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Behind the FAIR Brand:
Thinkers, Doers and Dreamers
Susanna-Assunta Sansone
ORCiD: 0000-0001-5306-5690 | Twitter: @SusannaASansone
Beilstein Open Science 2019 Symposium, 15 -17 October 2019
Slides: https://www.slideshare.net/SusannaSansone
sansonegroup.eng.ox.ac.uk
Associate Professor, Engineering Science
Associate Director, Oxford e-Research Centre
Principal Investigator and Group Leader
A set of principles to enhance the
value of all digital resources
2014
2016
Developed and endorsed by
researchers, service
providers, publishers, funding
agencies, industry partners
And the FAIR brand is born
https://publications.europa.eu/en/publication-detail/-
/publication/d375368c-1a0a-11e9-8d04-01aa75ed71a1
Everybody needs data that are
• Discoverable by humans and machines
• Retrievable and structured in standard format(s)
• Self-described so that third parties can make sense of it
Better data = better science and more efficiently
Datasets SOPs Figures, Photos Workflows Slides Codes Tools DatabasesAlgorithmsDocument
• A crisis in confidence in research integrity in certain fields
• Human-machine collaboration will be crucial to our future
• Data-relates mandates and policies by funders
• The changing world of scholarly publishing
• The need for recognition and credit
Driving factors
Datasets SOPs Figures, Photos Workflows Slides Codes Tools DatabasesAlgorithmsDocument
Depends upon several stakeholders in the research ecosystem
actively playing their parts
• to deliver research infrastructures, tools and standards,
policies, education and training
• to overcome technical, social and cultural challenges
It is not simple and it requires long term investment
Making FAIR a reality
My fair share
of the work
€3.3 billion
programme
2014 - 2020
€300 million
programme
2018 - 2020
European
intergovernmental
organisation
23 member
countries and
over 180 research
organisations
Since 2014
1
2
3 Started in 2019
FAIR-enabling EU and USA biomedical infrastructure
programmes and projects, e.g.
Since in 2014, several programs:
2014-2017
2017-2018
Organization and structure
• Hub and (national) Nodes
• Community-driven and rooted
• Strong focus on interoperability
• SMEs and Industry links
• Cross-nodes funded activities
model and related formats
Initiated in
2003
Open source tools and formats to help researchers to:
describe multi-modal experiments
follow community-developed standards
curate, analyze, release, share and publish
Nowadays ISA (format and/or tools)
powers over 30 public resources, e.g.,
The ‘curse’ of success:
• Time and (lack of) funds for:
- Maintenance
- Extensions
- Community coordination/training
• Not just about the software
- data curation know-how
Funded by
Part of the
ISA-InterMine project
Reproducibility – FAIR at the first mile
From curated, structured metadata to data paper
datascriptor.org
Academics from several ELIXIR Nodes, with Janssen, AstraZeneca, Eli Lilly,
GSK, Novartis, Bayer, Boehringer Ingelheim
Define, document and implement a data FAIRification process:
FAIR-driven biopharma R&D, e.g.
