1. PRESENTED BY:- GUIDED BY:-
Aprna Sabharwal Dr. Sajid Hussain

2.  Introduction and History
 Classification
 How do smart drugs work?
 Smart drugs delivery system
 Applications
 Smart drugs and diseases
 Smart drugs in cancer therapy
 Smart drugs in tooth decay
 Smart drugs and aging brain
 Health hazards
 Future of smart drugs
 Conclusion

3.  Smart drugs also referred as NOOTROPICS
 Were named by Dr. Corneliu E. Giurgea
 Are purported to improve mental functions
 Includes variety of substances like herbs,
vitamins, prescribed drugs
 Work by altering brains supply of
neurotransmitters, hormones ,enzymes etc.
 Used primarily to improve people with cognitive
difficulties

4.  Increased alertness , mental energy and
concentration
 Increased ability to memorize material
 Greater productivity, organization and planning
ability
 Improved problem solving ability
 Alleviation of depression

5.  Work started in 20th century
 June 9,1992 focus was made on smart drugs as
an aid to improve brain power
 April 11,1996-FDA warned against legal highs
from smart drugs
 2001,2002,2004,2006 smart drugs made its entry
in treatment of cancer
 2005…drug delivery system was revolutionized

6.  Classification based  Classification based
on methods of on derivation:-
consumption:-
 Tablets  Natural.
 Drops  Chemical
 Drinks
 Infusions

7.  NATURALLY  CHEMICALLY
DERIVED DERIVED
 Direct sources and  Caffeine based
supplements  Ephedrine based
 Direct hormones
 Secondary enhancers

8.  Increase in Brain metabolism
 Increased Cerebral circulation
 Protection of brain from Chemical damage

9.  Increased brain metabolism
Example :-linopiridine physostigmine, tacrine
 Increased cerebral circulation
Example:-vinpocetine, hydergine
 Protection of brain from chemical damage
Example:- antioxidant therapy

10.  Desmopressin
 DMAE (di methyl amino ethanol)
 Caffeine
 Hydergine and piracetam
 Choline

12.  Vehicles used for smart drug delivery system are
as follows:-
 Magnetic nanocapsules
 Dendrimers
 Microcapsules
 Microemulsions
 Liposomes

14.  One of the smart
drug releases
antibodies only when
an infection invades.
 Another example of
smart drug is
immunotoxin.
 Viral gene therapy is
another variation of
smart drugs.

15.  A new class of cancer drugs often called as
smart drugs, targets the genetic cascade,
jamming it up at various points.These smart
drugs act by:-
 Directly disrupting tumor cell replication
machinery.
 Other block growth signals from reaching the
cells.
 One class of smart drugs even cut off tumors

16.  Streptococcus mutans is the main organism for most
of the tooth related problems.
 Wenyuan Shi of the university of California ,L.A,
has created an antimicrobial agent that spares
commensal bugs.
 Unlike the traditional antibiotics that also kill the
friendly bacteria.

17. The anti-Parkinson and anti-aging drug
DEPRENYL for example acts primarily on the
brain .

18.  Down regulation of neurological activity upon
stimulation
 Serotonin syndrome from serotonergic agents
 Excessive acetylcholine receptor activation
 Heart failure
 Organ failure such as liver ,kidney failure

20.  Ampakines
 HT-0712
 Gene therapy

21. Smart drugs seem to be very promising in
increasing brains sharpness, memory.
The side effects observed are very rare and
few in comparison to the benefits they provide.
The fate of these drugs not only depends upon
the drug itself but also upon the user.