Optometry's Role in Laser Vision Correction

By The Right Contact Team
    http://www.therightcontact.com
   Although optometrists do not perform laser
    vision correction here in the United States, they
    can still provide a valuable role in this procedure
    that is gaining unprecedented popularity.
   According to recent data, a record 16 million
    people have had LASIK vision correction in the US
    though 20111.
   This is an amazing opportunity for optometry.
    Whether it is screening good candidates, co-
    managing post-ops or managing
    complications, there is a lot the optometric
    profession has to offer.
   LASIK
   Wavefront LASIK
   Intralase
   LASEK
   EPI-LASEK
   PRK
 Pre-Op
 Post-Op
 Complications
   There many issues that a practitioner should
    review when considering candidacy for laser
    vision correction.
   The following are a few concerns to be
    addressed prior to referring the patient for
    the procedure.
    ◦ Candidacy as defined by the FDA
    ◦ Anterior surface concerns
    ◦ Patient habits
Who is a good candidate for laser vision correction?
Since its FDA approval in 19952, many factors have remained
unchanged
   INDICATIONS
    *Age 18 years of age or older with stable refraction for one year.
    *Myopia (nearsightedness) up to -14 diopters either without astigmatism or from -0.5 to -5
    diopters of astigmatism
    *Hyperopia (farsightedness) from +1 to +4.5 diopters with less than 1 diopters of astigmatism
    *No history of eye disease, corneal scarring or retinal problems
    *Not pregnant or nursing for 3 months and not planning a pregnancy in the 3 months
    following surgery

   CONTRAINDICATIONS
    Laser refractive surgery is contraindicated:
    * in patients with collagen vascular, autoimmune or immunodeficiency diseases.
    * in pregnant or nursing women.
    * in patients with signs of keratoconus or abnormal corneal topography
    * in patients who are taking one or both of the following medications: isotretinoin (Accutane®)
    or amiodarone hydrochloride (Cordarone®).
Dry Eye
 Ideally you want to identify dry eye during the pre-op period
 Spend at least a few weeks to months treating it.
 Utilizing tools such as artificial tears, punctal plugs, cyclosporine
  eye drops and nutritional therapy (omega-3 fatty acids) 3 can
  prove very useful.

Blepharitis
 Laser vision correction causes significant inflammation in normal
  eyes. Consider the consequences surgery can have when
  handling patients that already suffer from anterior surface
  disease.
 Treatment options include
  ◦   oral tetracycline
  ◦   topical macrolide antibiotics
  ◦   combination steroid/antibiotic drops
  ◦   nutritional options (such as flaxseed oil).   4
   Does the patient work or live in environments
    of excessive heat?
   Does the patient suffer from allergies or
    habits that pre-dispose them to eye rubbing?


           Avoiding these issues can greatly
           affect the potential outcome of
           the procedure.
   Most surgeons recommend a very specific
    follow-up schedule to ensure proper healing.
   An average schedule would include
    ◦   1st day
    ◦   1st week
    ◦   1st month
    ◦   3 – 6 months
   Each post-op appointment has very specific
    concerns that are to be addressed.
   Each visit should take the opportunity to re-
    educate the patient on their status and the
    overall healing process.
   During this visit, the practitioner will access vision and make a
    corneal evaluation. The corneal evaluation will obviously vary
    depending on the procedure performed.
    ◦ If the patient has undergone LASIK, than flap evaluation will take place.
    ◦ If PRK or LASEK was performed, the corneal evaluation will be done under
      the bandage contact lens.

   Patient instruction is very specific at this visit.
    ◦ Remind the PRK and LASEK patients that discomfort within the first few
      days is common but will subside. After a discussion about all topical
      post-op medications, patient’s activities need to be discussed.