Human capital maximization
• Work in squads cross-cutting working packages and partners
• Address questions/issues, rather then perform technical duties
• Prioritization of the work based on pharma's needs
• Three months sprint cycles
FAIRcookbook
Rocca-Serra and Sansone:
10.5281/zenodo.3274256
Scientific Data (accepted)
Practical examples: data FAIRifications recipes
FAIRcookbook
1 2014-2017
12 centres of excellence
2 2017-2018
3 Started in 2019
10 multi-PIs teams, forming one consortium
around 3 data types/databases
A consortium of 6 teams
1
12 centres of excellence
2
3
10 multi-PIs teams, forming one consortium
around 3 data types/databases
A consortium of 6 teams
2014-2017
2017-2018
Started in 2019
1
12 centres of excellence
2
3
10 multi-PIs teams, forming one consortium
around 3 data types/databases
A consortium of 6 teams
2014-2017
2017-2018
Started in 2019
1
12 centres of excellence
2
3
10 multi-PIs teams, forming one consortium
around 3 data types/databases
A consortium of 6 teams
2014-2017
2017-2018
Started in 2019
1
Building on previous work
• Learn from positive and
negative outcomes
• Assessment of what did not
work well and why
• NIH centres/officers playing an
active role
• Evolving understanding of what
a FAIR Data Commons is
12 centres of excellence
2
3
10 multi-PIs teams, forming one consortium
around 3 data types/databases
A consortium of 6 teams
2014-2017
2017-2018
Started in 2019
Data for machines – Use of data at scale
Findable
Accessible
Interoperable
Reusable
• Globally unique, resolvable, and persistent identifiers
§ To retrieve and connect data
• Community defined descriptive metadata
§ To enhance discoverability
• Common terminologies
§ To use the same term mean the same thing
• Detailed provenance
§ To contextualize the data and facilitate reproducibility
• Terms of access
§ Open as possible, closed as necessary
• Terms of use
§ Clear licences, ideally to enable innovation and reuse
Findable
Accessible
Interoperable
20%
identifiers
80%
metadata
https://doi.org/10.2777/1524
Reusable
Two pillars of FAIR
Formats Terminologies Guidelines Identifiers
ID
Conceptual model,
conceptual schema,
exchange formats
Controlled
vocabularies,
thesauri, ontologies
Minimum information
reporting requirements,
checklists
Unambiguous, persistent
and context-independent
identifier schema
Standards for metadata and identifiers
metadata
390+
162+
729+
~1300
13
MIAME
MIRIAM
MIQAS
MIX
MIGEN
ARRIVE
MIAPE
MIASE
MIQE
MISFISHIE
….
REMARK
CONSORT
SRAxml
SOFT FASTA
DICOM
MzML
SBRML
SEDML
…
GELML
ISA
CML
MITAB
…
AAO
CHEBIOBI
PATO ENVO
MOD
BTO
IDO
…
TEDDY
PRO
XAO
DO
VO
EC number
URL
PURLLSID
HandleORCID
RRID
InChI
…
IVOA ID
DOI
standard
organizations
grass-roots
groups
Formats Terminologies Guidelines Identifiers
ID
COMMUNITY STANDARDS
for metadata and identifiers
Domain-specific standards for datasets, e.g.
https://doi.org/10.6084/m9.figshare.3795816.v2
https://doi.org/10.6084/m9.figshare.4055496.v1
2013
2016
Analysis of the standards landscape
Fragmentation, duplication and gaps:
• Perspective and focus vary:
• Motivation is diverse
• Governance and participation vary
2011-today
doi: 10.1126/science.1180598
2007
doi:10.1038/nbt1346
2008
doi:10.1038/nbt1346
OBO Portal and Foundry
Portal and Foundry
2009
doi: 10.1038/nbt.1411
Since
2011
Currently primarily funded by
Formats Terminologies Guidelines Identifiers
ID
REPOSITORIES,
databases and
knowledgebases
DATA POLICIES
by journals, funders, and
other organizations
COMMUNITY STANDARDS
for metadata and identifiers
informative and educational resource
Curated inter-linked
descriptions
Formats Terminologies Guidelines Identifiers
ID
informative and educational resource
Curated inter-linked
descriptions
All records are manually curated
in-house, verified and claimed by the
community behind each resource
Ready for use, implementation, or recommendation
In development
Status uncertain
Deprecated as subsumed or superseded
REPOSITORIES,
databases and
knowledgebases
DATA POLICIES
by journals, funders, and
other organizations
COMMUNITY STANDARDS
for metadata and identifiers
Formats Terminologies Guidelines Identifiers
ID
REPOSITORIES,
databases and
knowledgebases
DATA POLICIES
by journals, funders, and
other organizations
COMMUNITY STANDARDS
for metadata and identifiers
informative and educational resource
Curated inter-linked
descriptions
We guide consumers to discover, select and use these
resources with confidence
We help producers to make their resources more visible, more
widely adopted and cited
Researchers in academia,
industry, government
Developers and curators
of resources
Journal publishers or
organizations with data
policy
Research data facilitators,
librarians, trainers
Learned societies, unions
and associations
Funders and data
policy makers
A flagship output (and a WG) of the:
Recommended by funders, e.g.:
Core part of implementation networks in:
https://doi.org/10.1038/s41587-019-0080-8
Open Access CC-BY
69 authors (adopters, collaborators, users)
representing different stakeholder groups
Analysed the data policies by
journals/publishers, and the standards and
repositories they recommend
Working with journal editors and publishers
Discrepancy in recommendation across the data policies
• some repositories are named, but very few standards are
• cautious approach due to the wealth of existing resources
Recommendations are often driven by
• the editor’s familiarity with one or more standards, notably
for journals or publishers focusing on specific disciplines
• the engagement with learned societies and researchers
actively supporting and using certain resources
Ø Consensus: FAIRsharing plays a key role in helping editors
to discover and recommend appropriate resources
What have we learned and are doing now
“The interactive browser will allow us to discover which databases and standards
are not currently included in our author guidelines, enabling us to regularly
monitor and refine our policies as appropriate, in support of our mission to help
our authors enhance the reproducibility of their work.”
