Chromatography Technologies plays vital role in various industrial application sectors, this techniques as been used across various chemical and pharmaceutical industries. This technique is used to purify sugar from molasses, separation of enantiomers and purification of pharmaceutical proteins, pharmaceutical industry for the purification of enantiomers from racemic mixtures. Its applications were also used in food chemistry, biochemistry, petro chemistry, pharmaceutical chemistry. Also plays important roles in Purification of proteins, pharmaceuticals, fine chemicals
Ultraviolet-visible (UV-Vis) spectrophotometry is a technique used to measure light absorbance across the ultraviolet and visible ranges of the electromagnetic spectrum. When incident light strikes matter it can either be absorbed, reflected, or transmitted. The absorbance of radiation in the UV-Vis range causes atomic excitation, which refers to the transition of molecules from a low-energy ground state to an excited state.
Optimum performance laminar chromatography (OPLC) is a pumped flow chromatography techniques that combine the user – friendly interface of HPLC with the capacity of flash chromatography and multidimensionally of TLC .
Optimum performance laminar chromatography (OPLC ) , in a contrast , is a pumped flow chromatography system that uses a planar 2D column format .
The multidimensionally capacity of OPLC is not limited to the separation technique alone , but also to the multitude of sample application and detection methods that are available .
Content include basic introduction to chromatography. Brief view of Liquid Chromatography. HPLC introduction, other names, types of HPLC, detailed instrumentation with image of each part, and applications. Sources of content described in 'References' entitled slide. This presentation was prepared for the partial fulfillment of Master of Pharmacy.
Ultraviolet-visible (UV-Vis) spectrophotometry is a technique used to measure light absorbance across the ultraviolet and visible ranges of the electromagnetic spectrum. When incident light strikes matter it can either be absorbed, reflected, or transmitted. The absorbance of radiation in the UV-Vis range causes atomic excitation, which refers to the transition of molecules from a low-energy ground state to an excited state.
Optimum performance laminar chromatography (OPLC) is a pumped flow chromatography techniques that combine the user – friendly interface of HPLC with the capacity of flash chromatography and multidimensionally of TLC .
Optimum performance laminar chromatography (OPLC ) , in a contrast , is a pumped flow chromatography system that uses a planar 2D column format .
The multidimensionally capacity of OPLC is not limited to the separation technique alone , but also to the multitude of sample application and detection methods that are available .
Content include basic introduction to chromatography. Brief view of Liquid Chromatography. HPLC introduction, other names, types of HPLC, detailed instrumentation with image of each part, and applications. Sources of content described in 'References' entitled slide. This presentation was prepared for the partial fulfillment of Master of Pharmacy.
Handling High Titer Processes and Strategies for DSP Facility Fit | KBI Biop...KBI Biopharma
Handling High Titer Processes and Strategies for DSP Facility Fit. Originally presented at BioProcess International 2018 by Christopher Miller, Senior Scientist, Downstream Process Development, KBI Biopharma.
High-Capacity Capture of a Recombinant Growth Factor Directly From Refold Sol...Merck Life Sciences
In this work, the authors evaluate a salt tolerant tentacle resin targeting the purification of biomolecules from feeds at high salt concentration:
• Reviews process challenges presented by recombinant growth factors which are commonly expressed in E. coli as inclusion bodies
• Demonstrates how a salt tolerant resin facilitates easy process development with straightforward binding and elution conditions
• Presents cost analysis that compares salt tolerant with conventional cation exchanger for the growth factor purification
To learn more about this topic or collaborate with our technical experts, schedule an in-person or remote visit at our M Lab™ Collaboration Centers: www.merckmillipore.com/mlab
This presentation provides an introduction to the M Lab™ Collaboration Centers, an overview of chromatography theory, and highlights the benefits of next-generation chromatography.
To learn more about this topic or collaborate with our technical experts, schedule an in-person or remote visit at our M Lab™ Collaboration Centers: www.emdmillipore.com/mlab
This presentation provides an introduction to the M Lab™ Collaboration Centers, an overview of chromatography theory, and highlights the benefits of next-generation chromatography.