   Aggressive rubbing should be addressed.
    ◦ The patient should be discouraged from performing any tasks that could
      potentially hit the eye. Be specific, state avoiding things like water striking
      the eye during bathing, make-up (no mascara or eyeliner), sports, and
      exercise. The patient should wear a protective shield at night. Provided
      the vision is adequate, the patient is definitely able to resume deskwork or
      driving immediately.
   At this visit a re-assessment of vision and
    corneal integrity is taken.
   As compared to their first post-op, patients
    that underwent PRK and LASEK should note a
    dramatic increase in comfort and vision.
   Many times topical medications are
    discontinued at this visit.
   The patient is often informed that they can
    begin a moderate level of activities including
    exercise, swimming, hot tubs and contact
    sports.
   The 1 month post-op evaluation again
    evaluates the vision and corneal surface.
   At this stage the cornea should be completely
    attached and the patient is able to resume all
    activities.
    ◦ These activities would include those that were
      previously restricted such as gardening, scuba
      diving, etc.
   These visits are routine health evaluations.
   At this time, many doctors will have to
    manage issues associated with dryness.
   When discussing any type of surgery you
    always have to be aware of the risks
    associated with the procedure.
   Even though laser vision correction has a very
    good track record, sometimes there are
    unfortunate results that have to be
    addressed.
   The following is a listing of possible
    complications that can occur with laser vision
    correction.
   Doctors are trained not to be over concerned about
    initial signs of overcorrection.
    ◦ This is because immediate post-ops can show correction
      issues secondary to expected corneal swelling.
    ◦ The patient should be educated that these symptoms will
      subside within a few days to two weeks.

   Despite extensive pre-testing, sometimes the eyes do
    not respond in a predictable fashion. Regardless of
    the reason, the patient still has options.
    ◦ If the patient is interested in additional surgery, an
      enhancement may be considered.
    ◦ Non-surgical treatment options include glasses and
      contacts.
   Visual distortion can arise from several areas.
    Quite often this is related to the size of the
    treatment zone5.
    ◦ If the pupil is wider than the treatment zone the
      patients may report glare or haze.
   Retreatment is a possibility, but optic zone
    size can also be addressed with topical drops.
    ◦ The patient may be given a drop that has mitotic
      effects for things like night driving.
   Wrinkles
   Epithelial Ingrowth
   DLK (Diffuse Lamellar Keratitis)
   During surgery, if the flap is not made
    correctly, either to thin or to thick, it may not
    correctly adhere to the corneal surface.
    ◦ This can cause microscopic wrinkles, or striae which will
      interfere with the patient’s visual outcome.

   Wrinkles may also occur due to patient
    compliance issues. A patients rubbing or
    squeezing the eye too tightly within the first few
    hours of the procedure could also result in
    wrinkles.
    ◦ Patients should be discouraged from this behavior for
      the first 24-48 hours after the procedure.
   Epithelial ingrowth is another rare but
    potentially serious complication.
    ◦ Studies continue to show that early detection is
      vital.
    ◦ The use of optical coherence tomography has
      proven to be a useful tool in diagnosing this
      abnormal finding6.
   Not all cases of epithelial ingrowth need to be
    treated and therefore careful monitoring is
    required.
   Surgical removal of epithelial accumulation is
    indicated before the formation of a scar7.
   Diffuse lamellar keratitis (Sands of Sahara) is accumulation of white
    blood cells between the flap and stroma. These cells develop at the
    stromal interface and create unwanted inflammation.
    ◦ This presentation is usually evident 1-5 days after LASIK but can occur many months
      after the procedure8.
    ◦ With slit-lamp evaluation this finding appears as waves of sand.
    ◦ Patients present with pain, photophobia, foreign body sensation, and /or decreased
      vision.

   The cause of diffuse lamellar keratitis is unknown.
    ◦ These infiltrates are sterile, but the cornea attacks them causing serious damage.
      Because these infiltrates are not alive, these cells are able to elude proper sterilization
      techniques.