H. Murray. Publishing Editor, F1000Research
Collaboration:
Harmonize journals and publishers’ data deposition guidelines
by defining a common set of criteria for repository selection
Document being approved internally by publishers; out before / to be presented at RDA 14th Plenary, Helsinki
Criteria include:
• Access conditions
• Reuse condition
• Deposition conditions
• Unique ID schema
• User support
• Curation
• …….
Increase the number and the clarity of journals and funders
data policies by classifying the recommendations these policies contain
to improve their definition and guidance to researchers
Collaboration:
Workplan – phase 1:
Curate and assess their compliance to the Transparency and Openness Promotion
(TOP) guidelines and display the level in FAIRsharing
http://researchonresearch.org
https://www.turing.ac.uk/research/impact-stories/changing-culture-data-science
http://www.ukrn.org
The road to FAIRness
Credit to:
Robert Hanisch
Before FAIR
The road to FAIRness
Credit to:
Robert Hanisch
Before FAIR
After FAIR
The road to FAIRness
Credit to:
Robert Hanisch
Before FAIR
After FAIR
Congested and chaotic
infrastructures
standards
tools
policies
education
training
cultural normalization
incentives
long term investment
It is hard work but any FAIRy tale needs some magic….
New
member
starting Jan
2020
sansonegroup.eng.ox.ac.uk
and our collaborators

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Behind the FAIR brand: Thinkers, Doers and Dreamers

  • 1. Behind the FAIR Brand: Thinkers, Doers and Dreamers Susanna-Assunta Sansone ORCiD: 0000-0001-5306-5690 | Twitter: @SusannaASansone Beilstein Open Science 2019 Symposium, 15 -17 October 2019 Slides: https://www.slideshare.net/SusannaSansone sansonegroup.eng.ox.ac.uk Associate Professor, Engineering Science Associate Director, Oxford e-Research Centre Principal Investigator and Group Leader
  • 2. A set of principles to enhance the value of all digital resources 2014 2016 Developed and endorsed by researchers, service providers, publishers, funding agencies, industry partners
  • 3. And the FAIR brand is born
  • 5. Everybody needs data that are • Discoverable by humans and machines • Retrievable and structured in standard format(s) • Self-described so that third parties can make sense of it Better data = better science and more efficiently Datasets SOPs Figures, Photos Workflows Slides Codes Tools DatabasesAlgorithmsDocument
  • 6. • A crisis in confidence in research integrity in certain fields • Human-machine collaboration will be crucial to our future • Data-relates mandates and policies by funders • The changing world of scholarly publishing • The need for recognition and credit Driving factors Datasets SOPs Figures, Photos Workflows Slides Codes Tools DatabasesAlgorithmsDocument
  • 7. Depends upon several stakeholders in the research ecosystem actively playing their parts • to deliver research infrastructures, tools and standards, policies, education and training • to overcome technical, social and cultural challenges It is not simple and it requires long term investment Making FAIR a reality
  • 8. My fair share of the work
  • 9. €3.3 billion programme 2014 - 2020 €300 million programme 2018 - 2020 European intergovernmental organisation 23 member countries and over 180 research organisations Since 2014 1 2 3 Started in 2019 FAIR-enabling EU and USA biomedical infrastructure programmes and projects, e.g. Since in 2014, several programs: 2014-2017 2017-2018
  • 10. Organization and structure • Hub and (national) Nodes • Community-driven and rooted • Strong focus on interoperability • SMEs and Industry links • Cross-nodes funded activities
  • 11. model and related formats Initiated in 2003 Open source tools and formats to help researchers to: describe multi-modal experiments follow community-developed standards curate, analyze, release, share and publish
  • 12. Nowadays ISA (format and/or tools) powers over 30 public resources, e.g., The ‘curse’ of success: • Time and (lack of) funds for: - Maintenance - Extensions - Community coordination/training • Not just about the software - data curation know-how
  • 13.
