2020. Though
individual states have their requirements, cannabis companies still have to meet up with the one set up by the Consumer Product Safety…
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