Answer: Protein Kinase A is otherwise known as cyclic AMP dependent protein kinase A. In the molecular scheme of living organisms, cAMP has been a universal second messenger. Protein Kinase A consists of regulatory and catalytic sub units. When cAMP binds to the regulatory subunit of Protein Kinase A,it brings conformational change in catalytic subunit which inturn phosphorylate other proteins. If muation icAMP nbinding domain of regulatory unit will constantly activate PKA. Answer for , muation that causes constantly inactivation of PKA. Mutation in catalytic sub unit which phosphorylate other protein, will constantly inactivate protein kinase A. Because even though cAMP binds to regulatory unit , catalytic unit can not phosporylate the protein if mutation occurs in phosporylation domain. Solution Answer: Protein Kinase A is otherwise known as cyclic AMP dependent protein kinase A. In the molecular scheme of living organisms, cAMP has been a universal second messenger. Protein Kinase A consists of regulatory and catalytic sub units. When cAMP binds to the regulatory subunit of Protein Kinase A,it brings conformational change in catalytic subunit which inturn phosphorylate other proteins. If muation icAMP nbinding domain of regulatory unit will constantly activate PKA. Answer for , muation that causes constantly inactivation of PKA. Mutation in catalytic sub unit which phosphorylate other protein, will constantly inactivate protein kinase A. Because even though cAMP binds to regulatory unit , catalytic unit can not phosporylate the protein if mutation occurs in phosporylation domain..
Answer: Protein Kinase A is otherwise known as cyclic AMP dependent protein kinase A. In the molecular scheme of living organisms, cAMP has been a universal second messenger. Protein Kinase A consists of regulatory and catalytic sub units. When cAMP binds to the regulatory subunit of Protein Kinase A,it brings conformational change in catalytic subunit which inturn phosphorylate other proteins. If muation icAMP nbinding domain of regulatory unit will constantly activate PKA. Answer for , muation that causes constantly inactivation of PKA. Mutation in catalytic sub unit which phosphorylate other protein, will constantly inactivate protein kinase A. Because even though cAMP binds to regulatory unit , catalytic unit can not phosporylate the protein if mutation occurs in phosporylation domain. Solution Answer: Protein Kinase A is otherwise known as cyclic AMP dependent protein kinase A. In the molecular scheme of living organisms, cAMP has been a universal second messenger. Protein Kinase A consists of regulatory and catalytic sub units. When cAMP binds to the regulatory subunit of Protein Kinase A,it brings conformational change in catalytic subunit which inturn phosphorylate other proteins. If muation icAMP nbinding domain of regulatory unit will constantly activate PKA. Answer for , muation that causes constantly inactivation of PKA. Mutation in catalytic sub unit which phosphorylate other protein, will constantly inactivate protein kinase A. Because even though cAMP binds to regulatory unit , catalytic unit can not phosporylate the protein if mutation occurs in phosporylation domain..