   Quick diagnosis is a must, and topical or oral treatment is often
    adequate. Common treatment would include topical antibiotics and
    steroids.
    ◦ Accepted dosaging is every 2 hours on both, and possibly an ointment at night.
    ◦ If topical treatment is inadequate re-lifting the flap, and removal of the infiltrates
      may be required.
   Subconjuntival hemorrhages
    ◦ These often occur with no long term side effects.
    ◦ No topical treatment is required.
    ◦ The most important issue would be educating the
      patient on its presentation.
   Keratectasia is a very difficult complication to
    mange. This finding results in an increase in
    refractive error due to the progressive
    steepening of the cornea9.
   Corneal ectasia can occur as quickly as one
    week after the procedure but can also
    manifest several years post-operatively.
   Managing this condition may eventually begin
    with specialty contact lenses, but may mature
    to the need for additional surgery like a
    penetrating keratoplasty or intacs10.
   Technology continues to advance. One of the more recent
    advances would involve wave front technology. These
    methods now allow for an extremely precise individualized
    vision correction.
    ◦ The procedure addresses higher order aberrations, something
      earlier designs couldn’t come close to affecting.

   Post-operative care is also being modified. Researchers
    are looking at developing contact lenses designed to
    release a continuous supply of medication during the
    post-op period. These designs use vitamin E to help
    release the drugs automatically overtime11.
                Although optometrists cannot perform
                the procedure, as you can see, we can
                play quite an active role in the patient
                pre- and post care.
1. 2011 Market Scope, LLC


2. FDA. (2010). FDA-Approved Lasers for PRK and Other Refractive Surgeries. Retrieved from
     http://www.fda.gov/MedicalDevices/ProductsandMedicalProcedures/SurgeryandLifeSupport/LASIK/ucm192110.htm


3. Saadia Rashid, MD; Yiping Jin, MD, PhD; Tatiana Ecoiffier, MSc; Stefano Barabino, MD, PhD; Debra A. Schaumberg, ScD, MPH; M. Reza Dana, MD, MSc, MPH. Topical Omega-3 and
     Omega-6 Fatty Acids for Treatment of Dry Eye. Arch Ophthalmol. 2008;126(2):219-225.


4. Goldman D. Treating blepharitis to maximize surgical success. Cataract Refractive Surgery Today. 2009 May:61-3.


5. Gregory W. Schmidt, MD; Michael Yoon, MD; Gerald McGwin, PhD; Paul P. Lee, MD, JD; Stephen D. McLeod, MD. Evaluation of the Relationship Between Ablation Diameter, Pupil
     Size, and Visual Function With Vision-Specific Quality-of-Life Measures After Laser In Situ Keratomileusis. Arch Ophthalmol. 2007;125(8):1037-1042.


6. Alissa Coyne, O.D., and Joseph Shovlin, O.D.AS-OCT Technology: Analyzing the Anterior Segment. Review of Optometry. Continuing Education. April 2012;


7. Irene Naoumidi, PhD; Thekla Papadaki, MD; Ioannis Zacharopoulos, MD; Charalambos Siganos, MD, PhD; Ioannis Pallikaris, MD, PhD. Epithelial Ingrowth After Laser In Situ
      KeratomileusisA Histopathologic Study in Human Corneas. Arch Ophthalmol. 2003;121(7):950-955.


8. Bennie H. Jeng, MD; Jay M. Stewart, MD; Stephen D. McLeod, MD; David G. Hwang, MD. Relapsing Diffuse Lamellar Keratitis After Laser In Situ KeratomileusisAssociated With
     Recurrent Erosion Syndrome. Arch Ophthalmol. 2004;122(3):396-398.


9. Beeran Meghpara, BA; Hiroshi Nakamura, MD; Marian Macsai, MD; Joel Sugar, MD; Ahmed Hidayat, MD; Beatrice Y. J. T. Yue, PhD; Deepak P. Edward, MD. Keratectasia After Laser In
     Situ KeratomileusisA Histopathologic and Immunohistochemical Study. Arch Ophthalmol. 2008;126(12):1655-1663.


10. George D. Kymionis, MD, PhD; Charalambos S. Siganos, MD, PhD; George Kounis, BSc; Nikolaos Astyrakakis, OD; Maria I. Kalyvianaki, MD; Ioannis G. Pallikaris, MD, PhD.
      Management of Post-LASIK Corneal Ectasia With Intacs InsertsOne-Year Results. Arch Ophthalmol. 2003;121(3):322-326.