  • 14. Funded by Part of the ISA-InterMine project Reproducibility – FAIR at the first mile From curated, structured metadata to data paper datascriptor.org
  • 15. Academics from several ELIXIR Nodes, with Janssen, AstraZeneca, Eli Lilly, GSK, Novartis, Bayer, Boehringer Ingelheim Define, document and implement a data FAIRification process:
  • 17. Human capital maximization • Work in squads cross-cutting working packages and partners • Address questions/issues, rather then perform technical duties • Prioritization of the work based on pharma's needs • Three months sprint cycles FAIRcookbook
  • 18. Rocca-Serra and Sansone: 10.5281/zenodo.3274256 Scientific Data (accepted) Practical examples: data FAIRifications recipes FAIRcookbook
  • 19. 1 2014-2017 12 centres of excellence 2 2017-2018 3 Started in 2019 10 multi-PIs teams, forming one consortium around 3 data types/databases A consortium of 6 teams
  • 20. 1 12 centres of excellence 2 3 10 multi-PIs teams, forming one consortium around 3 data types/databases A consortium of 6 teams 2014-2017 2017-2018 Started in 2019
  • 21. 1 12 centres of excellence 2 3 10 multi-PIs teams, forming one consortium around 3 data types/databases A consortium of 6 teams 2014-2017 2017-2018 Started in 2019
  • 22. 1 12 centres of excellence 2 3 10 multi-PIs teams, forming one consortium around 3 data types/databases A consortium of 6 teams 2014-2017 2017-2018 Started in 2019
  • 23. 1 Building on previous work • Learn from positive and negative outcomes • Assessment of what did not work well and why • NIH centres/officers playing an active role • Evolving understanding of what a FAIR Data Commons is 12 centres of excellence 2 3 10 multi-PIs teams, forming one consortium around 3 data types/databases A consortium of 6 teams 2014-2017 2017-2018 Started in 2019
  • 24. Data for machines – Use of data at scale Findable Accessible Interoperable Reusable • Globally unique, resolvable, and persistent identifiers § To retrieve and connect data • Community defined descriptive metadata § To enhance discoverability • Common terminologies § To use the same term mean the same thing • Detailed provenance § To contextualize the data and facilitate reproducibility • Terms of access § Open as possible, closed as necessary • Terms of use § Clear licences, ideally to enable innovation and reuse
  • 26. Formats Terminologies Guidelines Identifiers ID Conceptual model, conceptual schema, exchange formats Controlled vocabularies, thesauri, ontologies Minimum information reporting requirements, checklists Unambiguous, persistent and context-independent identifier schema Standards for metadata and identifiers metadata
  • 27. 390+ 162+ 729+ ~1300 13 MIAME MIRIAM MIQAS MIX MIGEN ARRIVE MIAPE MIASE MIQE MISFISHIE …. REMARK CONSORT SRAxml SOFT FASTA DICOM MzML SBRML SEDML … GELML ISA CML MITAB … AAO CHEBIOBI PATO ENVO MOD BTO IDO … TEDDY PRO XAO DO VO EC number URL PURLLSID HandleORCID RRID InChI … IVOA ID DOI standard organizations grass-roots groups Formats Terminologies Guidelines Identifiers ID COMMUNITY STANDARDS for metadata and identifiers Domain-specific standards for datasets, e.g.