To learn more about this topic or collaborate with our technical experts, schedule an in-person or remote visit at our M Lab™ Collaboration Centers: www.merckmillipore.com/mlab
A comparison of a novel robust decentralized control strategy and MPC for ind...ISA Interchange
Abstract: In this work we have developed a novel, robust practical control structure to regulate an industrial methanol distillation column. This proposed control scheme is based on a override control framework and can manage a non-key trace ethanol product impurity specification while maintaining high product recovery. For comparison purposes, an MPC with a discrete process model (based on step tests) was also developed and tested. The results from process disturbance testing shows that, both the MPC and the proposed controller were capable of maintaining both the trace level ethanol specification in the distillate (XD) and high product recovery (β). Closer analysis revealed that the MPC controller has a tighter XD control, while the proposed controller was tighter in β control. The tight XD control allowed the MPC to operate at a higher XD set point (closer to the 10 ppm AA grade methanol standard), allowing for savings in energy usage. Despite the energy savings of the MPC, the proposed control scheme has lower installation and running costs. An economic analysis revealed a multitude of other external economic and plant design factors, that should be considered when making a decision between the two controllers. In general, we found relatively high energy costs favor MPC.
High-Capacity Capture of a Recombinant Growth Factor Directly From Refold Sol...MilliporeSigma
In this work, the authors evaluate a salt tolerant tentacle resin targeting the purification of biomolecules from feeds at high salt concentration:
• Reviews process challenges presented by recombinant growth factors which are commonly expressed in E. coli as inclusion bodies
• Demonstrates how a salt tolerant resin facilitates easy process development with straightforward binding and elution conditions
• Presents cost analysis that compares salt tolerant with conventional cation exchanger for the growth factor purification
To learn more about this topic or collaborate with our technical experts, schedule an in-person or remote visit at our M Lab™ Collaboration Centers: www.emdmillipore.com/mlab
Briefly introduce what flash chromatography is and its purpose in scientific research.
Explain the key principles of flash chromatography, including the differences between normal phase and reverse phase chromatography.
Discuss the equipment required for flash chromatography and the different types of media that can be used.
Provide examples of when flash chromatography is commonly used in scientific research, such as in drug discovery or natural product isolation.
Discuss the advantages and limitations of flash chromatography compared to other chromatography techniques.
Highlight any novel or innovative applications of flash chromatography that you may have explored in your research.
Conclude with a summary of the key takeaways from your presentation, including any practical tips or advice for those looking to use flash chromatography in their own work.
Implementing a Fully Single-Use, Integrated mAb Biosimilars Purification Plat...MilliporeSigma
Access the interactive recording here: https://bit.ly/2DONZaQ
Webinar summary:
1000L-scale implementation of fully connected, disposable, advanced DSP platform for next generation mAb production.
Within the biopharmaceutical industry, there is a significant shift toward higher productivity processes resulting in improved economics without compromising robustness. Therefore, integrated continuous production technologies are of greatest interest.
Next Generation Biopharmaceutical Downstream Process is a European-funded collaborative project that aims at implementing a fully integrated manufacturing platform for biosimilar mAb based on continuous chromatography, in combination with single-use disposable technologies for all unit operations of DSP on pilot/small production scale together with incorporation of advanced analytical tools.
In this webinar, you will see:
* new DSP purification template producing > 3.3 kg of mAb in 2.5 days in less than 30m²
* proof of concept for the mAb manufacturing of tomorrow
Implementing a Fully Single-Use, Integrated mAb Biosimilars Purification Plat...Merck Life Sciences
Access the interactive recording here: https://bit.ly/2DONZaQ
Webinar summary:
1000L-scale implementation of fully connected, disposable, advanced DSP platform for next generation mAb production.
Within the biopharmaceutical industry, there is a significant shift toward higher productivity processes resulting in improved economics without compromising robustness. Therefore, integrated continuous production technologies are of greatest interest.
Next Generation Biopharmaceutical Downstream Process is a European-funded collaborative project that aims at implementing a fully integrated manufacturing platform for biosimilar mAb based on continuous chromatography, in combination with single-use disposable technologies for all unit operations of DSP on pilot/small production scale together with incorporation of advanced analytical tools.
In this webinar, you will see:
* new DSP purification template producing > 3.3 kg of mAb in 2.5 days in less than 30m²
* proof of concept for the mAb manufacturing of tomorrow
Sustainable Approach Of Recycling Palm Oil Mill Effluent Using Integrated Bio...SAJJAD KHUDHUR ABBAS
In Malaysia, oil palm is a very significant crop. In the worldwide, the biggest palm oil exporter and producer is Indonesia and Malaysia is the 2nd exporter and producer. the production of crude palm oil (CPO) was increased significantly from 92,000 tonnes in year 1960 to 17.6 million tonnes in year 2009, The process to extract the palm oil needs massive and huge water quantity to sterilize the fresh fruit bunches (FFB) and clarify the extracted oil.
