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SORT-OUT III: A Prospective Randomized Comparison of Zotarolimus-Eluting and Sirolimus-Eluting Stents in Patients with Coronary Artery Disease Michael Maeng , Klaus Rasmussen, Per Thayssen, Henning Kelbæk, Jan Ravkilde, Ulrik Abildgaard, Lisette O. Jensen, Evald H. Christiansen, Knud N. Hansen, Hans-Henrik Tilsted, Peter R. Hansen, Lars R. Krusell, Thomas Engstrøm, Jens Aarøe, Jan S. Jensen, Hans E. Bøtker, Steen D. Kristensen, Steen Z. Abildstrøm, Anne Kaltoft, Morten Madsen, Søren P. Johnsen, Henrik T. Sørensen, Leif Thuesen & Jens F. Lassen

Conflicts of interests for Michael Maeng, M.D. Cordis, Johnson & Johnson: Speaker fees. Medtronic: Consultant fee SORT-OUT III: A Prospective Randomized Comparison of Zotarolimus-Eluting and Sirolimus-Eluting Stents in Patients with Coronary Artery Disease

Purpose To compare the clinical outcome in routine clinical care (“all-comer”) patients randomized to Endeavor or Cypher stent implantation

PCI Organization in Denmark Population of 5,5 million inhabitants 5 high volume PCI centers 12-month dual anti-platelet therapy is recommended PCI center 100 US miles

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Selected Patient Characteristics 26 21 7 70 54 15 73 64 1.162 END CYP No of patients 1.170 Age (yrs) 64 Male (%) 72 Diabetes (%) 14 Hypertension (%) 51 Lipid-lowering therapy (%) 68 Previous CABG (%) 7 Previous PCI (%) 17 Previous MI (%) 27

PCI Indication END CYP Stable angina (%) 53 51 NSTEMI/UAP (%) 38 38 STEMI (%) 6 9 Other (%) 4 3

Selected Lesion Characteristics 1.5 1.6 No of lesions/patient 1.7 1.8 Stents/patient 36 45 20 3.2 18 13 END CYP Lesion length (mm) 14 Stent length (mm) 18 Stent diameter (mm) 3.2 Lesion type A (%) 18 Lesion type B (%) 48 Lesion type C (%) 35

MACE HR = 2.19 (1.58 – 3.04) P < 0.0001 END : 9.7% CYP : 4.5%

All Cause Mortality HR = 1.61 (1.03 – 2.50) P = 0.035 END : 4.4% CYP : 2.7%

Cardiac Death HR = 1.51 (0.73 – 3.14) P = 0.27 END : 1.6% CYP : 1.0%

Myocardial Infarction HR = 2.22 (1.09 – 4.53) P = 0.029 END : 2.1% CYP : 0.9%

Definite Stent Thrombosis HR = 2.19 (0.83 – 5.77) P = 0.13 END : 1.1% CYP : 0.5%

Target Vessel Revascularization HR = 2.42 (1.67 – 3.52) P<0.0001 END : 7.9% CYP : 3.3%

Target Lesion Revascularization HR = 3.66 (2.23 – 6.01) P < 0.0001 END : 6.1% CYP : 1.7%

For further details ….. ,[object Object],Thank you for your attention

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