Slides for discussion of Essential Cell Biology chapter 5.

1. Cell & Molecular
Biology

2. Genes

3. Chapter 5

6. DNA Structure

7. The Double Helix
and Base Pairing

10. Figure 5-6a Essential Cell Biology (© Garland Science 2010)

11. Figure 5-6b Essential Cell Biology (© Garland Science 2010)

12. Figure 5-7 Essential Cell Biology (© Garland Science 2010)

13. Information
in a linear sequence

14. Figure 5-8 Essential Cell Biology (© Garland Science 2010)

15. Figure 5-9 Essential Cell Biology (© Garland Science 2010)

16. Genes

17. “A gene is usually defined as
a segment of DNA
that contains instructions
for making a particular protein.”

18. Genome

19. “The complete set of information
in an organism’s DNA...”

20. Figure 5-10 Essential Cell Biology (© Garland Science 2010)

21. Chromosomes

22. Figure 5-11 Essential Cell Biology (© Garland Science 2010)

23. Human somatic cells
have 23 pairs of
homologous chromosomes

24. Figure 5-10 Essential Cell Biology (© Garland Science 2010)

25. We often look at
mitotic chromosomes

26. Figure 5-17 Essential Cell Biology (© Garland Science 2010)

27. But interphase chromosomes
are “less compact”

28. Figure 5-15 Essential Cell Biology (© Garland Science 2010)

29. Figure 5-18 Essential Cell Biology (© Garland Science 2010)

30. Chromatin

31. Figure 5-19 Essential Cell Biology (© Garland Science 2010)

32. “The complex of
DNA and proteins...”

33. Figure 5-21 Essential Cell Biology (© Garland Science 2010)

34. Chromosomal Structure

35. Linear information,
highly structured

36. Figure 5-21 Essential Cell Biology (© Garland Science 2010)

37. Nucleosomes

40. Histones

41. Figure 5-23 Essential Cell Biology (© Garland Science 2010)

42. Chromosome Packing

43. Figure 5-25 Essential Cell Biology (© Garland Science 2010)

44. http://www.mun.ca/biology/scarr/Histone_Protein_Structure.html

45. http://www.mun.ca/biology/scarr/Histone_Protein_Structure.html

46. http://www.mun.ca/biology/scarr/Histone_Protein_Structure.html

47. Changing Nucleosome Structure

48. Chromatin-Remodeling Complexes

49. Figure 5-27a Essential Cell Biology (© Garland Science 2010)

50. Figure 5-27b Essential Cell Biology (© Garland Science 2010)

51. Chemical Modification of Histones

52. Acetyl, methyl and phosphate groups
can be added to or removed from
histone tails.

53. Figure 5-28a Essential Cell Biology (© Garland Science 2010)

54. Figure 5-28b Essential Cell Biology (© Garland Science 2010)

55. These modifications can affect
30-nm chromatin fiber stability
and the ability of histone tails
to bind specific proteins.

56. Heterochromatin

57. “The most highly condensed form
of interphase chromatin...”

58. Figure 5-29 Essential Cell Biology (© Garland Science 2010)

59. Figure 5-30 Essential Cell Biology (© Garland Science 2010)

60. Euchromatin

61. “...chromatin that exists
in a more extended state...”

62. Figure 5-31 Essential Cell Biology (© Garland Science 2010)

63. Figure 5-31 Essential Cell Biology (© Garland Science 2010)