Column chromatography in chemistry is a method used to purify individual chemical compounds from mixtures of compounds. It is often used for preparative applications on scales from micrograms up to kilograms. The main advantage of column chromatography is the relatively low cost and disposability of the stationary phase used in the process. The latter prevents cross-contamination and stationary phase degradation due to recycling
Similar to Industrial Applications Of Chromatography Technique (20)
Corrosion Technology Forum – A two-day conclave discusses about corrosion prevention opportunities in the four major industries across geographies. Discusses various issues related to corrosion control, mitigation and methodologies to assess the damage due to corrosion.
Get 15% off on subscription now!! Chemical today magazine is a book for chemistry or chemical industry professionals which covers all influential topics, exotic concept &, fantastic appearance has attracted tons of readers over the globe.
Since the beginning of history recorded, human beings have sought to mask or augment their own body odor by applying perfume, which imitates nature’s pleasant smells. Many natural and man-made materials have been utilized or extracted to make perfumes. No perfume smells
Distillation is a method that can be utilized to take out an unadulterated liquid from a combination of liquids. It works when the liquids have distinguished boiling points. Distillation is typically used to detach ethanol, which is the alcohol in alcoholic drinks - from water.
Few things about Acetic acid you must knowrita martin
Acetic acid which is also known as Ethanoic acid is a colorless organic acid with chemicals formula C2H4O2 is liquid with strong and distinctive pungent and sour smell. Acetic acid got its name from a word “Acetum”, which is a Latin word for vinegar.
Tin is the 49th most rich element in the earth’s crust, having 2 parts per million compared with 75 parts per million for zinc, 50 parts per million for copper, and 14 parts per million for lead.
Calcium carbonate or CaCO3 is one of chemical compound found in the rocks as a mineral calcite and aragonite mostly particularly as a limestone, chalk or a marble.
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4 vital things about zinc that you should knowrita martin
Zinc designated with the chemical symbol of Zn and an atomic number of 30. The number of electrons per shell is 2, 8, 18 and 2. The two valence electrons of zinc are in charge of shaping bonds with different atoms, which is determined by its electron affinity, electro-negativity and ionization energies.
Toluene Biodegration Using Jet Loop Reactorrita martin
Toluene aromatic hydrocarbon solvent is a solvent in paints, lacquers, thinners, glues, correction fluid, carbon nanotubes and nail polish remover used as an octane booster in gasoline fuels
AIDS stands for: Acquired Immunodeficiency Syndrome HIV stands for: Human immunodeficiency virus AIDS is a disease of the human immune system caused by the HIV
Why the statue of liberty is colored blue greenrita martin
Statue of Liberty is its own special colour because of its unique environmental conditions. It's not a simple single reaction between copper and oxygen to generate a green oxide, like you may think. The copper oxide continues to react to make copper carbonates, copper sulphide, and copper sulphate.
6 methods of preparation of caustic sodarita martin
Sodium hydroxide, also known as caustic soda or lye, is an inorganic compound with the chemical formula NaOH. It is a white solid, and is a highly caustic metallic base and alkali salt. It is available in pellets, flakes, granules, and as prepared solutions at a number of different concentrations.
A solvent can be any substance, that turns into a solution by dissolving a solid, liquid, or gaseous solute. The solvent is usually a liquid, but can also be a solid or gas.
Diethyl ether can be prepared both in laboratories and on an industrial scale by the process called acid ether synthesis.
Ethanol is mixed with a strong acid like sulfuric acid (H2SO4).This strong acid dissociates in the aqueous environment producing H3O+(hydronium ions).
Production of ethyl acetate by esterificationrita martin
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Basic Civil Engineering Notes of Chapter-6, Topic- Ecosystem, Biodiversity Green house effect & Hydrological cycle
Types of Ecosystem
(1) Natural Ecosystem
(2) Artificial Ecosystem
component of ecosystem
Biotic Components
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Embracing GenAI - A Strategic ImperativePeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
We all have good and bad thoughts from time to time and situation to situation. We are bombarded daily with spiraling thoughts(both negative and positive) creating all-consuming feel , making us difficult to manage with associated suffering. Good thoughts are like our Mob Signal (Positive thought) amidst noise(negative thought) in the atmosphere. Negative thoughts like noise outweigh positive thoughts. These thoughts often create unwanted confusion, trouble, stress and frustration in our mind as well as chaos in our physical world. Negative thoughts are also known as “distorted thinking”.
