1. Case Number: 69
A Case of Canine Glaucoma
Permission granted only for viewing on SEVPAC website
1Stephanie Shrader, 1Jennifer (Jey) Koehler, 2Roxanne Rodriguez, 2Phillip Moore
1Department of Pathobiology and 2Department of Clinical Sciences
Auburn University, College of Veterinary Medicine (AUCVM)

2.  4-year-old, castrated male, Labrador retriever mix
 One-week history of blepharospasm (OD)
 Intraocular pressure (IOP): 50-mmHg
 Normal: 12-mmHg to 25-mmHg
 Placed on triple antibiotic ophthalmic ointment and
referred to the AUCVM
SIGNALMENT AND HISTORY
Permission granted only for viewing on SEVPAC website

3.  Right eye: blepharospasm, buphthalmia, aqueous
flare, corneal edema, posterior synechiae, vascular
attenuation, cupped optic disc, IOP of 47-mmHg
 Left eye: reportedly unremarkable
 CBC and chemistry values: WNL
 Treated with latanoprost and dorzolamide
(decrease IOP) and tramadol (pain relief)
Owners opted for enucleation of the right globe
OPHTHALMIC EXAMINATION
Permission granted only for viewing on SEVPAC website

4. CORNEAL EDEMA
100-um
Permission granted only for viewing on SEVPAC website
20-um
H&E
H&E

5. CLOSED IRIDOCORNEAL ANGLE
Permission granted only for viewing on SEVPAC website
100-um
500-um
H&E
H&E

6. POSTERIOR SYNECHIAE
Permission granted only for viewing on SEVPAC website
100-um
20-um
H&E
H&E

7. Permission granted only for viewing on SEVPAC website
20-um
RETINAL DEGENERATION
Nerve fiber layer
Inner plexiform layer
Inner nuclear layer
Outer plexiform layer
Outer nuclear layer
Rods and conesH&E
H&E H&E
20-um
20-um

8. Right globe: Lymphohistiocytic endophthalmitis,
multifocal, scant, subacute with iridocorneal
angle closure, posterior synechiae, retinal
degeneration and atrophy, and corneal stromal
edema
MORPHOLOGIC DIAGNOSIS
Permission granted only for viewing on SEVPAC website

9. http://blogs.edweek.org/edweek/the_startup_blog/2014/02/but_wait_theres_more_building_a_solution_to_users_actual_problems_edthena.html
Permission granted only for viewing on SEVPAC website

10. DESCEMET’S MEMBRANE
Permission granted only for viewing on SEVPAC website
20-um
H&E PAS

11. Right globe: Goniodysgenesis with minimal
lymphohistiocytic endophthalmitis, iridocorneal
angle closure, posterior synechiae, retinal
degeneration and atrophy, and corneal stromal
edema
FINAL
MORPHOLOGIC DIAGNOSIS
Permission granted only for viewing on SEVPAC website

12.  Congenital anomaly of the iridocorneal angle
 Abnormal intraocular fluid egress1
 Risk factor for development of primary glaucoma
 Associated with abnormal development of:
 Pectinate ligament
 Trabecular meshwork
 Ciliary cleft
 Absence of concurrent ocular or systemic disease2
GONIODYSGENESIS
Permission granted only for viewing on SEVPAC website

13.  Hallmark histologic feature:
 Solid sheet of iridal tissue extending to the distorted
terminus of Descemet’s membrane3
 Although congenital, clinical signs in dogs manifest
at 4-8 years of age4,5
 Following diagnosis in one eye, the contralateral
eye may also develop glaucoma
 Clinical course can range from days to years
GONIODYSGENESIS
Permission granted only for viewing on SEVPAC website

14. 1. R. Sampaolesi, et al. Goniodysgenesis or Late Congenital Glaucoma.
Pigmentary Glaucoma. In: The Glaucomas. Vol. 1, Pediatric
Glaucomas. Berlin: Springer. 311-66. 2009.
2. "Read-Only Case Details Reviewed: May 2012." The Joint Pathology
Center, n.d. Web. 14 Apr. 2015.
<http://www.askjpc.org/vspo/show_page.php?id=713>.
3. R. Dubielzig, et al. Veterinary Ocular Pathology: A Comparative
Review. Edinburgh: Saunders/Elsevier. 45-46. 2010.
4. K Gelatt. The canine glaucomas. In: Veterinary Ophthalmology, 3rd
Ed. (ed. Gelatt KN) Lea & Febiger, Philadelphia, 701–754. 1999.
5. C Reilly, et al. Canine goniodysgenesis-related glaucoma: a
morphologic review of 100 cases looking at inflammation and pigment
dispersion. Veterinary Ophthalmology. 9(6):253-254. 2006.
REFERENCES
Permission granted only for viewing on SEVPAC website

15. QUESTIONS??
http://galleryhip.com/tumblr-brown-eyes-collage.html
Permission granted only for viewing on SEVPAC website