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CD Based Questions for Pharmacology Practical

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CD Based Questions for Pharmacology Practical

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Experimental pharmacology is a study through experimental design in controlled situations which involves testing of pharmacologically unknown substance and pharmaceutical products in human and animal

Experimental pharmacology is a study through experimental design in controlled situations which involves testing of pharmacologically unknown substance and pharmaceutical products in human and animal

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CD Based Questions for Pharmacology Practical

  1. 1. CD Based Questions Experiment No. 1 to 10 Prof. Amol Deore Department of Pharmacology MVP Samaj’s Institute of Pharmaceutical Sciences, Adgaon, Nashik
  2. 2. Identify this animal and mention its uses in experimental pharmacology. Answer: New Zealand Rabbit • Used in Pyrogen testing of parenterals • Used in Anti-diabetic studies • Used in Anti-asthmatic studies
  3. 3. Identify this animal and mention its uses in experimental pharmacology Answer: Wister rat • Used in toxicity studies • Used in anti-psychotic studies • Used in analgesic studies
  4. 4. Identify this animal and mention its uses in experimental pharmacology Answer: Guniea Pig • Used in study of local anesthetics • Used in Anti-TB studies • Used in Anti-asthmatic studies
  5. 5. Identify route of drug administration in mice as shown in figures. Answer • Intraperitoneal route of injection in peritoneal cavity
  6. 6. Identify route of drug administration in mice as shown in figure. Answer • Oral route of administration
  7. 7. Identify route of drug administration in mice as shown in figures. Answer • Intravenous route of injection in ventral tail vein
  8. 8. Identify route of drug administration in mice as shown in figures. Answer • Subcutaneous route of injection
  9. 9. • Which research or study is done within an entire living organism? Answer In vivo is Latin for “within the living.” It refers to tests, experiments, and procedures that researchers perform in or on a whole living organism, such as a person, laboratory animal, or plant.
  10. 10. • Which research or study is done outside of an living organism? Answer In vitro (“in glass”) It describes medical procedures, tests, and experiments that researchers perform outside of a living organism
  11. 11. • What is meant by in silico drug design? Answer In silico drug design is a term that means 'computer-aided molecular design', or in other words the rational design or discovery of drugs using a wide variety of computational methods.
  12. 12. Identify the blood withdrawal technique in mice as shown in figures. Answer • Blood sample collection by retro-orbial plexus in mice
  13. 13. Identify the blood withdrawal technique as shown in figures. Answer • Blood sample collection by ventral tail vein in rats
  14. 14. Identify and mention the uses of the instrument as shown in figure. Answer: Eddys hot plate Analgesiometer • The hot plate test is used in testing the effect of analgesics by observing the reaction to pain caused by heat.
  15. 15. Identify and mention the uses of the instrument as shown in figure. Answer: Electroconvulsiometer • Electroconvulsiometer was used to induce electroshock seizures in all experimental animals. Electrodes were applied to both the ear pinna of animals
  16. 16. Identify and mention the uses of the instrument as shown in figure. Answer: Actophotometer • Actophotometer is used to measure locomotor activity of animals.
  17. 17. Identify and mention the uses of the instrument as shown in figure. Answer: Elevated plus maze apparatus • The elevated plus maze test is one of the most widely used tests for measuring anxiety-like behavior.
  18. 18. Identify and mention the uses of the instrument as shown in figure. Answer: Rotarod apparatus • Rotarod apparatus is widely used to evaluate drug effects on motor coordination, balance and motor learning in rodents. The principle of this test is that rats or mice are first trained to walk on a rod rotating at a certain speed
  19. 19. Identify and mention the uses of the instrument as shown in figure. Answer: Cook's pole climbing apparatus • Cook's pole climbing apparatus was used to determine the antipsychotic activity.
  20. 20. Identify and mention the uses of the instrument as shown in figure. Answer: Rabbit holder • Rabbit holders are used for transporting and restraining rabbits during experimental protocols.
  21. 21. Identify and mention the uses of the instrument as shown in figure. Answer: Student organ bath assemly • This equipment is commonly used to study the physiology and pharmacology of in-vitro tissue preparations.
  22. 22. Label 1 to 5 as mentioned in this figure. Answer • 1- Dendrites, 2- Trigger Zone, 3- Axone, • 4- Cell Body, 5- Axone terminals
  23. 23. Label the no. 1 to 5 in eye diagram. 23 Answer • 1- Cornea, • 2- Pupil, • 3- Lens, • 4- Iris, • 5- Retina.
  24. 24. Give conclusion from observation table of effect of xylocaine. 24 Answer • Loss of corneal reflex from the test eye indicate loss of corneal sensation, therefore such drug xylocaine, procaine are used as local anesthetics.
  25. 25. Describe the state. Give two drugs showing similar action. 25 Answer • Because of midriasis an individual can see objects which are far away but fails to observe objects which are nearer. The inability is called as cycloplegia. • Mydriatics drugs: Atropine, Homatropine, Cyclopentolate
  26. 26. Describe the state. Give two drugs showing similar action. 26 Answer • Because of miosis an individual can see the objects which are nearer but fails to observe objects which are far away. This inability produced is called “paralysis of accommodation” or “accommodation of spasm” • Miotics drugs: Physostigmine, Pilocarpine,
  27. 27. Give conclusion from the observation table. 27 Answer • Cyclopentolate is an anticholinergics shows Mydriasis (increases pupil size) and produces photophobia.
  28. 28. Give conclusion from the observation table. Answer • Pilocarpine is parasypathomimetics shows miosis and dose not affect the corneal and light reflexes.

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