Palestine last event orientationfvgnh .pptxRaedMohamed3
An EFL lesson about the current events in Palestine. It is intended to be for intermediate students who wish to increase their listening skills through a short lesson in power point.
The Art Pastor's Guide to Sabbath | Steve ThomasonSteve Thomason
What is the purpose of the Sabbath Law in the Torah. It is interesting to compare how the context of the law shifts from Exodus to Deuteronomy. Who gets to rest, and why?
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This presentation provides a briefing on how to upload submissions and documents in Google Classroom. It was prepared as part of an orientation for new Sainik School in-service teacher trainees. As a training officer, my goal is to ensure that you are comfortable and proficient with this essential tool for managing assignments and fostering student engagement.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
2. Abstract
Chromatographic processes play an important role in the
production of bio-pharmaceuticals. Polypeptides, proteins,
enzymes and antibodies are captured, purified and polished by
ion exchange, size exclusion, reverse phase, hydrophobic
interaction or affinity chromatographic processes.
Their scales range from a few kilograms a year of very potent
compounds tolarge bulk productions of several tons. Only
recently research groups primarily from academics have started
to investigate continuous operating technologies such as
simulated moving bed chromatography (SMB) to increase
productivity of purification processes for bio-pharmaceuticals
which is based on counter-current moving bed chromatography.
This technology has been used in large scale operations in the
petrochemical and sugar industries for almost half a century.This
article will addresses the fundamentals of simulated moving bed
chromatography technology and its applications.
3. Introduction
In the last decade the concept of simulated moving bed (SMB)
chromatography has been successfully applied in several fields, e.g. for
the separation of enantiomers and purification of pharmaceutical
proteins. In order to further increase potential of SMB chromatography,
several increasingly sophisticated modes of operation have been
developed based on applying gradients and on dynamically varying
certain parameters during the separation.
Examples include new process variantsVariCol, PowerFeed and
ModiCon. Another alternative capable to enhance the process
performance is based on the introduction of an enrichment step
between zones I and II.
The process was developed in the 1960s for the purification of sugars
from molasses. It was used to pharmaceutical industry for the
purification of enantiomers from racemic mixtures. Its applications have
expanded beyond the sugar and racemic separations to more complex
separations.
4. Introduction Cont
SMB chromatography has received attention for chiral separations since early 1990s
and is today, considered as a cost-effective preparative scale purification technology
and common to tool for separating isomers at production scale, and several active
pharmaceutical ingredient (API) and intermediate producers. The design method was
verified with rate model simulations and then tested for enantioseparation of
phenylpropanolamine.
Both high purity (>99 per cent) and high yield (>99 per cent) were achieved
experimentally using an SMB with a pressure limit of 2.4 MPa. It enables substance
mixtures to be continuously separated and extracted in two fractions. By repeated
use of the SMB process each partial fraction can be separated into a further fraction-
up to binary substance mixtures.Typically, the SMB process is set up in advance for a
two component mixture. Following this, both substances can be immediately
extracted in pure form-up to 1000 kg per year.
It is a continuous multi-column chromatographic process has become one of the
preferred techniques for the separation of the enantiomers of a chiral compound.
Several active pharmaceutical ingredients, including blockbuster drugs, are
manufactured using the SMB technology. Compared to single column preparative
chromatography, SMB separations achieve higher productivity and purity, while
reducing the solvent consumption. In the last few years, rapid developments have
been made in the areas of design, improved process schemes, optimization and
6. General setup of the SMB
unit cont ..
imulated Moving Bed Chromatography is a continuous
purification technique that has higher throughput and
requires less solvent than regular batch chromatography. It
is used to separate particles and/or chemical compounds
that would be difficult separation problems in
petrochemical, fine chemical and pharmaceutical
industries.The SMB process employs a series connection of
several chromatographic columns.
It permits large amounts of mobile phase to be saved and
productivity increased, thus reducing production costs. Its
advantages such as reduction of solvent consumption, high
productivity and final purities as well as low investment
costs in comparison to eluent chromatography. Simulated
Moving Bed Chromatography units can operate under high
productivity overloaded conditions.
