E-QUESTION BANK ON COGNOSY. MULTIPLE CHOICE QUESTION, B. PHARM SYLLABUS

1. 1. Stas-otta process is used for extraction of :
a) Glycosides b) Alkaloids
c) Terpenoids d) Resins
Ans : a
2. Senna mainly contains :
a) O-glycosides b) N-glycosides
c) C-glycosides d) S-glycosides
Ans : a
3. Senna leaf if under the class of glycoside :
a) Cardiac b) Cyanogenic
c) Anthracene d) Saponin
Ans : c
4. Which drug is under the chemical class of cyanogentic glycoside?
a) Bitter almond b) Black mustard
c) Digitalis d) Rhubarb
Ans :a.
5. Drug under the class of isothiocyanate glycosides :
a) Black mustard b) Senega
c) Thevetia d) Aloe
Ans : a
6. Drug is not under the class of cardiac glycoside :
a) digitalis b) Thevetia
c) Indian squill d) Bitter almond
Ans : d
7. The drug showing cardio tonic activity:
a) Thevetia b) Cochineal
c) Rhubarb d) Aloe
Ans : a
8. Which drug is used as diuretic?
a) Quillaia b) Senega
c) Ginseng d) Gokhru
Ans : d
9. The drug used as nerve tonic :
a) Brahmi b) Mordica
c) Ginseng d) Senega
Ans: a
10. The family of Gokhru :
a) Liliaceae b) Cucurbitaceae
c) Zygophyllaceae d) Araliaceae
Ans: c

2. 11. Borntrager test is used for one of the following drugs:
a) Senna b) Aloe
c) Digitalis d) Stropanthus
Ans: a
12. In kiung’s isobarbaloin test, Curacao aloes shows colour :
a) Yellow b) Blue
c) Wine red d) Green
Ans: c
13. Alcoholic extract of aloe under UV light gives colour:
a) Blue b) Red
c) Deep brown d) Pink
Ans: c
14. The substitute for aloes :
a) Cape aloes b) Socotrine aloes
c) Curacao aloes d) Natal aloes
Ans: d
15. The biological source for cape aloes :
a) Curacao aloes b) Socotrine aloes
c) Aloe ferrox d) Zanziber aloes
Ans : c
16. Saponin glycoside shows one of the following property:
a) Laxative b) Anticonvulsant
c) Foaming d) Astringent
Ans: c
17. Out of the following, one is not the example of Cardinolide:
a) Digitoxin b) Digoxin
c) Gitoxigenin d) Scillarin A
Ans : d
18. The biological source for Dioscoria:
a) dioscoria deltoid b) dioscoria floribunda
c) dioscoria villosa d) Dioscorea compositae
Ans : a
19. Yam is the synonym of the drug:
a) Stropanthus b) Dioscoria
c) Safed musali d) Liquorice
Ans : b
20. Dioscoria is used in the treatment of :
a) Ulcer b) Cancer
c) Rheumatic arthritis d) Kidney stone
Ans : c

3. 21. ______________ Is not the synonym of Liquorice.
a) Glycyrrhiza b) Liquorice root
c) Mulethi d) Yam
Ans : d
22. Liquorice belongs to family :
a) Liliaceae b) Triterpenoid
c) Loganaceae d) Leguminosae
Ans : d
23. Glycyrrhizinic acid on hydrolysis gives :
a) Glycyrrhetic acid b) Glycyrrhizin
c) Liquiritin d) Isoliquiritin
Ans: a
24. Liquorice is used in the treatment of :
a) Conjuctivitis b) Peptic ulcer
c) Allergy d) Skin disease
Ans : b
25. When glycyrrhiza is treated with 80% sulphuric acid, then it shows
colour:
a) Yellow b) Red
c) Green d) Violet
Ans: a
26. Rhubarb is cultivated mainly in which state of India:
a) J and K b) Madhya Pradesh
c) Maharashtra d) Bengal
Ans: a
27. Rhubarb when treated with alkali, shows red colour due to presence of :
a) Anthroquionoe glycoside b) Cardiac glycoside
c) sapogenin glycoside d) Cyanogenic glycoside
Ans: a
28. Keller kiliani test is positive for:
a) Digitoxose b) Gitoxose
c) digitoxigenin d) gitoxigenin
Ans: a
29. Presence of star spots is the characteristic of drug:
a) Cascara b) Senna
c) Aloe d) Rhubarb
Ans: d
30. Modified Borntroger test is positive for drug:
a) Aloe b) Senna
c) Digitalis d) Senna pod

