1.
Nucleotides Metabolism

2.
• Purines are double ringed Nitrogenous bases
• Synthesis takes place in liver
• Nitrogen atoms are contributed by amino acids
(aspartate, glycine, glutamine)
• Carbon atoms are contributed by CO2 and N10
formyl THF
Synthesis of purine Nucleotides

3.
Precursor is preformed ribose 5-P

4.
Synthesis of phosphoribosyl
pyrophosphate (PRPP)

5.
Synthesis of 5-Phosphoribosylamine
Rate limiting step

6.
Salvage pathway of purine
synthesis
• Purines that result from the normal turnover of
cellular nucleic acids,
• or the small amount that is obtained from the diet
and not degraded,
• can be converted d to nucleotides and used by the
• body. This is referred to as the “salvage pathway”
for purines.

7.
Lesch nyhan Syndrome
• , X-linked recessive
• disorder associated with a virtually complete
deficiency of HGPRT.

8.
Degradation of purine
Nucleotides

9.
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