7. Principle and Method
1. Determine the phase volume ratio or porosity between
the stationary and mobile phase.
2. Determine the adsorption isotherms for each component
based on the overload chromatogram from each
component of the mixture.
3. Determine the isotherm parameters using the
isothermFit software.
4. Arrange the hardware.
5. Simulation of the process and optimization of the
interpretation using the SMB_Guide simulation software.
6. Carry out a continuous SMB separation.
7. Optimize the productivity.
9. Basic schematic diagram of
SMB Process
Simulated Moving Bed Chromatography is a chromatographic
technique based on a flow of liquid (mobile phase) moving
countercurrent to a constant flow of solid (stationary phase).
Countercurrent flow enhances the potential for the separation
and, hence, makes the process more efficient. It also allows a
continuous flow of feed material to be separated, which
improves the throughput of the equipment compared to
traditional batch chromatography.
Providing a constant flow of solid is impractical in a production
process.Therefore, the solid instead is packed into high pressure
columns.These columns are arranged in a ring formation made
up of four sections with one or more columns per section.Two
inlet streams (feed and eluent) and two outlets streams (extract
and raffinate) are directed in alternating order to and from the
column ring.The inlet and outlet position is switched at regular
time intervals in the direction of the liquid flow, thus simulating
countercurrent movement of columns.
10. Basic schematic diagram of
SMB Process
The flow rates in Sections II and III are
important because this is where the
separation occurs. Sections I and IV handle
cleaning. Mobile phase exiting Section IV is
directly recycled to section I.The solid is
regenerated there by desorbing the more
retained compound with a high flow rate so
the complete column can be moved into
section IV.
11. Advantages
The entire stationary phase is continuously covered
with the mixture to be separated which produces a
much higher productivity.
A 90 per cent reduction in the demand for solvent
due to solvent recycling
High plate counts or particle sizes are no longer
required, reducing packing material costs by 80 per
cent.
Extract and raffinate are extracted in high
concentration which makes it easier to remove
solvent.
The patented multi-function valve enables and
extremely small dead volume.
12. Applications
Simulated Moving Bed Chromatography is ideal for the
separation of
Enantiomers,
Diastereoismers,
Purification of proteins, pharmaceuticals, fine chemicals and
It can provide high purity and high recovery in a very short time.
Drugs like Prozac; Citalopram etc., can be purified.
Challenges
The major challenges of the SMB process principle are
Higher investment cost compared to single column operations
A higher complexity
As well as higher maintenance costs.
13. Conclusion
Since last 40 years, SMB chromatography has been used
successfully on a large scale in the petrochemical industry. More
recently, the high potential of SMB-approach has also been
recognized by the fine chemistry and pharmaceutical industries.
Applications in the biotechnology field are increasing, where an
SMB can be used for many different products and applications
such as: proteins, isomers, chiral compounds or in
desalting/polishing steps.
Previously designed for large scale production processes
(100,000 tonne/year), nowadays, SMB is also operated on a
comparatively small scale for production processes involving less
than 1 kg/run. Presently, some of the technology advancements
in chromatography, which are in the R&D phase, can help
improve performance of SMB. In the future, these technology
developments will overcome some of the challenges of the SMB
approach making it more efficient and effective, for various
industries
14. Reference
[1] Dr. Kathleen Mihlbachler, Ph.D., Eli Lilly and Company, Advances in
Large-Scale Biopharmaceutical Manufacturing and Scale-Up
Production, Available from -
http://www.bioplanassociates.com/asm/Abst21.html
[2]Yi Xie ,Yoon-Mo Koo,and Nien-Hwa LindaWang, Preparative
Chromatographic Separation: Simulated Moving Bed and Modified
Chromatography Methods, 2001, 6: 363-375, Available from -
http://www.bbe.or.kr/storage/journal/BBE/6_6/6726/articlefile/article.pd
f
[3]Arvind Rajendranb, Galatea Paredesa, Marco Mazzotti, Simulated
moving bed chromatography for the separation of enantiomers,Volume
1216, Issue 4, 23 January 2009, Pages 709-738, Available from
http://www.sciencedirect.com/science/article/pii/S0021967308018451
[4] Separations Analytical Instruments
bv website,http://www.separations.nl/docs/SMB%20Knauer%20SMB.pd
f