The research team hopes to show that ultrasound will kill cancer cells in a specific way that will also engage the body’s immune systems and ...https://info.atlantisworldwide.com/blog/ultrasound-technique-offers-new-approach-to-fighting-cancer

1. Sensible Solutions for Refurbished Radiology
By: Vikki Harmonay
Ultrasound Technique Offers New
Approach To Fighting Cancer

2. Sensible Solutions for Refurbished Radiology
It looks like a new ultrasound technique could selectively kill cancer cells
according to research recently published in Applied Physics Letters. While the
researchers are quick to note the findings are preliminary, the study results are
very promising.
Five years ago, Caltech’s Frank and Ora Lee Marble Professor of Aeronautics and
Mechanical Engineering Michael Ortiz wondered if the physical differences
between cancer cells and healthy cells might affect how they vibrate when
bombarded with sound waves and how the vibrations might trigger cancer cell
death.

3. Sensible Solutions for Refurbished Radiology
The physical differences included size, cell-wall thickness and the size of the
organelles within them. Ortiz built a mathematical model to see how cells would
react to different pulses and frequencies of sound waves. Working with then-
graduate student Stephanie Heyden (Ph. D. ’14), he published a paper in 2016 in
the Journal of the Mechanics and Physics of Solids showing that there was a gap in
the resonant growth rates of healthy and cancerous cells. In theory, that meant a
carefully tuned sound wave should cause the membranes of cancerous cells to
vibrate to the point that they ruptured; leaving healthy cells unharmed. Ortiz calls
the process “oncotripsy” from the Greek “oncos” for tumor and “tripsy” for
breaking.

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He subsequently applied for funding to continue the research through Caltech’s
Rothenberg innovation initiative which supports research projects with high
commercial potential. Ortiz also recruited doctoral student Erika F. Schibber (MS
’16, Ph.D. ’19) to work on the project. Her research involved the study of
vibrations on satellites.
Ortiz then invited Professor of Aeronautics and Bioinspired Engineering Hans. W.
Lipmann to attend a meeting of his research group. Gharib is a prolific inventor
and has brought numerous research development from the lab to the market,
including a prosthetic polymer heart valve and a smartphone app for monitoring
heart health. Gharib was intrigued by the idea and pitched the project to advisee
David Mittelstein, a graduate student in the MD-Ph.D. Program run by Caltech
and the Keck School of Medicine at USC.

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Mittelstein saw the opportunity to participate in the oncotripsy project from its
conception to its proof of concept and got onboard. He put together a team to
work on the project, including Caltech Professor of Chemical Engineering Mikhail
Shapiro. Shapiro created a system to allow ultrasound to reveal gene expression
in the body. He also designed bacteria that reflect soundwaves so they can be
tracked through the body with ultrasound.
Ortiz was also connected to City of Hope Department of Immuno-Oncology Chair
Eduardo A. Repetto, a physician-scientist who’s passionate about getting new
treatments to patients. City of Hope researchers Jian Ye and oncologist M.
Hourman Fekrazad also joined the team.

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If ultrasound can be used to cause cell death that looks like injury instead of
apoptosis, white blood cells could flood the site of the tumor and attack
remaining cancer cells.
While the testing has been done only in cell cultures in petri dishes, the study
will expand to testing solid tumors and ultimately in living animals.
“This is an exciting proof-of-concept for a new kind of cancer therapy that
doesn’t require the cancer to have unique molecular markers or to be located
separately from healthy cells to be targeted. Instead we may be able to target
cancer cells based on their unique physical properties,” said Mittelstein.

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