11. Peng CC, Burke MT, Chauhan A. Transport of topical anesthetics in vitamin e loaded silicone hydrogel contact lenses. Langmuir. 2012 Jan 17;28(2):1478-87. Epub 2011 Dec 22.
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Optometry's Role in Laser Vision Correction

  • 1. By The Right Contact Team http://www.therightcontact.com
  • 2. Although optometrists do not perform laser vision correction here in the United States, they can still provide a valuable role in this procedure that is gaining unprecedented popularity.  According to recent data, a record 16 million people have had LASIK vision correction in the US though 20111.  This is an amazing opportunity for optometry. Whether it is screening good candidates, co- managing post-ops or managing complications, there is a lot the optometric profession has to offer.
  • 3. LASIK  Wavefront LASIK  Intralase  LASEK  EPI-LASEK  PRK
  • 5. There many issues that a practitioner should review when considering candidacy for laser vision correction.  The following are a few concerns to be addressed prior to referring the patient for the procedure. ◦ Candidacy as defined by the FDA ◦ Anterior surface concerns ◦ Patient habits
  • 6. Who is a good candidate for laser vision correction? Since its FDA approval in 19952, many factors have remained unchanged  INDICATIONS *Age 18 years of age or older with stable refraction for one year. *Myopia (nearsightedness) up to -14 diopters either without astigmatism or from -0.5 to -5 diopters of astigmatism *Hyperopia (farsightedness) from +1 to +4.5 diopters with less than 1 diopters of astigmatism *No history of eye disease, corneal scarring or retinal problems *Not pregnant or nursing for 3 months and not planning a pregnancy in the 3 months following surgery  CONTRAINDICATIONS Laser refractive surgery is contraindicated: * in patients with collagen vascular, autoimmune or immunodeficiency diseases. * in pregnant or nursing women. * in patients with signs of keratoconus or abnormal corneal topography * in patients who are taking one or both of the following medications: isotretinoin (Accutane®) or amiodarone hydrochloride (Cordarone®).
  • 7. Dry Eye  Ideally you want to identify dry eye during the pre-op period  Spend at least a few weeks to months treating it.  Utilizing tools such as artificial tears, punctal plugs, cyclosporine eye drops and nutritional therapy (omega-3 fatty acids) 3 can prove very useful. Blepharitis  Laser vision correction causes significant inflammation in normal eyes. Consider the consequences surgery can have when handling patients that already suffer from anterior surface disease.  Treatment options include ◦ oral tetracycline ◦ topical macrolide antibiotics ◦ combination steroid/antibiotic drops ◦ nutritional options (such as flaxseed oil). 4
  • 8. Does the patient work or live in environments of excessive heat?  Does the patient suffer from allergies or habits that pre-dispose them to eye rubbing? Avoiding these issues can greatly affect the potential outcome of the procedure.
  • 9. Most surgeons recommend a very specific follow-up schedule to ensure proper healing.  An average schedule would include ◦ 1st day ◦ 1st week ◦ 1st month ◦ 3 – 6 months  Each post-op appointment has very specific concerns that are to be addressed.  Each visit should take the opportunity to re- educate the patient on their status and the overall healing process.
  • 10. During this visit, the practitioner will access vision and make a corneal evaluation. The corneal evaluation will obviously vary depending on the procedure performed. ◦ If the patient has undergone LASIK, than flap evaluation will take place. ◦ If PRK or LASEK was performed, the corneal evaluation will be done under the bandage contact lens.  Patient instruction is very specific at this visit. ◦ Remind the PRK and LASEK patients that discomfort within the first few days is common but will subside. After a discussion about all topical post-op medications, patient’s activities need to be discussed.  Aggressive rubbing should be addressed. ◦ The patient should be discouraged from performing any tasks that could potentially hit the eye. Be specific, state avoiding things like water striking the eye during bathing, make-up (no mascara or eyeliner), sports, and exercise. The patient should wear a protective shield at night. Provided the vision is adequate, the patient is definitely able to resume deskwork or driving immediately.