4. Ans: a
31. Botanical source of Arjuna bark:
a) Terminalis tamentosa b) Polygala chinesis
c) Poligala erioptera d) Terminalis arjuna
Ans: d
32. Presence of aleurone grain is the characteristic of the drug:
a) Belladonna b) Nux vomica
c) Hyoscyamus d) Vinca
Ans: b
33. Drug with the presence of plasmodesma:
a) Nux vomica b) Rauwolfia
c) Vinca rosea d) Phsysostigma
Ans: a
34. Digitalis leaves should be dried at temperature below:
a) 20 C b) 30 C
c) 40 C d) 60 C
Ans: d
35. Vein-islet no. is Indian senna is in the range of :
a) 10.5 to 12.5 b) 13.5 to 16.5
c) 16.5 to 18.0 d) 19.5 to 22.5
Ans: d
36. Stomatal Index in Indian senna is in the range of:
a) 17 to 20 b) 20 to 23
c) 23 to 26 d) 26 to 29
Ans: a
37. Palisade ratio in Alexandrian senna is :
a) 7 b) 10
c) 13 d) 16
Ans: a
38. Vein- islet no. in Alexandrian senna is in the range of:
a) 10 to 15.5 b) 16 to 20.5
c) 25 to 29.5 d) 20 to 24.5
Ans: c
39. Most potent narcotic antagonist is
a) Nalorphine b) Naltrexone
c) Naloxone d) Levorphanol
Ans: b
40. Which of the followings is a phenathrene derivative?
a) Fentanyl b) Morhine
c) Methadone d) Pentazocine

5. Ans: b
41. Which of the followings opioid analgesics is a strong mu recepator agonist ?
a) Pentazocine b) Naloxone
c) Buprenorphine d) Morphine
Ans: d
42. Which one Is the pure opioid antagonist among the followings ?
a) Nalorphine b) Nalbuphine
c) Naloxone d) Levallorphan
Ans: c
43. The drug naloxone
a) Produces morphine like activity b) Produces respiratory depression
c) Induces constipation d) Precipitates withdrawal systoms in morphine addicts
Ans: a
44. Which of the followings opioids analgesics is used in obstetric labor?
a) Fentanyl b) Pentazocine
c) Meperidine d) Buprenorphine
Ans: c
45. Which of the followings NSAIDs is a selective COX-2 inhibator ?
a) Diclofenac b) Celecoxib
c) Indomethacin d) Piroxicam
Ans: b
46. NSAID primarily promotes as an analgesic, not as an anti-inflammatory agent
a) Naproxen b) Ibuprofen
c) Ketorolac d) Piroxicam
Ans: c
47. Most of non-narcotic analgesic have
a) Anti-inflammatory effect b) Analgesiceffect
c) Antipyretic effect d) All of the above
Ans: d
48. Which of the followings ring is presenrt is sulindac ?
a) Indol b) Indene
c) Isoxazole d) Furan
Ans: b
49. Non-narcotic analgesic are all of the followings drugs EXPECT
a) Parecetamol b) Acetylsalicylic acid
c) Butorphanol d) Ketorolac
Ans: c
50. Non-narcotic analgesic are maninaly effective against pain associated with
a) Inflammation or tissue damage b) Trauma
c) Myocardial infarction d) Surgery