  • 28. https://doi.org/10.6084/m9.figshare.3795816.v2 https://doi.org/10.6084/m9.figshare.4055496.v1 2013 2016 Analysis of the standards landscape Fragmentation, duplication and gaps: • Perspective and focus vary: • Motivation is diverse • Governance and participation vary
  • 31. Formats Terminologies Guidelines Identifiers ID REPOSITORIES, databases and knowledgebases DATA POLICIES by journals, funders, and other organizations COMMUNITY STANDARDS for metadata and identifiers informative and educational resource Curated inter-linked descriptions
  • 32. Formats Terminologies Guidelines Identifiers ID informative and educational resource Curated inter-linked descriptions All records are manually curated in-house, verified and claimed by the community behind each resource Ready for use, implementation, or recommendation In development Status uncertain Deprecated as subsumed or superseded REPOSITORIES, databases and knowledgebases DATA POLICIES by journals, funders, and other organizations COMMUNITY STANDARDS for metadata and identifiers
  • 33. Formats Terminologies Guidelines Identifiers ID REPOSITORIES, databases and knowledgebases DATA POLICIES by journals, funders, and other organizations COMMUNITY STANDARDS for metadata and identifiers informative and educational resource Curated inter-linked descriptions We guide consumers to discover, select and use these resources with confidence We help producers to make their resources more visible, more widely adopted and cited
  • 34.
  • 35.
  • 36. Researchers in academia, industry, government Developers and curators of resources Journal publishers or organizations with data policy Research data facilitators, librarians, trainers Learned societies, unions and associations Funders and data policy makers A flagship output (and a WG) of the: Recommended by funders, e.g.: Core part of implementation networks in:
  • 37. https://doi.org/10.1038/s41587-019-0080-8 Open Access CC-BY 69 authors (adopters, collaborators, users) representing different stakeholder groups Analysed the data policies by journals/publishers, and the standards and repositories they recommend Working with journal editors and publishers
  • 38. Discrepancy in recommendation across the data policies • some repositories are named, but very few standards are • cautious approach due to the wealth of existing resources Recommendations are often driven by • the editor’s familiarity with one or more standards, notably for journals or publishers focusing on specific disciplines • the engagement with learned societies and researchers actively supporting and using certain resources Ø Consensus: FAIRsharing plays a key role in helping editors to discover and recommend appropriate resources What have we learned and are doing now
  • 39. “The interactive browser will allow us to discover which databases and standards are not currently included in our author guidelines, enabling us to regularly monitor and refine our policies as appropriate, in support of our mission to help our authors enhance the reproducibility of their work.” H. Murray. Publishing Editor, F1000Research
  • 40. Collaboration: Harmonize journals and publishers’ data deposition guidelines by defining a common set of criteria for repository selection Document being approved internally by publishers; out before / to be presented at RDA 14th Plenary, Helsinki Criteria include: • Access conditions • Reuse condition • Deposition conditions • Unique ID schema • User support • Curation • …….
  • 41. Increase the number and the clarity of journals and funders data policies by classifying the recommendations these policies contain to improve their definition and guidance to researchers Collaboration: Workplan – phase 1: Curate and assess their compliance to the Transparency and Openness Promotion (TOP) guidelines and display the level in FAIRsharing
  • 43. The road to FAIRness Credit to: Robert Hanisch Before FAIR
  • 44. The road to FAIRness Credit to: Robert Hanisch Before FAIR After FAIR
  • 45. The road to FAIRness Credit to: Robert Hanisch Before FAIR After FAIR Congested and chaotic
  • 46. infrastructures standards tools policies education training cultural normalization incentives long term investment It is hard work but any FAIRy tale needs some magic….