  • 11. At this visit a re-assessment of vision and corneal integrity is taken.  As compared to their first post-op, patients that underwent PRK and LASEK should note a dramatic increase in comfort and vision.  Many times topical medications are discontinued at this visit.  The patient is often informed that they can begin a moderate level of activities including exercise, swimming, hot tubs and contact sports.
  • 12. The 1 month post-op evaluation again evaluates the vision and corneal surface.  At this stage the cornea should be completely attached and the patient is able to resume all activities. ◦ These activities would include those that were previously restricted such as gardening, scuba diving, etc.
  • 13. These visits are routine health evaluations.  At this time, many doctors will have to manage issues associated with dryness.
  • 14. When discussing any type of surgery you always have to be aware of the risks associated with the procedure.  Even though laser vision correction has a very good track record, sometimes there are unfortunate results that have to be addressed.  The following is a listing of possible complications that can occur with laser vision correction.
  • 15. Doctors are trained not to be over concerned about initial signs of overcorrection. ◦ This is because immediate post-ops can show correction issues secondary to expected corneal swelling. ◦ The patient should be educated that these symptoms will subside within a few days to two weeks.  Despite extensive pre-testing, sometimes the eyes do not respond in a predictable fashion. Regardless of the reason, the patient still has options. ◦ If the patient is interested in additional surgery, an enhancement may be considered. ◦ Non-surgical treatment options include glasses and contacts.
  • 16. Visual distortion can arise from several areas. Quite often this is related to the size of the treatment zone5. ◦ If the pupil is wider than the treatment zone the patients may report glare or haze.  Retreatment is a possibility, but optic zone size can also be addressed with topical drops. ◦ The patient may be given a drop that has mitotic effects for things like night driving.
  • 17. Wrinkles  Epithelial Ingrowth  DLK (Diffuse Lamellar Keratitis)
  • 18. During surgery, if the flap is not made correctly, either to thin or to thick, it may not correctly adhere to the corneal surface. ◦ This can cause microscopic wrinkles, or striae which will interfere with the patient’s visual outcome.  Wrinkles may also occur due to patient compliance issues. A patients rubbing or squeezing the eye too tightly within the first few hours of the procedure could also result in wrinkles. ◦ Patients should be discouraged from this behavior for the first 24-48 hours after the procedure.
  • 19. Epithelial ingrowth is another rare but potentially serious complication. ◦ Studies continue to show that early detection is vital. ◦ The use of optical coherence tomography has proven to be a useful tool in diagnosing this abnormal finding6.  Not all cases of epithelial ingrowth need to be treated and therefore careful monitoring is required.  Surgical removal of epithelial accumulation is indicated before the formation of a scar7.
  • 20. Diffuse lamellar keratitis (Sands of Sahara) is accumulation of white blood cells between the flap and stroma. These cells develop at the stromal interface and create unwanted inflammation. ◦ This presentation is usually evident 1-5 days after LASIK but can occur many months after the procedure8. ◦ With slit-lamp evaluation this finding appears as waves of sand. ◦ Patients present with pain, photophobia, foreign body sensation, and /or decreased vision.  The cause of diffuse lamellar keratitis is unknown. ◦ These infiltrates are sterile, but the cornea attacks them causing serious damage. Because these infiltrates are not alive, these cells are able to elude proper sterilization techniques.  Quick diagnosis is a must, and topical or oral treatment is often adequate. Common treatment would include topical antibiotics and steroids. ◦ Accepted dosaging is every 2 hours on both, and possibly an ointment at night. ◦ If topical treatment is inadequate re-lifting the flap, and removal of the infiltrates may be required.