6. Ans: a
51. Ibuprofen is a
a) 2-(4-propylphenyl)propionic acid b) 2-(4-isobytylphenyl)propionic acid
c) 2-(4-ethylphenyl)propionic acid d) 2-(4-hexylphenyl)propionic acid
Ans: b
52. Which of the followings Sympathomimetics acts indirectly
a) Epinephrine b) NE
c) Ephedrine d) Methoxamine
Ans: c
53. Chemically alpha methyldopa is
a) 2-methyl-3 hydroxy-2-tyrosine b) 6-methyl-4 hydroxy-2-tyrosine
c) 3-methyl-2 hydroxy-2-tyrosine d) 3-hydroxy-α-methyl-2-tyrosine
Ans: d
54. DOPA is an important natural amino acid and precursor in the biosynthesis of
a) Nor-adrenaline b) Adrenaline
c) Methyldopa d) Dopamine
Ans: a
55. Catecholamine includes ther followings EXPECT
a) Norepinephrine b) Ephedrine
c) Isoproternol d) Epinephrine
Ans: b
56. Aromatic nucleus present in Propranolol
a) Naphthalene b) Benzene
c) Anthracene d) Pyridine
Ans: a
57. Propranolol is uded In the tretement all of the followings disease EXPECT
a) CVS disease b) Hyperthyroidism
c) Migraine d) Broncial asthma
Ans: d
58. β1 receptor stimulationm includes all of the followings effect EXPECT
a) Increase in heart ncontractility b) Bronchodilation
c) Tachycardia d) Increase in conduction velocity in the atrioventricular node
Ans: b
59. Salbutamol is synthesized from
a) Phenyl acetonitrile b) 4-Hydroxy propiophenone
c) Methyl salicylate d) Mesitylene derivative
Ans: c
60. Indicate the location of M2 cholinorecepator type
a) Heart b) Gland
c) Smooth muscle d) Endothelium

7. Ans: a
61. Atropine contains
a) One asymmetric carbon b) Three asymmetric carbon
c) Two asymmetric carbon d) Four asymmetric carbon
Ans: b
62. Acetylcholine is not used in clinical practice beacause
a) It is very toxic b) The doses require are very high
c) it is very rapidly hydrolysed d) it is very costly
Ans: c
63. Muscarine recepoator are located as
a) Autonomic ganglia b) Skeletal muscle neuromuscular junction
c) Autonomic effector cells d) Sensory carotid sinus baroreceptor zone
Ans: c
64. Indicate a reversible cholinsterase inhibator
a) Isoflurophate b) Carbacol
c) Physostigamine d) Parathion
Ans: c
65. What is often the first symptom of Parkinson disease
a) Headache b) Nausea
c) Shaking of a hand or foot d) Turning of the head
Ans: c
66. How is Parkinson disease treated?
a) Medicine b) Surgery
c) Radiation d) a and b
Ans: d
67. Which of the following beta-blockers is beta-1 selective with vasodilatation?
a) Propanolol b) Carvedilol
c) Nebivolol d) Atenolol
Ans: c
68. Which medication should be prescribe to all anginal patient to treat a acute attack ?
a) Isosorbide dinitrile b) Nitroglycerin
c) Nifidepine d) Parecetamol
Ans: b
69. Which of the followings precessor of nitroglycrine synthesis ?
a) Glycerol b) Glycol
c) Glucose d) Gluctiol
Ans: a
70. The calcium channel blocker belongs to diphenyl alkylamine category is
a) Diltizepam b) Verapamil

