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Crestor's Pharma Lifecycle

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Crestor's Pharma Lifecycle

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A showcase is presented of the lifecycle analysis of the blockbuster HMG-CoA reductase inhibitor (Statin) drug Crestor, prescribed for hypercholesterolemia and primary prevention of cardiovascular disease. Now considered a "legacy" product, Crestor with its decade history of regulatory and clinical trial milestones has cut out a unique pharma life cycle for itself...see this Slideshare for more details.

A showcase is presented of the lifecycle analysis of the blockbuster HMG-CoA reductase inhibitor (Statin) drug Crestor, prescribed for hypercholesterolemia and primary prevention of cardiovascular disease. Now considered a "legacy" product, Crestor with its decade history of regulatory and clinical trial milestones has cut out a unique pharma life cycle for itself...see this Slideshare for more details.

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Crestor's Pharma Lifecycle

  1. 1. 11/05/2011 aStatus based on the Boston Consulting Group Matrix bBased on regulatory news feeds and landmark clinical trial results 10 Years on is Crestor at the End of its Pharma Life Cycle? Year Sales USD Billion BCG Matrix Statusa; Factor(s) Impacting on Salesb 2006 2.1 Question Mark; Resubmission of dosing data, FDA advises on risk of rhabdomyolysis with greater risk to Asian populations. Releases of generic simvastatin (Zocor) 2007 2.8 Star; Crestor the only indication among its class to treat atherosclerosis 2008 3.6 Star; JUPITER trials supporting prevention of MI & stroke in normal LDL cholesterol subjects but with high levels of C-Reactive Protein (CRP) albeit diabetes concerns. 2009 5.4 Star; Lipitor loses marketing exclusivity in the US with sales losses to generics in other key markets. Impact of approval in Germany, Spain & Norway 2010 5.7 Cash Cow; Crestor gets approved prescription in the prevention of MI & stroke in healthy people with elevated CRP levels 2011 6.6 Cash Cow; In SATURN randomised trials LDL levels in Crestor group dropped to an average 62.6 mg/dL, c.f. 70.2 mg/dL for patients on Lipitor. Generic copies of Lipitor are launched in the US. 2012 6.2 Cash Cow; Competitive pricing amongst Lipitor generics limits switch to Crestor 2013 5.6 Cash Cow; Ongoing litigation cases 2014 5.5 Dog: Limited clinical data on clinical benefit vs. precription pricing of Lipitor generics 2015 5.0 Dog: Concerns over Statin associated myopathy 2016 3.4 Dog; Watson Laboratories, Inc. and Actavis, Inc. began selling its generic version of Crestor in May 2016
  2. 2. Crestor’s Pharma Life Cycle 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 0 1 2 3 4 5 6 7 Sales USD Billion • 2017 represents YTD sales of $2.8 billion, a reduction of 24%; further declines are anticipated based on multiple generic Crestor medicines launched on the US market July 2016 onwards. • Although Statins will remain the first-line prescription drug in LDLC-reducing dyslipidemia treatment management, further attrition of future sales will be from the approval of PCSK9 mAbs and CETP inhibitors used to treat niche patient subpopulations.
  3. 3. 11/05/2017i3 Consult Integrated Intelligence for Healthcare Industries 3 •We can provide you with strategic, operational and financial solutions for the challenges that your company is facing in today's highly competitive healthcare, pharmaceutical & life science industry •Unlike the blue chip consulting firms, our fees are very competitively priced and are based on the deliverables you specifically require. •Our deliverables are from dedicated specialists and experts in the healthcare and life science industry rather than from new graduates and mid-career hires of the big consulting firms. •We do not charge by the hour but more by the scope and critical need of the consultancy required. i3 Consult – Want to know more...? Please enquire within and we promise to be a listening ear to your affordability! www.i3consult.com wallace.macindoe@i3consult.com

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