mAchR is a GPCR receptor
• Amanita muscaria, the mushroom from which
muscarine was isolated.
• These receptors are sensitive to this
compound. Thus it is known as Muscarinic
Acetylcholine Receptors (mAchR)
G protein-coupled receptors
(GPCR) comprise the largest
family of drug targets
The 2012 Nobel prize in chemistry was awarded to Brian Kobilka and Robert Lefkowitz
for their work that was "crucial for understanding how G-protein–coupled receptors
Brian Kobilka Robert Lefkowitz
GPCR receptors have crosstalk with
the major oncogenic signaling
So in our proposal we have predicted that Muscarinic Acetylcholine
Receptors (mAchR) and its related pathway could be a possible
mediator of oncogenic crosstalks in neuroblastoma
The study will mainly focus on……
Quantitative in situ assessment of mAchR in different grades of
Role of mAchR in progressive neuroblastoma occurrence and
its effect on proliferation or apoptosis.
The possible existence of cross talk of mAchR and its pathway
members with other key signaling molecules affecting the
occurrence of malignant neuroblastomas.
Neuroblastoma is a disease exhibiting extreme
Therapy for high-risk neuroblastoma the past two decades
resulted in cures only about 20% of the pateint population.
Targeting mAchR in neuroblastoma may generate new
avenues in molecular biology and therapeutic strategies.
Thus novel drugs will be inducted into clinical practice
guidelines of high grade neuroblastoma treatment.