8. c) Bepridil d) Nitrendipine
Ans: b
71. The calcium channel blocker nifedipine is derivative of
a) Diaminopropranol ether b) Diphenyl alkylamine
c) Benzothiazepine d) Dihydropyridine
Ans: d
72. Which of the followings drugs is used in the tretement for the treatement of Glaucoma
a) Timolol b) Atenolol
c) Propranolol d) None of theses
Ans: a
73. Which of the followings drugs is ACE inhibitor
a) Timolol b) Losartan
c) Gaunabenz d) Lisinorpril
Ans: d
74. Heterocycles present in strcture of timolol is ?
a) Morpholin and thiadiazole b) Thiadiazole and pyrrazole
c) Morpholin and oxadiazole d) Oxadiazole and piperdine
Ans: a
75. Ther followings substance are considered to be a related to as an Eicosanoids
a) Prostaglandins b) Leukotrienes
c) Thromboxanes d) All of above
Ans: d
76. True about prostacycline
a) Vasoconstriction b) Aggregation of Platelets
c) Decrease BP d) Synthesis from vascular endothelium
Ans: c
77. QSAR study of Medicinal chemisrty Q stand for
a) Qualitative b) Quantitative
c) Both d) Quantum
Ans: b
78. Which of the following statements best describes a lead compound?
a) A compound that contains the element lead.
b) A compound from the research laboratory that is chosen to go forward for preclinical
and clinical trials
c) A molecule that shows some activity or property of interest and serves as the
starting point for the development of a drug
d) The first compound of a structural class of compounds to reach the marke
Ans: c
79. How many people will be selected for phase I trial?
a) The whole market will be under surveillance b) 300-3000 people
c) 20-300 people d) 20-50 people

9. Ans: d
80. In which of the followings phase of clinical trials healthy normal human volunteers
participate
a) Phase I b) Phase II
c) Phase III d) Phase IV
Ans: a
81. Meaning of P in QSAR equation stands for ____.
a) Permeability b) Partition coefficient
c) Porosity d) Purity
Ans: b
82. QSAR stands for
a) Qualitative structure activity relationship b) Quantitative structure action relationship
c) Quantitative structure activity relationship d) Qualitative structure activity relativity
Ans: c
83. Clinical trials are performed on
a) Animals b) Humans
c) Both d) None of the above
Ans: b
84. Combinatorial chemistry or parallel synthesis can be useful at various stages of the drug
design / development process. Which of the following is NOT such a stage?
a) Finding a lead compound
b) Optimising a lead compound
c) structure determination of the lead compound
d) structure-activity relationships of the lead compoun
Ans: c
85. What is the name of the process by which compounds related to a promising compound
are made on a larger scale?
a) Computational chemistry b) Combinational chemistry
c) Lead optimisation d) Improvement
Ans: c
86. Which of the following statements is true?
a) Parallel synthesis involves the synthesis of a large number of compounds using the same
reaction sequence, where there is a mixture of compounds in each reaction vessel.
b) Parallel synthesis involves the synthesis of a large number of compounds using the
same reaction sequence, where there is a different, single compound formed in each
reaction vessel.
c) Combinatorial synthesis involves the synthesis of a large number of compounds using a
variety of different synthetic routes to produce a mixture of compounds in each reaction
vessel.
d) A parallel synthesis carried out in a specified number of vessels will produce more
compounds than a combinatorial synthesis.
Ans: b

10. 87. Structure which is used as the starting point for drugs design and development
a) Active Compunds b) Pharmacophore
c) Lead compound d) Orphagn drug
Ans: c
88. Indicate cholinestrease activator.
a) Pralidoxime b) Edrophonium
c) Pilocrapine d) Isofluorophate
Ans: a
89. The meachinsm of atropine action is
a) Competitive ganglion blockade b) Competitive muscarinic blockade
c) Competitive Neuromuscular blockade d) Non- Competitive Neuromuscular blockade
Ans: b
90. Parasympathomimetic drugs causes
a) Bronchodilation b) Mydriasis
c) Bradycardia d) Constipation
Ans: c
91.Most widely drug used for motion sickness is
a) Atropine b) Hyoscyamine
c) Hyoscine d) None of these
Ans: c
92. Which of the followings alpha -2- adrenorecetor agonist used in treatement of
Hypertension
a) Clonidine b) Methyldopa
c) Both a & b d) None of above
Ans: c
93. Which of the followings is also used in the management of cyanide poisoning ?
a) isosorbide dinitrate b) Amyl nitrate
c) Nitroglycerin d) isosorbide mononitrate
Ans: b
94. In klung’s isobarbaloin test, Socotrine and Zanziber aloes show colour:
a) Red b) Faint yellow
c) Green d) No colouration
Ans: d
95. Shatavari is under the chemical class of glycoside:
a) Sterol b) Saponin
c) Cyanogentic d) Isothiocyanate
Ans : b