  • 21. Subconjuntival hemorrhages ◦ These often occur with no long term side effects. ◦ No topical treatment is required. ◦ The most important issue would be educating the patient on its presentation.
  • 22. Keratectasia is a very difficult complication to mange. This finding results in an increase in refractive error due to the progressive steepening of the cornea9.  Corneal ectasia can occur as quickly as one week after the procedure but can also manifest several years post-operatively.  Managing this condition may eventually begin with specialty contact lenses, but may mature to the need for additional surgery like a penetrating keratoplasty or intacs10.
  • 23. Technology continues to advance. One of the more recent advances would involve wave front technology. These methods now allow for an extremely precise individualized vision correction. ◦ The procedure addresses higher order aberrations, something earlier designs couldn’t come close to affecting.  Post-operative care is also being modified. Researchers are looking at developing contact lenses designed to release a continuous supply of medication during the post-op period. These designs use vitamin E to help release the drugs automatically overtime11. Although optometrists cannot perform the procedure, as you can see, we can play quite an active role in the patient pre- and post care.
  • 24. 1. 2011 Market Scope, LLC 2. FDA. (2010). FDA-Approved Lasers for PRK and Other Refractive Surgeries. Retrieved from http://www.fda.gov/MedicalDevices/ProductsandMedicalProcedures/SurgeryandLifeSupport/LASIK/ucm192110.htm 3. Saadia Rashid, MD; Yiping Jin, MD, PhD; Tatiana Ecoiffier, MSc; Stefano Barabino, MD, PhD; Debra A. Schaumberg, ScD, MPH; M. Reza Dana, MD, MSc, MPH. Topical Omega-3 and Omega-6 Fatty Acids for Treatment of Dry Eye. Arch Ophthalmol. 2008;126(2):219-225. 4. Goldman D. Treating blepharitis to maximize surgical success. Cataract Refractive Surgery Today. 2009 May:61-3. 5. Gregory W. Schmidt, MD; Michael Yoon, MD; Gerald McGwin, PhD; Paul P. Lee, MD, JD; Stephen D. McLeod, MD. Evaluation of the Relationship Between Ablation Diameter, Pupil Size, and Visual Function With Vision-Specific Quality-of-Life Measures After Laser In Situ Keratomileusis. Arch Ophthalmol. 2007;125(8):1037-1042. 6. Alissa Coyne, O.D., and Joseph Shovlin, O.D.AS-OCT Technology: Analyzing the Anterior Segment. Review of Optometry. Continuing Education. April 2012; 7. Irene Naoumidi, PhD; Thekla Papadaki, MD; Ioannis Zacharopoulos, MD; Charalambos Siganos, MD, PhD; Ioannis Pallikaris, MD, PhD. Epithelial Ingrowth After Laser In Situ KeratomileusisA Histopathologic Study in Human Corneas. Arch Ophthalmol. 2003;121(7):950-955. 8. Bennie H. Jeng, MD; Jay M. Stewart, MD; Stephen D. McLeod, MD; David G. Hwang, MD. Relapsing Diffuse Lamellar Keratitis After Laser In Situ KeratomileusisAssociated With Recurrent Erosion Syndrome. Arch Ophthalmol. 2004;122(3):396-398. 9. Beeran Meghpara, BA; Hiroshi Nakamura, MD; Marian Macsai, MD; Joel Sugar, MD; Ahmed Hidayat, MD; Beatrice Y. J. T. Yue, PhD; Deepak P. Edward, MD. Keratectasia After Laser In Situ KeratomileusisA Histopathologic and Immunohistochemical Study. Arch Ophthalmol. 2008;126(12):1655-1663. 10. George D. Kymionis, MD, PhD; Charalambos S. Siganos, MD, PhD; George Kounis, BSc; Nikolaos Astyrakakis, OD; Maria I. Kalyvianaki, MD; Ioannis G. Pallikaris, MD, PhD. Management of Post-LASIK Corneal Ectasia With Intacs InsertsOne-Year Results. Arch Ophthalmol. 2003;121(3):322-326. 11. Peng CC, Burke MT, Chauhan A. Transport of topical anesthetics in vitamin e loaded silicone hydrogel contact lenses. Langmuir. 2012 Jan 17;28(2):1478-87. Epub 2011 Dec 22.